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- Antibody Data
- Antigen structure
- References [682]
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- Product number
- 66369-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- PGC1a antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated PGC1a antibody (Cat. #66369-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1C1B2
- Vial size
- 20ul, 150ul
Submitted references Porphyromonas gingivalis Promotes Neuroinflammation by Microglial Ferroptosis via NOX4/PPAR-α/PGC-1α Pathway.
NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis.
Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury.
H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury.
Hyperglycemia in combination with excess fat intake promotes renal pyroptosis and fibrosis through Gα(12)-dependent endoplasmic reticulum stress.
Physiological safety and Multi-Tissue metabolic adaptation under a novel intermittent prolonged fasting regimen.
CIAPIN1 improves sepsis-induced acute kidney injury by inhibiting mitochondrial damage.
Shenkangling alleviates renal fibrosis induced by renal ischemia-reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway.
PGC-1α exacerbates apoptosis to induce HIF-1α/BNIP3 mediated mitophagy in heart failure.
Chaihu-Shugan San ameliorates perimenopausal obesity with depression by coordinately targeting hepatic PGC-1α/CYP8B1/PPARγ signaling and gut barrier integrity.
The mechanism of honeysuckle peptides in ameliorating hyperuricemia in mice via the PGC-1α/PPARγ/ABCG2 pathway.
Salvianolic Acid B Alleviates MAFLD by Targeting PPAR-α: Mechanistic Insights From Network Pharmacology and Lipidomics.
Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise-Induced Fatigue via AMPK/PGC-1α Pathway Activation.
Identification of Common Genes Regulated by ER Stress During the Development of Diabetic Nephropathy Based on Human Transcriptome Datasets and an In Vivo Mouse Model.
Asymmetric dimethylguanidino valeric acid as an independently associated risk factor for early hypertriglyceridemia and dyslipidemia.
Fermented Black Soybean and Dehulled Adlay Improve Metabolic Syndrome via AMPK-SIRT1 Activation and Gut Microbiota Modulation.
FBXO39 knockdown promotes spermatogenesis impairment by inducing mitochondrial dysfunction and ferroptosis via inhibiting KDM5A ubiquitination and regulating H3K4me3 demethylation.
Dendrobium officinale polysaccharide ameliorate hyperlipidemia through LKB1/AMPK and CD36/PGC-1α/UCP1 activation and gut microbiota modulation.
Lentinan mitigates age-related sarcopenia through the promotion of mitochondrial biogenesis.
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer.
Beta 2 adrenergic receptor agonists as a treatment for metabolic dysfunction-associated steatohepatitis (MASH).
Atractylodes macrocephala Koidz. water extract alleviates exercise-induced fatigue by activating mitochondrial biogenesis via the PGC-1α/NRF1/TFAM axis.
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control.
A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat.
Aerobic exercise improve physical endurance and muscle function by ameliorating oxidative stress and modulating mitochondrial dynamics in aged skeletal muscle.
Cardamonin represses gastric adenocarcinoma development by modulating c-Myc/GLUT4/PGC-1α axis mediated glucose uptake and energy metabolism reprogramming.
Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.
FUNDC1-dependent mitophagy determines axon regeneration capacity.
Allosteric activation of pyruvate carboxylase by Dracoflavan B(2) enhances endothelial energy metabolism to attenuate myocardial infarction.
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Swertia mussotii Franch. Improves skeletal muscle glucose uptake and mitochondrial function via Ampk/Pgc-1α signaling in type 2 diabetes mice.
PGC-1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti-Inflammatory Response.
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Nobiletin Ameliorates Skeletal Muscle Performance in D-Galactose-Induced Aging Mice by Boosting Aerobic Metabolism.
Mafu Yishen Formula ameliorates membranous nephropathy by promotion of regulatory T cell differentiation: a multi-omics study.
Yangjingzhongyu Decoction regulates primordial follicle initiation via LncRNA-Smad1/AMPK dual pathways in diminished ovarian reserve.
α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis.
Targeted PGC-1α gene delivery by GV-assisted ultrasound cavitation for renal ischemia-reperfusion injury therapy.
Aerobic exercise attenuates intramyocellular lipid accumulation by upregulating vitamin D receptor.
Nicotinamide N-methyltransferase mediates redox regulation and colonic epithelial barrier impairment by SIRT1/PPAR-γ/NLRP6/NRF2 axis in inflammatory bowel disease.
Selenomethionine alleviates aortic dissection via PGC-1α/NRF2/TFAM-mediated mitochondrial biosynthesis against ferroptosis: an experimental study.
Idebenone alleviates rotenone-induced mitochondrial dysfunction through mitophagy and mitochondrial biogenesis in muscle cells.
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
N-Lac-Phe Ameliorates Myocardial Cell Death by Improving Mitochondrial Dysfunction, Ultimately Improving TAC-induced Heart Failure.
PM(10) Disrupts Mitochondrial Homeostasis in Corneal Epithelial Cells: Protective Effects of SKQ1.
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
A coenzyme-based "interface-welding" hydrogel coating for titanium implants promotes diabetic osseointegration by regulating mitochondrial dynamics.
Di-(2-Ethylhexyl) phthalate causes testicular ferroptosis though deficiency of androgen receptor and disruption of mitochondrial quality control.
Gut microbiota-derived taurolithocholic acid modulates myofiber-type switching via p38 MAPK/PGC-1α signaling underlying breed differences between Arbor Acres and Taoyuan chickens.
SIRT3-mediated mitochondrial fatty acid oxidation protects against hepatic lipid deposition in fatty liver hemorrhagic syndrome.
ELABELA Targets Mitochondria to Modulate Heart Development.
Vitamin D Receptor/Sirtuin 3 Pathway Mediates the Cardioprotective Effects of Aerobic Exercise in Diabetic Mice.
Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD(+) Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection.
Astragaloside IV delays vascular aging by enhancing mitochondrial fatty acid β-oxidation via the MLXIPL-PPARα/PGC-1α axis.
Moxibustion delays ovarian aging by regulating mitochondrial biogenesis and improving oocyte quality.
Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice.
Pretreatment with a ketogenic diet inhibits mitochondrial damage in rat models of spinal cord injury via the PGC-1α/Sirt1/Nrf1 pathway.
SIRT3 is required for the protective function of ketogenic diet on neural inflammation and neuropathic pain.
TEAD1 Prevents Necroptosis and Inflammation in Cisplatin-Induced Acute Kidney Injury Through Maintaining Mitochondrial Function.
Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload.
Investigating the Relationship between Ulcerative Colitis and Circadian Rhythm Genes Using Bioinformatics Analysis and Machine Learning.
Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair.
Improved myocardial mitochondrial energy metabolism in rats with chronic heart failure by modifying fatty acid oxidation using an extract of sand-fired aconite (Jianchang gang processing).
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.
Biomimetic piezoelectric hydrogel system for energy metabolism reprogramming in spinal cord injury repair.
Astaxanthin alleviates oxidative stress and skeletal muscle damage by promoting mitochondrial biogenesis.
Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity.
Cancer-associated fibroblasts regulate mitochondrial metabolism and inhibit chemosensitivity via ANGPTL4-IQGAP1 axis in prostate cancer.
GW8510 alleviates muscle atrophy and skeletal muscle dysfunction in mice through AMPK/PGC1α signaling.
Sustained oxygen-releasing hydrogel implants enhance flap regeneration by promoting mitochondrial biogenesis under mild hypoxia.
Targeted energy metabolomics analysis-based mitochondrial restoration: Nutritional intervention of dairy-derived MFG-E8 synergistic with egg yolk phosphatidylcholine in skeletal muscle regeneration.
Asiaticoside Mitigates Chronic Obstructive Pulmonary Disease by Modulating TRIM27 Stability and Activating PGC-1α/Nrf2 Signaling.
Evaluation of ethanolic extract of Clinacanthus nutans leaves in C2C12 myotubes: anti-exercise fatigue activity.
Energy metabolism disturbance induced by atorvastatin exposure on yellowstripe goby (Mugilogobius chulae) larvae based on transcriptome and metabolome analysis.
Lactate induces oxidative phosphorylation in osteoblasts via Gpr81-Stat3 signaling.
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
CUMS stress facilitates hippocampal neural mitophagy through FIS1/MFF-mediated mitochondrial fragmentation.
Phosphatidylethanolamine/PKA signal axis mediated human milk extracellular vesicles enhance adipose thermogenesis and lipolysis via mitochondrial remodeling.
Combination of imeglimin and resistance exercise improves mitochondrial function and glucose metabolism in skeletal muscles.
Mitophagy-mediated S1P facilitates muscle adaptive responses to endurance exercise through SPHK1-S1PR1/S1PR2 in slow-twitch myofibers.
High-Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice.
IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression.
Fenofibrate alleviates sepsis-associated acute kidney injury by enhancing renal fatty acid oxidation.
CAMKK2 restored mitochondrial dynamics homeostasis to alleviate pulmonary fibrosis via AMPK/PGC-1α signaling pathway in lung fibroblasts.
3-n-butylphthalide improves cerebral ischemia/reperfusion injury by regulating neuronal mitochondrial biogenesis via AMPK/PGC-1α signaling pathway.
Taurodeoxycholic, taurocholic, and glycocholic acids promote hepatic gluconeogenesis via TGR5 in dairy cows.
SIRT1/PGC-1α/Mfn2 pathway regulates mitochondrial homeostasis in VSMC to attenuate aging-related vascular calcification.
A Novel Glucomannan from Dendrobium officinale Inhibits Obesity and Improves Insulin Sensitivity through Regulating Adipogenesis and Lipid Metabolism.
LLTH induces white adipose tissue browning via NF κB inhibition in ATM.
α-Ketoglutarate Ameliorates Sarcopenia in D-Galactose-Induced Aging Mice by Modulating Protein Homeostasis and Optimizing Mitochondrial Function.
Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway.
Hesperidin attenuates lipopolysaccharide-induced endometritis by inhibiting mitochondrial oxidative stress via activating the AMPK/PGC-1α signalling pathway.
Intercepting the complement amplification loop through podocyte MC5R signaling ameliorates membranous nephropathy.
Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner.
PLIN5 regulates lipid metabolism via PGC-1α/Drp1 signaling in islet β-cells.
1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity.
Eurotium Cristatum fermented instant dark tea prevents obesity and promotes adipose thermogenesis via modulating the gut microbiota.
Spinal p38 MAPK/PGC-1α/SIRT3 signaling pathway mediates remifentanil-induced hyperalgesia in rats via ROS release and NR2B activation.
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
Formononetin, a bioactive isoflavone compound in modified nuanxinkang, alleviates cardiorenal syndrome type 4-induced mitochondrial dysfunction by targeting Hippo-YAP signaling.
PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury.
Inhalation of Ultrafine Carbon Black-Induced Mitochondrial Dysfunction in Mouse Heart Through Changes in Acetylation.
Inhibition of SIRT1/PGC-1α Axis Exacerbates Fluorine and Aluminium Induced Neurotoxicity via Drp1-dependent Aggravated Mitochondrial Fission.
Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling.
Spermidine enhances macrophages anti-inflammatory and regenerative functions by improving mitochondrial fitness.
Liu-Jun-Zi decoction alleviates metabolic dysfunction-associated steatohepatitis by modulating myogenic irisin mediated skeletal muscle-liver crosstalk.
GSTK1 suppresses HCC aggravation via L-carnitine metabolism by PGAM5/DRP1 complex-mediated mitochondrial quality control.
Nicotine Improves Memory Impairment in Aged Rats Through Enhanced Mitochondrial Homeostasis.
Wogonin, a bioactive flavonoid from Scutellaria baicalensis, alleviates alcoholic pancreatitis via AMPK-mediated TFEB activation.
Improvement of Glucose Metabolism by Pennogenin 3-O-β-Chacotrioside via Activation of IRS/PI3K/Akt Signaling and Mitochondrial Respiration in Insulin-Resistant Hepatocytes.
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Ferulic acid protects against stress-induced myocardial injury in mice.
Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control.
Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration.
Reprogramming of Hypoxia-Induced Metabolic Disorder in Mouse Kidneys by Mesenchymal Stem Cells Through Improving Mitochondrial Dynamics and Function.
Eicosapentaenoic acid (EPA) reduced lipopolysaccharide-stimulated inflammatory response of RAW264.7 cells via the miR-125b-5p/CREB axis.
Structural characterization and alleviative effects of novel polysaccharides from Artemisia sphaerocephala Krasch seed on obese mice by regulating gut microbiota.
Phosphorylation-driven regulation of SIRT1 in muscle senescence: Insights from molecular dynamics simulation and experimental validation.
Vine tea (Ampelopsis grossedentata) ameliorates chronic alcohol-induced hepatic steatosis, oxidative stress, and inflammation via YTHDF2/PGC-1α/SIRT3 axis.
Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition.
Effective compound combination of Bufei Yishen formula ameliorates PM2.5-induced COPD by inhibiting mitochondrial oxidative stress through SIRT3-mediated FOXO3 deacetylation.
Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
Enhanced mitochondrial biogenesis facilitates the development of cutaneous squamous cell carcinoma.
Overexpression of c-Myc triggers p62 aggregation-mediated mitochondrial mitophagy in cabozantinib resistance of hepatocellular carcinoma.
A Comprehensive Study Employing Computational Analysis and Mendelian Randomization Has Revealed the Impact of Key Genes on Liver Cancer.
[Pachymic acid promotes brown/beige adipocyte differentiation and lipid metabolism in preadipocytes].
Nanoparticle-mediated targeting of PGC-1α reveals critical metabolic pathways in bladder cancer metastasis.
ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa.
High-dose vitamin C promotes mitochondrial biogenesis in HCT116 colorectal cancer cells by regulating the AMPK/PGC-1α signaling pathway.
Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes.
Mitochondrial-Derived Signaling Mediates Differentiation of Parietal Epithelial Cells into Podocytes.
Metformin delays the decline in thermogenic function of brown adipose tissue in a mouse model of Hutchinson-Gilford progeria syndrome.
TFE3-mediated neuroprotection: Clearance of aggregated α-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease.
Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.
Induction of UBQLN1-mediated PGC1α stability by isoliensinine overcame hypoxia-induced resistance in liver cancer cells.
Ginsenoside Rb(1) Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway.
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans.
Taurine ameliorates deoxynivalenol-induced intestinal injury in piglets: Restoration of mitochondrial function linked to the PGC1α-NRF1/2 axis.
Membrane-associated ring-CH-type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase.
Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice.
YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ.
RIPC improves myocardial injury by promoting mitochondrial protection via the PGC-1α/Nrf2 pathway.
Fibroblast growth factor 21/extracellular signal-regulated kinase 1/2 pathway as a key link mediates the effects of low-protein diet on skeletal muscle fiber type transformation in pigs.
Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury.
The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition.
Time-restricted feeding mitigates HFD-induced sarcopenic obesity in aging mice through improving the sensitivity of FGF21.
Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury.
In Vivo Reprogramming of Tissue-Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering.
Hawthorn total flavonoids ameliorate hyperlipidemia through AMPK/SREBP1-c and PPARα/PGC-1α/CPT-1A pathway activation and gut microbiota modulation.
Fecal Microbiota Transplantation from Mice Receiving Magnetic Mitohormesis Treatment Reverses High-Fat Diet-Induced Metabolic and Osteogenic Dysfunction.
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
Browning of Aldosterone-Producing Adenoma Adjacent Adipose Tissue Involved in Aldosterone Synthesis Regulation.
Initiating Empagliflozin and Sacubitril/Valsartan Early After Acute Myocardial Infarction: Mechanistic Study.
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Drp1 knockdown aggravates obesity-induced cardiac dysfunction and remodeling.
The role of mitochondrial dysfunction in the protective effect of ginger derived extracellular vesicles on hepatic stellate cells against cytotoxicity.
Activation of spinal PGC-1α regulates microglial polarization through a feedback loop between ROS-mediated mitochondrial dysfunction and the NLRP3 inflammasome in neuropathic pain.
Hesperidin mitigated deoxynivalenol-induced liver injury by inhibiting ROS/ P53/ PGC-1α-mediated disruption of mitochondrial dynamics and PANoptosis.
Decreased Expression and Secretion of the Myokine Fndc5/Irisin by Cisplatin Treatment in Mouse Skeletal Muscle.
Involvement of impaired carnitine-induced fatty acid oxidation in experimental and human diabetic kidney disease.
Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD(+)/Sirt1 pathway in the brain: a possible link between hyperhomocysteinemia and neurodegeneration.
Timosaponin AⅢ inhibits ectopic lipid deposition and enhances the browning of white adipose tissue.
Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition.
Chlorogenic acid and ferulic acid in SMYAD alleviate diabetic cardiomyopathy by inhibiting cardiac lipotoxicity via GCGR/PPARα and GCGR/AMPK pathways.
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy.
Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.
MSCs in acute kidney injury treatment: Modulating mitochondrial function and inhibiting pyroptosis via PGC-1α.
Aerobic Exercise Delays Age-Related Sarcopenia in Mice via Alleviating Imbalance in Mitochondrial Quality Control.
Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 pathway activation.
LC-MF-4, a Novel FGFR3 Degrader for Therapeutic Intervention in FGFR3-Altered Cancers.
Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage.
Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney.
Integrating network pharmacology and transcriptomics to study the potential mechanism of Jingzhi Niuhuang Jiedu tablet in rats with accumulation of heat in the lungs and stomach.
Comparison of chemical composition between imitation wild and transplanted Astragali Radix and their therapeutic effects on heart failure.
Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration.
Butyrate attenuates high-fat diet-induced glomerulopathy through GPR43-Sirt3 pathway.
Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice.
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
Chronic hyperglycemia induces hepatocyte pyroptosis via Gα(12)/Gα(13)-associated endoplasmic reticulum stress: Effect of pharmacological intervention.
1-Bromopropane induces mitochondrial damage and lipid metabolism imbalance in respiratory epithelial cells through the PGC-1α/PPARα pathway.
Jellyfish stings-induced cardiac failure was ameliorated through AAG-mediated glycogen-driven ATP production.
Involvement of mitochondrial dysfunction and oxidative stress in the nephrotoxicity induced by high-fat diet in Sprague-Dawley rats.
Hydroxyacyl-coenzyme A dehydrogenase: A biomarker for authentication of death from mechanical asphyxia.
The contributory role of GSK3β in hypertension exacerbating atherosclerosis by regulating the OMA1/PGC1α pathway.
Chronic alcohol consumption exacerbates ischemia-associated skeletal muscle mitochondrial dysfunction in a murine model of peripheral artery disease.
CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.
Tomatine Improves Glucose Metabolism and Mitochondrial Respiration in Insulin-Resistant Hepatocyte Cell Lines AML12 and HepG2 via an AMP-Activated Protein Kinase-Dependent Pathway.
Protective effect and mechanism of plant-derived Lactobacillus G11 on septic myocardial injury.
Bone marrow mesenchymal stem cells ameliorate diet-induced obesity by activating thermogenesis and alleviating inflammation in adipose tissue.
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
Regulatory effects of yam (Dioscorea opposita Thunb.) glycoprotein on energy metabolism in C2C12 and 3T3-L1 cells and on crosstalk between these two cells.
Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis.
PANAXADIOL SAPONIN ALLEVIATES LPS-INDUCED CARDIOMYOPATHY SIMILAR TO DEXAMETHASONE VIA IMPROVING MITOCHONDRIAL QUALITY CONTROL.
MDPAO1 peptide from human milk enhances brown adipose tissue thermogenesis and mitigates obesity.
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function.
Cedrol prevents UVB-induced photoaging by restoring mitochondrial function, metabolic homeostasis, and skin barrier integrity in HaCaT cells.
Canagliflozin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease via Mitochondrial Protection and Enhanced Mitophagy.
Alpha Ketoglutaric Acid attenuates LPS Induced Inflammatory Response by Inhibiting the PKCε/MAPK/P65 Signaling Pathway and Inhibit Oxidative Stress in Kupffer Cells.
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress.
Hsa_circ_0020491 promotes polycystic ovary syndrome by interacting with IGF2BP2 through regulation of granular cell autophagy and mitochondrial dysfunction.
M6a demethylase FTO regulates the oxidative stress, mitochondrial biogenesis of cardiomyocytes and PGC-1a stability in myocardial ischemia-reperfusion injury.
Analysis of the Protective Mechanism of PGC-1α/NRF1/2/TFAM Pathway in Cortical Neuron Injury Induced by Oxidative Stress.
Dietary cannabidiol oil mitigates metabolic dysfunction in mice with high-fat diet-induced obesity.
PSPC1-SMAD3 axis regulates iron-induced beiging of adipocytes in white adipose tissue.
Multi-Omics Analysis Reveals Distinct Lipid Remodelling and Mitochondrial Stress in SH-SY5Y Cells Modelling Parkinson's Disease.
Oral Supplementation of Indole-3-acetic Acid Alleviates High-Fat-Induced Obesity by Activating the Gpha2-Mediated Thyroid-Stimulating Hormone Pathway.
LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer.
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice.
Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats.
Genetic algorithm-back propagation artificial neural network model- and response surface methodology-based optimization of crude Lophatherum gracile Brongn. polysaccharides extraction and their anti-NAFLD effects via regulating liver-adipose tissue crosstalk.
Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models.
Housing temperature influences exercise-induced glucose regulation and expression of exerkines in mice.
Melatonin mitigates arsenic and fluoride-induced cardiotoxicity in chickens by maintaining mitochondrial homeostasis.
PGC1α regulates the mitochondrial metabolism response to cyclic stretch, which inhibits neointimal hyperplasia.
NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway.
Improvement effect of Shengxian Decoction on cardiac toxicity induced by arsenic trioxide in rats.
PDE4D Regulates Mitochondrial Homeostasis and Adult Hippocampal Neurogenesis via the cAMP/CREB Signaling Pathway in Chronic Stress-Induced Depressive-Like Behavior.
CGKRK-targeted lipid nanoparticles enhance in vivo rosiglitazone delivery to the placenta to ameliorate murine preeclampsia.
Buckwheat protein-derived peptide ameliorates insulin resistance by directing O-linked N-acetylglucosamine transferase to regulate the SIRT1/PGC1α pathway.
Environmentally relevant concentrations lithium exposure induces neurotoxicity in yellowstripe goby (Mugilogobius chulae): Responses of BDNF/AKT/FoxOs in regulating glutamate excitotoxicity and mitochondrial function.
Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy.
Vitamin C-Dependent Intergenerational Inheritance of Enhanced Endurance Performance Following Maternal Exercise.
Tangshenning formula alleviates tubular injury in diabetic kidney disease via the Sestrin2/AMPK/PGC-1α axis: Restoration of mitochondrial function and inhibition of ferroptosis.
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer's disease.
Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model.
Nobiletin Enhances Skeletal Muscle Mass and Modulates Bile Acid Composition in Diet-Induced Obese Mice.
A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue.
MicroRNA-29b Plays a Vital Role in Podocyte Injury and Glomerular Diseases through Inducing Mitochondrial Dysfunction.
Magnesium Ion-Doped Mesoporous Bioactive Glasses Loaded with Gallic Acid Against Myocardial Ischemia/Reperfusion Injury by Affecting the Biological Functions of Multiple Cells.
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Inflammation Can Be a High-Risk Factor for Mucosal Nonunion of MRONJ by Regulating SIRT1 Signaling When Treated with an Oncologic Dose of Zoledronate.
ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders.
Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.
Ling-gui-zhu-gan granules reduces obesity and ameliorates metabolic disorders by inducing white adipose tissue browning in obese mice.
ADRB2 serves as a novel biomarker and attenuates alcoholic hepatitis via the SIRT1/PGC-1α/PPARα pathway: integration of WGCNA, machine learning and experimental validation.
TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.
Ling-gui-zhu-gan promotes adipocytes browning via targeting the miR-27b/PRDM16 pathway in 3T3-L1 cells.
PPARGC1A regulates transcriptional control of mitochondrial biogenesis in early bovine embryos.
Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice.
Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning.
Transplantation of astrocyte-derived mitochondria into injured astrocytes has a protective effect following stretch injury.
Neuregulin4-ErbB4 signalling pathway is driven by electroacupuncture stimulation to remodel brown adipose tissue innervation.
SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106-126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis.
LncRNA PVT1 induces mitochondrial dysfunction of podocytes via TRIM56 in diabetic kidney disease.
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia.
Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis.
Mesenchymal stem cells in tumor microenvironment: drivers of bladder cancer progression through mitochondrial dynamics and energy production.
Effects and mechanisms of Polygonati Rhizoma polysaccharide on potassium oxonate and hypoxanthine-induced hyperuricemia in mice.
Autophagy aggravates multi-walled carbon nanotube-induced ferroptosis by suppressing PGC-1 dependent-mitochondrial biogenesis in lung epithelial cells.
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α.
SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway.
Melatonin-loaded bioactive microspheres accelerate aged bone regeneration by formation of tunneling nanotubes to enhance mitochondrial transfer.
Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP(SAA) knock-in mouse model of Alzheimer's disease.
Gui Qi Zhuang Jin Decoction ameliorates mitochondrial dysfunction in sarcopenia mice via AMPK/PGC-1α/Nrf2 axis revealed by a metabolomics approach.
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
Unveiling the regulatory role of SIRT1 in the oxidative stress response of bovine mammary cells.
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4.
Exogenous hydrogen sulfide enhances myogenic differentiation of C2C12 myoblasts under high palmitate stress.
m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.
Evidence of Browning and Inflammation Features in Visceral Adipose Tissue of Women with Endometriosis.
Quercetin prevents methylmercury-induced mitochondrial dysfunction in the cerebral cortex of mice.
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Hydrogen Protects Mitochondrial Function by Increasing the Expression of PGC-1α and Ameliorating Myocardial Ischaemia-Reperfusion Injury.
Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.
6-Gingerol improves lipid metabolism disorders in skeletal muscle by regulating AdipoR1/AMPK signaling pathway.
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Cannabidiol Enhances Mitochondrial Metabolism and Antioxidant Defenses in Human Intestinal Epithelial Caco-2 Cells.
Decreased in Mitochondrial Complex I Subunit NDUFS2 Is Critical for Oocyte Quality During Postovulatory Aging in Pigs.
CPT1A mediates radiation sensitivity in colorectal cancer.
Schwann cell-secreted frizzled-related protein 1 dictates neuroinflammation and peripheral nerve degeneration after neurotrauma.
Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis.
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Telomerase reverse transcriptase protects against diabetic kidney disease by promoting AMPK/PGC-1a-regulated mitochondrial energy homeostasis.
Unconjugated bilirubin promotes uric acid restoration by activating hepatic AMPK pathway.
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition.
Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models.
Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway.
Carcinoembryonic antigen potentiates non-small cell lung cancer progression via PKA-PGC-1ɑ axis.
Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission.
NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis.
Collagen I protects human keratinocytes HaCaT against UVB injury via restoring PINK1/parkin-mediated mitophagy.
Pterostilbene protects against H(2) O(2) -induced oxidative stress by regulating GAS6/Axl signaling in HL-1 cells.
Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy.
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway.
Exercise-inducible circulating extracellular vesicle irisin promotes browning and the thermogenic program in white adipose tissue.
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Isolation of Calenduloside E from Achyranthes bidentata Blume and its effects on LPS/D-GalN-induced acute liver injury in mice by regulating the AMPK-SIRT3 signaling pathway.
PM(2.5) induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage.
Pennogenin 3-O-β-Chacotrioside Attenuates Hypertrophied Lipid Accumulation by Enhancing Mitochondrial Oxidative Capacity.
Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway.
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
Electroacupuncture improves cognitive function in a rat model of mild traumatic brain injury by regulating the SIRT-1/PGC-1α/mitochondrial pathway.
Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway.
Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes.
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model.
Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co-regulate proteasomes and mitochondria.
ADSCs encapsulated in Gelatin methacrylate substrate promotes the repair of peripheral nerve injury by SIRT6/PGC-1α pathway.
