12075-1-AP

antibody from Proteintech Group

Targeting: PYGB

Provider product page for 12075-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [22]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 12075-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12075-1-AP, RRID:AB_2174885
Product name: PYGB antibody
Antibody type: Polyclonal
Description: KD/KO validated PYGB antibody (Cat. #12075-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PYGB protein structure - 12075-1-AP shown in red.

Submitted references Epm2b(P71A) and Epm2b(D148N) knock-in mouse models of Lafora disease exhibit distinct and pronounced neurological alterations.

Iglesias-Cabeza N, Zafra-Puerta L, Worby CA, Fernández-Burgos D, Sciaccaluga M, Imperatore V, Fermont L, Sánchez-Martín G, Sharmistha M, Gentry MS, Costa C, Serratosa JM, Sánchez MP
Progress in neurobiology 2026 Apr 3;261:102912

ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysis.

Raza M, Rajan AR, Kennedy BB, Reznicek TE, Oruji F, Mirza S, Rowley MJ, Stephan C, Kristiansen G, Datta K, Mohapatra BC, Band H, Band V
Oncogene 2025 Nov;44(42):4058-4074

Glycogen drives tumour initiation and progression in lung adenocarcinoma.

Clarke HA, Hawkinson TR, Shedlock CJ, Medina T, Ribas RA, Wu L, Liu Z, Ma X, Xia Y, Huang Y, He X, Chang JE, Young LEA, Juras JA, Buoncristiani MD, James AN, Rushin A, Merritt ME, Mestas A, Lamb JF, Manauis EC, Austin GL, Chen L, Singh PK, Bian J, Vander Kooi CW, Evers BM, Brainson CF, Allison DB, Gentry MS, Sun RC
Nature metabolism 2025 May;7(5):952-965

Hyper-Glycosylation as a Central Metabolic Driver of Alzheimer's Disease.

Hawkinson TR, Liu Z, Ribas RA, Medina T, Nielsen RS, Clarke HA, Ma X, Mueller AC, Plasencia AF, Shear AL, Simpson ST, Soto CM, Sudderth J, Cai F, Cantrell AR, Colpert MG, Shedlock CJ, Wu L, Young LEA, Kooser DD, Chen L, Ryan AM, Ribas RA, Azadi P, Deberardinis RJ, Prokop S, Allison D, Huang Y, He X, Bian J, Vander Kooi CW, Gentry MS, Sun RC
bioRxiv : the preprint server for biology 2025 May 5;

Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8(+) memory T cells.

Zhou Y, Zhang C, He L, Kang Y, Wang D, Wang S, Ling Z, Chen J, Zhou N, Zhou L, Wang Z, Zhang C, Tang K, Zhang H, Ma J, Qin B, Cui S, Lv J, Huang B
Molecular cell 2025 Jul 3;85(13):2535-2549.e10

Glycogenolysis-Induced Astrocytic Serping1 Expression Regulates Neuroinflammatory Effects on Hippocampal neuron.

Ishiyama M, Gotoh H, Oe S, Nomura T, Kitada M, Ono K
Molecular neurobiology 2025 Feb;62(2):1373-1387

Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression.

Pan Y, Zhou Y, Shen Y, Xu L, Liu H, Zhang N, Huang T, Meng K, Liu Y, Wang L, Bai G, Chen Q, Zhu Y, Zou X, Wang S, Wang Z, Wang L
Cancer research 2024 Nov 15;84(22):3803-3817

PYGB targeted by androgen receptor contributes to tumor progression and metabolic reprogramming in esophageal squamous carcinoma.

Miao H, Xu C, Gao W, Zhong L, Li H, Wen Z, Ren Q, Chen Y
Cellular signalling 2024 Dec;124:111481

PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer.

Ji Q, Li H, Cai Z, Yuan X, Pu X, Huang Y, Fu S, Chu L, Jiang C, Xue J, Zhang X, Li R
International journal of biological sciences 2023;19(6):1894-1909

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.

Hsu YH, Pintacuda G, Liu R, Nacu E, Kim A, Tsafou K, Petrossian N, Crotty W, Suh JM, Riseman J, Martin JM, Biagini JC, Mena D, Ching JKT, Malolepsza E, Li T, Singh T, Ge T, Egri SB, Tanenbaum B, Stanclift CR, Apffel AM, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Carr SA, Schenone M, Jaffe J, Fornelos N, Huang H, Eggan KC, Lage K
iScience 2023 May 19;26(5):106701

Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts.

Gerou M, Hall B, Woof R, Allsop J, Kolb SJ, Meyer K, Shaw PJ, Allen SP
Neurobiology of aging 2021 Sep;105:64-77

Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma.

Xie H, Song J, Godfrey J, Riscal R, Skuli N, Nissim I, Simon MC
Nature metabolism 2021 Mar;3(3):327-336

Glycogen Phosphorylase B Is Regulated by miR101-3p and Promotes Hepatocellular Carcinoma Tumorigenesis.

Cui G, Wang H, Liu W, Xing J, Song W, Zeng Z, Liu L, Wang H, Wang X, Luo H, Leng X, Shen S
Frontiers in cell and developmental biology 2020;8:566494

The different expression of glycogen phosphorylases in renal clear cell renal carcinoma and chromophobe renal carcinoma.

Lu Y, Luo G, Zhu S, Wang X, Chen Y, Dong Z, Wang S, Ma J, Deng H, Wu D, Dong J
Clinical proteomics 2020;17:7

Decreased Glycogenolysis by miR-338-3p Promotes Regional Glycogen Accumulation Within the Spinal Cord of Amyotrophic Lateral Sclerosis Mice.

Li C, Wei Q, Gu X, Chen Y, Chen X, Cao B, Ou R, Shang H
Frontiers in molecular neuroscience 2019;12:114

Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3p.

Zhou Y, Jin Z, Wang C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109449

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Allen SP, Hall B, Woof R, Francis L, Gatto N, Shaw AC, Myszczynska M, Hemingway J, Coldicott I, Willcock A, Job L, Hughes RM, Boschian C, Bayatti N, Heath PR, Bandmann O, Mortiboys H, Ferraiuolo L, Shaw PJ
Brain : a journal of neurology 2019 Dec 1;142(12):3771-3790

Multiomics Integration Reveals the Landscape of Prometastasis Metabolism in Hepatocellular Carcinoma.

Li Y, Zhuang H, Zhang X, Li Y, Liu Y, Yi X, Qin G, Wei W, Chen R
Molecular & cellular proteomics : MCP 2018 Apr;17(4):607-618

The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer.

Rahman SMJ, Ji X, Zimmerman LJ, Li M, Harris BK, Hoeksema MD, Trenary IA, Zou Y, Qian J, Slebos RJ, Beane J, Spira A, Shyr Y, Eisenberg R, Liebler DC, Young JD, Massion PP
JCI insight 2016 Nov 17;1(19):e88814

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory.

Tadi M, Allaman I, Lengacher S, Grenningloh G, Magistretti PJ
PloS one 2015;10(10):e0141568

Transient down-regulation and restoration of glycogen synthase levels in axotomized rat facial motoneurons.

Takezawa Y, Kohsaka S, Nakajima K
Brain research 2014 Oct 24;1586:34-45

Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.

Xi L, Zhu SG, Hobbs DC, Kukreja RC
Journal of cellular and molecular medicine 2011 Nov;15(11):2512-24

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PYGB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PYGB. This antibody recognizes human, mouse, rat antigen. The PYGB antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 12075-1-AP.pdf

: Show more