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Learn10837-1-AP
antibody from Proteintech Group
Targeting: OPTN
FIP-2, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [155]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 10837-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10837-1-AP, RRID:AB_2156665
- Product name
- OPTN antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OPTN antibody (Cat. #10837-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Optineurin enhances the chemoresistance by activating mitophagy in acute myeloid leukemia with NPM1 mutation.
Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS-STING and Toll-like receptors 3 and 4.
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.
OPTN knockout alleviates OVA-induced airway inflammation in a mouse model of asthma.
STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels.
Heart-Specific and Conditional Deletion of the Immt Gene Reveals Its Role in Regulating Mitochondrial Structure and Total Heart Metabolism.
Glaesserella parasuis serotype 5 disrupts the swine respiratory epithelial barrier via NBR1-mediated selective autophagic degradation of Claudin-1.
Paeoniflorin Ameliorates Osteoarthritis via Ring Finger Protein 216/Optineurin-Mediated Autophagy Activation in Chondrocytes.
Ketone body β-hydroxybutyrate restores neuronal Tau proteostasis via ketolysis-independent mechanism.
Pestiviruses utilize pyrimidine metabolism to regulate mitophagy for viral replication.
Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis.
Revealing the role of regulatory microglial IRF7-NLRP3 interactions in optic nerve damage of normal-tension glaucoma based on single-cell RNA sequencing.
Rab14 promotes Parkin-mediated mitophagy.
GLCCI1 ameliorates mitochondrial dysfunction in allergic asthma mice via DYRK1A/FAM117B-dependent NRF2 activation.
Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway.
PTEN-L dephosphorylates Parkin and Ub Ser65 to aggravate mitophagy dysfunction in prion disease cell models.
Spinal Cord Phosphoproteome of SCA2 Mouse Model Reveals Alteration of ATXN2-N-Term PRM-SH3-Actin Interactome and of Autophagy.
Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression.
Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Regulation on mitophagy in adenomyosis by Guizhi Fuling Wan.
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4.
The RNF8/OPTN/KDM6A axis controls macrophage polarization to maintain testicular microenvironment homeostasis.
Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.
STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NF-κB signaling.
Optineurin regulates motor and learning behaviors by affecting dopaminergic neuron survival in mice.
Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.
Mitochondrial bioenergetics stimulates autophagy for pathological MAPT/Tau clearance in tauopathy neurons.
Macrophage autophagy protects against acute kidney injury by inhibiting renal inflammation through the degradation of TARM1.
Bunyavirus SFTSV nucleoprotein exploits TUFM-mediated mitophagy to impair antiviral innate immunity.
Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis.
VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy.
Urolithin A provides cardioprotection and mitochondrial quality enhancement preclinically and improves human cardiovascular health biomarkers.
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration.
PPP2/PP2A-mediated dephosphorylation of LC3B links PINK1-PRKN/Parkin-mediated mitophagy to SCA12 pathogenesis.
PINK1-dependent NFKB signaling contributes to amyloid pathology in Alzheimer disease.
Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16-OPTN Axis in Glioblastoma.
TGFB signaling induces mitophagy via PLSCR3-mediated cardiolipin externalization in conjunction with a BNIP3L/NIX-, BNIP3-, and FUNDC1-dependent mechanism.
The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy.
PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation.
USP30 inhibition augments mitophagy to prevent T cell exhaustion.
Retromer promotes the lysosomal turnover of mtDNA.
TNIP1 and Autophagy Receptors regulate STING Signaling.
Peptides targeting RAB11A-FIP2 complex inhibit HPIV3, RSV, and IAV replication as broad-spectrum antivirals.
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers.
USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D.
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates.
Maternal prednisone exposure during pregnancy elevates susceptibility to osteoporosis in female offspring: The role of mitophagy/FNDC5 alteration in skeletal muscle.
MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy.
D-pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin-mediated endoplasmic reticulum stress and glycophagy signaling pathway.
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy.
Seneca Valley virus 3C protease cleaves OPTN (optineurin) to Impair selective autophagy and type I interferon signaling.
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer.
Clinical heterogeneity within the ALS-FTD spectrum in a family with a homozygous optineurin mutation.
TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance.
Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes.
NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
[Role of mitochondrial autophagy and the curative effect of rehmannia glutinosa leaves total glycoside capsules on nucleos(t)ide drug-induced renal injury].
Seeding competent TDP-43 persists in human patient and mouse muscle.
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration.
Magnolol promotes the autophagy of esophageal carcinoma cells by upregulating HACE1 gene expression.
Role of Pink1-mediated mitophagy in adenomyosis.
Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis.
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice.
Unconventional initiation of PINK1/Parkin mitophagy by Optineurin.
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
A cellular taxonomy of the adult human spinal cord.
BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α.
Sustained oral spermidine supplementation rescues functional and structural defects in COL6-deficient myopathic mice.
TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins.
The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets.
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Roles of Optineurin and Extracellular Vesicles in Glaucomatous Retinal Cell Loss.
The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling.
Evaluating mitophagy in embryonic stem cells by using fluorescence-based imaging.
Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles.
Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.
Panax notoginseng saponins protect PC12 cells against Aβ induced injury via promoting parkin-mediated mitophagy.
Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma.
A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP.
In Skeletal Muscle Fibers, Protein Kinase Subunit CSNK2A1/CK2α Is Required for Proper Muscle Homeostasis and Structure and Function of Neuromuscular Junctions.
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.
PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease.
Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation.
Autophagy Receptor Protein Tax1-Binding Protein 1/TRAF6-Binding Protein Is a Cellular Substrate of Enteroviral Proteinase.
Hypothermia promotes mitochondrial elongation In cardiac cells via inhibition of Drp1.
PINK1-mediated mitophagy maintains pluripotency through optineurin.
Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma.
Coordinate regulation of the senescent state by selective autophagy.
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.
TDP-43 and PINK1 mediate CHCHD10(S59L) mutation-induced defects in Drosophila and in vitro.
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro.
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury.
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy.
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.
Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis.
UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway.
Topology-dependent, bifurcated mitochondrial quality control under starvation.
Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu,Zn-superoxide dismutase.
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.
Quantitative patterns of motor cortex proteinopathy across ALS genotypes.
Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea.
Demethylation of HACE1 gene promoter by propofol promotes autophagy of human A549 cells.
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy.
GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon.
Proteomic analysis of seminal extracellular vesicle proteins involved in asthenozoospermia by iTRAQ.
Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab.
Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis.
Demethylation of the HACE1 gene promoter inhibits the proliferation of human liver cancer cells.
STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism.
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review.
Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology.
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.
Acteoside inhibits autophagic apoptosis of retinal ganglion cells to rescue glaucoma-induced optic atrophy.
