25343-1-AP

antibody from Proteintech Group

Targeting: AGTR1 AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R

Provider product page for 25343-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [54]
Comments [0]
Validations
Immunohistochemistry [2]

Submit

Product number: 25343-1-AP - Provider product page
Provider: Proteintech Group
Product name: AGTR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated AGTR1 antibody (Cat. #25343-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AGTR1 protein structure - 25343-1-AP shown in red.

Submitted references Eugenol Inhibits Ox-LDL-Induced Proliferation and Migration of Human Vascular Smooth Muscle Cells by Inhibiting the Ang II/MFG-E8/MCP-1 Signaling Cascade.

He JH, Li XJ, Wang SP, Guo X, Chu HX, Xu HC, Wang YS
Journal of inflammation research 2024;17:641-653

Preclinical evaluation of AGTR1-Targeting molecular probe for colorectal cancer imaging in orthotopic and liver metastasis mouse models.

Zhou K, Li G, Pan R, Xin S, Wen W, Wang H, Luo C, Han RPS, Gu Y, Tu Y
European journal of medicinal chemistry 2024 May 5;271:116452

Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development.

Wu HF, Saito-Diaz K, Huang CW, McAlpine JL, Seo DE, Magruder DS, Ishan M, Bergeron HC, Delaney WH, Santori FR, Krishnaswamy S, Hart GW, Chen YW, Hogan RJ, Liu HX, Ivanova NB, Zeltner N
Cell stem cell 2024 May 2;31(5):734-753.e8

Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.

Zhou L, Chen S, Wei Y, Sun Y, Yang Y, Lin B, Li Y, Wang C
European journal of pharmacology 2024 Mar 15;967:176365

Angiotensin II type 2 receptor agonist attenuates LPS-induced acute lung injury through modulating THP-1-derived macrophage reprogramming.

Chen L, Gong P, Su Y, Meng L, Wang M, Gao W, Liu Q
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jan;397(1):99-108

Hyperoxia-induced airflow restriction and Renin-Angiotensin System expression in a bronchopulmonary dysplasia mouse model.

Dowell J, Bice Z, Yan K, Konduri GG
Physiological reports 2024 Jan;12(1):e15895

Anti-hypertension effect of Wuwei Jiangya decoction via ACE2/Ang1-7/MAS signaling pathway in SHR based on network degree-distribution analysis.

Wang P, Hao D, Xiong X
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117121

Panax notoginseng saponin alleviates pulmonary fibrosis in rats by modulating the renin-angiotensin system.

Li H, Wang YG, Chen TF, Gao YH, Song L, Yang YF, Gao Y, Huo W, Zhang GP
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116979

Myeloid ACE2 protects against septic hypotension and vascular dysfunction through Ang-(1-7)-Mas-mediated macrophage polarization.

Li JX, Xiao X, Teng F, Li HH
Redox biology 2024 Feb;69:103004

High Dose of Estrogen Protects the Lungs from Ischemia-Reperfusion Injury by Downregulating the Angiotensin II Signaling Pathway.

Dai P, He J, Wei Y, Xu M, Zhao J, Zhou X, Tang H
Inflammation 2024 Aug;47(4):1248-1261

Valsartan Attenuated Homocysteine-Induced Impaired Autophagy and ER Stress in Human Umbilical Vein Endothelial Cells.

Wu X, Wang A, Xu L, Li M, Zhai Q, Wang W, Li C, Jin L
Cardiovascular therapeutics 2023;2023:8817431

Celastrol attenuates streptozotocin-induced diabetic cardiomyopathy in mice by inhibiting the ACE / Ang II / AGTR1 signaling pathway.

Zhao X, Huang B, Zhang J, Xiang W, Zhu N
Diabetology & metabolic syndrome 2023 Sep 12;15(1):186

XinLi formula, a traditional Chinese decoction, alleviates chronic heart failure via regulating the interaction of AGTR1 and AQP1.

