Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 12384-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12384-1-AP, RRID:AB_2210915
- Product name
- UCHL3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UCHL3 antibody (Cat. #12384-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Quantification Quality Control Emerges as a Crucial Factor to Enhance Single-Cell Proteomics Data Analysis.
CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3.
Porphyromonas gingivalis induced UCHL3 to promote colon cancer progression.
UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin.
The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway.
Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer.
Structural basis for specific inhibition of the deubiquitinase UCHL1.
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization.
The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.
An Interaction Landscape of Ubiquitin Signaling.
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
Yu SH, Chen SC, Wu PS, Kuo PI, Chen TA, Lee HY, Lin MH
Molecular & cellular proteomics : MCP 2024 May;23(5):100768
Molecular & cellular proteomics : MCP 2024 May;23(5):100768
CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3.
Xie G, Lei B, Yin Z, Xu F, Liu X
International journal of molecular sciences 2024 Feb 29;25(5)
International journal of molecular sciences 2024 Feb 29;25(5)
Porphyromonas gingivalis induced UCHL3 to promote colon cancer progression.
Lu Y, Huang R, Zhang Y, Xiang W, Zhang X, Chen F, An L, Yuan H, Wen F, Xu Y
American journal of cancer research 2023;13(12):5981-5995
American journal of cancer research 2023;13(12):5981-5995
UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin.
Ma Q, Lu Q, Lei X, Zhao J, Sun W, Wang J, Zhu Q, Huang D
Frontiers in oncology 2023;13:1088475
Frontiers in oncology 2023;13:1088475
The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway.
Tang J, Yang Q, Mao C, Xiao D, Liu S, Xiao L, Zhou L, Wu G, Tao Y
Cell death and differentiation 2023 May;30(5):1247-1259
Cell death and differentiation 2023 May;30(5):1247-1259
Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer.
Zhang W, Wang M, Song Z, Fu Q, Chen J, Zhang W, Gao S, Sun X, Yang G, Zhang Q, Yang J, Tang H, Wang H, Kou X, Wang H, Mao Z, Xu X, Gao S, Jiang Y
Nature communications 2023 Apr 3;14(1):1838
Nature communications 2023 Apr 3;14(1):1838
Structural basis for specific inhibition of the deubiquitinase UCHL1.
Grethe C, Schmidt M, Kipka GM, O'Dea R, Gallant K, Janning P, Gersch M
Nature communications 2022 Oct 10;13(1):5950
Nature communications 2022 Oct 10;13(1):5950
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Lei Q, Yi T, Li H, Yan Z, Lv Z, Li G, Wang Y
Scientific reports 2020 Jun 30;10(1):10604
Scientific reports 2020 Jun 30;10(1):10604
UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization.
Song Z, Li J, Zhang L, Deng J, Fang Z, Xiang X, Xiong J
American journal of cancer research 2019;9(9):1970-1981
American journal of cancer research 2019;9(9):1970-1981
The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.
Nishi R, Wijnhoven PWG, Kimura Y, Matsui M, Konietzny R, Wu Q, Nakamura K, Blundell TL, Kessler BM
Scientific reports 2018 Dec 17;8(1):17891
Scientific reports 2018 Dec 17;8(1):17891
An Interaction Landscape of Ubiquitin Signaling.
Zhang X, Smits AH, van Tilburg GB, Jansen PW, Makowski MM, Ovaa H, Vermeulen M
Molecular cell 2017 Mar 2;65(5):941-955.e8
Molecular cell 2017 Mar 2;65(5):941-955.e8
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
Luo K, Li L, Li Y, Wu C, Yin Y, Chen Y, Deng M, Nowsheen S, Yuan J, Lou Z
Genes & development 2016 Dec 1;30(23):2581-2595
Genes & development 2016 Dec 1;30(23):2581-2595
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12384-1-AP(UCHL3 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UCHL3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UCHL3. This antibody recognizes human,mouse,rat antigen. The UCHL3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.