Activation of PINK1-Parkin-dependent mitophagy in Tri-ortho-cresyl phosphate-treated Neuro2a cells.
The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau).
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.
Parkin is a disease modifier in the mutant SOD1 mouse model of ALS.
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes.
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy.
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology.
Interaction between optineurin and the bZIP transcription factor NRL.
Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina.
Optineurin in neurodegenerative diseases.
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS.
Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders.
Tang L, Wu N, Xiao Q, Yang J, Ren J, Chen X, Zhao W, Liu Y, Hu J, Yang Z, Gao X, Zhang L
Free radical biology & medicine 2026 May;248:162-176
Free radical biology & medicine 2026 May;248:162-176
Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS-STING and Toll-like receptors 3 and 4.
Betrancourt A, Cinko MT, Varanda AB, Arias M, Uranga-Murillo I, Peña N, Kaps LM, Chau LF, Buratti B, Brägelmann J, de Miguel D, Becker K, Casper R, Martin R, Alcami A, Ferguson BJ, Pardo J, Rieser E, Walczak H
Nature cell biology 2026 Mar;28(3):608-621
Nature cell biology 2026 Mar;28(3):608-621
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.
Li J, Yang Y, Ge Y, Zhang X, Liu H, Chen Y, Yang Y, Wu Z
Autophagy 2026 Mar;22(3):445-467
Autophagy 2026 Mar;22(3):445-467
OPTN knockout alleviates OVA-induced airway inflammation in a mouse model of asthma.
Zhang Y, Wang Z, Chen J, Wan Y
Molecular immunology 2026 Mar;191:107-113
Molecular immunology 2026 Mar;191:107-113
STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels.
Lin JY, Huang ZB, Zhang SQ, Wu Y, Cheng LJ, Gao X, Lautrup S, Cao SQ, Pan J, Rong D, Ai R, Weng Siong Tan H, Wang L, Wang H, Shen HM, Fang EF, Lu G
Cell reports 2026 Mar 27;45(4):117183
Cell reports 2026 Mar 27;45(4):117183
Heart-Specific and Conditional Deletion of the Immt Gene Reveals Its Role in Regulating Mitochondrial Structure and Total Heart Metabolism.
Kuwabara Y, Keezer C, Lin SJ, Rajput A, Molkentin JD
Cells 2026 Mar 12;15(6)
Cells 2026 Mar 12;15(6)
Glaesserella parasuis serotype 5 disrupts the swine respiratory epithelial barrier via NBR1-mediated selective autophagic degradation of Claudin-1.
Wang Q, Song C, Song C, Fang K, Yuan Y, Wang J, Fan H
Veterinary microbiology 2026 Jun;317:111030
Veterinary microbiology 2026 Jun;317:111030
Paeoniflorin Ameliorates Osteoarthritis via Ring Finger Protein 216/Optineurin-Mediated Autophagy Activation in Chondrocytes.
Peng C, Jiang D, Gao N, Zheng Y, Xu H
Chemical biology & drug design 2026 Feb;107(2):e70237
Chemical biology & drug design 2026 Feb;107(2):e70237
Ketone body β-hydroxybutyrate restores neuronal Tau proteostasis via ketolysis-independent mechanism.
Rossitto LM, Foo J, Di Silvestri JM, Lehmann L, Brunelli M, Nie Y, Muñoz-Mayorga D, Xiao Q, Dai-Liu AY, Jati S, Rossi M, Daneman R, Kelly JW, Newman JC, Myers SA, Chen X
bioRxiv : the preprint server for biology 2026 Feb 2;
bioRxiv : the preprint server for biology 2026 Feb 2;
Pestiviruses utilize pyrimidine metabolism to regulate mitophagy for viral replication.
Zhao B, Chen J, Cheng Y, Li Y, Zhong L, Chen J, Bi X, Bai J, Dai Q, Ye Y, Zou L, Wang L, Zhou B
Autophagy 2026 Apr 20;:1-22
Autophagy 2026 Apr 20;:1-22
Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis.
Zhao S, Chen R, An Y, Zhang Y, Ma C, Gao Y, Lu Y, Yang F, Bai X, Zhang J
Frontiers in aging neuroscience 2025;17:1522073
Frontiers in aging neuroscience 2025;17:1522073
Revealing the role of regulatory microglial IRF7-NLRP3 interactions in optic nerve damage of normal-tension glaucoma based on single-cell RNA sequencing.
Qiu L, Guo F, Liu X, Zhang D, Wang Q, Du M, Yuan Q, Zhang S, Song W, Yuan H
Frontiers in immunology 2025;16:1700998
Frontiers in immunology 2025;16:1700998
Rab14 promotes Parkin-mediated mitophagy.
Momtaz S, Padilla-Rodriguez M, Flores PC, Rulli N, Lee NY, Wilson JM
Molecular biology of the cell 2025 Sep 1;36(9):ar117
Molecular biology of the cell 2025 Sep 1;36(9):ar117
GLCCI1 ameliorates mitochondrial dysfunction in allergic asthma mice via DYRK1A/FAM117B-dependent NRF2 activation.
Xun Q, Yang Q, Wang W, Zhu G
Cellular signalling 2025 Oct;134:111929
Cellular signalling 2025 Oct;134:111929
Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway.
Guo QQ, Wang SS, Jiang XY, Xie XC, Zou Y, Liu JW, Guo Y, Li YH, Liu XY, Hao S, Zhang XY, Wu XX, Lu SM, Xu HD, Guo WD, Feng YL, Wang CG, Zhang SP, Li JB, Liu C, Song XY, Finkel T, Cao L
Proceedings of the National Academy of Sciences of the United States of America 2025 Oct 7;122(40):e2502841122
Proceedings of the National Academy of Sciences of the United States of America 2025 Oct 7;122(40):e2502841122
PTEN-L dephosphorylates Parkin and Ub Ser65 to aggravate mitophagy dysfunction in prion disease cell models.
Li X, Li J, Gou F, Dai Y, Zhao M, Wang D, Sun Z, Wen P, Wang J, Fan Q, Ma T, Wang X, Zhao D, Yang L
Life sciences 2025 Oct 15;379:123860
Life sciences 2025 Oct 15;379:123860
Spinal Cord Phosphoproteome of SCA2 Mouse Model Reveals Alteration of ATXN2-N-Term PRM-SH3-Actin Interactome and of Autophagy.
Almaguer-Mederos LE, Kandi AR, Sen NE, Canet-Pons J, Berger LM, Stokes MP, Abell K, Key J, Gispert S, Auburger G
Molecular & cellular proteomics : MCP 2025 Nov;24(11):101072
Molecular & cellular proteomics : MCP 2025 Nov;24(11):101072
Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression.