Cholesterol 25-hydroxylase prevents type 2 diabetes mellitus induced cardiomyopathy by alleviating cardiac lipotoxicity.
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
Arginine Regulates Skeletal Muscle Fiber Type Formation via mTOR Signaling Pathway.
PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence.
Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel.
Neferine inhibits BMECs pyroptosis and maintains blood-brain barrier integrity in ischemic stroke by triggering a cascade reaction of PGC-1α.
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
Diosmetin ameliorates psoriasis-associated inflammation and keratinocyte hyperproliferation by modulation of PGC-1α / YAP signaling pathway.
Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism.
Cornus officinalis Sieb. Et Zucc. attenuates Aβ(25-35)-induced mitochondrial damage and neuroinflammation in mice by modulating the ERK pathway.
Insights into the mechanism of action of pterostilbene against influenza A virus-induced acute lung injury.
Tangeretin Enhances Muscle Endurance and Aerobic Metabolism in Mice via Targeting AdipoR1 to Increase Oxidative Myofibers.
Structural Variances in Curcumin Degradants: Impact on Obesity in Mice.
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state.
Systematical Investigation on Anti-Fatigue Function and Underlying Mechanism of High Fischer Ratio Oligopeptides from Antarctic Krill on Exercise-Induced Fatigue in Mice.
Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ.
Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle.
Synergistic effects of MFG-E8 and whey protein on mitigating d-galactose-induced sarcopenia through PI3K/AKT/PGC-1α and MAPK/ERK signaling pathways.
Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens.
Mitochondria-derived peptide is an effective target for treating streptozotocin induced painful diabetic neuropathy through induction of activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1alpha -mediated mitochondrial biogenesis.
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Dietary oleic acid intake increases the proportion of type 1 and 2X muscle fibers in mice.
Jianpi Shengqing Huazhuo Formula improves abnormal glucose and lipid metabolism in obesity by regulating mitochondrial biogenesis.
MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning.
The promotion of fatty acid β-oxidation by hesperidin via activating SIRT1/PGC1α to improve NAFLD induced by a high-fat diet.
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Promising anti-ovarian aging herbal formulation He's Yangchao promotes in vitro maturation of oocytes from advanced maternal age mice.
Lycium barbarum polysaccharides attenuate oxidative stress and mitochondrial toxicity induced by mixed plasticizers in HepG2 cells through activation of Nrf2.
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
Microglia nuclear receptor corepressor 1 deficiency alleviates neuroinflammation in mice.
Alzheimer's Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells.
Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP (SAA) knock-in mouse model of Alzheimer's disease.
JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway.
Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease.
Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin†.
The use of a systems approach to increase NAD(+) in human participants.
M6A RNA Methylation-Mediated TUG1 Stability Maintains Mitochondrial Homeostasis during Kidney Aging by Epigenetically Regulating PGC1-α Expression.
Sirt1-mediated deacetylation of PGC-1α alleviated hepatic steatosis in type 2 diabetes mellitus via improving mitochondrial fatty acid oxidation.
Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC-1α-mediated Transcriptional Coactivation.
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Glia maturation factor-γ regulates amyloid-β42 phagocytosis through scavenger receptor class A type I in murine macrophages.
MicroRNA-668 alleviates renal fibrosis through PPARα/PGC-1α pathway.
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy.
Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARγ/PGC-1α/NF-κB axis to improve acute liver failure.
Inhibition of hepatitis B virus through PPAR-JAK/STAT pathway modulation by electroacupuncture and tenofovir disoproxil fumarate combination therapy.
AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection.
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Myricetin Alleviates Silica-Mediated Lung Fibrosis via PPARγ-PGC-1α Loop and Suppressing Mitochondrial Senescence in Epithelial Cells.
Total minor ginsenosides exert anti-fatigue effects via antioxidant, anti-inflammatory, regulating gut microbiota and serum metabolism.
DEHP regulates ferritinophagy to promote testicular ferroptosis via suppressing SIRT1/PGC-1α pathway.
Electroacupuncture improves cognitive impairment after ischemic stroke based on regulation of mitochondrial dynamics through SIRT1/PGC-1α pathway.
α-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1α/Nrf2 pathway.
Toxicity mechanism of acrolein on energy metabolism disorder and apoptosis in human ovarian granulosa cells.
Resveratrol suppresses hepatic fatty acid synthesis and increases fatty acid β-oxidation via the microRNA-33/SIRT6 signaling pathway.
Exerkine FNDC5/irisin-enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin-1.
PGC-1α/LDHA signaling facilitates glycolysis initiation to regulate mechanically induced bone remodeling under inflammatory microenvironment.
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes.
Mannan-binding lectin inhibits oxidative stress-induced senescence via the NAD+/Sirt1 pathway.
PGC-1α agonism induces fetal hemoglobin and exerts antisickling effects in sickle cell disease.
Adipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes.
Modulatory Effects of Lactobacillus paracasei-Fermented Turmeric on Metabolic Dysregulation and Gut Microbiota in High-Fat Diet-Induced Obesity in Mice.
Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS.
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Vigeo Promotes Myotube Differentiation and Protects Dexamethasone-Induced Skeletal Muscle Atrophy via Regulating the Protein Degradation, AKT/mTOR, and AMPK/Sirt-1/PGC1α Signaling Pathway In Vitro and In Vivo.
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Dietary purple potato supplement attenuates DSS-induced colitis in mice: impact on mitochondrial function.
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis.
Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment.
Beneficial Effects of High-Intensity Interval Training and Dietary Changes Intervention on Hepatic Fat Accumulation in HFD-Induced Obese Rats.
Nobiletin enhances mitochondrial function by regulating SIRT1/PGC-1α signaling in porcine oocytes during in vitro maturation.
Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia.
cGAS Activation Accelerates the Progression of Autosomal Dominant Polycystic Kidney Disease.
Chemerin affects blood lipid profile of high-fat diet male mice in sedentary and exercise states via glucose and lipid metabolism enzymes.
Corn peptides attenuate non-alcoholic fatty liver disease via PINK1/Parkin-mediated mitochondrial autophagy.
Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway.
Sodium Butyrate Ameliorates Type 2 Diabetes-Related Sarcopenia Through IL-33-Independent ILC2s/IL-13/STAT3 Signaling Pathway.
Cardiolipin externalization mediates prion protein (PrP) peptide 106-126-associated mitophagy and mitochondrial dysfunction.
Exercise prevents fatal stress-induced myocardial injury in obese mice.
The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity.
Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells.
Buyang Huanwu Decoction alleviates cerebral ischemic injury through modulating caveolin-1-mediated mitochondrial quality control.
Exosomal transfer leads to chemoresistance through oxidative phosphorylation-mediated stemness phenotype in colorectal cancer.
F-ATP synthase inhibitory factor 1 regulates metabolic reprogramming involving its interaction with c-Myc and PGC1α.
Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer.
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Lactate Improves Long-term Cognitive Impairment Induced By Repeated Neonatal Sevoflurane Exposures Through SIRT1-mediated Regulation of Adult Hippocampal Neurogenesis and Synaptic Plasticity in Male Mice.
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Autoantibodies against the NineTeen complex and U5 RNP in systemic sclerosis.
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice.
Melatonin Restores Autophagic Flux by Activating the Sirt3/TFEB Signaling Pathway to Attenuate Doxorubicin-Induced Cardiomyopathy.
The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells.
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Polysaccharide from Ziyang Selenium-Enriched Green Tea Prevents Obesity and Promotes Adipose Thermogenesis via Modulating the Gut Microbiota.
Astragaloside IV-mediated inhibition of oxidative stress by upregulation of ghrelin in type 2 diabetes-induced cognitive impairment.
In search for mitochondrial biomarkers of Parkinson's disease: Findings in parkin-mutant human fibroblasts.
Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction therapy.
Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells.
Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM(2.5) exposure by downregulating the PGC-1α/SIRT3 signaling pathway.
Modified rougan decoction attenuates hepatocyte apoptosis through ameliorating mitochondrial dysfunction by upregulated SIRT1/PGC-1α signaling pathway.
Aerobic exercise and metformin on intermuscular adipose tissue (IMAT): insights from multimodal MRI and histological changes in prediabetic rats.
Transcriptome Analysis Revealed Potential Genes of Skeletal Muscle Thermogenesis in Mashen Pigs and Large White Pigs under Cold Stress.
Indoxyl sulfate induced frailty in patients with end-stage renal disease by disrupting the PGC-1α-FNDC5 axis.
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca(2+) pathways.
MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of vidarabine against rotenone-induced neural cell injury.
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle.
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment.
Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis.
Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERRα-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats.
Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling.
Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells.
Butyrate mitigates metabolic dysfunctions via the ERα-AMPK pathway in muscle in OVX mice with diet-induced obesity.
Knockdown of 11β-hydroxysteroid dehydrogenase type 1 alleviates LPS-induced myocardial dysfunction through the AMPK/SIRT1/PGC-1α pathway.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Ripretinib induced skeletal muscle toxicity through mitochondrial impairment in C2C12 myotubes.
The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Impaired mitophagy causes mitochondrial DNA leakage and STING activation in ultraviolet B-irradiated human keratinocytes HaCaT.
Effects of dietary l-theanine supplementation on pork quality and muscle fiber type transformation in finishing pigs.
Novel antioxidant peptides from MFGM protein Hydrolysates: Separation, identification and effects on Dexamethasone-induced mitochondrial dysfunction.
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Ketogenic diets composed of long-chain and medium-chain fatty acids induce cardiac fibrosis in mice.
BNP protects against diabetic cardiomyopathy by promoting Opa1-mediated mitochondrial fusion via activating the PKG-STAT3 pathway.
Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis.
Exercise improves homeostasis of the intestinal epithelium by activation of apelin receptor-AMP-activated protein kinase signalling.
DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway.
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis.
Nicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system.
Bavachin protects against diet-induced hepatic steatosis and obesity in mice.
HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.
An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway.
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
High-intensity interval training induces renal injury and fibrosis in type 2 diabetic mice.
Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α.
PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity.
N-acetylcysteine delayed cadmium-induced chronic kidney injury by activating the sirtuin 1-P53 signaling pathway.
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice.
Dietary leucine and fish oil cooperatively regulate skeletal myofiber type transformation via the CaMKII signaling pathway of pigs.
PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice.
Mice harboring a R133L heterozygous mutation in LMNA exhibited ectopic lipid accumulation, aging, and mitochondrial dysfunction in adipose tissue.
Hypoxia aggravates the burden of yellowstripe goby (Mugilogobius chulae) under atorvastatin exposure.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling.
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM Pathway.
Aerobic exercise inhibits renal EMT by promoting irisin expression in SHR.
The Degree of Hydrolysis and Peptide Profile Affect the Anti-Fatigue Activities of Whey Protein Hydrolysates in Promoting Energy Metabolism in Exercise Mice.
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
Protective effect of Qingluotongbi formula against Tripterygium wilfordii induced liver injury in mice by improving fatty acid β-oxidation and mitochondrial biosynthesis.
Urolithin A protects severe acute pancreatitis-associated acute cardiac injury by regulating mitochondrial fatty acid oxidative metabolism in cardiomyocytes.
Efficacy of creatine nitrate supplementation on redox status and mitochondrial function in pectoralis major muscle of preslaughter transported broilers.
Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.
Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in calf hepatocytes.
Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway.
Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stress.
Styrax (Liquidambar orientalis Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1α signaling pathway.
Histone H3 Acetylation Is Involved in Retinoid Acid-Induced Neural Differentiation through Increasing Mitochondrial Function.
Effects of dapagliflozin monotherapy and combined aerobic exercise on skeletal muscle mitochondrial quality control and insulin resistance in type 2 diabetes mellitus rats.
High Concentrations of Nucleotides Prevent Capillary Regression during Hindlimb Unloading by Inhibiting Oxidative Stress and Enhancing Mitochondrial Metabolism of Soleus Muscles in Rats.
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Therapeutic Potential of Ginsenoside Rb1-PLGA Nanoparticles for Heart Failure Treatment via the ROS/PPARα/PGC1α Pathway.
Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway.
Prolonged fluoride exposure induces spatial-memory deficit and hippocampal dysfunction by inhibiting small heat shock protein 22 in mice.
LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway.
Oridonin ameliorates acetaminophen-induced acute liver injury through ATF4/PGC-1α pathway.
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Ginsenoside Rd promotes omentin secretion in adipose through TBK1-AMPK to improve mitochondrial biogenesis via WNT5A/Ca(2+) pathways in heart failure.
Resveratrol inhibits LPS-induced apoptosis in bovine mammary epithelial cells: the role of PGC1α-SIRT3 axis.
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice.
Nr2f2 Overexpression Aggravates Ferroptosis and Mitochondrial Dysfunction by Regulating the PGC-1α Signaling in Diabetes-Induced Heart Failure Mice.
Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis.
Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE.
An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model.
Rhein Ameliorates Cognitive Impairment in an APP/PS1 Transgenic Mouse Model of Alzheimer's Disease by Relieving Oxidative Stress through Activating the SIRT1/PGC-1α Pathway.
∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis.
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.
Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice.
Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy.
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis.
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages.
Growth Hormone Receptor Controls Adipogenic Differentiation of Chicken Bone Marrow Mesenchymal Stem Cells by Affecting Mitochondrial Biogenesis and Mitochondrial Function.
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Naringenin regulates gut microbiota and SIRT1/ PGC-1ɑ signaling pathway in rats with letrozole-induced polycystic ovary syndrome.
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3.
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
CHCHD10 Modulates Thermogenesis of Adipocytes by Regulating Lipolysis.
Hesperetin activated SIRT1 neutralizes cadmium effects on the early bovine embryo development.
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Naringenin activates beige adipocyte browning in high fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise.
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways.
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Artemisia sphaerocephala Krasch polysaccharide promotes adipose thermogenesis and decreases obesity by shaping the gut microbiota.
Dihydromyricetin alters myosin heavy chain expression via AMPK signaling pathway in porcine myotubes.
The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression.
Indole-3-acetic acid improves the hepatic mitochondrial respiration defects by PGC1a up-regulation.
Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α.
Targeting Wnt/β-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF.
Anti-fatigue effects of fermented soybean protein peptides in mice.
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.
Sirtuin 6 affects glucose reabsorption and gluconeogenesis in type 1 diabetes via FoxO1.
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
LncEDCH1 improves mitochondrial function to reduce muscle atrophy by interacting with SERCA2.
Dihydromyricetin improves meat quality and promotes skeletal muscle fiber type transformations via AMPK signaling in growing-finishing pigs.
IGF-1 Signaling Regulates Mitochondrial Remodeling during Myogenic Differentiation.
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.
Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia.
The anti-fatigue activity of corn peptides and their effect on gut bacteria.
Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway.
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
Exerkine apelin reverses obesity-associated placental dysfunction by accelerating mitochondrial biogenesis in mice.
Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin-induced acute kidney injury.
Selenium alleviates cadmium-induced aging via mitochondrial quality control in the livers of sheep.
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.
Effect of Qingyangshen glycosides on social defeat mice model.
Caloric restriction and Roux-en-Y Gastric Bypass promote white adipose tissue browning in mice.
Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress.
Sodium butyrate ameliorates the cognitive impairment of Alzheimer's disease by regulating the metabolism of astrocytes.
Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
d-Allulose Improves Endurance and Recovery from Exhaustion in Male C57BL/6J Mice.
Dopamine receptor D1 signaling stimulates lipolysis and browning of white adipocytes.
Arsenic causes mitochondrial biogenesis obstacles by inhibiting the AMPK/PGC-1α signaling pathway and also induces apoptosis and dysregulated mitophagy in the duck liver.
BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein.
circPTPN4 regulates myogenesis via the miR-499-3p/NAMPT axis.
Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway.
Quercetin, Engelitin and Caffeic Acid of Smilax china L. Polyphenols, Stimulate 3T3-L1 Adipocytes to Brown-like Adipocytes Via β3-AR/AMPK Signaling Pathway.
A plant-derived natural photosynthetic system for improving cell anabolism.
Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns.
Dietary L-theanine supplementation improves lipid metabolism and antioxidant capacity in weaning piglets.
Differential regulatory roles of microRNAs during intramuscular adipogenesis in Chinese Guizhou Congjiang Xiang pigs.
Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway.
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
Exercise-derived peptide protects against pathological cardiac remodeling.
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway.
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
DDB1 prepares brown adipocytes for cold-induced thermogenesis.
HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.
A pivotal role of selective autophagy in mitochondrial quality control: Implications for zinc oxide nanoparticles induced neurotoxicity.
PPARGC1A Is a Moderator of Skeletal Muscle Development Regulated by miR-193b-3p.
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome.
An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer's Disease.
Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming.
Construction and Validation of a Combined Ferroptosis and Hypoxia Prognostic Signature for Hepatocellular Carcinoma.
Vanadium Induces Oxidative Stress and Mitochondrial Quality Control Disorder in the Heart of Ducks.
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1.
l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
Protective Effects of Huangqi Shengmai Yin on Type 1 Diabetes-Induced Cardiomyopathy by Improving Myocardial Lipid Metabolism.
ZLN005 protects against ischemia-reperfusion-induced kidney injury by mitigating oxidative stress through the restoration of mitochondrial fatty acid oxidation.
Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity.
Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis.
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
The Protective Effects of Sulforaphane on High-Fat Diet-Induced Obesity in Mice Through Browning of White Fat.
The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
A novel supplement with yeast β-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice.
Effects of dietary ferulic acid supplementation on growth performance and skeletal muscle fiber type conversion in weaned piglets.
Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.
Multiplexed quantitative evaluation on mitochondrial toxicity of tris (2,3-dibromopropyl) phosphate in hepatocyte.
DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model.
Vitellogenin 2 promotes muscle development and stimulates the browning of white fat.
Differentiation of THP-1 monocytes to macrophages increased mitochondrial DNA copy number but did not increase expression of mitochondrial respiratory proteins or mitochondrial transcription factor A.
Naringin Promotes Skeletal Muscle Fiber Remodeling by the AdipoR1-APPL1-AMPK Signaling Pathway.
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice via gut microbia-mediated regulation of FGF21 signaling pathway.
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1.
A New Perspective on Ameliorating Depression-Like Behaviors: Suppressing Neuroinflammation by Upregulating PGC-1α.
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK.
Bezafibrate prevents aging in in vitro-matured porcine oocytes.
Theaflavin Promotes Mitochondrial Abundance and Glucose Absorption in Myotubes by Activating the CaMKK2-AMPK Signal Axis via Calcium-Ion Influx.
TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS.
Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor-dependent manner.
Selenium Deficiency-Induced Damage and Altered Expression of Mitochondrial Biogenesis Markers in the Kidneys of Mice.
Zinc-α2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice.
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cancer cells via nucleo-mitochondrial transcriptional feedback.
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway.
Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue.
Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease.
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.
Danqi Tablet () Regulates Energy Metabolism in Ischemic Heart Rat Model through AMPK/SIRT1-PGC-1α Pathway.
A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer's Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3.
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Network Pharmacology Approach to Explore the Potential Mechanisms of Jieduan-Niwan Formula Treating Acute-on-Chronic Liver Failure.
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes.
Postnatal growth retardation is associated with intestinal mucosa mitochondrial dysfunction and aberrant energy status in piglets.
SR18292 exerts potent antitumor effects in multiple myeloma via inhibition of oxidative phosphorylation.
MiR-23a-5p exacerbates intestinal ischemia-reperfusion injury by promoting oxidative stress via targeting PPAR alpha.
(-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels.
Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase.
OXPHOS-dependent metabolic reprogramming prompts metastatic potential of breast cancer cells under osteogenic differentiation.
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation.
A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility.
Effect of sitagliptin on expression of skeletal muscle peroxisome proliferator-activated receptor γ coactivator-1α and irisin in a rat model of type 2 diabetes mellitus.
Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway.
Resveratrol prevents benzo(a)pyrene-induced disruption of mitochondrial homeostasis via the AMPK signaling pathway in primary cultured neurons.
p53/PGC‑1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis.
Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.
Myopathy reversion in mice after restauration of mitochondrial complex I.
Zinc-α2-glycoprotein promotes browning of white adipose tissue in cold-exposed male mice.
Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice.
Maternal Inactivity Programs Skeletal Muscle Dysfunction in Offspring Mice by Attenuating Apelin Signaling and Mitochondrial Biogenesis.
Excessive Glucocorticoids During Pregnancy Impair Fetal Brown Fat Development and Predispose Offspring to Metabolic Dysfunctions.
(-)-Hydroxycitric acid regulates energy metabolism by activation of AMPK - PGC1α - NRF1 signal pathway in primary chicken hepatocytes.
TLR4 knockout upregulates the expression of Mfn2 and PGC-1α in a high-fat diet and ischemia-reperfusion mice model of liver injury.
Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice.
Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice.
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line.
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
MOTS-c inhibits Osteolysis in the Mouse Calvaria by affecting osteocyte-osteoclast crosstalk and inhibiting inflammation.
PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy.
Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes.
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
High-intensity interval training changes the expression of muscle RING-finger protein-1 and muscle atrophy F-box proteins and proteins involved in the mechanistic target of rapamycin pathway and autophagy in rat skeletal muscle.
Improvement of Mitochondrial Activity and Fibrosis by Resveratrol Treatment in Mice with Schistosoma japonicum Infection.
Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin-1 (SIRT1) Independent Manner.
Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy.
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
(-)-Hydroxycitric Acid Suppresses Lipid Droplet Accumulation and Accelerates Energy Metabolism via Activation of the Adiponectin-AMPK Signaling Pathway in Broiler Chickens.
Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice.
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
FXR activation alleviates tacrolimus-induced post-transplant diabetes mellitus by regulating renal gluconeogenesis and glucose uptake.
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Zinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice.
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS.
Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression.
The Role of Mitochondria in Methamphetamine-induced inhibitory effects on osteogenesis of Mesenchymal Stem Cells.
AMPK/α-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Li X, Wu Z, Yao C, Zhang P, Zhu Q, Nan S, Xiao L, Qi S
Research (Washington, D.C.) 2026;9:1163
Research (Washington, D.C.) 2026;9:1163
NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis.
Yan Y, Li C, Zhang J, Li R, Yin B, Zhang S, Zhang Y, Zhang X, Han J, Huang J
International journal of biological sciences 2026;22(3):1590-1610
International journal of biological sciences 2026;22(3):1590-1610
Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury.
Yao M, Wang X, Wei H, Wang L, Zhang D, Liang Z, He R, He Y, Jiang L, Cui Y
Frontiers in pharmacology 2026;17:1716078
Frontiers in pharmacology 2026;17:1716078
H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury.
Huang Y, Zhao E, Zhao G, Zhuo W, Zhao Y, Wang H, Lv G, Hu R, Zeng Z, Han S, Hu Y, Zhao G
Theranostics 2026;16(9):4768-4786
Theranostics 2026;16(9):4768-4786
Hyperglycemia in combination with excess fat intake promotes renal pyroptosis and fibrosis through Gα(12)-dependent endoplasmic reticulum stress.
Khan MS, Kim B, Jeon Y, Tak J, Kim YS, Lee SG, Lee EB, Lee CH, Eom CB, Lee HS, Jang HK, Lee N, Kie JH, Yang JM, Yang YM, Kim SG
Theranostics 2026;16(8):3996-4018
Theranostics 2026;16(8):3996-4018
Physiological safety and Multi-Tissue metabolic adaptation under a novel intermittent prolonged fasting regimen.
Sui X, Guo Y, Wu F, Wang H, Yang C, Zhang H, Jiang S, Dai Z
Life sciences in space research 2026 May;50:113-123
Life sciences in space research 2026 May;50:113-123
CIAPIN1 improves sepsis-induced acute kidney injury by inhibiting mitochondrial damage.
Huang J, Shi M, Zhang Z, Xu Z, Xi X
Pathology, research and practice 2026 May;281:156384
Pathology, research and practice 2026 May;281:156384
Shenkangling alleviates renal fibrosis induced by renal ischemia-reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway.
Mao Y, Lin S, Wu M, Ma H, Ji J, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158020
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158020
PGC-1α exacerbates apoptosis to induce HIF-1α/BNIP3 mediated mitophagy in heart failure.
Ni C, Hu P, Ni Y
Biochemical and biophysical research communications 2026 May 7;812:153592
Biochemical and biophysical research communications 2026 May 7;812:153592
Chaihu-Shugan San ameliorates perimenopausal obesity with depression by coordinately targeting hepatic PGC-1α/CYP8B1/PPARγ signaling and gut barrier integrity.
Chen Q, Liu J, Wang J, Yin T, Wu Y, Zhang T, Yu F
Journal of ethnopharmacology 2026 May 23;363:121407
Journal of ethnopharmacology 2026 May 23;363:121407
The mechanism of honeysuckle peptides in ameliorating hyperuricemia in mice via the PGC-1α/PPARγ/ABCG2 pathway.
Yang H, Liang Y, Chen Y, Liu L, Wang Y, Dou Q, Gong J, Liao Z, Dong J, Hu X
Journal of ethnopharmacology 2026 May 10;362:121358
Journal of ethnopharmacology 2026 May 10;362:121358
Salvianolic Acid B Alleviates MAFLD by Targeting PPAR-α: Mechanistic Insights From Network Pharmacology and Lipidomics.
Huang F, Qiu C, Wang D, Ni Y, Fu Z, Fu L, Liang C, Huang S, Deng Z
Food science & nutrition 2026 Mar;14(3):e71646
Food science & nutrition 2026 Mar;14(3):e71646
Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise-Induced Fatigue via AMPK/PGC-1α Pathway Activation.
Zhu J, Peng F, Zhang L, Guo Y, Liu W, Li J, Shang S, Zhang B, Qiu T
Food science & nutrition 2026 Mar;14(3):e71596
Food science & nutrition 2026 Mar;14(3):e71596
Identification of Common Genes Regulated by ER Stress During the Development of Diabetic Nephropathy Based on Human Transcriptome Datasets and an In Vivo Mouse Model.
Karekezi J, Yves Roger A, Jang H, Kim JW, Yun SP, Kim HJ, Miao J, Park SW, Kim H
International journal of molecular sciences 2026 Mar 8;27(5)
International journal of molecular sciences 2026 Mar 8;27(5)
Asymmetric dimethylguanidino valeric acid as an independently associated risk factor for early hypertriglyceridemia and dyslipidemia.
Han Y, Xiong Q, Wang J, Wang A, Chen Q, Liu Y, Cheng K
Metabolomics : Official journal of the Metabolomic Society 2026 Mar 7;22(2)
Metabolomics : Official journal of the Metabolomic Society 2026 Mar 7;22(2)
Fermented Black Soybean and Dehulled Adlay Improve Metabolic Syndrome via AMPK-SIRT1 Activation and Gut Microbiota Modulation.
Kuo YR, Zheng YW, Ho PY, Lo YC, Tsai PJ, Pan MH
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6864-6877
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6864-6877
FBXO39 knockdown promotes spermatogenesis impairment by inducing mitochondrial dysfunction and ferroptosis via inhibiting KDM5A ubiquitination and regulating H3K4me3 demethylation.
Li T, Wang K, Chen Y, Li Z, Li S, Zhang Y, Zhu X, Shi H, Gao L, Jiang H
Cell biology and toxicology 2026 Mar 4;42(1)
Cell biology and toxicology 2026 Mar 4;42(1)
Dendrobium officinale polysaccharide ameliorate hyperlipidemia through LKB1/AMPK and CD36/PGC-1α/UCP1 activation and gut microbiota modulation.
Gong Y, Fang H, Wu L, Zhang J, Wen Y, Rao Y, Zhao Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 4;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 4;
Lentinan mitigates age-related sarcopenia through the promotion of mitochondrial biogenesis.
He Y, Zhang J, Sun X, Fang Y, Fu A, Han X, Zhang J
Food research international (Ottawa, Ont.) 2026 Mar 31;228:118449
Food research international (Ottawa, Ont.) 2026 Mar 31;228:118449
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer.
