BCL10

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

Description

B-cell CLL/lymphoma 10

Protein family

-

Chromosome

1:p22.3 (85731931 - 85743771)

Ensembl ID

ENSG00000142867  (ver. 69.37)

Orthologs

Mouse Bcl10: ENSMUSG00000028191

Human splice variants
Mouse splice variants