Wei XH, Liu WJ, Jiang W, Lan TH, Pan H, Ma MY, You LZ, Shang HC
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154722

Losartan attenuates acetic acid enema-induced visceral hypersensitivity by inhibiting the ACE1/Ang II/AT1 receptor axis in enteric glial cells.

Sun Y, Liu X, Wang L, Li L, Quan X, Shi H, Wang T, Mei L, Chen Y, Zhang Y, Li J, Meng R, Wang J, Dai F
European journal of pharmacology 2023 May 5;946:175650

Angiotensin receptor blockers retard the progression and fibrosis via inhibiting the viability of (AGTR1+) CAFs in intrahepatic cholangiocarcinoma.

Li JH, Wu X, Ni X, Li YX, Xu L, Hao XY, Zhao W, Zhu XX, Yin XY
Clinical and translational medicine 2023 Mar;13(3):e1213

Effect of Extracellular Matrix Stiffness on Candesartan Efficacy in Anti-Fibrosis and Antioxidation.

Zhu T, Song J, Gao B, Zhang J, Li Y, Ye Z, Zhao Y, Guo X, Xu F, Li F
Antioxidants (Basel, Switzerland) 2023 Mar 9;12(3)

Formaldehyde causes an increase in blood pressure by activating ACE/AT1R axis.

Wang S, Han Q, Wei Z, Wang Y, Deng L, Chen M
Toxicology 2023 Mar 1;486:153442

Perinatal Fat-Diets Increased Angiotensin II-Mediated Ca(2+) through PKC-L-Type Calcium Channel Axis in Resistance Arteries via Agtr1a-Prkcb Gene Methylation.

Zheng Q, He Y, Li L, Rui C, Li N, Zhang Y, Ye Y, Zhang Z, Yang X, Tang J, Xu Z
Nutrients 2023 Jan 3;15(1)

Differential Regulation of Intracisternally Injected Angiotensin II-Induced Mechanical Allodynia and Thermal Hyperalgesia in Rats.

Park KD, Son JY, Kim HK, Kim YM, Ju JS, Jo MJ, Park MK, Lee MK, Ahn DK
Biomedicines 2023 Dec 12;11(12)

Inhibition of angiotensin II type 1 receptor reduces oxidative stress damage to the intestinal barrier in severe acute pancreatitis.

Gao ZY, Jiang YJ, Wang J, Li C, Zhang DL
The Kaohsiung journal of medical sciences 2023 Aug;39(8):824-833

Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.

Fu S, Song X, Tang X, Qian X, Du Z, Hu Y, Xu X, Zhang M
Journal of ethnopharmacology 2023 Apr 24;306:116050

Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.

Wang H, Cui Y, Gong H, Xu J, Huang S, Tang A
Frontiers in bioengineering and biotechnology 2022;10:929979

Salt-Sensitive Hypertension Induces Osteoclastogenesis and Bone Resorption via Upregulation of Angiotensin II Type 1 Receptor Expression in Osteoblasts.

Pramusita A, Kitaura H, Ohori F, Noguchi T, Marahleh A, Nara Y, Kinjo R, Ma J, Kanou K, Tanaka Y, Mizoguchi I
Frontiers in cell and developmental biology 2022;10:816764

Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.

Zhu Z, Zhao Z, Chen X, Chu Z, He Y, Tan Y, Zhou J, Tang C
BMC molecular and cell biology 2022 Sep 29;23(1):42

Exercise Normalized the Hippocampal Renin-Angiotensin System and Restored Spatial Memory Function, Neurogenesis, and Blood-Brain Barrier Permeability in the 2K1C-Hypertensive Mouse.

Chang YS, Lin CL, Lee CW, Lin HC, Wu YT, Shih YH
International journal of molecular sciences 2022 May 16;23(10)

The effects of angiotensin I-converting enzyme inhibitory peptide VGINYW and the hydrolysate of α-lactalbumin on blood pressure, oxidative stress and gut microbiota of spontaneously hypertensive rats.

Xie D, Shen Y, Su E, Du L, Xie J, Wei D
Food & function 2022 Mar 7;13(5):2743-2755

Extract of Corallodiscus flabellata attenuates renal fibrosis in SAMP8 mice via the Wnt/β-catenin/RAS signaling pathway.