Yang F, Wang M, Hu S, Guan X, Zhao K, Zhou Y, Yao H, Zhang T, Li L, Gao Y, Zhao S, Liu N, Xiao W, Xiang Y, Miao H
Signal transduction and targeted therapy 2026 Mar 26;11(1)
Signal transduction and targeted therapy 2026 Mar 26;11(1)
Beta 2 adrenergic receptor agonists as a treatment for metabolic dysfunction-associated steatohepatitis (MASH).
Winkler BS, Stayer KM, Rao AK, Arif E, Mendenhall TT, Thomas KL, Driggers KR, Zuo X, Fitzgibbon W, Deng P, Su Y, Dang Y, Gerges M, Kagan D, Pasham V, Wolf B, Rockey DC, Hartman JH, Lipschutz JH
npj metabolic health and disease 2026 Mar 25;4(1)
npj metabolic health and disease 2026 Mar 25;4(1)
Atractylodes macrocephala Koidz. water extract alleviates exercise-induced fatigue by activating mitochondrial biogenesis via the PGC-1α/NRF1/TFAM axis.
Ying G, Yu J, Jiao L, Liang J, Wu Z, Pan B, Gao S, Chen S, Lv G
Journal of ethnopharmacology 2026 Mar 25;359:121053
Journal of ethnopharmacology 2026 Mar 25;359:121053
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control.
Gao L, Shen J, Gao J, Li T, Yan D, Zeng X, Meng J, Li H, Chen D, Wu J
Antioxidants (Basel, Switzerland) 2026 Mar 23;15(3)
Antioxidants (Basel, Switzerland) 2026 Mar 23;15(3)
A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat.
Su D, Yang H, Li X, Jiang T, Zhan S, Zhong T, Guo J, Wang Y, Li L, Zhang H, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 23;:e18153
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 23;:e18153
Aerobic exercise improve physical endurance and muscle function by ameliorating oxidative stress and modulating mitochondrial dynamics in aged skeletal muscle.
Zheng F, Zhou J, Cao Y, Lin L, Wang W, Zhang L, Li W, Li T, Wang L
Journal of physiology and biochemistry 2026 Mar 17;82(1)
Journal of physiology and biochemistry 2026 Mar 17;82(1)
Cardamonin represses gastric adenocarcinoma development by modulating c-Myc/GLUT4/PGC-1α axis mediated glucose uptake and energy metabolism reprogramming.
Liang X, Zhang Y, Jin J, Wang P, Wang L, Yu M, Mi J, Huang F, Wu H, Chai Z, Wu X, Shi H
Journal of ethnopharmacology 2026 Mar 1;358:121009
Journal of ethnopharmacology 2026 Mar 1;358:121009
Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.
Shin C, Chen LW, Hossain MN, Li X, Islam S, Kou Z, Cui Q, de Avila JM, Zhu MJ, Du M
American journal of physiology. Endocrinology and metabolism 2026 Mar 1;330(3):E390-E400
American journal of physiology. Endocrinology and metabolism 2026 Mar 1;330(3):E390-E400
FUNDC1-dependent mitophagy determines axon regeneration capacity.
Li W, Liu Y, Liu R, Fan Y, Liu J, Guo Y, Hu Z, Liu L, Chen Q, Zhou B
Autophagy 2026 Jun;22(6):1256-1272
Autophagy 2026 Jun;22(6):1256-1272
Allosteric activation of pyruvate carboxylase by Dracoflavan B(2) enhances endothelial energy metabolism to attenuate myocardial infarction.
Hong C, Li H, Liu RY, Wang R, Sun YJ, Huang YL, Wei TT, Tu PF, Zeng KW, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158145
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158145
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Zhang Y, Luo X, Wu S, Qin Y, Xue Q, Ye W, Hou S, Liu B, Huang D, Yuan W, Ao H, Tong G, Liao M
Journal of ethnopharmacology 2026 Jun 28;365:121585
Journal of ethnopharmacology 2026 Jun 28;365:121585
Swertia mussotii Franch. Improves skeletal muscle glucose uptake and mitochondrial function via Ampk/Pgc-1α signaling in type 2 diabetes mice.
Huang W, Huang Y, Shu Y, Liao S, Chen H, Chu M, Yang K, Liu S, Jiensi A, Tadesse MG, Huang M, Yang X
Journal of ethnopharmacology 2026 Jul 15;366:121625
Journal of ethnopharmacology 2026 Jul 15;366:121625
PGC-1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti-Inflammatory Response.
Hu Z, Pang J, Liu X, Zhao Y, Lu Y, Chen H, Zeng H, Yu Y, Zhao Y, Gao L, Zhang X, Jin J, Wang K, Shi Y, Zhan H, Wu W
CNS neuroscience & therapeutics 2026 Jan;32(1):e70744
CNS neuroscience & therapeutics 2026 Jan;32(1):e70744
Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.
Gao X, Zhang J, Lin Y, Tian K, Tu J, Wu Z, Lv X, Hu H, Liu X, Lin S, Zhu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688
Nobiletin Ameliorates Skeletal Muscle Performance in D-Galactose-Induced Aging Mice by Boosting Aerobic Metabolism.
Wang H, Zhang Y, Zhang Y, Wang X, Li Y, Ren F, Sun Y
Food science & nutrition 2026 Jan;14(1):e71416
Food science & nutrition 2026 Jan;14(1):e71416
Mafu Yishen Formula ameliorates membranous nephropathy by promotion of regulatory T cell differentiation: a multi-omics study.
Zhao Q, Dai H, Zhang N, Huang S, Cui X, Cui Y, Jiang H, Liu W, Chen Y, Zheng Y, Ding Q, Hu Y, Li G, Tang X, Zheng Y, Rui H, Liu B
Chinese medicine 2026 Jan 6;21(1):5
Chinese medicine 2026 Jan 6;21(1):5
Yangjingzhongyu Decoction regulates primordial follicle initiation via LncRNA-Smad1/AMPK dual pathways in diminished ovarian reserve.
Li W, Zhang J, Shi D, Wang J, Luo S, Yang J, Deng D
Journal of ovarian research 2026 Jan 5;19(1):43
Journal of ovarian research 2026 Jan 5;19(1):43
α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis.
Dong K, Zhang M, Xu J, Bai X, Yang J
Nutrients 2026 Jan 26;18(3)
Nutrients 2026 Jan 26;18(3)
Targeted PGC-1α gene delivery by GV-assisted ultrasound cavitation for renal ischemia-reperfusion injury therapy.
Kuai Y, Xu W, Wang X, Xu X, Huang P
iScience 2026 Jan 16;29(1):114374
iScience 2026 Jan 16;29(1):114374
Aerobic exercise attenuates intramyocellular lipid accumulation by upregulating vitamin D receptor.
Wang K, Zhang JH, Cui XN, Niu YJ, Liu JJ, Lu SQ, Liu XM, Zhu Z, Cao ZB
Molecular and cellular endocrinology 2026 Jan 1;611:112677
Molecular and cellular endocrinology 2026 Jan 1;611:112677
Nicotinamide N-methyltransferase mediates redox regulation and colonic epithelial barrier impairment by SIRT1/PPAR-γ/NLRP6/NRF2 axis in inflammatory bowel disease.
Chen C, Tao M, Wang L, Yan W, Lin R, Fu Y
International immunopharmacology 2026 Jan 1;168(Pt 2):115882
International immunopharmacology 2026 Jan 1;168(Pt 2):115882
Selenomethionine alleviates aortic dissection via PGC-1α/NRF2/TFAM-mediated mitochondrial biosynthesis against ferroptosis: an experimental study.
Lai S, Qin H, Wang X, Bi Y, Lai Z, Ji S, Guo W
International journal of surgery (London, England) 2026 Jan 1;112(1):553-569
International journal of surgery (London, England) 2026 Jan 1;112(1):553-569
Idebenone alleviates rotenone-induced mitochondrial dysfunction through mitophagy and mitochondrial biogenesis in muscle cells.
Zhang C, Li M, Meng L, Xia W, Wu G
Cellular signalling 2026 Feb;138:112221
Cellular signalling 2026 Feb;138:112221
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
Sun Y, Wei T, Xu H, Li H, Zhou C, Liu X, Li Y, Huang S, Zhang Q, Duan X
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
N-Lac-Phe Ameliorates Myocardial Cell Death by Improving Mitochondrial Dysfunction, Ultimately Improving TAC-induced Heart Failure.
Sha L, Du A, Xu X, Li Z, Xu B, Kang L
Cardiovascular drugs and therapy 2026 Feb 26;
Cardiovascular drugs and therapy 2026 Feb 26;
PM(10) Disrupts Mitochondrial Homeostasis in Corneal Epithelial Cells: Protective Effects of SKQ1.
Somayajulu M, Wright R, Muhammed FS, McClellan SA, Ibrahim AS, Hazlett LD
Antioxidants (Basel, Switzerland) 2026 Feb 25;15(3)
Antioxidants (Basel, Switzerland) 2026 Feb 25;15(3)
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
Zheng X, Huang R, Liu Z, Liu T, Lin H, Yin L, Wu Q, Zhao M
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
A coenzyme-based "interface-welding" hydrogel coating for titanium implants promotes diabetic osseointegration by regulating mitochondrial dynamics.
Duan Q, Geng W, He T, Yang J, Li K, Yang F, Fu Z, Liao X, Luo H, Zhao P, Cai K
Biomaterials 2026 Aug;331:124115
Biomaterials 2026 Aug;331:124115
Di-(2-Ethylhexyl) phthalate causes testicular ferroptosis though deficiency of androgen receptor and disruption of mitochondrial quality control.
Tian Q, Yan X, Xu J, Ma J, Sun X, Li J, Wang N, Yao X, Qiu T, Zhang C, Deng H, Yang G
Free radical biology & medicine 2026 Apr;247:348-360
Free radical biology & medicine 2026 Apr;247:348-360
Gut microbiota-derived taurolithocholic acid modulates myofiber-type switching via p38 MAPK/PGC-1α signaling underlying breed differences between Arbor Acres and Taoyuan chickens.
Peng F, Zeng YY, Chang L, Huang YX, Deng JT, Liu YX, He X, Song ZH
Poultry science 2026 Apr 9;105(7):106914
Poultry science 2026 Apr 9;105(7):106914
SIRT3-mediated mitochondrial fatty acid oxidation protects against hepatic lipid deposition in fatty liver hemorrhagic syndrome.
Cao P, Chen J, Zeng C, Hu Y, Yuan J, Guo X, Cao H, Zhang C, Zhuang Y, Hu G
Poultry science 2026 Apr 7;105(7):106901
Poultry science 2026 Apr 7;105(7):106901
ELABELA Targets Mitochondria to Modulate Heart Development.
Wang J, Wang Q, Xu Z, Zhou S, Zhou Y, Yang J, Tong L, Meng Z, Yang M, Zhao W, Yang T, Wang H, Zhang J, Tan R, Wang L, Huang Y, Zhou B, Chen S, Zhang B, Yuan J, Zhao J, Chen AF, Sun K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 7;:e06525
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 7;:e06525
Vitamin D Receptor/Sirtuin 3 Pathway Mediates the Cardioprotective Effects of Aerobic Exercise in Diabetic Mice.
Cui XN, Li C, Qin YH, Liu JJ, Jia CK, Sun XY, Lu SQ, Zhu Z, Cao ZB
Free radical biology & medicine 2026 Apr 28;
Free radical biology & medicine 2026 Apr 28;
Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD(+) Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection.
Liu J, Guo X, Wang N, Zhang X, Wang X, Li G, Hou X, Yu L, Chen Y, Li R
Advanced materials (Deerfield Beach, Fla.) 2026 Apr 21;:e19122
Advanced materials (Deerfield Beach, Fla.) 2026 Apr 21;:e19122
Astragaloside IV delays vascular aging by enhancing mitochondrial fatty acid β-oxidation via the MLXIPL-PPARα/PGC-1α axis.
Chen X, Chen X, Xiao N, Yang Y, Li C, Pan Y, Huang H, Duan X, Deng Y, Chen C, Zeng S, Yang S, Huang Y, Huang D, Yang Y, Shu Z, Zhang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 15;156:158183
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 15;156:158183
Moxibustion delays ovarian aging by regulating mitochondrial biogenesis and improving oocyte quality.
Yin Y, Xu Y, Li Z, Chen M, Song Z, Li H, Lu G, Shen M
Chinese medicine 2026 Apr 10;21(1)
Chinese medicine 2026 Apr 10;21(1)
Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice.
Jiang H, Ni S, Li Z, Chen S, Li X, Zhang H, Shen WL, Jiang X, Luo P, Shu Y, Yuan F, Tong K, Xiao F, Guo F
Nature communications 2026 Apr 10;
Nature communications 2026 Apr 10;
Pretreatment with a ketogenic diet inhibits mitochondrial damage in rat models of spinal cord injury via the PGC-1α/Sirt1/Nrf1 pathway.
Wang X, Lan W, Liao Y, Lu H
Iranian journal of basic medical sciences 2025;28(11):1516-1522
Iranian journal of basic medical sciences 2025;28(11):1516-1522
SIRT3 is required for the protective function of ketogenic diet on neural inflammation and neuropathic pain.
Deng M, Fang Y, Chu Y, Ding R, Fan X, Wei H, Song H, Jiang G, Zhang H, Han C, Yuan H
International journal of biological sciences 2025;21(7):3011-3029
International journal of biological sciences 2025;21(7):3011-3029
TEAD1 Prevents Necroptosis and Inflammation in Cisplatin-Induced Acute Kidney Injury Through Maintaining Mitochondrial Function.
Tran M, Jiao B, Du H, Zhou D, Yechoor V, Wang Y
International journal of biological sciences 2025;21(2):565-578
International journal of biological sciences 2025;21(2):565-578
Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload.
Hou XX, Wang S, Ma XX, Wen Y, Li ZJ, Liu XY, Zhang X, Zhang Y, Qin XY
Drug design, development and therapy 2025;19:2433-2452
Drug design, development and therapy 2025;19:2433-2452
Investigating the Relationship between Ulcerative Colitis and Circadian Rhythm Genes Using Bioinformatics Analysis and Machine Learning.
Wang J, You M, Li J, Wang X, Liu Y, Chen S, Wang P
International journal of general medicine 2025;18:3239-3251
International journal of general medicine 2025;18:3239-3251
Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair.
Xu MR, Lin CH, Wang CH, Wang SY
Frontiers in pharmacology 2025;16:1619537
Frontiers in pharmacology 2025;16:1619537
Improved myocardial mitochondrial energy metabolism in rats with chronic heart failure by modifying fatty acid oxidation using an extract of sand-fired aconite (Jianchang gang processing).
Zhang H, Huang Y, Yang S, Gong F, Gu Y, Xie Q, Ye Y, Lu X, Zhong L
Frontiers in pharmacology 2025;16:1600410
Frontiers in pharmacology 2025;16:1600410
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Xu P, Zhou W, Wang S, Wang L, Bai Y, Xing S, Xue W, Li M, Shi J, Wu H
Theranostics 2025;15(18):9415-9446
Theranostics 2025;15(18):9415-9446
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.
Hu P, Liu M, Wu T, Zhang Y, Liu C, Wang L, Zhang W, Que Y, You J, Yu W, Tong X
Theranostics 2025;15(15):7567-7583
Theranostics 2025;15(15):7567-7583
Biomimetic piezoelectric hydrogel system for energy metabolism reprogramming in spinal cord injury repair.
Shi G, Su T, Li J, Wang A, Gao G, Tao B, Chen N, Tian L, Yan J, Zhao L, Zhang J, Zhao Y
Theranostics 2025;15(11):4955-4969
Theranostics 2025;15(11):4955-4969
Astaxanthin alleviates oxidative stress and skeletal muscle damage by promoting mitochondrial biogenesis.
Li C, Yan Y, Wang K, Jiang T
Frontiers in veterinary science 2025;12:1577408
Frontiers in veterinary science 2025;12:1577408
Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity.
Deng Y, Xu L, Jiang Z, Chen L, Zhu G, Xu C, Chu X, Wang L, Niu X, Chen L, Xiao Z, Hu J, Ge G
Redox biology 2025 Sep;85:103737
Redox biology 2025 Sep;85:103737
Cancer-associated fibroblasts regulate mitochondrial metabolism and inhibit chemosensitivity via ANGPTL4-IQGAP1 axis in prostate cancer.
Xiong Z, Zhuang RL, Yu SL, Xie ZX, Peng SR, Li ZA, Li BH, Xie JJ, Li YN, Li KW, Huang H
Journal of advanced research 2025 Sep;75:663-678
Journal of advanced research 2025 Sep;75:663-678
GW8510 alleviates muscle atrophy and skeletal muscle dysfunction in mice through AMPK/PGC1α signaling.
Chen Y, Liu Z, Liu C, Yang D, Xiao M, Li Z, Xie Z
International journal of molecular medicine 2025 Sep;56(3)
International journal of molecular medicine 2025 Sep;56(3)
Sustained oxygen-releasing hydrogel implants enhance flap regeneration by promoting mitochondrial biogenesis under mild hypoxia.
Jeon S, Jeong SH, Lee MH, Seo JW, Kim DS, Bassous NJ, Lozano Soto JA, Choi C, Gonzalez ML, Nolasco Díaz EB, Kim H, Shin SR, Park JU
Bioactive materials 2025 Sep;51:559-574
Bioactive materials 2025 Sep;51:559-574
Targeted energy metabolomics analysis-based mitochondrial restoration: Nutritional intervention of dairy-derived MFG-E8 synergistic with egg yolk phosphatidylcholine in skeletal muscle regeneration.
Guan K, Liu X, Liu R, Xiao R, Lu W, Ma Y, Wang R, Niu T
International journal of biological macromolecules 2025 Sep;323(Pt 2):147215
International journal of biological macromolecules 2025 Sep;323(Pt 2):147215
Asiaticoside Mitigates Chronic Obstructive Pulmonary Disease by Modulating TRIM27 Stability and Activating PGC-1α/Nrf2 Signaling.
Zhu F, Ji Y, You Q, Dong Q, Tang Y, Zhang Y
Applied biochemistry and biotechnology 2025 Sep;197(9):6234-6254
Applied biochemistry and biotechnology 2025 Sep;197(9):6234-6254
Evaluation of ethanolic extract of Clinacanthus nutans leaves in C2C12 myotubes: anti-exercise fatigue activity.
Lyu R, Shi J, Xiao X, Gu W, Chen J, Wu X, Wang J, Liu C
Fitoterapia 2025 Sep;185:106643
Fitoterapia 2025 Sep;185:106643
Energy metabolism disturbance induced by atorvastatin exposure on yellowstripe goby (Mugilogobius chulae) larvae based on transcriptome and metabolome analysis.
Zhao Y, Wang Y, Gong W, Duan C, Ren J, Zhang H, Nie X
Journal of environmental sciences (China) 2025 Sep;155:475-487
Journal of environmental sciences (China) 2025 Sep;155:475-487
Lactate induces oxidative phosphorylation in osteoblasts via Gpr81-Stat3 signaling.
Hu X, Shen J, Wang R, Han C, Shi X, Hu J, Zhang M, Wang P, Zhang X, Wu Y
Cellular signalling 2025 Sep;133:111877
Cellular signalling 2025 Sep;133:111877
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Li H, Cai S, Mu H, Chang T, Wang X, Tang T, Dong T, Zhang Y, Zhang L, Li H, Zhou L, Xiang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
Xia C, Zhang J, Chen H, Jiang W, Zhou S, Zheng H, Sun W
International immunopharmacology 2025 Sep 23;162:115121
International immunopharmacology 2025 Sep 23;162:115121
CUMS stress facilitates hippocampal neural mitophagy through FIS1/MFF-mediated mitochondrial fragmentation.
Qiu X, Lai S, Zhang Y, Huang S, Zhang J, Tan Y, Li H, Liu J, Huang Y, Zhang Z
Journal of neurophysiology 2025 Sep 1;134(3):952-961
Journal of neurophysiology 2025 Sep 1;134(3):952-961
Phosphatidylethanolamine/PKA signal axis mediated human milk extracellular vesicles enhance adipose thermogenesis and lipolysis via mitochondrial remodeling.
Peng Z, Gao J, Xu L, Huang S, Wang R, Du J, Zhang Z, Zhang L, Feng L, Wang X, Guo X
International journal of obesity (2005) 2025 Oct;49(10):2081-2093
International journal of obesity (2005) 2025 Oct;49(10):2081-2093
Combination of imeglimin and resistance exercise improves mitochondrial function and glucose metabolism in skeletal muscles.
Ishiguro H, Minato K, Iwaasa K, Wu S, Antao G, Tsuchida T, Suwabe T, Katagiri T, Suzuki H, Masuko M, Watanabe KI, Ushiki T, Sone H
Journal of diabetes and its complications 2025 Oct;39(10):109145
Journal of diabetes and its complications 2025 Oct;39(10):109145
Mitophagy-mediated S1P facilitates muscle adaptive responses to endurance exercise through SPHK1-S1PR1/S1PR2 in slow-twitch myofibers.
Leng M, Yang F, Zhao J, Xiong Y, Zhou Y, Zhao M, Jia S, Liu L, Zheng Q, Gan L, Ye J, Zheng M
Autophagy 2025 Oct;21(10):2111-2129
Autophagy 2025 Oct;21(10):2111-2129
High-Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice.
Son JS, Chae SA, Chun YH, Wang H, Jiang Z, Du M
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70027
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70027
IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression.
He Z, Feng YD, Zhang YX, Gao X, Liu JJ, Liu S, Wu GQ
Cellular signalling 2025 Oct;134:111932
Cellular signalling 2025 Oct;134:111932
Fenofibrate alleviates sepsis-associated acute kidney injury by enhancing renal fatty acid oxidation.
Zeng S, Wang J, Guan C, Yao Z, Zhang Y, Li Y, Zheng J, Wang H
BMC pharmacology & toxicology 2025 Oct 7;26(1):160
BMC pharmacology & toxicology 2025 Oct 7;26(1):160
CAMKK2 restored mitochondrial dynamics homeostasis to alleviate pulmonary fibrosis via AMPK/PGC-1α signaling pathway in lung fibroblasts.
Zhou Y, Wang Y, Wang M, Li B, Xu K, Pan X, Li Z, Wang Q, He W, Pang J, Guo Y, Zhang Y, Sakamoto K, Yang J, Wang L, Yu G
Molecular medicine (Cambridge, Mass.) 2025 Oct 6;31(1):308
Molecular medicine (Cambridge, Mass.) 2025 Oct 6;31(1):308
3-n-butylphthalide improves cerebral ischemia/reperfusion injury by regulating neuronal mitochondrial biogenesis via AMPK/PGC-1α signaling pathway.
Li J, Zhu X
International immunopharmacology 2025 Oct 30;164:115343
International immunopharmacology 2025 Oct 30;164:115343
Taurodeoxycholic, taurocholic, and glycocholic acids promote hepatic gluconeogenesis via TGR5 in dairy cows.
Zhu M, Zheng Y, Lou S, Zhang R, Feng D, Lei X, Chen L, Wang J, Yao J, Deng L
Journal of animal science and biotechnology 2025 Oct 30;16(1):142
Journal of animal science and biotechnology 2025 Oct 30;16(1):142
SIRT1/PGC-1α/Mfn2 pathway regulates mitochondrial homeostasis in VSMC to attenuate aging-related vascular calcification.
Wu C, Wu Z, Hu L, Tang L, Hu X, Fang C
Scientific reports 2025 Oct 30;15(1):38045
Scientific reports 2025 Oct 30;15(1):38045
A Novel Glucomannan from Dendrobium officinale Inhibits Obesity and Improves Insulin Sensitivity through Regulating Adipogenesis and Lipid Metabolism.
Chen J, Zhang M, Yang Y, Peng H, Zhang J, Shou Y, Tang Y, Du X, Guo C, Wang X
Journal of agricultural and food chemistry 2025 Oct 29;73(43):27751-27770
Journal of agricultural and food chemistry 2025 Oct 29;73(43):27751-27770
LLTH induces white adipose tissue browning via NF κB inhibition in ATM.
Lu Y, Feng J, Yan Y, Qiu J, Feng L
Scientific reports 2025 Oct 28;15(1):37716
Scientific reports 2025 Oct 28;15(1):37716
α-Ketoglutarate Ameliorates Sarcopenia in D-Galactose-Induced Aging Mice by Modulating Protein Homeostasis and Optimizing Mitochondrial Function.
Zhang Y, Wang H, Zhang Y, Wang X, Qiao Z, Wang J, Li Y, Sun Y
Nutrients 2025 Oct 23;17(21)
Nutrients 2025 Oct 23;17(21)
Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway.
Luo W, Bu W, Zhang G, Dong Y, Wang Y, Wang J, Liu C, Hu X, Jia Y, Ren H
Behavioural brain research 2025 Oct 18;495:115805
Behavioural brain research 2025 Oct 18;495:115805
Hesperidin attenuates lipopolysaccharide-induced endometritis by inhibiting mitochondrial oxidative stress via activating the AMPK/PGC-1α signalling pathway.
Wu L, Wang J, Yan Y, Wang L, Huang Q, Peng J, Li L
European journal of pharmacology 2025 Oct 15;1005:178100
European journal of pharmacology 2025 Oct 15;1005:178100
Intercepting the complement amplification loop through podocyte MC5R signaling ameliorates membranous nephropathy.
Liu J, Zhang M, Ge Y, Gunning W, Dworkin LD, Gong R
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Oct 1;33(10):5231-5247
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Oct 1;33(10):5231-5247
Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner.
Shu M, Ma Y, Zhao D, Meng C, Chen L, Wang L, Liu J, Yang D
Journal of translational medicine 2025 Oct 1;23(1):1041
Journal of translational medicine 2025 Oct 1;23(1):1041
PLIN5 regulates lipid metabolism via PGC-1α/Drp1 signaling in islet β-cells.
Sun Z, Zhao J, Fan S, Huang X, Fu H, Liu H, Sun W, Zhou Z, Wu D, Zhu X
Endocrine 2025 Nov;90(2):617-629
Endocrine 2025 Nov;90(2):617-629
1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity.
Wang R, Zhu T, Lu J, Cheng M, Wang X, Guo X, Huang S, Gao J
Journal of lipid research 2025 Nov;66(11):100914
Journal of lipid research 2025 Nov;66(11):100914
Eurotium Cristatum fermented instant dark tea prevents obesity and promotes adipose thermogenesis via modulating the gut microbiota.
Wang X, Li Y, Yu P, Zhang L, Wang Y, Yang X, Ren D
Food research international (Ottawa, Ont.) 2025 Nov;219:116969
Food research international (Ottawa, Ont.) 2025 Nov;219:116969
Spinal p38 MAPK/PGC-1α/SIRT3 signaling pathway mediates remifentanil-induced hyperalgesia in rats via ROS release and NR2B activation.
Feng G, Song F, Wang A, Wang L, Zhang H, Wang S, Hou H, Zhang L, Deng L
Neurochemistry international 2025 Nov;190:106061
Neurochemistry international 2025 Nov;190:106061
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
Yong W, Li Z, Xu W, Gao D, Sha B, Jin Y, Shen Y, Zhang Y, Pan Y, Liu J, Zhang F, Yu J, Jin L, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
Formononetin, a bioactive isoflavone compound in modified nuanxinkang, alleviates cardiorenal syndrome type 4-induced mitochondrial dysfunction by targeting Hippo-YAP signaling.
Yao M, Wen R, Zhuang H, Li Y, Lin X, Pang S, Zhang J, Guan Z, Liang B, Li H, Huang Y, Wang L, Wang J, Dong X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157152
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157152
PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury.