Pan Y, Zhang N, Fu X, Wang X, Ma Y, Chen Q, Zhou Y, Liu H, Zhu Y, Xu L, Wang Q, Chen D, Wang Z, Wang L
Journal of experimental & clinical cancer research : CR 2025 Nov 25;44(1):310
Journal of experimental & clinical cancer research : CR 2025 Nov 25;44(1):310
Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
Huber LS, Merline R, Zeng-Brouwers J, Vutukuri R, Kraus N, Ortiz C, Guenther S, Buhl EM, Hahnefeld L, Gurke R, Bein J, Karimova M, Wurzel P, Boor P, Welsch C, Wild P, Pfeilschifter J, Kögel D, Wygrecka M, Trebicka J, Bartoszewski R, Dikic I, Schaefer L
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1360-C1379
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1360-C1379
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Regulation on mitophagy in adenomyosis by Guizhi Fuling Wan.
Liu S, Li C, Fu X, Chen M, Wang M, Wang K, Du L
Journal of ethnopharmacology 2025 Mar 26;344:119570
Journal of ethnopharmacology 2025 Mar 26;344:119570
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4.
Liu W, Zhu Y, Ye W, Xiong J, Wang H, Gao Y, Huang S, Zhang Y, Zhou X, Zhou X, Ge X, Cai W, Zheng X
Cell death and differentiation 2025 Jun;32(6):1041-1057
Cell death and differentiation 2025 Jun;32(6):1041-1057
The RNF8/OPTN/KDM6A axis controls macrophage polarization to maintain testicular microenvironment homeostasis.
Guo Y, Xia P, Tian Y, Fu D, Hu X, Xie K, Dong W, Zhang W, Liu D, Shen R, Wang D
Cell death discovery 2025 Jul 24;11(1):339
Cell death discovery 2025 Jul 24;11(1):339
Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.
Sun N, Barta H, Chaudhuri S, Chen K, Jin J, Luo H, Yang M, Krigman J, Zhang R, Sanghvi S, Sekine S, Sanders H, Kolonay D, Patel M, Baskin K, Singh H, Zhang P, Xin G, Finkel T
Nature communications 2025 Jul 1;16(1):5465
Nature communications 2025 Jul 1;16(1):5465
STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NF-κB signaling.
Fischer TD, Bunker EN, Zhu PP, Le Guerroué F, Hadjian M, Dominguez-Martin E, Scavone F, Cohen R, Yao T, Wang Y, Werner A, Youle RJ
The EMBO journal 2025 Jan;44(1):141-165
The EMBO journal 2025 Jan;44(1):141-165
Optineurin regulates motor and learning behaviors by affecting dopaminergic neuron survival in mice.
Yang X, Zheng R, Zhang H, Ou Z, Wan S, Lin D, Yan J, Jin M, Tan J
Experimental neurology 2025 Jan;383:115007
Experimental neurology 2025 Jan;383:115007
Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.
Sun Z, Ma Z, Cao W, Jiang C, Guo L, Liu K, Gao Y, Bai J, Pi J, Jiang P, Liu X
PLoS pathogens 2025 Jan;21(1):e1012872
PLoS pathogens 2025 Jan;21(1):e1012872
Mitochondrial bioenergetics stimulates autophagy for pathological MAPT/Tau clearance in tauopathy neurons.
Jia N, Ganesan D, Guan H, Jeong YY, Han S, Rajapaksha G, Nissenbaum M, Kusnecov AW, Cai Q
Autophagy 2025 Jan;21(1):54-79
Autophagy 2025 Jan;21(1):54-79
Macrophage autophagy protects against acute kidney injury by inhibiting renal inflammation through the degradation of TARM1.
Huang XR, Ye L, An N, Wu CY, Wu HL, Li HY, Huang YH, Ye QR, Liu MD, Yang LW, Liu JX, Tang JX, Pan QJ, Wang P, Sun L, Xia Y, Lan HY, Yang C, Liu HF
Autophagy 2025 Jan;21(1):120-140
Autophagy 2025 Jan;21(1):120-140
Bunyavirus SFTSV nucleoprotein exploits TUFM-mediated mitophagy to impair antiviral innate immunity.
Zhang WK, Yan JM, Chu M, Li B, Gu XL, Jiang ZZ, Li ZM, Liu PP, Yu TM, Zhou CM, Yu XJ
Autophagy 2025 Jan;21(1):102-119
Autophagy 2025 Jan;21(1):102-119
Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis.
Zhang MN, Duan R, Chen GH, Chen MJ, Hong CG, Wang X, Pang ZL, Chen CY, Liu HF, Zhong D, Xie H, Hu WB, Liu ZZ
Communications biology 2025 Jan 16;8(1):68
Communications biology 2025 Jan 16;8(1):68
VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy.
Jiang H, Xie Y, Hu Z, Lu J, Zhang J, Li H, Zeng K, Peng W, Yang C, Huang J, Han Z, Bai X, Yu X
PLoS biology 2025 Feb;23(2):e3002961
PLoS biology 2025 Feb;23(2):e3002961
Urolithin A provides cardioprotection and mitochondrial quality enhancement preclinically and improves human cardiovascular health biomarkers.
Liu S, Faitg J, Tissot C, Konstantopoulos D, Laws R, Bourdier G, Andreux PA, Davey T, Gallart-Ayala H, Ivanisevic J, Singh A, Rinsch C, Marcinek DJ, D'Amico D
iScience 2025 Feb 21;28(2):111814
iScience 2025 Feb 21;28(2):111814
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration.
Liu D, Webber HC, Bian F, Xu Y, Prakash M, Feng X, Yang M, Yang H, You IJ, Li L, Liu L, Liu P, Huang H, Chang CY, Liu L, Shah SH, La Torre A, Welsbie DS, Sun Y, Duan X, Goldberg JL, Braun M, Lansky Z, Hu Y
Nature communications 2025 Feb 20;16(1):1789
Nature communications 2025 Feb 20;16(1):1789
PPP2/PP2A-mediated dephosphorylation of LC3B links PINK1-PRKN/Parkin-mediated mitophagy to SCA12 pathogenesis.
Li N, Hou H, Su D, Yang B, Ni R, Ma G, Sun S, Ma Q, Peng Q, Chen S, Tam KY, Wang H, Ying Z
Autophagy 2025 Dec;21(12):3182-3194
Autophagy 2025 Dec;21(12):3182-3194
PINK1-dependent NFKB signaling contributes to amyloid pathology in Alzheimer disease.
Du F, Yu Q, Hu G, Lin CS, ShiDu Yan S
Autophagy 2025 Dec;21(12):2561-2577
Autophagy 2025 Dec;21(12):2561-2577
Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16-OPTN Axis in Glioblastoma.
