DNAJA1

This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

Description

DnaJ heat shock protein family (Hsp40) member A1

Tissue specificity

Low tissue specificity

Subcell location

Microtubules, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (33025273 - 33039907)

Ensembl ID

ENSG00000086061  (ver. 103.38)

Orthologs

Mouse Dnaja1: ENSMUSG00000028410

UniProt

P31689

neXtProt

NX_P31689

Human splice variants
Mouse splice variants

Protein structure