Leng J, Cao Z, Li L, Hu D, Luo Y, Tu B, Cao X, Tao R, Jiang Y, Tie H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Nov 6;74(1):156
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Nov 6;74(1):156
Inhalation of Ultrafine Carbon Black-Induced Mitochondrial Dysfunction in Mouse Heart Through Changes in Acetylation.
Islam R, Stewart JE, Mullen WE, Lin D, Hussain S, Thapa D
Cells 2025 Nov 4;14(21)
Cells 2025 Nov 4;14(21)
Inhibition of SIRT1/PGC-1α Axis Exacerbates Fluorine and Aluminium Induced Neurotoxicity via Drp1-dependent Aggravated Mitochondrial Fission.
Yang L, Qian X, Jiang H, Xie C
Molecular neurobiology 2025 Nov 26;63(1):177
Molecular neurobiology 2025 Nov 26;63(1):177
Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling.
Cheng S, Zhao A, Lin X, Wang Z
Animals : an open access journal from MDPI 2025 Nov 26;15(23)
Animals : an open access journal from MDPI 2025 Nov 26;15(23)
Spermidine enhances macrophages anti-inflammatory and regenerative functions by improving mitochondrial fitness.
Liu R, Cao L, Zhou Y, Li Y, Wang T, Meng Z, Yang T, Feng C, Yang Q, Liu X, Chen Y, Agostini M, Li P, Melino G, Wang Y, Shao C, Shi Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157349
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157349
Liu-Jun-Zi decoction alleviates metabolic dysfunction-associated steatohepatitis by modulating myogenic irisin mediated skeletal muscle-liver crosstalk.
Wang C, Liu K, Ji J, Ma W, Zhang H, Wang K, Lin Y, Ma C, Wang X, Cheng F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157218
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157218
GSTK1 suppresses HCC aggravation via L-carnitine metabolism by PGAM5/DRP1 complex-mediated mitochondrial quality control.
Shi Y, Zhang J, Song B, Zhang H, He J, Ding K, Wang F, Yu W, Zhangyuan G, Jin K, Zhang W, Sun B
Journal of experimental & clinical cancer research : CR 2025 Nov 24;45(1):1
Journal of experimental & clinical cancer research : CR 2025 Nov 24;45(1):1
Nicotine Improves Memory Impairment in Aged Rats Through Enhanced Mitochondrial Homeostasis.
Ni Z, Li Y, Wang G, Wang S, Chen H, Hou H, Hu Q
Molecular neurobiology 2025 Nov 14;63(1):38
Molecular neurobiology 2025 Nov 14;63(1):38
Wogonin, a bioactive flavonoid from Scutellaria baicalensis, alleviates alcoholic pancreatitis via AMPK-mediated TFEB activation.
Qin Z, Sun X, Zeng J, Li G, Wang H, Chen S, Tan S, An L, Wang C, Wang L, Wang J, Ma X, Zhao Z, Chao X, Liu Z, Wang S
Journal of advanced research 2025 Nov 10;
Journal of advanced research 2025 Nov 10;
Improvement of Glucose Metabolism by Pennogenin 3-O-β-Chacotrioside via Activation of IRS/PI3K/Akt Signaling and Mitochondrial Respiration in Insulin-Resistant Hepatocytes.
Lee JI, Lee HM, Park JH, Lee YG
Molecular nutrition & food research 2025 May;69(9):e70010
Molecular nutrition & food research 2025 May;69(9):e70010
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Chen L, Tang J, Zuo X, Li B, Liu C, Hong S, Min J, Hu M, Li S, Zhou M, Chen M, He Y, Xiao Y, Huang X, Hong L
Cell proliferation 2025 May;58(5):e70009
Cell proliferation 2025 May;58(5):e70009
Ferulic acid protects against stress-induced myocardial injury in mice.
Li S, He P, Liu J, Zang S, Luo J, Luo Y, Zhu S, Zang L
Toxicology and applied pharmacology 2025 May;498:117309
Toxicology and applied pharmacology 2025 May;498:117309
Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control.
Wang L, Zhang L, Yun Y, Liang T, Yan C, Mao Z, Zhang J, Liu B, Zhang J, Liang T
Molecular and cellular biochemistry 2025 May;480(5):3079-3095
Molecular and cellular biochemistry 2025 May;480(5):3079-3095
Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration.
Zheng X, Wang J, Zhou H, Chai Y, Li Z, Chen M, Yang Z, Xu C, Lei C, He Y, Zou D, Ye Q
Bioactive materials 2025 May;47:313-326
Bioactive materials 2025 May;47:313-326
Reprogramming of Hypoxia-Induced Metabolic Disorder in Mouse Kidneys by Mesenchymal Stem Cells Through Improving Mitochondrial Dynamics and Function.
Wang Y, Ding Y, Wuren T, Luo P
Journal of biochemical and molecular toxicology 2025 May;39(5):e70291
Journal of biochemical and molecular toxicology 2025 May;39(5):e70291
Eicosapentaenoic acid (EPA) reduced lipopolysaccharide-stimulated inflammatory response of RAW264.7 cells via the miR-125b-5p/CREB axis.
Zhang L, Lin L, Xiao B, Huang K, Liu J, Chen YL, Lu L, Zhang Z, Zhang L, Li J, Ho KT, Luo L, Huang SY, Li G
International journal of biological macromolecules 2025 May;310(Pt 4):143511
International journal of biological macromolecules 2025 May;310(Pt 4):143511
Structural characterization and alleviative effects of novel polysaccharides from Artemisia sphaerocephala Krasch seed on obese mice by regulating gut microbiota.
Zeng X, Yu P, Li D, Li Y, Wang X, Yang X, Ren D
International journal of biological macromolecules 2025 May;310(Pt 4):143407
International journal of biological macromolecules 2025 May;310(Pt 4):143407
Phosphorylation-driven regulation of SIRT1 in muscle senescence: Insights from molecular dynamics simulation and experimental validation.
Liu S, Shan L, Li Y, Xiang J, Zhang H
International journal of biological macromolecules 2025 May;306(Pt 4):141734
International journal of biological macromolecules 2025 May;306(Pt 4):141734
Vine tea (Ampelopsis grossedentata) ameliorates chronic alcohol-induced hepatic steatosis, oxidative stress, and inflammation via YTHDF2/PGC-1α/SIRT3 axis.
Luo Q, Qiu J, Chen M, Yang N, Li X, Huang S, Ma Q, Li Z, Lou D, Du Y, Chen L, Shen Q, Chen F, Li C, Qiu P
Food research international (Ottawa, Ont.) 2025 May;209:116321
Food research international (Ottawa, Ont.) 2025 May;209:116321
Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition.
Wang N, Gao Z, Zhan H, Jing L, Meng F, Chen M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 May;199:115335
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 May;199:115335
Effective compound combination of Bufei Yishen formula ameliorates PM2.5-induced COPD by inhibiting mitochondrial oxidative stress through SIRT3-mediated FOXO3 deacetylation.
Wang J, Yue H, Dong Y, Liu T, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156568
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156568
Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.
Xi H, Shan W, Li M, Wang Z, Li Y
Andrology 2025 May;13(4):911-920
Andrology 2025 May;13(4):911-920
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
Duan C, Zhao Y, Xiao Y, Hou Y, Gong W, Zhang H, Wang Y, Nie X
Journal of hazardous materials 2025 May 5;488:137420
Journal of hazardous materials 2025 May 5;488:137420
Enhanced mitochondrial biogenesis facilitates the development of cutaneous squamous cell carcinoma.
Wang Z, He K, Liu M, Lv W, Cheng B, Zhang G, Wang X, Zeng M, Jiao L, Han S, Zheng Y, Feng Z
Cancer letters 2025 May 28;618:217623
Cancer letters 2025 May 28;618:217623
Overexpression of c-Myc triggers p62 aggregation-mediated mitochondrial mitophagy in cabozantinib resistance of hepatocellular carcinoma.
Yang K, Zhang X, Yang K, Liu S, Zhang J, Fu Y, Liu T, Wu K, Li J, Liu C, Huang Q, Qu K
Molecular medicine (Cambridge, Mass.) 2025 May 27;31(1):209
Molecular medicine (Cambridge, Mass.) 2025 May 27;31(1):209
A Comprehensive Study Employing Computational Analysis and Mendelian Randomization Has Revealed the Impact of Key Genes on Liver Cancer.
Li S, Qi W, Wu J, Luo C, Zheng S, Cao X, Wang W, Liu Q, Du H, Li X, Zao X, Ye Y
Biomedicines 2025 May 27;13(6)
Biomedicines 2025 May 27;13(6)
[Pachymic acid promotes brown/beige adipocyte differentiation and lipid metabolism in preadipocytes].
Chen K, Dou X, Lin Y, Bai D, Luo Y, Zhou L
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2025 May 25;54(3):333-341
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2025 May 25;54(3):333-341
Nanoparticle-mediated targeting of PGC-1α reveals critical metabolic pathways in bladder cancer metastasis.
Liu Z, Xin P, Wu W, Jin M, Du Y, Jiang Y, Liu T, Zhang H
Communications biology 2025 May 23;8(1):788
Communications biology 2025 May 23;8(1):788
ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa.
Hu C, Ren C, Wu Y, Lin R, Shen T, Li T, Yu D, Jiang L, Wan Z, Luo Y, Su T, Yu J, Qiu Y
Neuropharmacology 2025 May 15;269:110361
Neuropharmacology 2025 May 15;269:110361
High-dose vitamin C promotes mitochondrial biogenesis in HCT116 colorectal cancer cells by regulating the AMPK/PGC-1α signaling pathway.
Hong R, Min S, Huang J, Zou M, Zhou D, Liang Y
Journal of cancer research and clinical oncology 2025 May 15;151(5):167
Journal of cancer research and clinical oncology 2025 May 15;151(5):167
Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes.
Guo Z, Liu S, Hou X, Zhou X, Wang Y, Rong Y, Li X, Yang R, Ma K
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Mitochondrial-Derived Signaling Mediates Differentiation of Parietal Epithelial Cells into Podocytes.
Wang M, Wu W, Lu J, Lu R, Min L, Song A, Zhao B, Li Y, Xie K, Gu L
Antioxidants & redox signaling 2025 Mar;42(7-9):393-407
Antioxidants & redox signaling 2025 Mar;42(7-9):393-407
Metformin delays the decline in thermogenic function of brown adipose tissue in a mouse model of Hutchinson-Gilford progeria syndrome.
Xiang X, Feng Y, Li H, Li W, Li J, Xia Z, Pang H, Wang Z
Experimental gerontology 2025 Mar;201:112702
Experimental gerontology 2025 Mar;201:112702
TFE3-mediated neuroprotection: Clearance of aggregated α-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease.
He X, Chen M, Fan Y, Wu B, Dong Z
Genes & diseases 2025 Mar;12(2):101429
Genes & diseases 2025 Mar;12(2):101429
Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.
Fu XX, Wei B, Huang ZH, Duan R, Deng Y, E Y, Wang SY, Chen SY, Zhang YD, Jiang T
Journal of Alzheimer's disease : JAD 2025 Mar;104(1):209-220
Journal of Alzheimer's disease : JAD 2025 Mar;104(1):209-220
Induction of UBQLN1-mediated PGC1α stability by isoliensinine overcame hypoxia-induced resistance in liver cancer cells.
Xu X, Li W, Zhou Y, Wang M, Ji S, Xia S, Li Y, Guo X, Huan S, Wang F, Zhang F, Cheng H, Yin G, Zheng S
BioFactors (Oxford, England) 2025 Mar-Apr;51(2):e70008
BioFactors (Oxford, England) 2025 Mar-Apr;51(2):e70008
Ginsenoside Rb(1) Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway.
Zhou Z, Song Z, Guo X, Wang Q, Li M, Zhang M, Gong M
Pharmaceuticals (Basel, Switzerland) 2025 Mar 30;18(4)
Pharmaceuticals (Basel, Switzerland) 2025 Mar 30;18(4)
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Xu Y, You J, Yao J, Hou B, Wang W, Hao Z
Urolithiasis 2025 Mar 29;53(1):61
Urolithiasis 2025 Mar 29;53(1):61
A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans.
Ping J, Liu X, Lu Y, Quan C, Fan P, Lu H, Li Q, Wang C, Zhang Z, Liu M, Chen S, Chang L, Jiang Y, Huang Q, Liu J, Wuren T, Liu H, Hao Y, Kang L, Liu G, Lu H, Wei X, Wang Y, Li Y, Guo H, Cui Y, Zhang H, Zhang Y, Zhai Y, He Y, Zheng W, Qi X, Ouzhuluobu, Ma H, Yang L, Wang X, Jin W, Cui Y, Ge R, Wu S, Wei Y, Su B, He F, Zhang H, Zhou G
Cell genomics 2025 Mar 12;5(3):100782
Cell genomics 2025 Mar 12;5(3):100782
Taurine ameliorates deoxynivalenol-induced intestinal injury in piglets: Restoration of mitochondrial function linked to the PGC1α-NRF1/2 axis.
Ji X, Ding H, Zhou F, Zhang F, Wu D
Ecotoxicology and environmental safety 2025 Mar 1;292:117938
Ecotoxicology and environmental safety 2025 Mar 1;292:117938
Membrane-associated ring-CH-type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase.
Ni D, Qi Z, Ma S, Wang Y, Liang D, Zhang X, Man Y, Chen J, Dou K, Li G
Molecular metabolism 2025 Jun;96:102137
Molecular metabolism 2025 Jun;96:102137
Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice.
Zhang Y, Chen H, Feng Y, Liu M, Lu Z, Hu B, Chen L, Zhang Y, Liu J, Cai F, Zhao Y, Pan W, Liao X, Pan S, Bestard-Lorigados I, Wu Y, Song W
Nature aging 2025 Jun;5(6):1097-1113
Nature aging 2025 Jun;5(6):1097-1113
YTHDC1 promotes postnatal brown adipose tissue development and thermogenesis by stabilizing PPARγ.
Wang L, Wang Y, Ding K, Li Z, Zhang Z, Li X, Song Y, Xie L, Chen Z
The EMBO journal 2025 Jun;44(12):3360-3380
The EMBO journal 2025 Jun;44(12):3360-3380
RIPC improves myocardial injury by promoting mitochondrial protection via the PGC-1α/Nrf2 pathway.
Zhao Z, Zhang Z, Li X, Ding J, Li M
The Journal of biological chemistry 2025 Jun;301(6):108476
The Journal of biological chemistry 2025 Jun;301(6):108476
Fibroblast growth factor 21/extracellular signal-regulated kinase 1/2 pathway as a key link mediates the effects of low-protein diet on skeletal muscle fiber type transformation in pigs.
Li S, Liang P, Wang B, Chen J, You J, Zou T
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Jun;21:207-221
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Jun;21:207-221
Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury.
Li L, Yuan H, Li H, Cheng R, Zhou Z, Hu F, Xu L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jun;200:115428
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jun;200:115428
The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition.
Wang L, Ge S, Zhang Y, Feng D, Zhu T, Zhang L, Zhang C
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3125-3148
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3125-3148
Time-restricted feeding mitigates HFD-induced sarcopenic obesity in aging mice through improving the sensitivity of FGF21.
Wang T, Lin H, Deng Y, Chen W, Xu Y, Wang L, Zhou A, Zhang Y, Wang Z, Jin X, Zhang L, Wang X, Zhou Y, Wang R, Rong S
The Journal of nutritional biochemistry 2025 Jun;140:109893
The Journal of nutritional biochemistry 2025 Jun;140:109893
Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury.
Cheng N, Luo Q, Yang Y, Shao N, Nie T, Deng X, Chen J, Zhang S, Huang Y, Hu K, Luo L, Xiao Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(24):e2410590
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(24):e2410590
In Vivo Reprogramming of Tissue-Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering.
Zhao M, Liu S, Wang Y, Lou P, Lv K, Wu T, Li L, Wu Q, Zhu J, Lu Y, Wan M, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415556
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415556
Hawthorn total flavonoids ameliorate hyperlipidemia through AMPK/SREBP1-c and PPARα/PGC-1α/CPT-1A pathway activation and gut microbiota modulation.
Zheng L, Lu Z, Ma Y, Cui P, Zhang X, Gan J, Li G
Journal of the science of food and agriculture 2025 Jun;105(8):4326-4337
Journal of the science of food and agriculture 2025 Jun;105(8):4326-4337
Fecal Microbiota Transplantation from Mice Receiving Magnetic Mitohormesis Treatment Reverses High-Fat Diet-Induced Metabolic and Osteogenic Dysfunction.
Wong JKC, Patel BK, Tai YK, Tan TZ, Khine WWT, Chen WC, Kukumberg M, Ching J, Lee LS, Chua KV, Tan TY, Wu KY, Bai X, Iversen JN, Purnamawati K, Abdul Jalil R, Kumar AP, Lee YK, Moochhala SM, Franco-Obregón A
International journal of molecular sciences 2025 Jun 6;26(12)
International journal of molecular sciences 2025 Jun 6;26(12)
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
Wu C, Miao H, Yi Z, Jia H, Huang A, Zhang H, Liu Z, Sun X, Zheng Y, Gao L, Ma S
International immunopharmacology 2025 Jun 5;157:114778
International immunopharmacology 2025 Jun 5;157:114778
Browning of Aldosterone-Producing Adenoma Adjacent Adipose Tissue Involved in Aldosterone Synthesis Regulation.
Xie L, Yang S, Chen M, Li J, He Y, Peng C, Xu Y, Huang W, Luo T, Fang Y, Hu J, Li Q, Ma L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70722
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70722
Initiating Empagliflozin and Sacubitril/Valsartan Early After Acute Myocardial Infarction: Mechanistic Study.
Martínez-Falguera D, Aranyó J, Ferrer-Curriu G, Teis A, Revuelta-Lopez E, Diaz-Güemes I, Monguió-Tortajada M, Fadeuilhe E, Rodríguez-Leor O, Poblador F, Montejo B, Roura S, Villuendas R, Sarrias A, Bazan V, Jorge E, Delgado V, Jimenez-Trinidad FR, Rigol M, Martinez-Micaelo N, Amigó N, Bayes-Genis A, Bisbal F, Gálvez-Montón C
Journal of the American Heart Association 2025 Jun 3;14(11):e040214
Journal of the American Heart Association 2025 Jun 3;14(11):e040214
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
Ying W, Weng W, Wang P, Pan C, Qiu J, Huang Q, Zhan G, Chen X
Journal of neuroinflammation 2025 Jun 27;22(1):167
Journal of neuroinflammation 2025 Jun 27;22(1):167
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Zhao H, Zhang S, Gong Z, Chen T, Guo H, Yang M, Wang L, Zhou X, Xie J, Li H, Lu Y, Zhu Z
Journal of ethnopharmacology 2025 Jun 26;350:120036
Journal of ethnopharmacology 2025 Jun 26;350:120036
Drp1 knockdown aggravates obesity-induced cardiac dysfunction and remodeling.
Wu D, Hu Q, Li H, Yin Y, Wang P, Wang W
Mitochondrion 2025 Jul;83:102023
Mitochondrion 2025 Jul;83:102023
The role of mitochondrial dysfunction in the protective effect of ginger derived extracellular vesicles on hepatic stellate cells against cytotoxicity.
Yang J, Yang Y, Zhang X, Qin Y, Sato T, Qing S, Wang Y, Ye X, Xu M, Liu Y, He Q, Zheng Y
Molecular and cellular biochemistry 2025 Jul;480(7):4297-4309
Molecular and cellular biochemistry 2025 Jul;480(7):4297-4309
Activation of spinal PGC-1α regulates microglial polarization through a feedback loop between ROS-mediated mitochondrial dysfunction and the NLRP3 inflammasome in neuropathic pain.
Chen Y, Ling G, Xu Q, Zhu Q, Huang T, Su T, Xie Y, Zhong Y
Brain research bulletin 2025 Jul;227:111365
Brain research bulletin 2025 Jul;227:111365
Hesperidin mitigated deoxynivalenol-induced liver injury by inhibiting ROS/ P53/ PGC-1α-mediated disruption of mitochondrial dynamics and PANoptosis.
Wang X, Nie T, Li A, Ma J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156747
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156747
Decreased Expression and Secretion of the Myokine Fndc5/Irisin by Cisplatin Treatment in Mouse Skeletal Muscle.
Miyauchi Y, Soga S, Nanri H, Yonamine S, Ogiwara T, Kiyama M, Kon R, Ikarashi N, Chiba Y, Hosoe T, Sakai H
Calcified tissue international 2025 Jul 9;116(1):96
Calcified tissue international 2025 Jul 9;116(1):96
Involvement of impaired carnitine-induced fatty acid oxidation in experimental and human diabetic kidney disease.
Ito S, Taguchi K, Kodama G, Kubo S, Moriyama T, Yamashita Y, Yokota Y, Nakayama Y, Kaida Y, Shinohara M, Tashiro K, Ohta K, Yamagishi SI, Fukami K
JCI insight 2025 Jul 8;10(13)
JCI insight 2025 Jul 8;10(13)
Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD(+)/Sirt1 pathway in the brain: a possible link between hyperhomocysteinemia and neurodegeneration.
Chai G, Mao Y, Gong J, Bi S, Zhang Y, Wu J, Yang L, Gao T, Fu H, Yu C, Ren C, Zhang G, Zhu X, Guan X, Yu H, Tang C, Nie Y, Yu H
Cell death & disease 2025 Jul 7;16(1):499
Cell death & disease 2025 Jul 7;16(1):499
Timosaponin AⅢ inhibits ectopic lipid deposition and enhances the browning of white adipose tissue.
Zhao W, Wang X, Liu Y, Lu L, Ding Y, Zhang T
European journal of pharmacology 2025 Jul 5;998:177506
European journal of pharmacology 2025 Jul 5;998:177506
Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition.
Lu C, Lin Q, Guo X, Luo T, Zhou H, Cai Z, Peng C, Yang G, Wang W
International immunopharmacology 2025 Jul 28;160:114960
International immunopharmacology 2025 Jul 28;160:114960
Chlorogenic acid and ferulic acid in SMYAD alleviate diabetic cardiomyopathy by inhibiting cardiac lipotoxicity via GCGR/PPARα and GCGR/AMPK pathways.
Li L, Huang K, Wang D, Yang D, Gao K, Tang J, Wei X, Pu H, Yu J, Zhang D, Guo S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156906
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156906
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy.
Ai S, Tao J, Wang Y, Zhou J, Liu W, Li X, Wang L, Hou J, Zhao L, Wang Z, Peng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156901
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156901
Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.
Luo Y, Ali T, Hu Y, Gong Q, Zheng C, Li L, Li S, Hao L
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 21;20(1):73
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 21;20(1):73
MSCs in acute kidney injury treatment: Modulating mitochondrial function and inhibiting pyroptosis via PGC-1α.
Wang Y, Ding Y, Dong H, Wuren T, Luo P
Experimental cell research 2025 Jul 15;450(2):114583
Experimental cell research 2025 Jul 15;450(2):114583
Aerobic Exercise Delays Age-Related Sarcopenia in Mice via Alleviating Imbalance in Mitochondrial Quality Control.
Zhu D, Wang L, Gao H, Wang Z, Li K, Ma X, Zhao L, Xiao W
Metabolites 2025 Jul 11;15(7)
Metabolites 2025 Jul 11;15(7)
Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 pathway activation.
Yang C, Yu H, Zhou L, Su H, Li X, Qi W, Lian F
Scientific reports 2025 Jul 11;15(1):25069
Scientific reports 2025 Jul 11;15(1):25069
LC-MF-4, a Novel FGFR3 Degrader for Therapeutic Intervention in FGFR3-Altered Cancers.
Zheng L, Cao J, Ma L, Chen S, Cao X, Luo R, Wang Y, Ke D, Huang P, Liang G, Chen L
Journal of medicinal chemistry 2025 Jul 10;68(13):13858-13871
Journal of medicinal chemistry 2025 Jul 10;68(13):13858-13871
Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage.
Li J, Hao G, Yan Y, Li M, Li G, Lu Z, Sun Z, Chen Y, Liu H, Zhao Y, Wu M, Bao X, Wang Y, Li Y
Neurochemistry international 2025 Jan;182:105914
Neurochemistry international 2025 Jan;182:105914
Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney.
Zou H, Song J, Luo X, Ali W, Li S, Xiong L, Chen Y, Yuan Y, Ma Y, Tong X, Liu Z
Poultry science 2025 Jan;104(1):104490
Poultry science 2025 Jan;104(1):104490
Integrating network pharmacology and transcriptomics to study the potential mechanism of Jingzhi Niuhuang Jiedu tablet in rats with accumulation of heat in the lungs and stomach.
Dai ZQ, Guo ZQ, Zhang T, Chu YF, Yan Y, Gao F, Li SL, Gu YH, Jiao JY, Lin YX, Zhao SW, Xu B, Lei HM
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118890
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118890
Comparison of chemical composition between imitation wild and transplanted Astragali Radix and their therapeutic effects on heart failure.
Zhang C, Zhu Y, Wang M, Chen R, Sun X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118827
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118827
Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.
Kamchonemenukool S, Koh YC, Ho PY, Pan MH, Weerawatanakorn M
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration.
Zhu J, Zhang Y, Sun Y, Yu F, Lu Y, Hu Q, Guo J, Zhang H, Chen T, Lian F, Wang J, Li X, Xiao J
Journal of nanobiotechnology 2025 Jan 2;23(1):1
Journal of nanobiotechnology 2025 Jan 2;23(1):1
Butyrate attenuates high-fat diet-induced glomerulopathy through GPR43-Sirt3 pathway.
Shi Y, Xing L, Zheng R, Luo X, Yue F, Xiang X, Qiu A, Xie J, Russell R, Zhang D
The British journal of nutrition 2025 Jan 14;133(1):1-10
The British journal of nutrition 2025 Jan 14;133(1):1-10
Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice.
Geng J, Zhang X, Guo Y, Wen H, Guo D, Liang Q, Pu S, Wang Y, Liu M, Li Z, Hu W, Yang X, Chang P, Hu L, Li Y
Nature communications 2025 Jan 12;16(1):613
Nature communications 2025 Jan 12;16(1):613
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
Song Y, Zhu X, Wang B, Li Q, Song B
Scientific reports 2025 Jan 10;15(1):1614
Scientific reports 2025 Jan 10;15(1):1614
Chronic hyperglycemia induces hepatocyte pyroptosis via Gα(12)/Gα(13)-associated endoplasmic reticulum stress: Effect of pharmacological intervention.
Khan MS, Tak J, Kim YS, Lee SG, Lee EB, Kim SG
Life sciences 2025 Jan 1;360:123180
Life sciences 2025 Jan 1;360:123180
1-Bromopropane induces mitochondrial damage and lipid metabolism imbalance in respiratory epithelial cells through the PGC-1α/PPARα pathway.
Wu Q, Jin C, Liu X, Zhang Q, Jiao B, Yu H
Ecotoxicology and environmental safety 2025 Jan 1;289:117492
Ecotoxicology and environmental safety 2025 Jan 1;289:117492
Jellyfish stings-induced cardiac failure was ameliorated through AAG-mediated glycogen-driven ATP production.
Qin Z, Chen J, Liu F, Li B, Zhang C, Wang X, Liu L, Wang M, Wang T, Wang S, Yu F, Wang S, Yang J
Exploration (Beijing, China) 2025 Feb;5(1):20230089
Exploration (Beijing, China) 2025 Feb;5(1):20230089
Involvement of mitochondrial dysfunction and oxidative stress in the nephrotoxicity induced by high-fat diet in Sprague-Dawley rats.
Zhang B, Xu J, Wang M, Yu C
Toxicology letters 2025 Feb;404:28-36
Toxicology letters 2025 Feb;404:28-36
Hydroxyacyl-coenzyme A dehydrogenase: A biomarker for authentication of death from mechanical asphyxia.
