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LearnTissue expression
Cell line expression
Protein structure
CTTN
CortactinEMS1
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Top validated antibodies |
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| Proteintech Group |  11381-1-AP |
4 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | 11381-1-AP |
Polyclonal |
WB
ICC
IP
IHC
FC
OA
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| NovoPro Bioscience Inc. | 109478 |
Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Wuhan Fine Biotech Co., Ltd. | FNab01886 |
Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Novus Biologicals | NBP2-67632 |
Monoclonal |
WB
ICC
IP
IHC
FC
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