Cao B, Zeng M, Si Y, Zhang B, Wang Y, Xu R, Huang Y, Feng W, Zheng X
BMC complementary medicine and therapies 2022 Feb 28;22(1):52

The Role of Nrf2 in the PM-Induced Vascular Injury Under Real Ambient Particulate Matter Exposure in C57/B6 Mice.

Gao M, Ma Y, Luo J, Li D, Jiang M, Jiang Q, Pi J, Chen R, Chen W, Zhang R, Zheng Y, Cui L
Frontiers in pharmacology 2021;12:618023

Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction.

Deng D, Qu Y, Sun L, Jia L, Bu J, Ye M, Chen Z, Geng Y, Zhou S, Fang B
Frontiers in pharmacology 2021;12:616165

A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons.

Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S
eLife 2021 Sep 22;10

Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling.

Dang R, Yang M, Cui C, Wang C, Zhang W, Geng C, Han W, Jiang P
Aging cell 2021 Oct;20(10):e13480

Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects.

Liu X, Deng R, Wei X, Wang Y, Weng J, Lao Y, Lu J, Xiong G, Li S
Bioscience reports 2021 Oct 29;41(10)

Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring.

Hu C, Tao Y, Deng Y, Cai Q, Ren H, Yu C, Zheng S, Yang J, Zeng C
Clinical science (London, England : 1979) 2021 Nov 26;135(22):2575-2588

A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors.

Gu WT, Zhou F, Xie WQ, Wang S, Yao H, Liu YT, Gao L, Wu ZB
Endocrine 2021 May;72(2):340-348

Prenatal High-Sucrose Diet Induced Vascular Dysfunction in Thoracic Artery of Fetal Offspring.

Feng X, Yu T, Zhang Y, Li L, Qu M, Wang J, Dong F, Zhang L, Wang F, Zhang F, Zhou X, Xu Z, Man D
Molecular nutrition & food research 2021 Jun;65(12):e2100072

Parental PM(2) (.5) exposure changes Th17/Treg cells in offspring, is associated with the elevation of blood pressure.

Pan K, Jiang S, Du X, Zeng X, Zhang J, Song L, Lei L, Zhou J, Kan H, Sun Q, Xie Y, Dong C, Zhao J
Environmental toxicology 2021 Jun;36(6):1152-1161

Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.

Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun J, Kong W
Cell research 2021 Jul;31(7):773-790

Increased AT(1) receptor expression mediates vasoconstriction leading to hypertension in Snx1(-/-) mice.

Liu C, Li X, Fu J, Chen K, Liao Q, Wang J, Chen C, Luo H, Jose PA, Yang Y, Yang J, Zeng C
Hypertension research : official journal of the Japanese Society of Hypertension 2021 Aug;44(8):906-917

Electroacupuncture Improved Chronic Cerebral Hypoperfusion-Induced Anxiety-Like Behavior and Memory Impairments in Spontaneously Hypertensive Rats by Downregulating the ACE/Ang II/AT1R Axis and Upregulating the ACE2/Ang-(1-7)/MasR Axis.

Feng P, Wu Z, Liu H, Shen Y, Yao X, Li X, Shen Z
Neural plasticity 2020;2020:9076042

PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma.

Chen Q, Yu WY, Zhang HH, Zhang SZ, Fang J, Wu F, Ying HZ, Yu CH
BioMed research international 2020;2020:8954513

Ambient fine particulate matter induced the elevation of blood pressure through ACE2/Ang(1-7) pathway: The evidence from urine metabolites.

Du X, Zeng X, Zhang J, Pan K, Song L, Zhou J, Zhou L, Xie Y, Sun Q, Ge W, Chen R, Zhao J, Kan H
Ecotoxicology and environmental safety 2020 Oct 15;203:111044

HUANGKUISIWUFANG inhibits pyruvate dehydrogenase to improve glomerular injury in anti-Thy1 nephritis model.