Wu T, Li W, Hu Y, Zhang D, Tian L, Xu H, Zhang F, Xiao B, Shi Y, Chen Y, Liao X, Ma K, Chen L
Forensic science international 2025 Feb;367:112371
Forensic science international 2025 Feb;367:112371
The contributory role of GSK3β in hypertension exacerbating atherosclerosis by regulating the OMA1/PGC1α pathway.
Bao H, Wang C, Jin Y, Meng Q, Wu J, Liu Q, Sun H
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):117-130
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):117-130
Chronic alcohol consumption exacerbates ischemia-associated skeletal muscle mitochondrial dysfunction in a murine model of peripheral artery disease.
Fletcher E, Miserlis D, Papoutsi E, Steiner JL, Gordon B, Haynatzki G, Pacher P, Koutakis P
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167584
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167584
CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.
Wu J, Chen L, Wen P
Scientific reports 2025 Feb 4;15(1):4298
Scientific reports 2025 Feb 4;15(1):4298
Tomatine Improves Glucose Metabolism and Mitochondrial Respiration in Insulin-Resistant Hepatocyte Cell Lines AML12 and HepG2 via an AMP-Activated Protein Kinase-Dependent Pathway.
Lee YG, Kim D
Cells 2025 Feb 23;14(5)
Cells 2025 Feb 23;14(5)
Protective effect and mechanism of plant-derived Lactobacillus G11 on septic myocardial injury.
Zhang J, Tian Y, Yan H, Wu X, Deng C, Zhou Y, Liu J, Li X, Tian J, Bian Z, Yang Y, Chen Y
International immunopharmacology 2025 Feb 20;148:114021
International immunopharmacology 2025 Feb 20;148:114021
Bone marrow mesenchymal stem cells ameliorate diet-induced obesity by activating thermogenesis and alleviating inflammation in adipose tissue.
Wang Y, Fu J, He W, Gao Y, Du J, Xu J, Guo L, Liu Y
Biochemical and biophysical research communications 2025 Feb 2;747:151172
Biochemical and biophysical research communications 2025 Feb 2;747:151172
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
Zhao L, Li M, Zhu Q, Fang X, Yang H, Zhao Y
International journal of molecular sciences 2025 Feb 14;26(4)
International journal of molecular sciences 2025 Feb 14;26(4)
Regulatory effects of yam (Dioscorea opposita Thunb.) glycoprotein on energy metabolism in C2C12 and 3T3-L1 cells and on crosstalk between these two cells.
Li W, Shi J, Wu X, Qiu H, Liu C
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119013
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119013
Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis.
Zhao Q, Cui X, Zhu Q, Li F, Bao R, Shi T, Liu H, Lv W, Xu Y, Gao Y, Tang QQ, Zhang M, Pan D
Nature communications 2025 Feb 10;16(1):1483
Nature communications 2025 Feb 10;16(1):1483
PANAXADIOL SAPONIN ALLEVIATES LPS-INDUCED CARDIOMYOPATHY SIMILAR TO DEXAMETHASONE VIA IMPROVING MITOCHONDRIAL QUALITY CONTROL.
Yang Z, Gao Y, Li D, Zhao L, Du Y
Shock (Augusta, Ga.) 2025 Feb 1;63(2):282-291
Shock (Augusta, Ga.) 2025 Feb 1;63(2):282-291
MDPAO1 peptide from human milk enhances brown adipose tissue thermogenesis and mitigates obesity.
Gao Y, Zhang J, Cao M, Zhang Y, Cao M, Gu W, Wang M
Molecular and cellular endocrinology 2025 Feb 1;597:112443
Molecular and cellular endocrinology 2025 Feb 1;597:112443
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function.
Yang X, Wang S, Liu H, Zhang T, Cheng S, Du M
Journal of advanced research 2025 Dec;78:47-62
Journal of advanced research 2025 Dec;78:47-62
Cedrol prevents UVB-induced photoaging by restoring mitochondrial function, metabolic homeostasis, and skin barrier integrity in HaCaT cells.
Xu MR, Lin CH, Lee HH, Wang SY
Pharmaceutical biology 2025 Dec;63(1):859-876
Pharmaceutical biology 2025 Dec;63(1):859-876
Canagliflozin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease via Mitochondrial Protection and Enhanced Mitophagy.
Lu M, Zhao Y, Liu Z, Zhang Y, Liu J
Hepatology research : the official journal of the Japan Society of Hepatology 2025 Dec;55(12):1598-1609
Hepatology research : the official journal of the Japan Society of Hepatology 2025 Dec;55(12):1598-1609
Alpha Ketoglutaric Acid attenuates LPS Induced Inflammatory Response by Inhibiting the PKCε/MAPK/P65 Signaling Pathway and Inhibit Oxidative Stress in Kupffer Cells.
Li Y, Kuang H, Fan G, Yang X
Inflammation 2025 Dec;48(6):4020-4030
Inflammation 2025 Dec;48(6):4020-4030
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455
Renal failure 2025 Dec;47(1):2521455
Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress.
Zhang L, Zhang G, Mao W, Sun S, Tao S, Gao Y, Zhang N, Jiang G, Chen M, Lu X, Chen S
Renal failure 2025 Dec;47(1):2483986
Renal failure 2025 Dec;47(1):2483986
Hsa_circ_0020491 promotes polycystic ovary syndrome by interacting with IGF2BP2 through regulation of granular cell autophagy and mitochondrial dysfunction.
Huang X, Yu F
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2025 Dec;41(1):2536579
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2025 Dec;41(1):2536579
M6a demethylase FTO regulates the oxidative stress, mitochondrial biogenesis of cardiomyocytes and PGC-1a stability in myocardial ischemia-reperfusion injury.
Jiang Q, Chen X, Gong K, Xu Z, Chen L, Zhang F
Redox report : communications in free radical research 2025 Dec;30(1):2454892
Redox report : communications in free radical research 2025 Dec;30(1):2454892
Analysis of the Protective Mechanism of PGC-1α/NRF1/2/TFAM Pathway in Cortical Neuron Injury Induced by Oxidative Stress.
Li J, Zhang W, Hu W, Gao W, Wang J, Li J, Wang Y, Wang W, Gao H, Yi B
Bulletin of experimental biology and medicine 2025 Dec;180(2):259-266
Bulletin of experimental biology and medicine 2025 Dec;180(2):259-266
Dietary cannabidiol oil mitigates metabolic dysfunction in mice with high-fat diet-induced obesity.
Bravo Iniguez A, Sun Q, Tian Q, Du M, Zhu MJ
The Journal of nutritional biochemistry 2025 Dec;146:110040
The Journal of nutritional biochemistry 2025 Dec;146:110040
PSPC1-SMAD3 axis regulates iron-induced beiging of adipocytes in white adipose tissue.
Peng XM, He R, Wang HY, Liu JD, Xie YY, Wang ZH, Deng HY, Wang WS, Zhu ZZ, Ge J, Liu YL, Gao RH, Yang M, Li DP, Kang QQ, Pan RP, Chen Y
Cell communication and signaling : CCS 2025 Dec 4;24(1):12
Cell communication and signaling : CCS 2025 Dec 4;24(1):12
Multi-Omics Analysis Reveals Distinct Lipid Remodelling and Mitochondrial Stress in SH-SY5Y Cells Modelling Parkinson's Disease.
Wang S, Ni Z, Wang G, Zhang J, Tan Y, Hong E, Wang Y, Chen H, Hou H, Hu Q
Metabolites 2025 Dec 4;15(12)
Metabolites 2025 Dec 4;15(12)
Oral Supplementation of Indole-3-acetic Acid Alleviates High-Fat-Induced Obesity by Activating the Gpha2-Mediated Thyroid-Stimulating Hormone Pathway.
Wang Y, Wan Y, Wang H, Yan J, Sun J, Yang J, Zhang F, Cao H, Li D
Journal of agricultural and food chemistry 2025 Dec 31;73(52):33126-33140
Journal of agricultural and food chemistry 2025 Dec 31;73(52):33126-33140
LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer.
Wu Y, Zhang W, Jiang S, Liu S, Su J, Sun L
International journal of molecular sciences 2025 Dec 31;27(1)
International journal of molecular sciences 2025 Dec 31;27(1)
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
Shen QH, Xia JY, Ma Y, Xu SS
European journal of medical research 2025 Dec 30;31(1):173
European journal of medical research 2025 Dec 30;31(1):173
α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice.
Zheng L, Wang Y, Xiao Z, Rao Z, Shi R
International journal of molecular sciences 2025 Dec 30;27(1)
International journal of molecular sciences 2025 Dec 30;27(1)
Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats.
Li RT, Lan BJ, Xiao ZY, Shi QH, Chen XY, Li F
World journal of psychiatry 2025 Dec 19;15(12):108867
World journal of psychiatry 2025 Dec 19;15(12):108867
Genetic algorithm-back propagation artificial neural network model- and response surface methodology-based optimization of crude Lophatherum gracile Brongn. polysaccharides extraction and their anti-NAFLD effects via regulating liver-adipose tissue crosstalk.
Wu C, Chen QC, Ni Q, Cai WF, Jiang CP, Yi YK, Liu L, Shen CY
International journal of biological macromolecules 2025 Aug;320(Pt 1):145806
International journal of biological macromolecules 2025 Aug;320(Pt 1):145806
Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models.
Yang RZ, Li F, Liu J, Li SA, Liu DH, Wu Z, Liu PP, Liu W, Zhou B, Jiang C, Zhang H, Yu Y, Kang JS
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e07210
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e07210
Housing temperature influences exercise-induced glucose regulation and expression of exerkines in mice.
Rao Z, Geng X, Huang P, Wei Q, Liu S, Qu C, Zhao J
Experimental physiology 2025 Aug;110(8):1099-1113
Experimental physiology 2025 Aug;110(8):1099-1113
Melatonin mitigates arsenic and fluoride-induced cardiotoxicity in chickens by maintaining mitochondrial homeostasis.
Yuan X, Wen B, Hu X, Yang M, Han L, Zhao S, Zhang J, Ma Y
Poultry science 2025 Aug;104(8):105325
Poultry science 2025 Aug;104(8):105325
PGC1α regulates the mitochondrial metabolism response to cyclic stretch, which inhibits neointimal hyperplasia.
Zou M, Ye K, Yan J, Zhang S, Bao H, Li Z, Tao Y, Zhang X, Tian W, Qi Y, Huo Y, Han Y
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):303
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):303
NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway.
Zhao X, He M, He L, Han R, Liu Y
Scientific reports 2025 Aug 7;15(1):28975
Scientific reports 2025 Aug 7;15(1):28975
Improvement effect of Shengxian Decoction on cardiac toxicity induced by arsenic trioxide in rats.
Wang Y, Hou J, Yu Y, He K, Guo H, Liu N, Wang H, Song Y, Ma D
Journal of ethnopharmacology 2025 Aug 29;352:120163
Journal of ethnopharmacology 2025 Aug 29;352:120163
PDE4D Regulates Mitochondrial Homeostasis and Adult Hippocampal Neurogenesis via the cAMP/CREB Signaling Pathway in Chronic Stress-Induced Depressive-Like Behavior.
Zhao W, Wang Z, Chen X, Zhao S, Zong F, Zhang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 15;39(15):e70882
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 15;39(15):e70882
CGKRK-targeted lipid nanoparticles enhance in vivo rosiglitazone delivery to the placenta to ameliorate murine preeclampsia.
Li K, Jia X, Guo D, Wang H, Shui H, Qi H, Zhang H
iScience 2025 Aug 15;28(8):112744
iScience 2025 Aug 15;28(8):112744
Buckwheat protein-derived peptide ameliorates insulin resistance by directing O-linked N-acetylglucosamine transferase to regulate the SIRT1/PGC1α pathway.
Yang J, Hou S, Zhao Y, Sun Z, Zhang L, Deng Y, Shang X, Yu H, Li Z, Li H
International journal of biological macromolecules 2025 Apr;304(Pt 2):140925
International journal of biological macromolecules 2025 Apr;304(Pt 2):140925
Environmentally relevant concentrations lithium exposure induces neurotoxicity in yellowstripe goby (Mugilogobius chulae): Responses of BDNF/AKT/FoxOs in regulating glutamate excitotoxicity and mitochondrial function.
Gong W, Zhao Y, Zhang H, Duan C, Xiao Y, Wang Y, Wang C, Nie X
Aquatic toxicology (Amsterdam, Netherlands) 2025 Apr;281:107294
Aquatic toxicology (Amsterdam, Netherlands) 2025 Apr;281:107294
Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy.
Huang X, Li S, Wang H, Zhao L, Li X, Fan S, Hu W, Tong H, Guo G, Xu D, Zhang L, Jiang Z, Yu Q
Journal of cachexia, sarcopenia and muscle 2025 Apr;16(2):e13807
Journal of cachexia, sarcopenia and muscle 2025 Apr;16(2):e13807
Vitamin C-Dependent Intergenerational Inheritance of Enhanced Endurance Performance Following Maternal Exercise.
Shi H, Li J, Li F, Yu H, Zhang F, Wu T, Yang L, Li Y, Hu R, Chen M, Sg N, Zhuang X, Feng S, Zhu L, Duan R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2408912
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2408912
Tangshenning formula alleviates tubular injury in diabetic kidney disease via the Sestrin2/AMPK/PGC-1α axis: Restoration of mitochondrial function and inhibition of ferroptosis.
Shan XM, Lu C, Chen CW, Wang CT, Liu TT, An T, Zhu ZY, Zou DW, Gao YB
Journal of ethnopharmacology 2025 Apr 9;345:119579
Journal of ethnopharmacology 2025 Apr 9;345:119579
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.
Li M, Wang Y, Li X, Xu J, Yan L, Tang S, Liu C, Shi M, Liu R, Zhao Y, Zhang Y, Yang L, Zhang Y, Wang G, Li Z, Guo Y, Feng Y, Liu P
Cell death & disease 2025 Apr 6;16(1):257
Cell death & disease 2025 Apr 6;16(1):257
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer's disease.
Chen H, Li N, Liu N, Zhu H, Ma C, Ye Y, Shi X, Luo G, Dong X, Tan T, Wei X, Yin H
Alzheimer's research & therapy 2025 Apr 5;17(1):72
Alzheimer's research & therapy 2025 Apr 5;17(1):72
Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model.
Cai J, Zhu Y, Deng G, Ouyang L, Xiao W, Zhou F, Han Y, Yuan F, Huang L, Li X
BMC complementary medicine and therapies 2025 Apr 23;25(1):151
BMC complementary medicine and therapies 2025 Apr 23;25(1):151
Nobiletin Enhances Skeletal Muscle Mass and Modulates Bile Acid Composition in Diet-Induced Obese Mice.
Koh YC, Liu CP, Leung SY, Lin WS, Ho PY, Ho CT, Pan MH
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9076-9087
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9076-9087
A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue.
Yang J, Shi L, Cubito AL, Collins JF, Cheng Z
Autophagy reports 2024;3(1):2396696
Autophagy reports 2024;3(1):2396696
MicroRNA-29b Plays a Vital Role in Podocyte Injury and Glomerular Diseases through Inducing Mitochondrial Dysfunction.
Liu J, Xiong Y, Mo H, Niu H, Miao J, Shen W, Zhou S, Wang X, Li X, Zhang Y, Ma K, Zhou L
International journal of biological sciences 2024;20(12):4654-4673
International journal of biological sciences 2024;20(12):4654-4673
Magnesium Ion-Doped Mesoporous Bioactive Glasses Loaded with Gallic Acid Against Myocardial Ischemia/Reperfusion Injury by Affecting the Biological Functions of Multiple Cells.
Yu W, Ding J, Chen J, Jiang Y, Zhao J, Liu J, Zhou J, Liu J
International journal of nanomedicine 2024;19:347-366
International journal of nanomedicine 2024;19:347-366
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Zhou X, Wang X, Li J, Zhang M, Yang Y, Lei S, He Y, Yang H, Zhou D, Guo C
Drug design, development and therapy 2024;18:699-717
Drug design, development and therapy 2024;18:699-717
Inflammation Can Be a High-Risk Factor for Mucosal Nonunion of MRONJ by Regulating SIRT1 Signaling When Treated with an Oncologic Dose of Zoledronate.
Zhu S, Cui Y, Zhang W, Ji Y, Li L, Luo S, Cui J, Li M
Drug design, development and therapy 2024;18:2793-2812
Drug design, development and therapy 2024;18:2793-2812
ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders.
Wu X, Ding S, Wang G, Zhang W, He K
Journal of inflammation research 2024;17:8135-8146
Journal of inflammation research 2024;17:8135-8146
Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.
Yao B, Ma J, Ran Q, Chen H, He X
Frontiers in pharmacology 2024;15:1483518
Frontiers in pharmacology 2024;15:1483518
Ling-gui-zhu-gan granules reduces obesity and ameliorates metabolic disorders by inducing white adipose tissue browning in obese mice.
Li Y, Ye Z, Zhao Y, Xu B, Xue W, Wang Z, An R, Wang F, Wu R
Frontiers in physiology 2024;15:1427722
Frontiers in physiology 2024;15:1427722
ADRB2 serves as a novel biomarker and attenuates alcoholic hepatitis via the SIRT1/PGC-1α/PPARα pathway: integration of WGCNA, machine learning and experimental validation.
Song L, Huang S, Yan H, Ma Q, Luo Q, Qiu J, Chen M, Li Z, Jiang H, Chen Y, Chen F, Du Y, Fu H, Zhao L, Zhao K, Qiu P
Frontiers in pharmacology 2024;15:1423031
Frontiers in pharmacology 2024;15:1423031
TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.
Lin Y, Gao R, Jing D, Liu Y, Da H, Birnbaumer L, Yang Y, Gao X, Gao Z, Cao Q
Frontiers in pharmacology 2024;15:1392328
Frontiers in pharmacology 2024;15:1392328
Ling-gui-zhu-gan promotes adipocytes browning via targeting the miR-27b/PRDM16 pathway in 3T3-L1 cells.
Ye Z, Zhao Y, Cui Y, Xu B, Wang F, Zhao D, Dong G, Wang Z, Wu R
Frontiers in pharmacology 2024;15:1386794
Frontiers in pharmacology 2024;15:1386794
PPARGC1A regulates transcriptional control of mitochondrial biogenesis in early bovine embryos.
Idrees M, Haider Z, Perera CD, Ullah S, Lee SH, Lee SE, Kang SS, Kim SW, Kong IK
Frontiers in cell and developmental biology 2024;12:1531378
Frontiers in cell and developmental biology 2024;12:1531378
Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice.
Cilenti L, Di Gregorio J, Mahar R, Liu F, Ambivero CT, Periasamy M, Merritt ME, Zervos AS
Frontiers in molecular biosciences 2024;11:1397565
Frontiers in molecular biosciences 2024;11:1397565
Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning.
Liu X, Jiang X, Hu J, Ding M, Lee SK, Korivi M, Qian Y, Li T, Wang L, Li W
Frontiers in nutrition 2024;11:1393343
Frontiers in nutrition 2024;11:1393343
Transplantation of astrocyte-derived mitochondria into injured astrocytes has a protective effect following stretch injury.
Gong QY, Wang W, Cai L, Jing Y, Yang DX, Yuan F, Tian HL, Ding J, Chen H, Xu ZM
Mitochondrion 2024 Sep;78:101902
Mitochondrion 2024 Sep;78:101902
Neuregulin4-ErbB4 signalling pathway is driven by electroacupuncture stimulation to remodel brown adipose tissue innervation.
Yu Z, Zhang T, Yang X, Xu B, Yu Z, An L, Xu T, Jing X, Wang Y, Lu M
Diabetes, obesity & metabolism 2024 Sep;26(9):3880-3896
Diabetes, obesity & metabolism 2024 Sep;26(9):3880-3896
SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106-126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis.
Zhao M, Li J, Li Z, Yang D, Wang D, Sun Z, Wen P, Gou F, Dai Y, Ji Y, Li W, Zhao D, Yang L
International journal of molecular sciences 2024 Sep 7;25(17)
International journal of molecular sciences 2024 Sep 7;25(17)
LncRNA PVT1 induces mitochondrial dysfunction of podocytes via TRIM56 in diabetic kidney disease.
Lv Z, Wang Z, Hu J, Su H, Liu B, Lang Y, Yu Q, Liu Y, Fan X, Yang M, Shen N, Zhang D, Zhang X, Wang R
Cell death & disease 2024 Sep 30;15(9):697
Cell death & disease 2024 Sep 30;15(9):697
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia.
Chen X, Wu Q, Gong W, Ju S, Fan J, Gao X, Liu X, Lei X, Liu S, Ming X, Wang Q, Fu M, Song Y, Wang Y, Zhan Q
Signal transduction and targeted therapy 2024 Sep 26;9(1):253
Signal transduction and targeted therapy 2024 Sep 26;9(1):253
Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis.
Liu W, Zhong X, Yi Y, Xie L, Zhou W, Cao W, Chen L
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21041-21051
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21041-21051
Mesenchymal stem cells in tumor microenvironment: drivers of bladder cancer progression through mitochondrial dynamics and energy production.
Yang E, Jing S, Wang F, Wang H, Fu S, Yang L, Tian J, Golijanin DJ, El-Deiry WS, Cheng L, Wang Z
Cell death & disease 2024 Sep 20;15(9):688
Cell death & disease 2024 Sep 20;15(9):688
Effects and mechanisms of Polygonati Rhizoma polysaccharide on potassium oxonate and hypoxanthine-induced hyperuricemia in mice.
Zhang N, Zhang B, Chen X, Zhang Y, Wang Y, Lu S, Zhang H, Chen Y, Jiang H, Zhou H
International journal of biological macromolecules 2024 Sep 13;280(Pt 1):135550
International journal of biological macromolecules 2024 Sep 13;280(Pt 1):135550
Autophagy aggravates multi-walled carbon nanotube-induced ferroptosis by suppressing PGC-1 dependent-mitochondrial biogenesis in lung epithelial cells.
Zhu L, Zhu D, Ran J, Li M, Lai Z, Zhou Y, Luo L, Liu X, Mao K, Tian K
Chemico-biological interactions 2024 Sep 1;400:111158
Chemico-biological interactions 2024 Sep 1;400:111158
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Tao J, Rao Y, Wang J, Tan S, Zhao J, Cao Z, He L, Meng J, Wu P, Wang Z
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α.
Su X, Li Q, Yang M, Zhang W, Liu X, Ba Y, Deng Q, Zhang Y, Han L, Huang H
Experimental neurology 2024 Oct;380:114899
Experimental neurology 2024 Oct;380:114899
SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway.
Xu H, Song X, Zhang X, Wang G, Cheng X, Zhang L, Wang Z, Li R, Ai C, Wang X, Pu L, Chen Z, Liu W
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1663-1678
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1663-1678
Melatonin-loaded bioactive microspheres accelerate aged bone regeneration by formation of tunneling nanotubes to enhance mitochondrial transfer.
Xiong H, Qiu H, Wang C, Qiu Y, Tan S, Chen K, Zhao F, Song J
Materials today. Bio 2024 Oct;28:101175
Materials today. Bio 2024 Oct;28:101175
Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP(SAA) knock-in mouse model of Alzheimer's disease.
Norambuena A, Sagar VK, Wang Z, Raut P, Feng Z, Wallrabe H, Pardo E, Kim T, Alam SR, Hu S, Periasamy A, Bloom GS
Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Oct;20(10):6844-6859
Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Oct;20(10):6844-6859
Gui Qi Zhuang Jin Decoction ameliorates mitochondrial dysfunction in sarcopenia mice via AMPK/PGC-1α/Nrf2 axis revealed by a metabolomics approach.
Wang D, Qi W, Mao X, Zhang Y, Miao Z, Zhu C, Shao Y, Ge G, Zhang W, Jin H, Zhu H, Pan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155908
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155908
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
Xu Z, Li M, Lyu D, Xiao H, Li S, Li Z, Li M, Xiao J, Huang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
Unveiling the regulatory role of SIRT1 in the oxidative stress response of bovine mammary cells.
Zhang Y, Liu J, Yuan S, Liu S, Zhang M, Hu H, Cao Y, Hu G, Fu S, Guo W
Journal of dairy science 2024 Oct;107(10):8722-8735
Journal of dairy science 2024 Oct;107(10):8722-8735
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4.
Xuan W, Wu X, Zheng L, Jia H, Zhang X, Zhang X, Cao B
Cellular and molecular life sciences : CMLS 2024 Oct 25;81(1):438
Cellular and molecular life sciences : CMLS 2024 Oct 25;81(1):438
Exogenous hydrogen sulfide enhances myogenic differentiation of C2C12 myoblasts under high palmitate stress.
Lu F, Zhang S, Dong S, Wang M, Pang K, Zhao Y, Huang J, Kang J, Liu N, Zhang X, Zhao D, Lu F, Zhang W
Heliyon 2024 Oct 15;10(19):e38661
Heliyon 2024 Oct 15;10(19):e38661
m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.
Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Tsuji T, Cero C, Männistö V, Manninen SM, Wei S, Ijaduola O, Blüher M, Cypess AM, Pihlajamäki J, Tseng YH, He C, Kulkarni RN
Cell metabolism 2024 Oct 1;36(10):2207-2227.e9
Cell metabolism 2024 Oct 1;36(10):2207-2227.e9
Evidence of Browning and Inflammation Features in Visceral Adipose Tissue of Women with Endometriosis.
Abobeleira JP, Neto AC, Mauersberger J, Salazar M, Botelho M, Fernandes AS, Martinho M, Serrão MP, Rodrigues AR, Almeida H, Gouveia AM, Neves D
Archives of medical research 2024 Nov;55(7):103064
Archives of medical research 2024 Nov;55(7):103064
Quercetin prevents methylmercury-induced mitochondrial dysfunction in the cerebral cortex of mice.
Liu H, Jiang L, Xu S, Wang C, Sun J
Drug and chemical toxicology 2024 Nov;47(6):1124-1138
Drug and chemical toxicology 2024 Nov;47(6):1124-1138
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Zhao Z, Song X, Wang Y, Yu L, Huang G, Li Y, Zong R, Liu T, Ji Q, Zheng Y, Liu B, Zhu Q, Chen L, Gao C, Liu H
Cell death and differentiation 2024 Nov;31(11):1410-1421
Cell death and differentiation 2024 Nov;31(11):1410-1421
Hydrogen Protects Mitochondrial Function by Increasing the Expression of PGC-1α and Ameliorating Myocardial Ischaemia-Reperfusion Injury.
Zuo Y, Wang J, Gong Z, Wang Y, Wang Q, Yang X, Liu F, Liu T
Journal of cellular and molecular medicine 2024 Nov;28(22):e70236
Journal of cellular and molecular medicine 2024 Nov;28(22):e70236
Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.
Dai Y, Chen J, Fang J, Liang S, Zhang H, Li H, Chen W
Biochemical pharmacology 2024 Nov;229:116518
Biochemical pharmacology 2024 Nov;229:116518
6-Gingerol improves lipid metabolism disorders in skeletal muscle by regulating AdipoR1/AMPK signaling pathway.
Peng Z, Zeng Y, Zeng X, Tan Q, He Q, Wang S, Wang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117462
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117462
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Wang Y, Yang Y, Cai Y, Aobulikasimu A, Wang Y, Hu C, Miao Z, Shao Y, Zhao M, Hu Y, Xu C, Chen X, Li Z, Chen J, Wang L, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Cannabidiol Enhances Mitochondrial Metabolism and Antioxidant Defenses in Human Intestinal Epithelial Caco-2 Cells.
Bravo Iniguez A, Sun Q, Cui Q, Du M, Zhu MJ
Nutrients 2024 Nov 9;16(22)
Nutrients 2024 Nov 9;16(22)
Decreased in Mitochondrial Complex I Subunit NDUFS2 Is Critical for Oocyte Quality During Postovulatory Aging in Pigs.