Chang H, Hou J, Hu X, Hou N, Xu M, Du Y, Xu J, Wang Y, Xie Z, Shi J, Zhang Y, Cui H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e02915
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e02915
TGFB signaling induces mitophagy via PLSCR3-mediated cardiolipin externalization in conjunction with a BNIP3L/NIX-, BNIP3-, and FUNDC1-dependent mechanism.
Yan J, Chen X, Choksi S, Liu ZG
Autophagy 2025 Aug;21(8):1791-1801
Autophagy 2025 Aug;21(8):1791-1801
The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy.
Huang Z, Gao C, Huang S, Lin S, Zhang W, You J, Chen X, Zhou P, Zhang G, Gong L
Autophagy 2025 Aug;21(8):1644-1661
Autophagy 2025 Aug;21(8):1644-1661
PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation.
Yang L, Qian Q, Sun Y-g, Chen X-x, Xing G, Zhang J-q, Xing B-s, Qiao S, Li R, Zhang G
Journal of virology 2025 Aug 19;99(8):e0049825
Journal of virology 2025 Aug 19;99(8):e0049825
USP30 inhibition augments mitophagy to prevent T cell exhaustion.
Zhang R, Gao F, Li J, Jin J, Chen K, Chaudhuri S, Liao Z, Xiao T, Xu Y, Wen H, He K, Li Z, Xin G, Sun N
Science advances 2025 Aug 15;11(33):eadv6902
Science advances 2025 Aug 15;11(33):eadv6902
Retromer promotes the lysosomal turnover of mtDNA.
Kakanj P, Bonse M, Kshirsagar A, Gökmen A, Gaedke F, Sen A, Mollá B, Vogelsang E, Schauss A, Wodarz A, Pla-Martín D
Science advances 2025 Apr 4;11(14):eadr6415
Science advances 2025 Apr 4;11(14):eadr6415
TNIP1 and Autophagy Receptors regulate STING Signaling.
Bunker EN, Fischer TD, Zhu PP, Le Guerroué F, Youle RJ
bioRxiv : the preprint server for biology 2025 Apr 23;
bioRxiv : the preprint server for biology 2025 Apr 23;
Peptides targeting RAB11A-FIP2 complex inhibit HPIV3, RSV, and IAV replication as broad-spectrum antivirals.
Jiang Y, Zhao Y, Deng J, Wu X, Li J, Guo D, Xu K, Qin Y, Chen M
Cell & bioscience 2025 Apr 21;15(1):50
Cell & bioscience 2025 Apr 21;15(1):50
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers.
Hnath B, Dokholyan NV
bioRxiv : the preprint server for biology 2025 Apr 10;
bioRxiv : the preprint server for biology 2025 Apr 10;
USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D.
Wang L, Li M, Lian G, Yang S, Wu Y, Cui J
Research (Washington, D.C.) 2024;7:0380
Research (Washington, D.C.) 2024;7:0380
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
Ji Y, Li C, Wan S, Dong Z, Liu C, Guo L, Shi S, Ci M, Xu M, Li Q, Hu H, Cui H, Liu Y
Journal of pharmaceutical analysis 2024 Oct;14(10):101036
Journal of pharmaceutical analysis 2024 Oct;14(10):101036
Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates.
Yang Z, Yoshii SR, Sakai Y, Zhang J, Chino H, Knorr RL, Mizushima N
The EMBO journal 2024 Nov;43(22):5613-5634
The EMBO journal 2024 Nov;43(22):5613-5634
Maternal prednisone exposure during pregnancy elevates susceptibility to osteoporosis in female offspring: The role of mitophagy/FNDC5 alteration in skeletal muscle.
Du ZY, Zhu HL, Chang W, Zhang YF, Ling Q, Wang KW, Zhang J, Zhang QB, Kan XL, Wang QN, Wang H, Zhou Y
Journal of hazardous materials 2024 May 5;469:133997
Journal of hazardous materials 2024 May 5;469:133997
MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy.
Li Y, Zhao K, Hu Y, Yang F, Li P, Liu Y
iScience 2024 May 17;27(5):109764
iScience 2024 May 17;27(5):109764
D-pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin-mediated endoplasmic reticulum stress and glycophagy signaling pathway.
Li X, Yu X, Yu F, Fu C, Zhao W, Liu X, Dai C, Gao H, Cheng M, Li B
Phytotherapy research : PTR 2024 Mar;38(3):1681-1694
Phytotherapy research : PTR 2024 Mar;38(3):1681-1694
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy.
Saunders TL, Windley SP, Gervinskas G, Balka KR, Rowe C, Lane R, Tailler M, Nguyen TN, Ramm G, Lazarou M, De Nardo D, Kile BT, McArthur K
Cell death and differentiation 2024 Mar;31(3):335-347
Cell death and differentiation 2024 Mar;31(3):335-347
Seneca Valley virus 3C protease cleaves OPTN (optineurin) to Impair selective autophagy and type I interferon signaling.
Song J, Guo Y, Wang D, Quan R, Wang J, Liu J
Autophagy 2024 Mar;20(3):614-628
Autophagy 2024 Mar;20(3):614-628
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S, Zhang Z, Chen N
Autophagy 2024 Mar;20(3):590-613
Autophagy 2024 Mar;20(3):590-613
AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer.
Yeo SK, Haas M, Manupati K, Hao M, Yang F, Chen S, Guan JL
Autophagy 2024 Mar;20(3):525-540
Autophagy 2024 Mar;20(3):525-540
Clinical heterogeneity within the ALS-FTD spectrum in a family with a homozygous optineurin mutation.
Parvizi T, Klotz S, Keritam O, Caliskan H, Imhof S, König T, Haider L, Traub-Weidinger T, Wagner M, Brunet T, Brugger M, Zimprich A, Rath J, Stögmann E, Gelpi E, Cetin H
Annals of clinical and translational neurology 2024 Jun;11(6):1579-1589
Annals of clinical and translational neurology 2024 Jun;11(6):1579-1589
TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance.
Zhu YF, Yu RH, Zhou S, Tang PP, Zhang R, Wu YX, Xu R, Wei JM, Wang YY, Zhang JL, Li MK, Shi XJ, Zhang YW, Liu GZ, Thorne RF, Zhang XD, Wu M, Chen S
Zoological research 2024 Jul 18;45(4):937-950
Zoological research 2024 Jul 18;45(4):937-950
Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes.