Lu T, Bian Y, Zhu Y, Guo M, Yang Y, Guo J, Gu C, Duan JA
Journal of ethnopharmacology 2020 May 10;253:112682

In utero hypoxia altered Ang II-induced contraction via PKCβ in fetal cerebral arteries.

Su H, Chen X, Zhang Y, Qi L, He Y, Lv J, Zhang Y, Li X, Tang J, Xu Z
The Journal of endocrinology 2020 Jan;244(1):213-222

Losartan protects against intermittent hypoxia-induced peritubular capillary loss by modulating the renal renin-angiotensin system and angiogenesis factors.

Wu J, Chu Y, Jiang Z, Yu Q
Acta biochimica et biophysica Sinica 2020 Jan 2;52(1):38-48

Aldosterone from endometrial glands is benefit for human decidualization.

Li SY, Song Z, Yan YP, Li B, Song MJ, Liu YF, Yang ZS, Li MY, Liu AX, Quan S, Yang ZM
Cell death & disease 2020 Aug 13;11(8):679

Therapeutic effects of higenamine combined with [6]-gingerol on chronic heart failure induced by doxorubicin via ameliorating mitochondrial function.

Wen J, Zhang L, Wang J, Wang J, Wang L, Wang R, Li R, Liu H, Wei S, Li H, Zou W, Zhao Y
Journal of cellular and molecular medicine 2020 Apr;24(7):4036-4050

Puerarin Reduces Blood Pressure in Spontaneously Hypertensive Rats by Targeting eNOS.

Shi W, Yuan R, Chen X, Xin Q, Wang Y, Shang X, Cong W, Chen K
The American journal of Chinese medicine 2019;47(1):19-38

Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system.

Cui C, Xu P, Li G, Qiao Y, Han W, Geng C, Liao D, Yang M, Chen D, Jiang P
Redox biology 2019 Sep;26:101295

Endogenous hydrogen sulfide and ERK1/2-STAT3 signaling pathway may participate in the association between homocysteine and hypertension.

Shi L, Liu XY, Huang ZG, Ma ZY, Xi Y, Wang LY, Sun NL
Journal of geriatric cardiology : JGC 2019 Nov;16(11):822-834

Comparing the effects of diethylhexyl phthalate and dibutyl phthalate exposure on hypertension in mice.

Xie X, Deng T, Duan J, Ding S, Yuan J, Chen M
Ecotoxicology and environmental safety 2019 Jun 15;174:75-82

Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats.

Bian X, Bai Y, Su X, Zhao G, Sun G, Li D
Journal of cellular physiology 2019 Dec;234(12):22857-22873

The Kidney Injury Induced by Short-Term PM(2.5) Exposure and the Prophylactic Treatment of Essential Oils in BALB/c Mice.

Zhang Y, Li Q, Fang M, Ma Y, Liu N, Yan X, Zhou J, Li F
Oxidative medicine and cellular longevity 2018;2018:9098627

Losartan Ameliorates Calcium Oxalate-Induced Elevation of Stone-Related Proteins in Renal Tubular Cells by Inhibiting NADPH Oxidase and Oxidative Stress.

Qin B, Wang Q, Lu Y, Li C, Hu H, Zhang J, Wang Y, Zhu J, Zhu Y, Xun Y, Wang S
Oxidative medicine and cellular longevity 2018;2018:1271864

Inhibition of tumor-promoting stroma to enforce subsequently targeting AT(1)R on tumor cells by pathological inspired micelles.

Zhu Y, Wen L, Shao S, Tan Y, Meng T, Yang X, Liu Y, Liu X, Yuan H, Hu F
Biomaterials 2018 Apr;161:33-46

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemistry of paraffin-embedded human heart tissue slide using 25343-1-AP( AGTR1 Antibody) at dilution of 1:50 (under 10x lens)
Validation comment: IHC
Appendix: 25343-1-AP.pdf

: Show more

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemistry of paraffin-embedded human heart tissue slide using 25343-1-AP( AGTR1 Antibody) at dilution of 1:50 (under 40x lens)
Validation comment: IHC
Appendix: 25343-1-AP.pdf

: Show more