Zhou D, Lee SH, Li XH, Kim JD, Lee GH, Sim JM, Cui XS
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2024 Nov 4;30(5):953-961
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2024 Nov 4;30(5):953-961
CPT1A mediates radiation sensitivity in colorectal cancer.
Chen Z, Yu L, Zheng Z, Wang X, Guo Q, Chen Y, Zhang Y, Zhang Y, Xiao J, Chen K, Fan H, Ding Y
eLife 2024 Nov 28;13
eLife 2024 Nov 28;13
Schwann cell-secreted frizzled-related protein 1 dictates neuroinflammation and peripheral nerve degeneration after neurotrauma.
Yao X, Kong L, Qiao Y, Brand D, Li J, Yan Z, Zheng SG, Qian Y, Fan C
Cell reports. Medicine 2024 Nov 19;5(11):101791
Cell reports. Medicine 2024 Nov 19;5(11):101791
Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis.
Zheng L, Rao Z, Wu J, Ma X, Jiang Z, Xiao W
International journal of molecular sciences 2024 Nov 19;25(22)
International journal of molecular sciences 2024 Nov 19;25(22)
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Ren C, Xi L, Li H, Pan Z, Li Y, Wang G, Dai J, He D, Fan S, Wang Q
Life sciences 2024 Nov 15;357:123084
Life sciences 2024 Nov 15;357:123084
Telomerase reverse transcriptase protects against diabetic kidney disease by promoting AMPK/PGC-1a-regulated mitochondrial energy homeostasis.
Ma N, Xu C, Wang Y, Cui K, Kuang H
Chemico-biological interactions 2024 Nov 1;403:111238
Chemico-biological interactions 2024 Nov 1;403:111238
Unconjugated bilirubin promotes uric acid restoration by activating hepatic AMPK pathway.
Zhang Y, Chen Y, Chen X, Gao Y, Luo J, Lu S, Li Q, Li P, Bai M, Jiang T, Zhang N, Zhang B, Chen B, Zhou H, Jiang H, Lin N
Free radical biology & medicine 2024 Nov 1;224:644-659
Free radical biology & medicine 2024 Nov 1;224:644-659
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition.
Yang Z, Jiang J, Tan Y, Yang G, Chen M, Huang J, Liu J, Wei X, Wang S, Luo X, Han Z
Journal of physiology and biochemistry 2024 May;80(2):407-420
Journal of physiology and biochemistry 2024 May;80(2):407-420
Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models.
He Y, Li R, Yu Y, Huang C, Xu Z, Wang T, Chen M, Huang H, Qi Z
Neurochemistry international 2024 May;175:105700
Neurochemistry international 2024 May;175:105700
Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway.
Zeng Q, Luo Y, Sang X, Liao M, Wen B, Hu Z, Sun M, Luo Z, Huang X, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2024 May 31;13(6)
Antioxidants (Basel, Switzerland) 2024 May 31;13(6)
Carcinoembryonic antigen potentiates non-small cell lung cancer progression via PKA-PGC-1ɑ axis.
Lei J, Wu L, Zhang N, Liu X, Zhang J, Kuang L, Chen J, Chen Y, Li D, Li Y
Molecular biomedicine 2024 May 24;5(1):19
Molecular biomedicine 2024 May 24;5(1):19
Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission.
Yin H, Li X, Wang C, Li X, Liu J
Chemico-biological interactions 2024 May 1;394:110975
Chemico-biological interactions 2024 May 1;394:110975
NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis.
Zhou WY, Liu P, Xia YF, Shi YJ, Xu HY, Ding M, Yang QQ, Qian SW, Tang Y, Lu Y, Tang QQ, Liu Y
Molecular metabolism 2024 Mar;81:101891
Molecular metabolism 2024 Mar;81:101891
Collagen I protects human keratinocytes HaCaT against UVB injury via restoring PINK1/parkin-mediated mitophagy.
Zhu Y, Xiang W, He S, San Z, Liu W, Wu J, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Archives of biochemistry and biophysics 2024 Mar;753:109905
Archives of biochemistry and biophysics 2024 Mar;753:109905
Pterostilbene protects against H(2) O(2) -induced oxidative stress by regulating GAS6/Axl signaling in HL-1 cells.
Di W, Zhao A, Li X, Chen J, Dai Y, Li J, Lei W, Yang Y, Lu H
Cell biochemistry and function 2024 Mar;42(2):e3956
Cell biochemistry and function 2024 Mar;42(2):e3956
Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy.
Takahashi K, Kurokawa K, Hong L, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M
Experimental neurology 2024 Mar;373:114671
Experimental neurology 2024 Mar;373:114671
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway.
Sun F, Sun Y, Wang X, Zhu J, Chen S, Yu Y, Zhu M, Xu W, Qian H
Bioactive materials 2024 Mar;33:444-459
Bioactive materials 2024 Mar;33:444-459
Exercise-inducible circulating extracellular vesicle irisin promotes browning and the thermogenic program in white adipose tissue.
Shi H, Hao X, Sun Y, Zhao Y, Wang Y, Cao X, Gong Z, Ji S, Lu J, Yan Y, Yu X, Luo X, Wang J, Wang H
Acta physiologica (Oxford, England) 2024 Mar;240(3):e14103
Acta physiologica (Oxford, England) 2024 Mar;240(3):e14103
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Jia C, Wu Y, Gao F, Liu W, Li N, Chen Y, Sun L, Wang S, Yu C, Bao Y, Song Z
Free radical biology & medicine 2024 Mar;214:2-18
Free radical biology & medicine 2024 Mar;214:2-18
Isolation of Calenduloside E from Achyranthes bidentata Blume and its effects on LPS/D-GalN-induced acute liver injury in mice by regulating the AMPK-SIRT3 signaling pathway.
Guo P, Zeng M, Liu M, Zhang Y, Jia J, Zhang Z, Liang S, Zheng X, Feng W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155353
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155353
PM(2.5) induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage.
Chen J, Zhang M, Aniagu S, Jiang Y, Chen T
Environmental toxicology and pharmacology 2024 Mar;106:104393
Environmental toxicology and pharmacology 2024 Mar;106:104393
Pennogenin 3-O-β-Chacotrioside Attenuates Hypertrophied Lipid Accumulation by Enhancing Mitochondrial Oxidative Capacity.
Yu S, Lee HM, Lee J, Hwang JT, Choi HK, Lee YG
International journal of molecular sciences 2024 Mar 4;25(5)
International journal of molecular sciences 2024 Mar 4;25(5)
Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.
Yang Y, Qiu W, Xiao J, Sun J, Ren X, Jiang L
Journal of translational medicine 2024 Mar 26;22(1):309
Journal of translational medicine 2024 Mar 26;22(1):309
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway.
Zhang Y, Deng Q, Hong H, Qian Z, Wan B, Xia M
Journal of translational medicine 2024 Mar 25;22(1):304
Journal of translational medicine 2024 Mar 25;22(1):304
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
Shi L, Yang J, Tao Z, Zheng L, Bui TF, Alonso RL, Yue F, Cheng Z
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
Electroacupuncture improves cognitive function in a rat model of mild traumatic brain injury by regulating the SIRT-1/PGC-1α/mitochondrial pathway.
Jin B, Gao Y, Fu Y, Zhang S, Zhang K, Su Y
Chinese medical journal 2024 Mar 20;137(6):711-719
Chinese medical journal 2024 Mar 20;137(6):711-719
Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway.
Li S, Zhong H, Wang Z, Chen J, Huang Z, Zou T, You J
iScience 2024 Mar 15;27(3):109249
iScience 2024 Mar 15;27(3):109249
Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes.
Yuan Q, Zhang X, Yang X, Zhang Q, Wei X, Ding Z, Chen J, Hua H, Huang D, Xu Y, Wang X, Gao C, Liu S, Zhang H
Heliyon 2024 Mar 15;10(5):e27618
Heliyon 2024 Mar 15;10(5):e27618
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model.
Zhu Y, Fang Y, Wang Y, Han D, Liu J, Tian L, Xu M, Wang Y, Cao F
ACS biomaterials science & engineering 2024 Mar 11;10(3):1530-1543
ACS biomaterials science & engineering 2024 Mar 11;10(3):1530-1543
Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co-regulate proteasomes and mitochondria.
Al Rawi S, Simpson L, Agnarsdóttir G, McDonald NQ, Chernuha V, Elpeleg O, Zeviani M, Barker RA, Spiegel R, Laman H
The FEBS journal 2024 Jun;291(12):2565-2589
The FEBS journal 2024 Jun;291(12):2565-2589
ADSCs encapsulated in Gelatin methacrylate substrate promotes the repair of peripheral nerve injury by SIRT6/PGC-1α pathway.
Xiang Y, Li X, Huang Y, Gao S, Wei P, Wu L, Dong J
Regenerative therapy 2024 Jun;26:671-682
Regenerative therapy 2024 Jun;26:671-682
Cholesterol 25-hydroxylase prevents type 2 diabetes mellitus induced cardiomyopathy by alleviating cardiac lipotoxicity.
Zhang J, Zhou H, Lei F, Jiang K, Liao Y, Huang F, Chen M
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167158
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167158
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
Tian Z, Li J, Tang H, Liu W, Hou H, Wang C, Li D, Chen G, Xia T, Wang A
Journal of hazardous materials 2024 Jun 5;471:134331
Journal of hazardous materials 2024 Jun 5;471:134331
Arginine Regulates Skeletal Muscle Fiber Type Formation via mTOR Signaling Pathway.
Zhou M, Wei Y, Feng Y, Zhang S, Ma N, Wang K, Tan P, Zhao Y, Zhao J, Ma X
International journal of molecular sciences 2024 Jun 4;25(11)
International journal of molecular sciences 2024 Jun 4;25(11)
PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence.
He B, Zeng Q, Tian Y, Luo Y, Liao M, Huang W, Wu B, Luo Z, Huang X, Liu W, Tang S
Biomedicines 2024 Jun 27;12(7)
Biomedicines 2024 Jun 27;12(7)
Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel.
Huang T, Chen X, He J, Zheng P, Luo Y, Wu A, Yan H, Yu B, Chen D, Huang Z
eLife 2024 Jun 24;12
eLife 2024 Jun 24;12
Neferine inhibits BMECs pyroptosis and maintains blood-brain barrier integrity in ischemic stroke by triggering a cascade reaction of PGC-1α.
Zheng ZJ, Zhu LZ, Qiu H, Zheng WY, You PT, Chen SH, Hu CL, Huang JR, Zhou YJ
Scientific reports 2024 Jun 23;14(1):14438
Scientific reports 2024 Jun 23;14(1):14438
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
Feng X, Zheng Y, Mao N, Shen M, Chu L, Fang Y, Pang M, Wang Z, Lin Z
International immunopharmacology 2024 Jun 15;134:112257
International immunopharmacology 2024 Jun 15;134:112257
Diosmetin ameliorates psoriasis-associated inflammation and keratinocyte hyperproliferation by modulation of PGC-1α / YAP signaling pathway.
Yang D, Peng M, Fu F, Zhao W, Zhang B
International immunopharmacology 2024 Jun 15;134:112248
International immunopharmacology 2024 Jun 15;134:112248
Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism.
Pan L, Xu Z, Wen M, Li M, Lyu D, Xiao H, Li Z, Xiao J, Cheng Y, Huang H
Chinese medicine 2024 Jun 11;19(1):82
Chinese medicine 2024 Jun 11;19(1):82
Cornus officinalis Sieb. Et Zucc. attenuates Aβ(25-35)-induced mitochondrial damage and neuroinflammation in mice by modulating the ERK pathway.
Cao B, Zeng M, Hao F, Hao Z, Liang X, Zhang Z, Wu Y, Zhang Y, Wang R, Feng W, Zheng X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155709
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155709
Insights into the mechanism of action of pterostilbene against influenza A virus-induced acute lung injury.
Zhang Y, Li J, Qiu Z, Huang L, Yang S, Li J, Li K, Liang Y, Liu X, Chen Z, Li J, Zhou B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155534
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155534
Tangeretin Enhances Muscle Endurance and Aerobic Metabolism in Mice via Targeting AdipoR1 to Increase Oxidative Myofibers.
Li J, Li J, Ullah A, Shi X, Zhang X, Cui Z, Lyu Q, Kou G
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16687-16699
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16687-16699
Structural Variances in Curcumin Degradants: Impact on Obesity in Mice.
Koh YC, Hsu HW, Ho PY, Hsu KY, Lin WS, Nagabhushanam K, Ho CT, Pan MH
Journal of agricultural and food chemistry 2024 Jul 3;72(26):14786-14798
Journal of agricultural and food chemistry 2024 Jul 3;72(26):14786-14798
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Jiang T, Sun L, Wang Y, Zhang F, Guo J, Sun L, Jiang Y, Xue J, Duan J, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state.
Gao Q, Jiang Y, Song Z, Ren H, Kong Y, Wang C, Zheng M, Shan C, Yang Y
Scientific reports 2024 Jul 23;14(1):16878
Scientific reports 2024 Jul 23;14(1):16878
Systematical Investigation on Anti-Fatigue Function and Underlying Mechanism of High Fischer Ratio Oligopeptides from Antarctic Krill on Exercise-Induced Fatigue in Mice.
Mao SY, Suo SK, Wang YM, Chi CF, Wang B
Marine drugs 2024 Jul 19;22(7)
Marine drugs 2024 Jul 19;22(7)
Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ.
Chen Y, Liu X, Ma J, Wang W, Li Z, Wu H, Lu Z, Zhang D, Zhang X, Zhang Y, Zhang S
Journal of ethnopharmacology 2024 Jul 15;329:118156
Journal of ethnopharmacology 2024 Jul 15;329:118156
Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle.
Sato K, Satoshi Y, Miyauchi Y, Sato F, Kon R, Ikarashi N, Chiba Y, Hosoe T, Sakai H
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166877
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166877
Synergistic effects of MFG-E8 and whey protein on mitigating d-galactose-induced sarcopenia through PI3K/AKT/PGC-1α and MAPK/ERK signaling pathways.
Li H, Guan K, Wang R, Zhu A, Ma Y
Journal of dairy science 2024 Jan;107(1):9-23
Journal of dairy science 2024 Jan;107(1):9-23
Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens.
Li L, Lu Z, Wang Y, Yang Y, Wang H, Ma H
Poultry science 2024 Jan;103(1):103251
Poultry science 2024 Jan;103(1):103251
Mitochondria-derived peptide is an effective target for treating streptozotocin induced painful diabetic neuropathy through induction of activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1alpha -mediated mitochondrial biogenesis.
Xu L, Tang X, Yang L, Chang M, Xu Y, Chen Q, Lu C, Liu S, Jiang J
Molecular pain 2024 Jan-Dec;20:17448069241252654
Molecular pain 2024 Jan-Dec;20:17448069241252654
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Shang X, Hao X, Hou W, Liu J, Chi R, Deng X, Pan C, Xu T
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Dietary oleic acid intake increases the proportion of type 1 and 2X muscle fibers in mice.
Komiya Y, Iseki S, Ochiai M, Takahashi Y, Yokoyama I, Suzuki T, Tatsumi R, Sawano S, Mizunoya W, Arihara K
Scientific reports 2024 Jan 8;14(1):755
Scientific reports 2024 Jan 8;14(1):755
Jianpi Shengqing Huazhuo Formula improves abnormal glucose and lipid metabolism in obesity by regulating mitochondrial biogenesis.
Wang W, Chen S, Xu S, Liao G, Li W, Yang X, Li T, Zhang H, Huang H, Zhou Y, Pan H, Lin C
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117102
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117102
MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning.
Wang Q, Su Y, Sun R, Xiong X, Guo K, Wei M, Yang G, Ru Y, Zhang Z, Li J, Zhang J, Qiao Q, Li X
Cell & bioscience 2024 Jan 20;14(1):12
Cell & bioscience 2024 Jan 20;14(1):12
The promotion of fatty acid β-oxidation by hesperidin via activating SIRT1/PGC1α to improve NAFLD induced by a high-fat diet.
Nie T, Wang X, Li A, Shan A, Ma J
Food & function 2024 Jan 2;15(1):372-386
Food & function 2024 Jan 2;15(1):372-386
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Liu J, Wei B, Ma Q, Shi D, Pan X, Liu Z, Li J, Zhao P
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Promising anti-ovarian aging herbal formulation He's Yangchao promotes in vitro maturation of oocytes from advanced maternal age mice.
Yang L, Shang J, Wang H, Ma J, Wang L, Ma Y, Shuo J, Xu X, Cheng R, Duan X, Zhang Q
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116890
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116890
Lycium barbarum polysaccharides attenuate oxidative stress and mitochondrial toxicity induced by mixed plasticizers in HepG2 cells through activation of Nrf2.
Zhou L, Yang J, Liu H, Rang Y, Xu L, Wang X, Li Y, Liu C
Life sciences 2024 Jan 1;336:122346
Life sciences 2024 Jan 1;336:122346
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Wan TT, Li Y, Li JX, Xiao X, Liu L, Li HH, Guo SB
Archives of biochemistry and biophysics 2024 Feb;752:109855
Archives of biochemistry and biophysics 2024 Feb;752:109855
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
Meng M, Wang J, Wang C, Zhao J, Wang H, Zhang Y, Sun H, Liu M
Calcified tissue international 2024 Feb;114(2):182-199
Calcified tissue international 2024 Feb;114(2):182-199
Microglia nuclear receptor corepressor 1 deficiency alleviates neuroinflammation in mice.
Qiu S, Xian Z, Chen J, Huang P, Wang H, Wang H, Xu J
Neuroscience letters 2024 Feb 6;822:137643
Neuroscience letters 2024 Feb 6;822:137643
Alzheimer's Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells.
Li R, Li Y, Zuo H, Pei G, Huang S, Hou Y
Biomolecules 2024 Feb 4;14(2)
Biomolecules 2024 Feb 4;14(2)
Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP (SAA) knock-in mouse model of Alzheimer's disease.
Norambuena A, Sagar VK, Wang Z, Raut P, Feng Z, Wallrabe H, Pardo E, Kim T, Alam SR, Hu S, Periasamy A, Bloom GS
bioRxiv : the preprint server for biology 2024 Feb 4;
bioRxiv : the preprint server for biology 2024 Feb 4;
JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway.
Li Z, He R, Liu J, Jin X, Jiang B, Lao Y, Yang S
BMC complementary medicine and therapies 2024 Feb 24;24(1):101
BMC complementary medicine and therapies 2024 Feb 24;24(1):101
Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease.
Zhang XJ, Liu CC, Li ZL, Ding L, Zhou Y, Zhang DJ, Zhang Y, Hou ST, Ma RX
Diabetology & metabolic syndrome 2024 Feb 10;16(1):40
Diabetology & metabolic syndrome 2024 Feb 10;16(1):40
Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin†.
Chae SA, Du M, Zhu MJ, Son JS
Biology of reproduction 2024 Feb 10;110(2):355-364
Biology of reproduction 2024 Feb 10;110(2):355-364
The use of a systems approach to increase NAD(+) in human participants.
Henderson JD, Quigley SNZ, Chachra SS, Conlon N, Ford D
npj aging 2024 Feb 1;10(1):7
npj aging 2024 Feb 1;10(1):7
M6A RNA Methylation-Mediated TUG1 Stability Maintains Mitochondrial Homeostasis during Kidney Aging by Epigenetically Regulating PGC1-α Expression.
Zhu Y, Yang B, Chen S, Chen G, Zeng X, Min H, Xu L
Antioxidants & redox signaling 2024 Dec;41(16-18):993-1013
Antioxidants & redox signaling 2024 Dec;41(16-18):993-1013
Sirt1-mediated deacetylation of PGC-1α alleviated hepatic steatosis in type 2 diabetes mellitus via improving mitochondrial fatty acid oxidation.
Pang J, Yin L, Jiang W, Wang H, Cheng Q, Jiang Z, Cao Y, Zhu X, Li B, Qian S, Yin X, Wang T, Lu Q, Yang T
Cellular signalling 2024 Dec;124:111478
Cellular signalling 2024 Dec;124:111478
Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC-1α-mediated Transcriptional Coactivation.
Duan C, Li B, Liu H, Zhang Y, Yao X, Liu K, Wu X, Mao X, Wu H, Xu Z, Zhong Y, Hu Z, Gong Y, Xu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408945
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408945
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Zheng Y, Fang Y, Luo Y, Fan Y, Fang Z
Journal of ethnopharmacology 2024 Dec 5;335:118610
Journal of ethnopharmacology 2024 Dec 5;335:118610
Glia maturation factor-γ regulates amyloid-β42 phagocytosis through scavenger receptor class A type I in murine macrophages.
Aerbajinai W, Zhu J, Chin K, Rodgers GP
Journal of leukocyte biology 2024 Dec 31;117(1)
Journal of leukocyte biology 2024 Dec 31;117(1)
MicroRNA-668 alleviates renal fibrosis through PPARα/PGC-1α pathway.
Wang X, Gu Z, Huang Y, Wang J, Tang S, Yang X, Wang J
European journal of medical research 2024 Dec 28;29(1):631
European journal of medical research 2024 Dec 28;29(1):631
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy.
Wu G, Ying L, Zhang Q, Xiong H, Wang J, Chen S, Yang C, Jin Y, Lai Z, Feng N, Ge Y
Chinese medicine 2024 Dec 26;19(1):178
Chinese medicine 2024 Dec 26;19(1):178
Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARγ/PGC-1α/NF-κB axis to improve acute liver failure.
Wu H, Wu L, Luo L, Wu YT, Zhang QX, Li HY, Zhang BF
International immunopharmacology 2024 Dec 25;143(Pt 2):113444
International immunopharmacology 2024 Dec 25;143(Pt 2):113444
Inhibition of hepatitis B virus through PPAR-JAK/STAT pathway modulation by electroacupuncture and tenofovir disoproxil fumarate combination therapy.
Yang Y, Ge F, Luo C, Chen Y, Deng J, Yang Y, Guo X, Zhang S, Bai Z, Xiao X, Tang C
International immunopharmacology 2024 Dec 25;143(Pt 1):113304
International immunopharmacology 2024 Dec 25;143(Pt 1):113304
AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection.
Murakawa T, Ito J, Rusu MC, Taneike M, Omiya S, Moncayo-Arlandi J, Nakanishi C, Sugihara R, Nishida H, Mine K, Fleck R, Zhang M, Nishida K, Shah AM, Yamaguchi O, Sakata Y, Otsu K
Cell reports 2024 Dec 24;43(12):115001
Cell reports 2024 Dec 24;43(12):115001
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Qi XM, Zhang WZ, Zuo YQ, Qiao YB, Zhang YL, Ren JH, Li QS
Cell biology and toxicology 2024 Dec 20;41(1):2
Cell biology and toxicology 2024 Dec 20;41(1):2
Myricetin Alleviates Silica-Mediated Lung Fibrosis via PPARγ-PGC-1α Loop and Suppressing Mitochondrial Senescence in Epithelial Cells.
Xie W, Deng L, Zhang X, Huang X, Ding J, Liu W, Tang SY
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27737-27749
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27737-27749
Total minor ginsenosides exert anti-fatigue effects via antioxidant, anti-inflammatory, regulating gut microbiota and serum metabolism.
Zhang Y, Yang G, Gao Y, Gao L, Kang Y, Zhao Y, Zhao L, Li S
Life sciences 2024 Dec 15;359:123231
Life sciences 2024 Dec 15;359:123231
DEHP regulates ferritinophagy to promote testicular ferroptosis via suppressing SIRT1/PGC-1α pathway.
Zhu Q, Zhai J, Chen Z, Guo Z, Sun X, Li J, Wang N, Yao X, Zhang C, Deng H, Wang S, Yang G
The Science of the total environment 2024 Dec 1;954:176497
The Science of the total environment 2024 Dec 1;954:176497
Electroacupuncture improves cognitive impairment after ischemic stroke based on regulation of mitochondrial dynamics through SIRT1/PGC-1α pathway.
Chen L, Chen S, Bai Y, Zhang Y, Li X, Wang Y, Xiao Y, Wan J, Sun K
Brain research 2024 Dec 1;1844:149139
Brain research 2024 Dec 1;1844:149139
α-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1α/Nrf2 pathway.
Cheng D, Zhang M, Zheng Y, Wang M, Gao Y, Wang X, Liu X, Lv W, Zeng X, Belosludtsev KN, Su J, Zhao L, Liu J
Redox biology 2024 Aug;74:103230
Redox biology 2024 Aug;74:103230
Toxicity mechanism of acrolein on energy metabolism disorder and apoptosis in human ovarian granulosa cells.
Liu X, Li R, Xiu Z, Tang S, Duan Y
Toxicology 2024 Aug;506:153861
Toxicology 2024 Aug;506:153861
Resveratrol suppresses hepatic fatty acid synthesis and increases fatty acid β-oxidation via the microRNA-33/SIRT6 signaling pathway.
Liu C, Pan X, Hao Z, Wang X, Wang C, Song G
Experimental and therapeutic medicine 2024 Aug;28(2):326
Experimental and therapeutic medicine 2024 Aug;28(2):326
Exerkine FNDC5/irisin-enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin-1.
Tao L, Wang J, Wang K, Liu Q, Li H, Xu S, Gu C, Zhu Y
Aging cell 2024 Aug;23(8):e14181
Aging cell 2024 Aug;23(8):e14181
PGC-1α/LDHA signaling facilitates glycolysis initiation to regulate mechanically induced bone remodeling under inflammatory microenvironment.
Liu J, Wang J, Wang Z, Ren H, Zhang Z, Fu Y, Li L, Shen Z, Li T, Tang S, Wei F
Bone 2024 Aug;185:117132
Bone 2024 Aug;185:117132
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.
Li L, Zou J, Zhou M, Li H, Zhou T, Liu X, Huang Q, Yang S, Xiang Q, Yu R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117008
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117008
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes.
Tao T, Shu Q, Zhao Y, Guo W, Wang J, Shi Y, Jia S, Zhai H, Chen H, Wang C, Xu G
Acta pharmaceutica Sinica. B 2024 Aug;14(8):3576-3590
Acta pharmaceutica Sinica. B 2024 Aug;14(8):3576-3590
Mannan-binding lectin inhibits oxidative stress-induced senescence via the NAD+/Sirt1 pathway.
Lei Y, Meng J, Shi H, Shi C, Li C, Yang Z, Zhang W, Zuo D, Wang F, Wang M
International immunopharmacology 2024 Aug 20;137:112468
International immunopharmacology 2024 Aug 20;137:112468
PGC-1α agonism induces fetal hemoglobin and exerts antisickling effects in sickle cell disease.
Sun Y, Benmhammed H, Al Abdullatif S, Habara A, Fu E, Brady J, Williams C, Ilinski A, Sharma A, Mahdaviani K, Alekseyev YO, Campbell JD, Steinberg MH, Cui S
Science advances 2024 Aug 2;10(31):eadn8750
Science advances 2024 Aug 2;10(31):eadn8750
Adipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes.
Zhang Y, Zeng X, Wu F, Yang X, Che T, Zheng Y, Li J, Zhang Y, Zhang X, Wu Z
Nanomaterials (Basel, Switzerland) 2024 Aug 19;14(16)
Nanomaterials (Basel, Switzerland) 2024 Aug 19;14(16)
Modulatory Effects of Lactobacillus paracasei-Fermented Turmeric on Metabolic Dysregulation and Gut Microbiota in High-Fat Diet-Induced Obesity in Mice.
Lin WS, Hwang SE, Koh YC, Ho PY, Pan MH
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17924-17937
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17924-17937
Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS.
Xu Y, Li G, Ge D, Chen Y, Hou B, Hao Z
Urolithiasis 2024 Aug 13;52(1):117
Urolithiasis 2024 Aug 13;52(1):117
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Xie B, Chen Q, Dai Z, Jiang C, Chen X
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
Vigeo Promotes Myotube Differentiation and Protects Dexamethasone-Induced Skeletal Muscle Atrophy via Regulating the Protein Degradation, AKT/mTOR, and AMPK/Sirt-1/PGC1α Signaling Pathway In Vitro and In Vivo.