Yamada K, St Croix C, Stolz DB, Tyurina YY, Tyurin VA, Bradley LR, Kapralov AA, Deng Y, Zhou X, Wei Q, Liao B, Fukuda N, Sullivan M, Trudeau J, Ray A, Kagan VE, Zhao J, Wenzel SE
Nature communications 2024 Jul 10;15(1):5818
Nature communications 2024 Jul 10;15(1):5818
NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
Paul S, Sarraf SA, Nam KH, Zavar L, DeFoor N, Biswas SR, Fritsch LE, Yaron TM, Johnson JL, Huntsman EM, Cantley LC, Ordureau A, Pickrell AM
The Journal of cell biology 2024 Feb 5;223(2)
The Journal of cell biology 2024 Feb 5;223(2)
[Role of mitochondrial autophagy and the curative effect of rehmannia glutinosa leaves total glycoside capsules on nucleos(t)ide drug-induced renal injury].
Zhong K, Zhang MM, Zhu ZX, Liao X, Zhang BF, Cheng ML
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2024 Feb 20;32(2):125-132
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2024 Feb 20;32(2):125-132
Seeding competent TDP-43 persists in human patient and mouse muscle.
Lynch EM, Pittman S, Daw J, Ikenaga C, Chen S, Dhavale DD, Jackrel ME, Ayala YM, Kotzbauer P, Ly CV, Pestronk A, Lloyd TE, Weihl CC
bioRxiv : the preprint server for biology 2024 Apr 4;
bioRxiv : the preprint server for biology 2024 Apr 4;
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration.
Liu D, Webber HC, Bian F, Xu Y, Prakash M, Feng X, Yang M, Yang H, You IJ, Li L, Liu L, Liu P, Huang H, Chang CY, Liu L, Shah SH, Torre A, Welsbie DS, Sun Y, Duan X, Goldberg JL, Braun M, Lansky Z, Hu Y
bioRxiv : the preprint server for biology 2024 Apr 3;
bioRxiv : the preprint server for biology 2024 Apr 3;
Magnolol promotes the autophagy of esophageal carcinoma cells by upregulating HACE1 gene expression.
Huang K, Zhang B, Feng Y, Ma H
Acta biochimica et biophysica Sinica 2024 Apr 25;56(7):1044-1054
Acta biochimica et biophysica Sinica 2024 Apr 25;56(7):1044-1054
Role of Pink1-mediated mitophagy in adenomyosis.
Chen M, Wang W, Fu X, Yi Y, Wang K, Wang M
PeerJ 2023;11:e16497
PeerJ 2023;11:e16497
Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis.
Luo ZY, Jiang TX, Zhang T, Xu P, Qiu XB
Cells 2023 Sep 5;12(18)
Cells 2023 Sep 5;12(18)
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L
Neuron 2023 Nov 15;111(22):3634-3649.e7
Neuron 2023 Nov 15;111(22):3634-3649.e7
Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice.
Zheng Y, Wang L, Liu Q, Xian H, Zhang C, Cai S, Yang S, Jin S, Cui J
Nature microbiology 2023 May;8(5):958-972
Nature microbiology 2023 May;8(5):958-972
Unconventional initiation of PINK1/Parkin mitophagy by Optineurin.
Nguyen TN, Sawa-Makarska J, Khuu G, Lam WK, Adriaenssens E, Fracchiolla D, Shoebridge S, Bernklau D, Padman BS, Skulsuppaisarn M, Lindblom RSJ, Martens S, Lazarou M
Molecular cell 2023 May 18;83(10):1693-1709.e9
Molecular cell 2023 May 18;83(10):1693-1709.e9
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
Jiang Y, Li Y, Zhang Y, Hu D, Zhang S, Wang C, Huang S, Zhang A, Jia Z, You R
International immunopharmacology 2023 Mar;116:109847
International immunopharmacology 2023 Mar;116:109847
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
Le Guerroué F, Bunker EN, Rosencrans WM, Nguyen JT, Basar MA, Werner A, Chou TF, Wang C, Youle RJ
Molecular cell 2023 Mar 16;83(6):927-941.e8
Molecular cell 2023 Mar 16;83(6):927-941.e8
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK
Cell 2023 Feb 16;186(4):786-802.e28
Cell 2023 Feb 16;186(4):786-802.e28
A cellular taxonomy of the adult human spinal cord.
Yadav A, Matson KJE, Li L, Hua I, Petrescu J, Kang K, Alkaslasi MR, Lee DI, Hasan S, Galuta A, Dedek A, Ameri S, Parnell J, Alshardan MM, Qumqumji FA, Alhamad SM, Wang AP, Poulen G, Lonjon N, Vachiery-Lahaye F, Gaur P, Nalls MA, Qi YA, Maric D, Ward ME, Hildebrand ME, Mery PF, Bourinet E, Bauchet L, Tsai EC, Phatnani H, Le Pichon CE, Menon V, Levine AJ
Neuron 2023 Feb 1;111(3):328-344.e7
Neuron 2023 Feb 1;111(3):328-344.e7
BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α.
Lu JJ, Wu PF, He JG, Li YK, Long LH, Yao XP, Yang JH, Chen HS, Zhang XN, Hu ZL, Chen Z, Wang F, Chen JG
Molecular psychiatry 2023 Dec;28(12):5062-5076
Molecular psychiatry 2023 Dec;28(12):5062-5076
Sustained oral spermidine supplementation rescues functional and structural defects in COL6-deficient myopathic mice.
Gambarotto L, Metti S, Corpetti M, Baraldo M, Sabatelli P, Castagnaro S, Cescon M, Blaauw B, Bonaldo P
Autophagy 2023 Dec;19(12):3221-3229
Autophagy 2023 Dec;19(12):3221-3229
TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins.
Hayashi Y, Takatori S, Warsame WY, Tomita T, Fujisawa T, Ichijo H
The EMBO journal 2023 Dec 1;42(23):e114272
The EMBO journal 2023 Dec 1;42(23):e114272
The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets.
Chung J, Park J, Lai ZW, Lambert TJ, Richards RC, Zhang J, Walther TC, Farese RV Jr
Nature cell biology 2023 Aug;25(8):1101-1110
Nature cell biology 2023 Aug;25(8):1101-1110
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Zhou Y, Luo D, Shi J, Yang X, Xu W, Gao W, Guo Y, Zhao Q, Xie X, He Y, Du G, Pang X
Journal of ethnopharmacology 2023 Aug 10;312:116455
Journal of ethnopharmacology 2023 Aug 10;312:116455
Roles of Optineurin and Extracellular Vesicles in Glaucomatous Retinal Cell Loss.
Duan CY, Fan WL, Chen F
Current medical science 2023 Apr;43(2):367-375
Current medical science 2023 Apr;43(2):367-375
The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling.
Zhang R, Ozgen S, Luo H, Krigman J, Zhao Y, Xin G, Sun N
Frontiers in pharmacology 2022;13:816551
Frontiers in pharmacology 2022;13:816551
Evaluating mitophagy in embryonic stem cells by using fluorescence-based imaging.
