VPS35

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

Description

vacuolar protein sorting 35 homolog (S. cerevisiae)

Protein family

Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

16:q11.2 (46690054 - 46723430)

Ensembl ID

ENSG00000069329  (ver. 71.37)

Orthologs

Mouse Vps35: ENSMUSG00000031696

Human splice variants
Mouse splice variants