Cheon YH, Lee CH, Chung CH, Kim JY, Lee MS
Nutrients 2024 Aug 13;16(16)
Nutrients 2024 Aug 13;16(16)
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.
Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett AM, Diano S, Huang Y
Diabetologia 2024 Apr;67(4):724-737
Diabetologia 2024 Apr;67(4):724-737
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
Yang M, Liu Y, Luo SL, Liu CB, Jiang N, Li CR, Zhao H, Han YC, Chen W, Li L, Sun L
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Lin S, Wang L, Jia Y, Sun Y, Qiao P, Quan Y, Liu J, Hu H, Yang B, Zhou H
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Dietary purple potato supplement attenuates DSS-induced colitis in mice: impact on mitochondrial function.
Sun Q, Bibi S, Xue Y, Du M, Chew B, Zhu MJ
The Journal of nutritional biochemistry 2024 Apr;126:109585
The Journal of nutritional biochemistry 2024 Apr;126:109585
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis.
Hassab AH, Hur DJ, Vallabhajosyula P, Tellides G, Assi R
JCI insight 2024 Apr 9;9(9)
JCI insight 2024 Apr 9;9(9)
Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment.
Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, Nejo T, Levine LS, Spitzer MH, Okada H
JCI insight 2024 Apr 8;9(7)
JCI insight 2024 Apr 8;9(7)
Beneficial Effects of High-Intensity Interval Training and Dietary Changes Intervention on Hepatic Fat Accumulation in HFD-Induced Obese Rats.
Yuan XM, Xiang MQ, Ping Y, Zhang PW, Liu YT, Liu XW, Wei J, Tang Q, Zhang Y
Physiological research 2024 Apr 30;73(2):273-284
Physiological research 2024 Apr 30;73(2):273-284
Nobiletin enhances mitochondrial function by regulating SIRT1/PGC-1α signaling in porcine oocytes during in vitro maturation.
Lee SH, Li XH, Lu QY, Zhan CL, Kim JD, Lee GH, Sim JM, Cui XS
Biochemical and biophysical research communications 2024 Apr 30;706:149747
Biochemical and biophysical research communications 2024 Apr 30;706:149747
Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia.
Ye L, Gao Y, Mok SWF, Liao W, Wang Y, Chen C, Yang L, Zhang J, Shi L
Journal of nanobiotechnology 2024 Apr 18;22(1):190
Journal of nanobiotechnology 2024 Apr 18;22(1):190
cGAS Activation Accelerates the Progression of Autosomal Dominant Polycystic Kidney Disease.
Yoo M, Haydak JC, Azeloglu EU, Lee K, Gusella GL
Journal of the American Society of Nephrology : JASN 2024 Apr 1;35(4):466-482
Journal of the American Society of Nephrology : JASN 2024 Apr 1;35(4):466-482
Chemerin affects blood lipid profile of high-fat diet male mice in sedentary and exercise states via glucose and lipid metabolism enzymes.
Jia Y, Yang Y, Qu J, Yin L, Wang X
Endocrine connections 2024 Apr 1;13(4)
Endocrine connections 2024 Apr 1;13(4)
Corn peptides attenuate non-alcoholic fatty liver disease via PINK1/Parkin-mediated mitochondrial autophagy.
Yao Z, Li X, Wang W, Ren P, Song S, Wang H, Xie Y, Li X, Li Z
Food & nutrition research 2023;67
Food & nutrition research 2023;67
Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway.
Jin X, He R, Lin Y, Liu J, Wang Y, Li Z, Liao Y, Yang S
Drug design, development and therapy 2023;17:3363-3383
Drug design, development and therapy 2023;17:3363-3383
Sodium Butyrate Ameliorates Type 2 Diabetes-Related Sarcopenia Through IL-33-Independent ILC2s/IL-13/STAT3 Signaling Pathway.
Cao Y, Li Y, Han W, Jia X, Zhu P, Wei B, Cong X, Wang Z
Journal of inflammation research 2023;16:343-358
Journal of inflammation research 2023;16:343-358
Cardiolipin externalization mediates prion protein (PrP) peptide 106-126-associated mitophagy and mitochondrial dysfunction.
Yang D, Li J, Li Z, Zhao M, Wang D, Sun Z, Wen P, Gou F, Dai Y, Ji Y, Li W, Zhao D, Yang L
Frontiers in molecular neuroscience 2023;16:1163981
Frontiers in molecular neuroscience 2023;16:1163981
Exercise prevents fatal stress-induced myocardial injury in obese mice.
Dun Y, Hu Z, You B, Du Y, Zeng L, Zhao Y, Liu Y, Wu S, Cui N, Yang F, Liu S
Frontiers in endocrinology 2023;14:1223423
Frontiers in endocrinology 2023;14:1223423
The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity.
Xu J, Zhang LW, Feng H, Tang Y, Fu SQ, Liu XM, Zhu XY
Frontiers in pharmacology 2023;14:1176443
Frontiers in pharmacology 2023;14:1176443
Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells.
Tian L, Jia Z, Yan Y, Jia Q, Shi W, Cui S, Chen H, Han Y, Zhao X, He K
Frontiers in pharmacology 2023;14:1155414
Frontiers in pharmacology 2023;14:1155414
Buyang Huanwu Decoction alleviates cerebral ischemic injury through modulating caveolin-1-mediated mitochondrial quality control.
Xu Y, Chen B, Yi J, Tian F, Liu Y, Ouyang Y, Yuan C, Liu B
Frontiers in pharmacology 2023;14:1137609
Frontiers in pharmacology 2023;14:1137609
Exosomal transfer leads to chemoresistance through oxidative phosphorylation-mediated stemness phenotype in colorectal cancer.
Deng J, Pan T, Lv C, Cao L, Li L, Zhou X, Li G, Li H, Vicencio JM, Xu Y, Wei F, Wang Y, Liu Z, Zhou G, Yin M
Theranostics 2023;13(14):5057-5074
Theranostics 2023;13(14):5057-5074
F-ATP synthase inhibitory factor 1 regulates metabolic reprogramming involving its interaction with c-Myc and PGC1α.
Guo L, Gu Z
Frontiers in oncology 2023;13:1207603
Frontiers in oncology 2023;13:1207603
Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer.
Koc ZC, Sollars VE, Bou Zgheib N, Rankin GO, Koc EC
Frontiers in oncology 2023;13:1129352
Frontiers in oncology 2023;13:1129352
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Koh YC, Lin SJ, Hsu KY, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Lactate Improves Long-term Cognitive Impairment Induced By Repeated Neonatal Sevoflurane Exposures Through SIRT1-mediated Regulation of Adult Hippocampal Neurogenesis and Synaptic Plasticity in Male Mice.
Qiu LL, Tan XX, Yang JJ, Ji MH, Zhang H, Zhao C, Xia JY, Sun J
Molecular neurobiology 2023 Sep;60(9):5273-5291
Molecular neurobiology 2023 Sep;60(9):5273-5291
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Cui Y, Zhang W, Yang P, Zhu S, Luo S, Li M
Free radical biology & medicine 2023 Sep;206:33-49
Free radical biology & medicine 2023 Sep;206:33-49
Autoantibodies against the NineTeen complex and U5 RNP in systemic sclerosis.
Vulsteke JB, Smith V, Bonroy C, Lenaerts JL, Derua R, Wuyts WA, Blockmans D, De Haes P, Piette Y, De Langhe E, Bossuyt X
Journal of autoimmunity 2023 Sep;139:103056
Journal of autoimmunity 2023 Sep;139:103056
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
Zhu A, Duan Z, Chen Y, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice.
Jian L, Gao X, Wang C, Sun X, Xu Y, Han R, Wang Y, Xu S, Ding L, Zhou J, Gu Y, Zhao Y, Yang Y, Yuan Y, Ye J, Zhang L
Biology direct 2023 Sep 4;18(1):54
Biology direct 2023 Sep 4;18(1):54
Melatonin Restores Autophagic Flux by Activating the Sirt3/TFEB Signaling Pathway to Attenuate Doxorubicin-Induced Cardiomyopathy.
Ma Y, Ma J, Lu L, Xiong X, Shao Y, Ren J, Yang J, Liu J
Antioxidants (Basel, Switzerland) 2023 Sep 4;12(9)
Antioxidants (Basel, Switzerland) 2023 Sep 4;12(9)
The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells.
Fujimaki A, Ohuchi K, Takizawa S, Murakami T, Kurita H, Hozumi I, Wen X, Kitamura Y, Wu Z, Maekawa Y, Inden M
Scientific reports 2023 Sep 20;13(1):15629
Scientific reports 2023 Sep 20;13(1):15629
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Zhong G, Li Y, Li L, Huo Y, Zhang W, Li T, Ma F, Liao J, Li Y, Zhang H, Guo J, Pan J, Yu W, Hu L, Tang Z
Journal of hazardous materials 2023 Sep 15;458:131908
Journal of hazardous materials 2023 Sep 15;458:131908
Polysaccharide from Ziyang Selenium-Enriched Green Tea Prevents Obesity and Promotes Adipose Thermogenesis via Modulating the Gut Microbiota.
Li D, Cheng Y, Zeng X, Li Y, Xia Z, Yang X, Ren D
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13363-13375
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13363-13375
Astragaloside IV-mediated inhibition of oxidative stress by upregulation of ghrelin in type 2 diabetes-induced cognitive impairment.
Zhang RH, Cao SS, Shi Y, Wang X, Shi LL, Zhang YH, Han CJ, Wang B, Feng L, Liu JP
Naunyn-Schmiedeberg's archives of pharmacology 2023 Oct;396(10):2637-2650
Naunyn-Schmiedeberg's archives of pharmacology 2023 Oct;396(10):2637-2650
In search for mitochondrial biomarkers of Parkinson's disease: Findings in parkin-mutant human fibroblasts.
Kamienieva I, Charzyńska A, Duszyński J, Malińska D, Szczepanowska J
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166787
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166787
Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction therapy.
Guo Y, Luo C, Sun Y, Guo W, Zhang R, Zhang X, Ke X, Wei L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115342
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115342
Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells.
Song Y, Sun W, Li W, Li W
International immunopharmacology 2023 Oct;123:110751
International immunopharmacology 2023 Oct;123:110751
Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM(2.5) exposure by downregulating the PGC-1α/SIRT3 signaling pathway.
Huang L, Xu J, Duan K, Bao T, Cheng Y, Zhang H, Zhang Y, Lin Y, Li F
Toxicology research 2023 Oct;12(5):756-764
Toxicology research 2023 Oct;12(5):756-764
Modified rougan decoction attenuates hepatocyte apoptosis through ameliorating mitochondrial dysfunction by upregulated SIRT1/PGC-1α signaling pathway.
Wang W, Wu D, Ding J, Wang J, Meng J, Ming K, Li S, Qiu T, Liu J, Yang DA
Poultry science 2023 Oct;102(10):102992
Poultry science 2023 Oct;102(10):102992
Aerobic exercise and metformin on intermuscular adipose tissue (IMAT): insights from multimodal MRI and histological changes in prediabetic rats.
Yu F, Xing C, Fan Y, Liu Y, Su P, Yang Q, Dong Y, Hou Y, Pan S
Diabetology & metabolic syndrome 2023 Oct 30;15(1):221
Diabetology & metabolic syndrome 2023 Oct 30;15(1):221
Transcriptome Analysis Revealed Potential Genes of Skeletal Muscle Thermogenesis in Mashen Pigs and Large White Pigs under Cold Stress.
Li W, Chen Y, Zhang Y, Zhao N, Zhang W, Shi M, Zhao Y, Cai C, Lu C, Gao P, Guo X, Li B, Kim SW, Yang Y, Cao G
International journal of molecular sciences 2023 Oct 24;24(21)
International journal of molecular sciences 2023 Oct 24;24(21)
Indoxyl sulfate induced frailty in patients with end-stage renal disease by disrupting the PGC-1α-FNDC5 axis.
Hou YC, Liao MT, Tsai KW, Zheng CM, Chiu HW, Lu KC
Aging 2023 Oct 23;15(20):11532-11545
Aging 2023 Oct 23;15(20):11532-11545
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca(2+) pathways.
Cui Z, Gu L, Liu T, Liu Y, Yu B, Kou J, Li F, Yang K
European journal of pharmacology 2023 Oct 15;957:176044
European journal of pharmacology 2023 Oct 15;957:176044
MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM
Nature communications 2023 Oct 14;14(1):6493
Nature communications 2023 Oct 14;14(1):6493
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of vidarabine against rotenone-induced neural cell injury.
Li L, Zhang Y, Chen Z, Yao R, Xu Z, Xu C, He F, Pei H, Hao C
Heliyon 2023 Nov;9(11):e21695
Heliyon 2023 Nov;9(11):e21695
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Sun W, Yue J, Xu T, Cui Y, Huang D, Shi H, Xiong J, Sun W, Yi Q
Heliyon 2023 Nov;9(11):e21282
Heliyon 2023 Nov;9(11):e21282
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle.
Liang J, Wei X, Hou W, Wang H, Ma R, Gao Y, Du Y, Zhang Q
Chinese medicine 2023 Nov 30;18(1):157
Chinese medicine 2023 Nov 30;18(1):157
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Liu W, Li F, Guo D, Du C, Zhao S, Li J, Yan Z, Hao J
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C
Nature communications 2023 Nov 18;14(1):7527
Nature communications 2023 Nov 18;14(1):7527
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Zheng P, Zhang Q, Ma W, Hu R, Gu Y, Bian Z, Yang D, Chen X, Wu H
European journal of pharmacology 2023 Nov 15;959:176085
European journal of pharmacology 2023 Nov 15;959:176085
Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment.
Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, Nejo T, Levine LS, Spitzer MH, Okada H
bioRxiv : the preprint server for biology 2023 Nov 15;
bioRxiv : the preprint server for biology 2023 Nov 15;
Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis.
Gui Y, Wang Y, Palanza Z, Wang JL, Gupta P, Tao J, Qiao Y, Hargis G, Kreutzer DL, Bastacky SI, Yu Y, Wang Y, Liu S, Fu H, Zhou D
Molecular metabolism 2023 May;71:101712
Molecular metabolism 2023 May;71:101712
Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERRα-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats.
Li M, Yu Y, Xue K, Li J, Son G, Wang J, Qian W, Wang S, Zheng J, Yang C, Ge J
Redox biology 2023 May;61:102649
Redox biology 2023 May;61:102649
Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling.
Chen B, Wu J, Hu S, Liu Q, Yang H, You Y
Neurochemical research 2023 May;48(5):1504-1515
Neurochemical research 2023 May;48(5):1504-1515
Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells.
Ye F, Zeng Q, Dan G, Zhao Y, Yu W, Cheng J, Chen M, Wang B, Zhao J, Sai Y, Zou Z
Toxicology mechanisms and methods 2023 May;33(4):271-278
Toxicology mechanisms and methods 2023 May;33(4):271-278
Butyrate mitigates metabolic dysfunctions via the ERα-AMPK pathway in muscle in OVX mice with diet-induced obesity.
Fu Q, Li T, Zhang C, Ma X, Meng L, Liu L, Shao K, Wu G, Zhu X, Zhao X
Cell communication and signaling : CCS 2023 May 4;21(1):95
Cell communication and signaling : CCS 2023 May 4;21(1):95
Knockdown of 11β-hydroxysteroid dehydrogenase type 1 alleviates LPS-induced myocardial dysfunction through the AMPK/SIRT1/PGC-1α pathway.
Zhu D, Luo L, Zeng H, Zhang Z, Huang M, Zhou S
Journal of biomedical research 2023 May 29;37(4):303-314
Journal of biomedical research 2023 May 29;37(4):303-314
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626
Diabetes 2023 May 1;72(5):611-626
Ripretinib induced skeletal muscle toxicity through mitochondrial impairment in C2C12 myotubes.
Boran T, Zengin OS, Seker Z, Akyildiz AG, Oztas E, Özhan G
Toxicology 2023 May 1;489:153489
Toxicology 2023 May 1;489:153489
The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.
Zhou X, Zhang H, Jiang Y, Wei L, Chen Y, Zhang J, Gao P, Zhu S, Fang C, Du Y, Su R, He M, Yu J, Wang S, Ding W, Feng L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22806
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22806
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Chen L, Mao M, Liu D, Liu W, Wang Y, Xie L, Deng Y, Lin Y, Xu Y, Zhong X, Cao W
International immunopharmacology 2023 Mar;116:109648
International immunopharmacology 2023 Mar;116:109648
Impaired mitophagy causes mitochondrial DNA leakage and STING activation in ultraviolet B-irradiated human keratinocytes HaCaT.
Li C, Zhu Y, Liu W, Xiang W, He S, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Archives of biochemistry and biophysics 2023 Mar 15;737:109553
Archives of biochemistry and biophysics 2023 Mar 15;737:109553
Effects of dietary l-theanine supplementation on pork quality and muscle fiber type transformation in finishing pigs.
Dai H, Chen X, Chen D, Yu B, He J, Chen H, Yan H, Zheng P, Luo Y, Huang Z
Journal of the science of food and agriculture 2023 Mar 15;103(4):2106-2115
Journal of the science of food and agriculture 2023 Mar 15;103(4):2106-2115
Novel antioxidant peptides from MFGM protein Hydrolysates: Separation, identification and effects on Dexamethasone-induced mitochondrial dysfunction.
Li H, Guan K, Liu M, Liu D, Wang W, Zhu A
Food chemistry 2023 Mar 1;403:134473
Food chemistry 2023 Mar 1;403:134473
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Hong JR, Jin L, Zhang CY, Zhong WJ, Yang HH, Wang GM, Ma SC, Guan CX, Li Q, Zhou Y
Heliyon 2023 Jun;9(6):e17361
Heliyon 2023 Jun;9(6):e17361
Ketogenic diets composed of long-chain and medium-chain fatty acids induce cardiac fibrosis in mice.
Sternberg F, Sternberg C, Dunkel A, Beikbaghban T, Gregor A, Szarzynski A, Somoza V, Walter I, Duszka K, Kofler B, Pohl EE
Molecular metabolism 2023 Jun;72:101711
Molecular metabolism 2023 Jun;72:101711
BNP protects against diabetic cardiomyopathy by promoting Opa1-mediated mitochondrial fusion via activating the PKG-STAT3 pathway.
Chang P, Zhang X, Zhang J, Wang J, Wang X, Li M, Wang R, Yu J, Fu F
Redox biology 2023 Jun;62:102702
Redox biology 2023 Jun;62:102702
Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis.
Liu Q, Wang X, Hu Y, Zhao JN, Huang CH, Li T, Zhang BG, He Y, Wu YQ, Zhang ZJ, Wang GP, Liu GP
Redox biology 2023 Jun;62:102697
Redox biology 2023 Jun;62:102697
Exercise improves homeostasis of the intestinal epithelium by activation of apelin receptor-AMP-activated protein kinase signalling.
Chae SA, Du M, Son JS, Zhu MJ
The Journal of physiology 2023 Jun;601(12):2371-2389
The Journal of physiology 2023 Jun;601(12):2371-2389
DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway.
Liu H, Xu L, Zhou L, Han W, Li Z, Liu C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113782
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113782
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Koh YC, Chok D, Chang CH, Wei CC, Wu CT, Cheng KC, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis.
Zhong S, Chen W, Wang B, Gao C, Liu X, Song Y, Qi H, Liu H, Wu T, Wang R, Chen B
Redox biology 2023 Jul;63:102760
Redox biology 2023 Jul;63:102760
Nicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system.
Yoon H, Park SG, Kim HJ, Shin HR, Kim KT, Cho YD, Moon JI, Park MS, Kim WJ, Ryoo HM
Experimental & molecular medicine 2023 Jul;55(7):1531-1543
Experimental & molecular medicine 2023 Jul;55(7):1531-1543
Bavachin protects against diet-induced hepatic steatosis and obesity in mice.
Wei X, Lin L, Yuan QQ, Wang XY, Zhang Q, Zhang XM, Tang KC, Guo MY, Dong TY, Han W, Huang DK, Qi YL, Zhang M, Zhang HB
Acta pharmacologica Sinica 2023 Jul;44(7):1416-1428
Acta pharmacologica Sinica 2023 Jul;44(7):1416-1428
HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.
Li BY, Peng WQ, Liu Y, Guo L, Tang QQ
Cell reports 2023 Jul 25;42(7):112731
Cell reports 2023 Jul 25;42(7):112731
An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway.
Liu Y, Yang H, Luo N, Fu Y, Qiu F, Pan Z, Li X, Jian W, Yang X, Xue Q, Luo Y, Yu B, Liu Z
Journal of translational medicine 2023 Jul 20;21(1):486
Journal of translational medicine 2023 Jul 20;21(1):486
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Zhu Y, Han Y, Wang W, Liang G, Qi J
Journal of ethnopharmacology 2023 Jul 15;311:116286
Journal of ethnopharmacology 2023 Jul 15;311:116286
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Li F, Xu M, Miao J, Hu N, Wang Y, Wang L
Toxicology letters 2023 Jul 1;383:98-111
Toxicology letters 2023 Jul 1;383:98-111
High-intensity interval training induces renal injury and fibrosis in type 2 diabetic mice.
Zheng L, Qin R, Rao Z, Xiao W
Life sciences 2023 Jul 1;324:121740
Life sciences 2023 Jul 1;324:121740
Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α.
Huang S, Chen X, Pan J, Zhang H, Ke J, Gao L, Yu Chang AC, Zhang J, Zhang H
Nitric oxide : biology and chemistry 2023 Jul 1;136-137:12-23
Nitric oxide : biology and chemistry 2023 Jul 1;136-137:12-23
PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity.
Qi XM, Qiao YB, Zhang YL, Wang AC, Ren JH, Wei HZ, Li QS
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113513
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113513
N-acetylcysteine delayed cadmium-induced chronic kidney injury by activating the sirtuin 1-P53 signaling pathway.
Dong W, Zhang K, Gong Z, Luo T, Li J, Wang X, Zou H, Song R, Zhu J, Ma Y, Liu G, Liu Z
Chemico-biological interactions 2023 Jan 5;369:110299
Chemico-biological interactions 2023 Jan 5;369:110299
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Tian Z, Li J, Song L, Xie L, Li D, Xia T, Wang A
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice.
Yan J, Ren C, Dong Y, Wali JA, Song H, Zhang Y, Zhang H, Kou G, Raubenheimer D, Cui Z
Nutrients 2023 Jan 3;15(1)
Nutrients 2023 Jan 3;15(1)
Dietary leucine and fish oil cooperatively regulate skeletal myofiber type transformation via the CaMKII signaling pathway of pigs.
Gong S, Yin Y, Han M, Guo L, Duan Y, Guo Q, Yin J, Li F
Food & function 2023 Jan 3;14(1):133-147
Food & function 2023 Jan 3;14(1):133-147
PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice.
Liu T, Chen X, Wei Z, Han X, Liu Y, Ma Z, Xia T, Gu X
Translational neuroscience 2023 Jan 1;14(1):20220317
Translational neuroscience 2023 Jan 1;14(1):20220317
Mice harboring a R133L heterozygous mutation in LMNA exhibited ectopic lipid accumulation, aging, and mitochondrial dysfunction in adipose tissue.
Qiu R, Wang S, Lin D, He Y, Huang S, Wu B, Li H, Wang M, Zheng F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22730
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22730
Hypoxia aggravates the burden of yellowstripe goby (Mugilogobius chulae) under atorvastatin exposure.
Wang Y, Tang T, Ren J, Zhao Y, Hou Y, Nie X
Aquatic toxicology (Amsterdam, Netherlands) 2023 Feb;255:106381
Aquatic toxicology (Amsterdam, Netherlands) 2023 Feb;255:106381
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling.
Pan Z, Wu X, Zhang X, Hu K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114095
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114095
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM Pathway.
Han X, Wang J, Li R, Huang M, Yue G, Guan L, Deng Y, Cai W, Xu J
International journal of molecular sciences 2023 Feb 28;24(5)
International journal of molecular sciences 2023 Feb 28;24(5)
Aerobic exercise inhibits renal EMT by promoting irisin expression in SHR.
Luo M, Luo S, Xue Y, Chang Q, Yang H, Dong W, Zhang T, Cao S
iScience 2023 Feb 17;26(2):105990
iScience 2023 Feb 17;26(2):105990
The Degree of Hydrolysis and Peptide Profile Affect the Anti-Fatigue Activities of Whey Protein Hydrolysates in Promoting Energy Metabolism in Exercise Mice.
Zhao C, Gong Y, Zheng L, Zhao M
Journal of agricultural and food chemistry 2023 Feb 15;71(6):3010-3021
Journal of agricultural and food chemistry 2023 Feb 15;71(6):3010-3021
Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep.
Lin S, Yang F, Hu M, Chen J, Chen G, Hu A, Li X, Fu D, Xing C, Xiong Z, Wu Y, Cao H
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120954
Protective effect of Qingluotongbi formula against Tripterygium wilfordii induced liver injury in mice by improving fatty acid β-oxidation and mitochondrial biosynthesis.
Zhou J, Li M, Yu Z, Li C, Zhou L, Zhou X
Pharmaceutical biology 2023 Dec;61(1):80-88
Pharmaceutical biology 2023 Dec;61(1):80-88
Urolithin A protects severe acute pancreatitis-associated acute cardiac injury by regulating mitochondrial fatty acid oxidative metabolism in cardiomyocytes.
Yang Y, Hu Q, Kang H, Li J, Zhao X, Zhu L, Tang W, Wan M
MedComm 2023 Dec;4(6):e459
MedComm 2023 Dec;4(6):e459
Efficacy of creatine nitrate supplementation on redox status and mitochondrial function in pectoralis major muscle of preslaughter transported broilers.
Xu J, Xing T, Li J, Zhang L, Gao F
Animal biotechnology 2023 Dec;34(8):3988-3999
Animal biotechnology 2023 Dec;34(8):3988-3999
Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.
Yan J, Xie J, Xu S, Guo Y, Ji K, Li C, Gao H, Zhao L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115737
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115737
Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in calf hepatocytes.
Wang GY, Qin SL, Zheng YN, Geng HJ, Chen L, Yao JH, Deng L
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Dec;15:88-98
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Dec;15:88-98
Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway.
Meng T, Zhang D, Zhang Y, Tian P, Chen J, Liu A, Li Y, Song C, Zheng Y, Su G
International immunopharmacology 2023 Dec;125(Pt A):110978
International immunopharmacology 2023 Dec;125(Pt A):110978
Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stress.
Wei L, Luo H, Jin Y, Shu Y, Wen C, Qin T, Yang X, Ma L, Liu Y, You Y, Zhou C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155080
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155080
Styrax (Liquidambar orientalis Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1α signaling pathway.
Mu F, Zhao J, Zhao M, Lin R, Liu K, Zhao S, Tao X, Li W, Dai Q, Xi M, Tang H, Wang J
The Journal of pharmacy and pharmacology 2023 Dec 8;75(12):1496-1508
The Journal of pharmacy and pharmacology 2023 Dec 8;75(12):1496-1508
Histone H3 Acetylation Is Involved in Retinoid Acid-Induced Neural Differentiation through Increasing Mitochondrial Function.
Zhang Y, Wang X, Mu Q, Hou X, Yu W, Guo J
Biomedicines 2023 Dec 8;11(12)
Biomedicines 2023 Dec 8;11(12)
Effects of dapagliflozin monotherapy and combined aerobic exercise on skeletal muscle mitochondrial quality control and insulin resistance in type 2 diabetes mellitus rats.
Zhang L, Lin H, Yang X, Shi J, Sheng X, Wang L, Li T, Quan H, Zhai X, Li W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115852
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115852
High Concentrations of Nucleotides Prevent Capillary Regression during Hindlimb Unloading by Inhibiting Oxidative Stress and Enhancing Mitochondrial Metabolism of Soleus Muscles in Rats.