Liu K, Li X, Li Z, Cao J, Li X, Xu Y, Liu L, Zhao T
Frontiers in cell and developmental biology 2022;10:910464
Frontiers in cell and developmental biology 2022;10:910464
Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles.
Hernandez D, Walsh S, Saavedra Sanchez L, Dickinson MS, Coers J
mBio 2022 Oct 26;13(5):e0188822
mBio 2022 Oct 26;13(5):e0188822
Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.
Li Y, Jiang Y, Zhou W, Wu Y, Zhang S, Ding G, Zhang Y, Zhang A, Huang S, Jia Z, You R
Free radical biology & medicine 2022 Mar;181:270-287
Free radical biology & medicine 2022 Mar;181:270-287
Panax notoginseng saponins protect PC12 cells against Aβ induced injury via promoting parkin-mediated mitophagy.
Jiang Y, Li H, Huang P, Li S, Li B, Huo L, Zhong J, Pan Z, Li Y, Xia X
Journal of ethnopharmacology 2022 Mar 1;285:114859
Journal of ethnopharmacology 2022 Mar 1;285:114859
Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma.
Zhuang A, Chai P, Wang S, Zuo S, Yu J, Jia S, Ge S, Jia R, Zhou Y, Shi W, Xu X, Ruan J, Fan X
Clinical and translational medicine 2022 Jan;12(1):e660
Clinical and translational medicine 2022 Jan;12(1):e660
A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.
Deng Q, Yang S, Sun L, Huang K, Dong K, Zhu Y, Cao Y, Li Y, Wu S, Huang R
Redox biology 2022 Feb;49:102217
Redox biology 2022 Feb;49:102217
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
Liu D, Zhao Z, She Y, Zhang L, Chen X, Ma L, Cui J
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 15;119(7)
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 15;119(7)
WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP.
Lu G, Tan HWS, Schmauck-Medina T, Wang L, Chen J, Cho YL, Chen K, Zhang JZ, He W, Wu Y, Xia D, Zhou J, Fang EF, Fang L, Liu W, Shen HM
Autophagy 2022 Dec;18(12):2865-2879
Autophagy 2022 Dec;18(12):2865-2879
In Skeletal Muscle Fibers, Protein Kinase Subunit CSNK2A1/CK2α Is Required for Proper Muscle Homeostasis and Structure and Function of Neuromuscular Junctions.
Merholz M, Jian Y, Wimberg J, Gessler L, Hashemolhosseini S
Cells 2022 Dec 7;11(24)
Cells 2022 Dec 7;11(24)
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.
Walsh SC, Reitano JR, Dickinson MS, Kutsch M, Hernandez D, Barnes AB, Schott BH, Wang L, Ko DC, Kim SY, Valdivia RH, Bastidas RJ, Coers J
Cell host & microbe 2022 Dec 14;30(12):1671-1684.e9
Cell host & microbe 2022 Dec 14;30(12):1671-1684.e9
PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease.
Wang XJ, Qi L, Cheng YF, Ji XF, Chi TY, Liu P, Zou LB
Acta pharmacologica Sinica 2022 Aug;43(8):1916-1927
Acta pharmacologica Sinica 2022 Aug;43(8):1916-1927
Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation.
Hou M, Shao Z, Zhang S, Liu X, Fan P, Jiang M, Zhao Y, Xiao R, Yuan H
Cell death & disease 2022 Apr 18;13(4):362
Cell death & disease 2022 Apr 18;13(4):362
Autophagy Receptor Protein Tax1-Binding Protein 1/TRAF6-Binding Protein Is a Cellular Substrate of Enteroviral Proteinase.
Mohamud Y, Xue YC, Liu H, Ng CS, Bahreyni A, Luo H
Frontiers in microbiology 2021;12:647410
Frontiers in microbiology 2021;12:647410
Hypothermia promotes mitochondrial elongation In cardiac cells via inhibition of Drp1.
Taylor D, Germano J, Song Y, Hadj-Moussa H, Marek-Iannucci S, Dhanji R, Sin J, Czer LSC, Storey KB, Gottlieb RA
Cryobiology 2021 Oct;102:42-55
Cryobiology 2021 Oct;102:42-55
PINK1-mediated mitophagy maintains pluripotency through optineurin.
Wang C, Liu K, Cao J, Wang L, Zhao Q, Li Z, Zhang H, Chen Q, Zhao T
Cell proliferation 2021 May;54(5):e13034
Cell proliferation 2021 May;54(5):e13034
Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma.
Liu X, Wang Q, Shao Z, Zhang S, Hou M, Jiang M, Du M, Li J, Yuan H
Human molecular genetics 2021 May 31;30(11):1030-1044
Human molecular genetics 2021 May 31;30(11):1030-1044
Coordinate regulation of the senescent state by selective autophagy.
Lee Y, Kim J, Kim MS, Kwon Y, Shin S, Yi H, Kim H, Chang MJ, Chang CB, Kang SB, Kim VN, Kim JH, Kim JS, Elledge SJ, Kang C
Developmental cell 2021 May 17;56(10):1512-1525.e7
Developmental cell 2021 May 17;56(10):1512-1525.e7
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.
Franco-Iborra S, Plaza-Zabala A, Montpeyo M, Sebastian D, Vila M, Martinez-Vicente M
Autophagy 2021 Mar;17(3):672-689
Autophagy 2021 Mar;17(3):672-689
TDP-43 and PINK1 mediate CHCHD10(S59L) mutation-induced defects in Drosophila and in vitro.
Baek M, Choe YJ, Bannwarth S, Kim J, Maitra S, Dorn GW 2nd, Taylor JP, Paquis-Flucklinger V, Kim NC
Nature communications 2021 Mar 26;12(1):1924
Nature communications 2021 Mar 26;12(1):1924
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Zellner S, Schifferer M, Behrends C
Molecular cell 2021 Mar 18;81(6):1337-1354.e8
Molecular cell 2021 Mar 18;81(6):1337-1354.e8
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro.
Zhang S, Shao Z, Liu X, Hou M, Cheng F, Lei D, Yuan H
Cell death discovery 2021 Mar 15;7(1):49
Cell death discovery 2021 Mar 15;7(1):49
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M
The Journal of cell biology 2021 Jun 7;220(6)
The Journal of cell biology 2021 Jun 7;220(6)
Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.
Wang W, Qin Y, Song H, Wang L, Jia M, Zhao C, Gong M, Zhao W
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2692-2699
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2692-2699
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Friesen O, Wu W, Stuhldreier F, Sun Y, Berning L, Friedrich A, Mendiburo MJ, Peter C, Wiek C, Hanenberg H, Stefanski A, Stühler K, Stork B
Scientific reports 2021 Jul 5;11(1):13863
Scientific reports 2021 Jul 5;11(1):13863
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Tai Y, Pu M, Yuan L, Guo H, Qiao J, Lu H, Wang G, Chen J, Qi X, Tao Z, Ren J
Life sciences 2021 Jul 1;276:119415
Life sciences 2021 Jul 1;276:119415
The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury.
Wang Y, Zhu J, Liu Z, Shu S, Fu Y, Liu Y, Cai J, Tang C, Liu Y, Yin X, Dong Z
Redox biology 2021 Jan;38:101767
Redox biology 2021 Jan;38:101767
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Zhang C, Nie P, Zhou C, Hu Y, Duan S, Gu M, Jiang D, Wang Y, Deng Z, Chen J, Chen S, Wang L
Cell death & disease 2021 Feb 24;12(2):209
Cell death & disease 2021 Feb 24;12(2):209
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy.
Tang Y, Wang L, Yi T, Xu J, Wang J, Qin JJ, Chen Q, Yip KM, Pan Y, Hong P, Lu Y, Shen HM, Chen HB
Acta pharmaceutica Sinica. B 2021 Dec;11(12):3966-3982
Acta pharmaceutica Sinica. B 2021 Dec;11(12):3966-3982
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
Sun H, Ou T, Hu J, Yang Z, Lei Q, Li Y, Wang G, Li Y, Wu K, Wang S, Wu S
Biochemical pharmacology 2021 Aug;190:114588
Biochemical pharmacology 2021 Aug;190:114588
Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.
Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, Matsuda N
The Journal of cell biology 2020 Sep 7;219(9)
The Journal of cell biology 2020 Sep 7;219(9)
Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis.
Rimessi A, Pozzato C, Carparelli L, Rossi A, Ranucci S, De Fino I, Cigana C, Talarico A, Wieckowski MR, Ribeiro CMP, Trapella C, Rossi G, Cabrini G, Bragonzi A, Pinton P
Science advances 2020 May;6(19):eaax9093
Science advances 2020 May;6(19):eaax9093
UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway.
Chen T, Zhang W, Huang B, Chen X, Huang C
Cells 2020 May 13;9(5)
Cells 2020 May 13;9(5)
Topology-dependent, bifurcated mitochondrial quality control under starvation.
Zhou Y, Long Q, Wu H, Li W, Qi J, Wu Y, Xiang G, Tang H, Yang L, Chen K, Li L, Bao F, Li H, Wang Y, Li M, Liu X
Autophagy 2020 Mar;16(3):562-574
Autophagy 2020 Mar;16(3):562-574
Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu,Zn-superoxide dismutase.
Homma K, Takahashi H, Tsuburaya N, Naguro I, Fujisawa T, Ichijo H
The Journal of biological chemistry 2020 Mar 6;295(10):3148-3158
The Journal of biological chemistry 2020 Mar 6;295(10):3148-3158
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.
Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B, Yue Z
Nature communications 2020 Mar 13;11(1):1386
Nature communications 2020 Mar 13;11(1):1386
Quantitative patterns of motor cortex proteinopathy across ALS genotypes.
Nolan M, Scott C, Gamarallage MP, Lunn D, Carpenter K, McDonough E, Meyer D, Kaanumalle S, Santamaria-Pang A, Turner MR, Talbot K, Ansorge O
Acta neuropathologica communications 2020 Jul 2;8(1):98
Acta neuropathologica communications 2020 Jul 2;8(1):98
Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.
Wong SW, Huang BW, Hu X, Ho Kim E, Kolb JP, Padilla RJ, Xue P, Wang L, Oguin TH 3rd, Miguez PA, Tseng HC, Ko CC, Martinez J
Cell death and differentiation 2020 Jan;27(1):71-84
Cell death and differentiation 2020 Jan;27(1):71-84
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
Thayer JA, Awad O, Hegdekar N, Sarkar C, Tesfay H, Burt C, Zeng X, Feldman RA, Lipinski MM
Autophagy 2020 Jan;16(1):140-153
Autophagy 2020 Jan;16(1):140-153
Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea.
Xia B, Yu J, He T, Liu X, Su J, Wang M, Wang J, Zhu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2821-2839
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2821-2839
Demethylation of HACE1 gene promoter by propofol promotes autophagy of human A549 cells.
Li S, Yang H, Zhao M, Gong L, Wang Y, Lv Z, Quan Y, Wang Z
Oncology letters 2020 Dec;20(6):280
Oncology letters 2020 Dec;20(6):280
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
Sarraf SA, Shah HV, Kanfer G, Pickrell AM, Holtzclaw LA, Ward ME, Youle RJ
Molecular cell 2020 Dec 3;80(5):779-795.e10
Molecular cell 2020 Dec 3;80(5):779-795.e10
The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy.
Zheng L, Shu WJ, Li YM, Mari M, Yan C, Wang D, Yin ZH, Jiang W, Zhou Y, Okamoto K, Reggiori F, Klionsky DJ, Song Z, Du HN
Autophagy 2020 Aug;16(8):1366-1379
Autophagy 2020 Aug;16(8):1366-1379
GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon.
Zhang Z, Gu H, Li Q, Zheng J, Cao S, Weng C, Jia H
Infection and immunity 2020 Apr 20;88(5)
Infection and immunity 2020 Apr 20;88(5)
Proteomic analysis of seminal extracellular vesicle proteins involved in asthenozoospermia by iTRAQ.
Lin Y, Liang A, He Y, Li Z, Li Z, Wang G, Sun F
Molecular reproduction and development 2019 Sep;86(9):1094-1105
Molecular reproduction and development 2019 Sep;86(9):1094-1105
Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab.
Wang D, Xu Q, Yuan Q, Jia M, Niu H, Liu X, Zhang J, Young CY, Yuan H
Oncogene 2019 May;38(18):3458-3474
Oncogene 2019 May;38(18):3458-3474
Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis.
Cairó M, Campderrós L, Gavaldà-Navarro A, Cereijo R, Delgado-Anglés A, Quesada-López T, Giralt M, Villarroya J, Villarroya F
EMBO reports 2019 May;20(5)
EMBO reports 2019 May;20(5)
Demethylation of the HACE1 gene promoter inhibits the proliferation of human liver cancer cells.
Yu Z, Li Y, Han T, Liu Z
Oncology letters 2019 May;17(5):4361-4368
Oncology letters 2019 May;17(5):4361-4368
STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism.
Xian H, Yang Q, Xiao L, Shen HM, Liou YC
Nature communications 2019 May 3;10(1):2059
Nature communications 2019 May 3;10(1):2059
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M
Nature communications 2019 May 17;10(1):2205
Nature communications 2019 May 17;10(1):2205
Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review.
Yu H, Yu W, Luo SS, Yang YJ, Liu FT, Zhang Y, Chen Y, Sun YM, Wu JJ
Molecular genetics & genomic medicine 2019 Mar;7(3):e547
Molecular genetics & genomic medicine 2019 Mar;7(3):e547
Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology.
Zhang P, Fan B, Yang P, Temirov J, Messing J, Kim HJ, Taylor JP
eLife 2019 Mar 20;8
eLife 2019 Mar 20;8
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Li H, Ham A, Ma TC, Kuo SH, Kanter E, Kim D, Ko HS, Quan Y, Sardi SP, Li A, Arancio O, Kang UJ, Sulzer D, Tang G
Autophagy 2019 Jan;15(1):113-130
Autophagy 2019 Jan;15(1):113-130
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.
Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D
Nature communications 2019 Jan 18;10(1):329
Nature communications 2019 Jan 18;10(1):329
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.
D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J
Molecular cell 2019 Feb 21;73(4):775-787.e10
Molecular cell 2019 Feb 21;73(4):775-787.e10
Acteoside inhibits autophagic apoptosis of retinal ganglion cells to rescue glaucoma-induced optic atrophy.
Chen Q, Xi X, Zeng Y, He Z, Zhao J, Li Y
Journal of cellular biochemistry 2019 Aug;120(8):13133-13140
Journal of cellular biochemistry 2019 Aug;120(8):13133-13140
Activation of PINK1-Parkin-dependent mitophagy in Tri-ortho-cresyl phosphate-treated Neuro2a cells.
Wang Y, Zhang C, Shen Z, Kou R, Xie K, Song F
Chemico-biological interactions 2019 Aug 1;308:70-79
Chemico-biological interactions 2019 Aug 1;308:70-79
The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau).
Xu Y, Zhang S, Zheng H
Autophagy 2019 Apr;15(4):583-598
Autophagy 2019 Apr;15(4):583-598
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.
Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, Rudolf R, Friedrich O, Litchfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S
Autophagy 2018;14(2):311-335
Autophagy 2018;14(2):311-335
Parkin is a disease modifier in the mutant SOD1 mouse model of ALS.
Palomo GM, Granatiero V, Kawamata H, Konrad C, Kim M, Arreguin AJ, Zhao D, Milner TA, Manfredi G
EMBO molecular medicine 2018 Oct;10(10)
EMBO molecular medicine 2018 Oct;10(10)
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N
EMBO reports 2018 Dec;19(12)
EMBO reports 2018 Dec;19(12)
Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes.
Puri M, La Pietra L, Mraheil MA, Lucas R, Chakraborty T, Pillich H
Toxins 2017 Sep 5;9(9)
Toxins 2017 Sep 5;9(9)
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, Caswell PT, Campbell AD, Hogeweg A, Sansom OJ, Morton JP, Norman JC
Nature communications 2017 Mar 15;8:14646
Nature communications 2017 Mar 15;8:14646
Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.
Andres AM, Tucker KC, Thomas A, Taylor DJ, Sengstock D, Jahania SM, Dabir R, Pourpirali S, Brown JA, Westbrook DG, Ballinger SW, Mentzer RM Jr, Gottlieb RA
JCI insight 2017 Feb 23;2(4):e89303
JCI insight 2017 Feb 23;2(4):e89303
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M
Cell 2016 Feb 25;164(5):896-910
Cell 2016 Feb 25;164(5):896-910
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.
Nguyen TN, Padman BS, Usher J, Oorschot V, Ramm G, Lazarou M
The Journal of cell biology 2016 Dec 19;215(6):857-874
The Journal of cell biology 2016 Dec 19;215(6):857-874
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy.
Zhang J, Chen K, Wang L, Wan X, Shrestha C, Zhou J, Mo Z
Biochemical and biophysical research communications 2016 Aug 5;476(4):299-305
Biochemical and biophysical research communications 2016 Aug 5;476(4):299-305
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F
Nature communications 2016 Aug 24;7:12547
Nature communications 2016 Aug 24;7:12547
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.
Slowicka K, Vereecke L, Mc Guire C, Sze M, Maelfait J, Kolpe A, Saelens X, Beyaert R, van Loo G
European journal of immunology 2016 Apr;46(4):971-80
European journal of immunology 2016 Apr;46(4):971-80
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G, Ying Z
Human molecular genetics 2015 May 1;24(9):2426-41
Human molecular genetics 2015 May 1;24(9):2426-41
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ
Nature 2015 Aug 20;524(7565):309-314
Nature 2015 Aug 20;524(7565):309-314
Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology.
Gao J, Ohtsubo M, Hotta Y, Minoshima S
PloS one 2014;9(7):e101206
PloS one 2014;9(7):e101206
Interaction between optineurin and the bZIP transcription factor NRL.
Wang C, Hosono K, Ohtsubo M, Ohishi K, Gao J, Nakanishi N, Hikoya A, Sato M, Hotta Y, Minoshima S
Cell biology international 2014 Jan;38(1):16-25
Cell biology international 2014 Jan;38(1):16-25
Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina.
Meng Q, Xiao Z, Yuan H, Xue F, Zhu Y, Zhou X, Yang B, Sun J, Meng B, Sun X, Cheng F
Molecular biology reports 2012 Feb;39(2):1119-24
Molecular biology reports 2012 Feb;39(2):1119-24
Optineurin in neurodegenerative diseases.
Osawa T, Mizuno Y, Fujita Y, Takatama M, Nakazato Y, Okamoto K
Neuropathology : official journal of the Japanese Society of Neuropathology 2011 Dec;31(6):569-74
Neuropathology : official journal of the Japanese Society of Neuropathology 2011 Dec;31(6):569-74
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS.
Al-Sarraj S, King A, Troakes C, Smith B, Maekawa S, Bodi I, Rogelj B, Al-Chalabi A, Hortobágyi T, Shaw CE
Acta neuropathologica 2011 Dec;122(6):691-702
Acta neuropathologica 2011 Dec;122(6):691-702
Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders.
Hortobágyi T, Troakes C, Nishimura AL, Vance C, van Swieten JC, Seelaar H, King A, Al-Sarraj S, Rogelj B, Shaw CE
Acta neuropathologica 2011 Apr;121(4):519-27
Acta neuropathologica 2011 Apr;121(4):519-27
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10837-1-AP(OPTN antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using OPTN antibody 10837-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-OPTN (IP:10837-1-AP, 3ug; Detection:10837-1-AP 1:800) with mouse brain tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 10837-1-AP(OPTN antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 10837-1-AP(OPTN antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