Nakanishi R, Hashimoto N, Takuwa M, Xing J, Uemura M, Un Nisa B, Tanaka M, Hirabayashi T, Tanaka M, Fujino H
Acta histochemica et cytochemica 2023 Dec 28;56(6):95-104
Acta histochemica et cytochemica 2023 Dec 28;56(6):95-104
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Wan L, Qian Y, Ni W, Lu Y, Li W, Pan Y, Chen W
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Yang JW, Zou Y, Chen J, Cui C, Song J, Yang MM, Gao J, Hu HQ, Xia LQ, Wang LM, Lv XY, Chen L, Hou XG
Journal of translational medicine 2023 Dec 19;21(1):921
Journal of translational medicine 2023 Dec 19;21(1):921
Therapeutic Potential of Ginsenoside Rb1-PLGA Nanoparticles for Heart Failure Treatment via the ROS/PPARα/PGC1α Pathway.
Du L, Lu H, Wang Z, Liu C, Xiao Y, Guo Z, Li Y
Molecules (Basel, Switzerland) 2023 Dec 15;28(24)
Molecules (Basel, Switzerland) 2023 Dec 15;28(24)
Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway.
Zhao TQ, Li Y, Zhang M, Zhao MC, Cao X, Hou SZ
Current medical science 2023 Aug;43(4):696-707
Current medical science 2023 Aug;43(4):696-707
Prolonged fluoride exposure induces spatial-memory deficit and hippocampal dysfunction by inhibiting small heat shock protein 22 in mice.
Xin J, Zhu B, Wang H, Zhang Y, Sun N, Cao X, Zheng L, Zhou Y, Fang J, Jing B, Pan K, Zeng Y, Zeng D, Li F, Xia Y, Xu P, Ni X
Journal of hazardous materials 2023 Aug 15;456:131595
Journal of hazardous materials 2023 Aug 15;456:131595
LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway.
Bai Y, Hei N, Gao M, Dong X, Li M, Jiang S, Zhang L
Toxicology letters 2023 Aug 1;384:30-43
Toxicology letters 2023 Aug 1;384:30-43
Oridonin ameliorates acetaminophen-induced acute liver injury through ATF4/PGC-1α pathway.
Yu D, Li J, Wang Y, Guo D, Zhang X, Chen M, Zhou Z
Drug development research 2023 Apr;84(2):211-225
Drug development research 2023 Apr;84(2):211-225
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Wang Y, Chen X, Baker JS, Davison GW, Xu S, Zhou Y, Bao X
European journal of nutrition 2023 Apr;62(3):1453-1466
European journal of nutrition 2023 Apr;62(3):1453-1466
Ginsenoside Rd promotes omentin secretion in adipose through TBK1-AMPK to improve mitochondrial biogenesis via WNT5A/Ca(2+) pathways in heart failure.
Wan S, Cui Z, Wu L, Zhang F, Liu T, Hu J, Tian J, Yu B, Liu F, Kou J, Li F
Redox biology 2023 Apr;60:102610
Redox biology 2023 Apr;60:102610
Resveratrol inhibits LPS-induced apoptosis in bovine mammary epithelial cells: the role of PGC1α-SIRT3 axis.
Ouyang L, Tang H, Liu Z, Tian Y, Gao X, Peng T, Wang Z, Lan X, Shen W, Xiao D, Wan F, Liu L
In vitro cellular & developmental biology. Animal 2023 Apr;59(4):264-276
In vitro cellular & developmental biology. Animal 2023 Apr;59(4):264-276
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Liang Z, Yang Y, Wu X, Lu C, Zhao H, Chen K, Zhao A, Li X, Xu J
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.
Li Y, Liu Y, Chen Z, Tang K, Yang L, Jiang Y, Wang J, Huang P, Wang J, Zheng P, Song H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114319
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
Chen H, Qi X, Guan K, Wang R, Li Q, Ma Y
Journal of dairy science 2023 Apr;106(4):2271-2288
Journal of dairy science 2023 Apr;106(4):2271-2288
Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice.
Yang M, Wang J
Journal of nutritional science and vitaminology 2022;68(3):228-235
Journal of nutritional science and vitaminology 2022;68(3):228-235
Nr2f2 Overexpression Aggravates Ferroptosis and Mitochondrial Dysfunction by Regulating the PGC-1α Signaling in Diabetes-Induced Heart Failure Mice.
Miao W, Chen M, Chen M, Cui C, Zhu Y, Luo X, Wu B
Mediators of inflammation 2022;2022:8373389
Mediators of inflammation 2022;2022:8373389
Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis.
Liu H, Xie J, Fan L, Xia Y, Peng X, Zhou J, Ni X
Oxidative medicine and cellular longevity 2022;2022:8011850
Oxidative medicine and cellular longevity 2022;2022:8011850
Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE.
Ren C, Hu C, Wu Y, Li T, Zou A, Yu D, Shen T, Cai W, Yu J
Oxidative medicine and cellular longevity 2022;2022:5961123
Oxidative medicine and cellular longevity 2022;2022:5961123
An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model.
Zhao J, Ouyang Y, Wang H, Lai H, Hu S, Tang L, Yang H, Wu H
Oxidative medicine and cellular longevity 2022;2022:3712500
Oxidative medicine and cellular longevity 2022;2022:3712500
Rhein Ameliorates Cognitive Impairment in an APP/PS1 Transgenic Mouse Model of Alzheimer's Disease by Relieving Oxidative Stress through Activating the SIRT1/PGC-1α Pathway.
Yin Z, Gao D, Du K, Han C, Liu Y, Wang Y, Gao X
Oxidative medicine and cellular longevity 2022;2022:2524832
Oxidative medicine and cellular longevity 2022;2022:2524832
∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis.
Chen Q, Chen X, Jia Z, Du Y, Zhang S, Xu W, Pan B, Lou J, Zhou J, Zhou J, Sun J
Oxidative medicine and cellular longevity 2022;2022:1231970
Oxidative medicine and cellular longevity 2022;2022:1231970
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway.
Li Q, Tan JX, He Y, Bai F, Li SW, Hou YW, Ji LS, Gao YT, Zhang X, Zhou ZH, Yu Z, Fang M, Gao YQ, Li M
International journal of biological sciences 2022;18(4):1594-1611
International journal of biological sciences 2022;18(4):1594-1611
Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.
He K, Zhang J, Zhang W, Wang S, Li D, Ma X, Wu X, Chai X, Liu Q
Frontiers in aging neuroscience 2022;14:772066
Frontiers in aging neuroscience 2022;14:772066
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
Zhu Z, Wang X, Song Z, Zuo X, Ma Y, Zhang Z, Ju C, Liang Z, Li K, Hu X, Wang Z
Frontiers in pharmacology 2022;13:991421
Frontiers in pharmacology 2022;13:991421
Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.
Jiang XL, Tai H, Xiao XS, Zhang SY, Cui SC, Qi SB, Hu DD, Zhang LN, Kuang JS, Meng XS, Li SM
Frontiers in endocrinology 2022;13:962154
Frontiers in endocrinology 2022;13:962154
Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice.
Ye Z, Ma J, Liu Y, Xu B, Dai X, Fu M, Tian T, Sui X, Mo F, Gao S, Zhao D, Zhang D
Frontiers in pharmacology 2022;13:950535
Frontiers in pharmacology 2022;13:950535
Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy.
Xin R, Xu Y, Long D, Mao G, Liao H, Zhang Z, Kang Y
Frontiers in pharmacology 2022;13:911716
Frontiers in pharmacology 2022;13:911716
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis.
Guo K, Liu R, Jing R, Wang L, Li X, Zhang K, Fu M, Ye J, Hu Z, Zhao W, Xu N
Frontiers in pharmacology 2022;13:1036013
Frontiers in pharmacology 2022;13:1036013
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages.
Xia L, Zhang C, Lv N, Liang Z, Ma T, Cheng H, Xia Y, Shi L
Theranostics 2022;12(6):2928-2947
Theranostics 2022;12(6):2928-2947
Growth Hormone Receptor Controls Adipogenic Differentiation of Chicken Bone Marrow Mesenchymal Stem Cells by Affecting Mitochondrial Biogenesis and Mitochondrial Function.
Zhao C, Hu B, Liao Z, Wei H, Zhao Y, Liang J, Luo W, Nie Q, Luo Q, Zhang D, Zhang X, Li H
Frontiers in cell and developmental biology 2022;10:827623
Frontiers in cell and developmental biology 2022;10:827623
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Peng Y, Liao K, Tan F, Liang Y, Sun X, Cui Z, Ye B, Chen Z, Tang S, Chen J
Experimental eye research 2022 Sep;222:109158
Experimental eye research 2022 Sep;222:109158
Naringenin regulates gut microbiota and SIRT1/ PGC-1ɑ signaling pathway in rats with letrozole-induced polycystic ovary syndrome.
Wu YX, Yang XY, Han BS, Hu YY, An T, Lv BH, Lian J, Wang TY, Bao XL, Gao L, Jiang GJ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113286
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113286
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3.
Wang D, Cao L, Zhou X, Wang G, Ma Y, Hao X, Fan H
Journal of hazardous materials 2022 Sep 5;437:129381
Journal of hazardous materials 2022 Sep 5;437:129381
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
Liu J, Shi D, Ma Q, Zhao P
Journal of ethnopharmacology 2022 Sep 15;295:115398
Journal of ethnopharmacology 2022 Sep 15;295:115398
CHCHD10 Modulates Thermogenesis of Adipocytes by Regulating Lipolysis.
Ding M, Ma YJ, Du RQ, Zhou WY, Dou X, Yang QQ, Tang Y, Qian SW, Liu Y, Pan DN, Tang QQ, Liu Y
Diabetes 2022 Sep 1;71(9):1862-1879
Diabetes 2022 Sep 1;71(9):1862-1879
Hesperetin activated SIRT1 neutralizes cadmium effects on the early bovine embryo development.
Idrees M, Kumar V, Khan AM, Joo MD, Uddin Z, Lee KW, Kong IK
Theriogenology 2022 Sep 1;189:209-221
Theriogenology 2022 Sep 1;189:209-221
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Wang F, Han J, Wang X, Liu Y, Zhang Z
Journal of molecular histology 2022 Oct;53(5):833-842
Journal of molecular histology 2022 Oct;53(5):833-842
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L
International journal of molecular sciences 2022 Oct 4;23(19)
International journal of molecular sciences 2022 Oct 4;23(19)
Naringenin activates beige adipocyte browning in high fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Zhang S, Li J, Shi X, Tan X, Si Q
Food & function 2022 Oct 3;13(19):9918-9930
Food & function 2022 Oct 3;13(19):9918-9930
Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.
Jiang XL, Tai H, Kuang JS, Zhang JY, Cui SC, Lu YX, Qi SB, Zhang SY, Li SM, Chen JP, Meng XS
Aging 2022 Oct 27;14(20):8321-8345
Aging 2022 Oct 27;14(20):8321-8345
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise.
Barsky ST, Monks DA
Biology of sex differences 2022 Oct 23;13(1):59
Biology of sex differences 2022 Oct 23;13(1):59
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways.
Zhuang X, Ma J, Xu G, Sun Z
Molecular medicine (Cambridge, Mass.) 2022 Oct 22;28(1):125
Molecular medicine (Cambridge, Mass.) 2022 Oct 22;28(1):125
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Tai H, Cui XZ, He J, Lan ZM, Li SM, Li LB, Yao SC, Jiang XL, Meng XS, Kuang JS
Aging 2022 Oct 20;14(20):8302-8320
Aging 2022 Oct 20;14(20):8302-8320
Artemisia sphaerocephala Krasch polysaccharide promotes adipose thermogenesis and decreases obesity by shaping the gut microbiota.
Zeng X, Ren D, Li D, Du H, Yang X
Food & function 2022 Oct 17;13(20):10651-10664
Food & function 2022 Oct 17;13(20):10651-10664
Dihydromyricetin alters myosin heavy chain expression via AMPK signaling pathway in porcine myotubes.
Guo Z, Chen X, Chen D, Yu B, He J, Zheng P, Luo Y, Chen H, Yan H, Huang Z
Food & function 2022 Oct 17;13(20):10525-10534
Food & function 2022 Oct 17;13(20):10525-10534
The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression.
Luo XM, Lam SM, Dong Y, Ma XJ, Yan C, Zhang YJ, Cao Y, Su L, Lu G, Yang JK, Shui G, Feng YM
Communications biology 2022 Oct 12;5(1):1088
Communications biology 2022 Oct 12;5(1):1088
Indole-3-acetic acid improves the hepatic mitochondrial respiration defects by PGC1a up-regulation.
Zhang C, Fu Q, Shao K, Liu L, Ma X, Zhang F, Zhang X, Meng L, Yan C, Zhao X
Cellular signalling 2022 Nov;99:110442
Cellular signalling 2022 Nov;99:110442
Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α.
Wu H, Lu C, Li X, Xu X, Wu S
Annals of translational medicine 2022 Nov;10(22):1241
Annals of translational medicine 2022 Nov;10(22):1241
Targeting Wnt/β-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF.
Wang H, Zhang H, Chen Y, Wang H, Tian Y, Yi X, Shi Q, Zhao T, Zhang B, Gao T, Guo S, Li C, Guo W
Cells 2022 Nov 12;11(22)
Cells 2022 Nov 12;11(22)
Anti-fatigue effects of fermented soybean protein peptides in mice.
Fang L, Zhang RX, Wei Y, Ling K, Lu L, Wang J, Pan XC, Cai MY
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Zhang W, Ho CT, Lu M
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.
Wei S, Yin D, Yu S, Lin X, Savani MR, Du K, Ku Y, Wu D, Li S, Liu H, Tian M, Chen Y, Bowie M, Hariharan S, Waitkus M, Keir ST, Sugarman ET, Deek RA, Labrie M, Khasraw M, Lu Y, Mills GB, Herlyn M, Wu K, Liu L, Wei Z, Flaherty KT, Abdullah K, Zhang G, Ashley DM
Clinical cancer research : an official journal of the American Association for Cancer Research 2022 May 13;28(10):2180-2195
Clinical cancer research : an official journal of the American Association for Cancer Research 2022 May 13;28(10):2180-2195
Sirtuin 6 affects glucose reabsorption and gluconeogenesis in type 1 diabetes via FoxO1.
Bian C, Zhang R, Wang Y, Li J, Song Y, Guo D, Gao J, Ren H
Molecular and cellular endocrinology 2022 May 1;547:111597
Molecular and cellular endocrinology 2022 May 1;547:111597
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Shen R, Yang K, Cheng X, Guo C, Xing X, Sun H, Liu D, Liu X, Wang D
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
LncEDCH1 improves mitochondrial function to reduce muscle atrophy by interacting with SERCA2.
Cai B, Ma M, Zhang J, Wang Z, Kong S, Zhou Z, Lian L, Zhang J, Li J, Wang Y, Li H, Zhang X, Nie Q
Molecular therapy. Nucleic acids 2022 Mar 8;27:319-334
Molecular therapy. Nucleic acids 2022 Mar 8;27:319-334
Dihydromyricetin improves meat quality and promotes skeletal muscle fiber type transformations via AMPK signaling in growing-finishing pigs.
Guo Z, Chen X, Huang Z, Chen D, Li M, Yu B, He J, Luo Y, Yan H, Zheng P
Food & function 2022 Mar 21;13(6):3649-3659
Food & function 2022 Mar 21;13(6):3649-3659
IGF-1 Signaling Regulates Mitochondrial Remodeling during Myogenic Differentiation.
Guan X, Yan Q, Wang D, Du G, Zhou J
Nutrients 2022 Mar 16;14(6)
Nutrients 2022 Mar 16;14(6)
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Tai H, Tong YJ, Yu R, Yu Y, Yao SC, Li LB, Liu Y, Cui XZ, Kuang JS, Meng XS, Jiang XL
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.
Li S, Ma Y, Ye S, Su Y, Hu D, Xiao F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113071
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113071
Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia.
Ito A, Hashimoto M, Tanihata J, Matsubayashi S, Sasaki R, Fujimoto S, Kawamoto H, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Takekoshi D, Ito S, Minagawa S, Numata T, Hara H, Matsuoka T, Udaka J, Araya J, Saito M, Kuwano K
Journal of cachexia, sarcopenia and muscle 2022 Jun;13(3):1864-1882
Journal of cachexia, sarcopenia and muscle 2022 Jun;13(3):1864-1882
The anti-fatigue activity of corn peptides and their effect on gut bacteria.
Feng Z, Wei Y, Xu Y, Zhang R, Li M, Qin H, Gu R, Cai M
Journal of the science of food and agriculture 2022 Jun;102(8):3456-3466
Journal of the science of food and agriculture 2022 Jun;102(8):3456-3466
Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway.
Kou G, Li P, Shi Y, Traore SS, Shi X, Amoah AN, Cui Z, Lyu Q
Journal of agricultural and food chemistry 2022 Jun 29;70(25):7704-7715
Journal of agricultural and food chemistry 2022 Jun 29;70(25):7704-7715
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Chen Z, Wang H, Hu B, Chen X, Zheng M, Liang L, Lyu J, Zeng Q
European journal of histochemistry : EJH 2022 Jun 21;66(3)
European journal of histochemistry : EJH 2022 Jun 21;66(3)
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
Zhou M, Dai Y, Ma Y, Yan Y, Hua M, Gao Q, Geng X, Zhou Q
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
Exerkine apelin reverses obesity-associated placental dysfunction by accelerating mitochondrial biogenesis in mice.
Chae SA, Son JS, Zhao L, Gao Y, Liu X, Marie de Avila J, Zhu MJ, Du M
American journal of physiology. Endocrinology and metabolism 2022 Jun 1;322(6):E467-E479
American journal of physiology. Endocrinology and metabolism 2022 Jun 1;322(6):E467-E479
Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin-induced acute kidney injury.
Yu C, Li T, Li J, Cui B, Liu N, Bayliss G, Zhuang S
Journal of cellular and molecular medicine 2022 Jul;26(14):4061-4075
Journal of cellular and molecular medicine 2022 Jul;26(14):4061-4075
Selenium alleviates cadmium-induced aging via mitochondrial quality control in the livers of sheep.
Xiong Z, Yang F, Xu T, Yang Y, Wang F, Zhou G, Wang Q, Guo X, Xing C, Bai H, Chen J, Wu Y, Yang S, Cao H
Journal of inorganic biochemistry 2022 Jul;232:111818
Journal of inorganic biochemistry 2022 Jul;232:111818
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.
Liu R, Liu B, Tian L, Jiang X, Li X, Cai D, Sun J, Bai W, Jin Y
International journal of molecular sciences 2022 Jul 21;23(14)
International journal of molecular sciences 2022 Jul 21;23(14)
Effect of Qingyangshen glycosides on social defeat mice model.
Liu D, Wang J, Chang L, Zhu Q, Jiang N, Azhar M, Zeng G
Journal of ethnopharmacology 2022 Jul 15;293:115253
Journal of ethnopharmacology 2022 Jul 15;293:115253
Caloric restriction and Roux-en-Y Gastric Bypass promote white adipose tissue browning in mice.
Huang D, Zhang Z, Dong Z, Liu R, Huang J, Xu G
Journal of endocrinological investigation 2022 Jan;45(1):139-148
Journal of endocrinological investigation 2022 Jan;45(1):139-148
Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress.
Hao X, Bu W, Lv G, Xu L, Hou D, Wang J, Liu X, Yang T, Zhang X, Liu Q, Gong Y, Shao C
Oncogene 2022 Jan;41(3):427-443
Oncogene 2022 Jan;41(3):427-443
Sodium butyrate ameliorates the cognitive impairment of Alzheimer's disease by regulating the metabolism of astrocytes.
Wang C, Zheng D, Weng F, Jin Y, He L
Psychopharmacology 2022 Jan;239(1):215-227
Psychopharmacology 2022 Jan;239(1):215-227
Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway.
Liu J, Jiang J, Qiu J, Wang L, Zhuo J, Wang B, Sun D, Yu S, Lou H
Food & function 2022 Jan 4;13(1):375-385
Food & function 2022 Jan 4;13(1):375-385
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
d-Allulose Improves Endurance and Recovery from Exhaustion in Male C57BL/6J Mice.
Liu B, Gou Y, Tsuzuki T, Yamada T, Iida T, Wang S, Banno R, Toyoda Y, Koike T
Nutrients 2022 Jan 18;14(3)
Nutrients 2022 Jan 18;14(3)
Dopamine receptor D1 signaling stimulates lipolysis and browning of white adipocytes.
Yu J, Zhu J, Deng J, Shen J, Du F, Wu X, Chen Y, Li M, Wen Q, Xiao Z, Zhao Y
Biochemical and biophysical research communications 2022 Jan 15;588:83-89
Biochemical and biophysical research communications 2022 Jan 15;588:83-89
Arsenic causes mitochondrial biogenesis obstacles by inhibiting the AMPK/PGC-1α signaling pathway and also induces apoptosis and dysregulated mitophagy in the duck liver.
Zhong G, Hu T, Tang L, Li T, Wu S, Duan X, Pan J, Zhang H, Tang Z, Feng X, Hu L
Ecotoxicology and environmental safety 2022 Jan 15;230:113117
Ecotoxicology and environmental safety 2022 Jan 15;230:113117
BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice.
Li L, Zhang H, Chen B, Xia B, Zhu R, Liu Y, Dai X, Ye Z, Zhao D, Mo F, Gao S, Orekhov AN, Prentki M, Wang L, Guo S, Zhang D
Journal of ethnopharmacology 2022 Jan 10;282:114653
Journal of ethnopharmacology 2022 Jan 10;282:114653
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X
The Journal of biological chemistry 2022 Feb;298(2):101561
The Journal of biological chemistry 2022 Feb;298(2):101561
High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein.
Shen Z, Wu J, Gao Z, Zhang S, Chen J, He J, Guo Y, Deng Q, Xie Y, Liu J, Zhang J
Nucleic acids research 2022 Feb 28;50(4):2157-2171
Nucleic acids research 2022 Feb 28;50(4):2157-2171
circPTPN4 regulates myogenesis via the miR-499-3p/NAMPT axis.
Cai B, Ma M, Zhou Z, Kong S, Zhang J, Zhang X, Nie Q
Journal of animal science and biotechnology 2022 Feb 14;13(1):2
Journal of animal science and biotechnology 2022 Feb 14;13(1):2
Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway.
Wang Y, Liu B, Wu P, Chu Y, Gui S, Zheng Y, Chen X
Antioxidants (Basel, Switzerland) 2022 Feb 10;11(2)
Antioxidants (Basel, Switzerland) 2022 Feb 10;11(2)
Quercetin, Engelitin and Caffeic Acid of Smilax china L. Polyphenols, Stimulate 3T3-L1 Adipocytes to Brown-like Adipocytes Via β3-AR/AMPK Signaling Pathway.
Kong L, Zhang W, Liu S, Zhong Z, Zheng G
Plant foods for human nutrition (Dordrecht, Netherlands) 2022 Dec;77(4):529-537
Plant foods for human nutrition (Dordrecht, Netherlands) 2022 Dec;77(4):529-537
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns.
Liu X, Li D, Liu Z, Song Y, Zhang B, Zang Y, Zhang W, Niu Y, Shen C
Burns : journal of the International Society for Burn Injuries 2022 Dec;48(8):1922-1932
Burns : journal of the International Society for Burn Injuries 2022 Dec;48(8):1922-1932
Dietary L-theanine supplementation improves lipid metabolism and antioxidant capacity in weaning piglets.
Chen X, Chen L, Qin Y, Mao Z, Huang Z, Jia G, Zhao H, Liu G
Animal biotechnology 2022 Dec;33(7):1407-1415
Animal biotechnology 2022 Dec;33(7):1407-1415
Differential regulatory roles of microRNAs during intramuscular adipogenesis in Chinese Guizhou Congjiang Xiang pigs.
Tan L, Chen Z, Ruan Y, Xu H
Epigenetics 2022 Dec;17(12):1800-1819
Epigenetics 2022 Dec;17(12):1800-1819
Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway.
Sun J, Leng P, Li X, Guo Q, Zhao J, Liang Y, Zhang X, Yang X, Li J
Adipocyte 2022 Dec;11(1):562-571
Adipocyte 2022 Dec;11(1):562-571
miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes.
Tan X, Zhu T, Zhang L, Fu L, Hu Y, Li H, Li C, Zhang J, Liang B, Liu J
Adipocyte 2022 Dec;11(1):120-132
Adipocyte 2022 Dec;11(1):120-132
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
Chai X, Pan M, Wang J, Feng M, Wang Y, Zhang Q, Sun Y
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
Exercise-derived peptide protects against pathological cardiac remodeling.
Yin A, Yuan R, Xiao Q, Zhang W, Xu K, Yang X, Yang W, Xu L, Wang X, Zhuang F, Li Y, Cai Z, Sun Z, Zhou B, He B, Shen L
EBioMedicine 2022 Aug;82:104164
EBioMedicine 2022 Aug;82:104164
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway.
Yuan Z, Xiao-Wei L, Juan W, Xiu-Juan L, Nian-Yun Z, Lei S
Journal of physiology and biochemistry 2022 Aug;78(3):641-652
Journal of physiology and biochemistry 2022 Aug;78(3):641-652
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Zhang S, Wu X, Wang J, Shi Y, Hu Q, Cui W, Bai H, Zhou J, Du Y, Han L, Li L, Feng D, Ge S, Qu Y
Redox biology 2022 Aug;54:102390
Redox biology 2022 Aug;54:102390
DDB1 prepares brown adipocytes for cold-induced thermogenesis.
Wang X, Liu SY, Hu GS, Wang HY, Zhang GL, Cen X, Xiang ST, Liu W, Li P, Ye H, Zhao TJ
Life metabolism 2022 Aug;1(1):39-53
Life metabolism 2022 Aug;1(1):39-53
HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.
Liu D, Sun H, Li K, Zhao Z, Liu Z, Zhang G, Ge Y, Zhang J, Wang D, Leng Y
Biochemical and biophysical research communications 2022 Aug 27;618:15-23
Biochemical and biophysical research communications 2022 Aug 27;618:15-23
A pivotal role of selective autophagy in mitochondrial quality control: Implications for zinc oxide nanoparticles induced neurotoxicity.
Wang L, Duan Z, Liang M, Wang C, Liang T, Sun L, Yan C, Li Q, Liang T
Chemico-biological interactions 2022 Aug 25;363:110003
Chemico-biological interactions 2022 Aug 25;363:110003
PPARGC1A Is a Moderator of Skeletal Muscle Development Regulated by miR-193b-3p.
Ma M, Cai B, Kong S, Zhou Z, Zhang J, Zhang X, Nie Q
International journal of molecular sciences 2022 Aug 24;23(17)
International journal of molecular sciences 2022 Aug 24;23(17)
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Cheng F, Dun Y, Cheng J, Ripley-Gonzalez JW, Jiang W, You B, Liu S
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome.
Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q, Gao S
Frontiers in cell and developmental biology 2021;9:658112
Frontiers in cell and developmental biology 2021;9:658112
An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer's Disease.
Li YQ, Chen Y, Jiang SQ, Shi YY, Jiang XL, Wu SS, Zhou P, Wang HY, Li P, Li F
Frontiers in cell and developmental biology 2021;9:652310
Frontiers in cell and developmental biology 2021;9:652310
Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming.
Li W, Wang S, Zhang H, Li B, Xu L, Li Y, Kong C, Jiao H, Wang Y, Pang Y, Qin W, Jia L, Jia J
Journal of Alzheimer's disease : JAD 2021;82(4):1475-1485
Journal of Alzheimer's disease : JAD 2021;82(4):1475-1485
Construction and Validation of a Combined Ferroptosis and Hypoxia Prognostic Signature for Hepatocellular Carcinoma.
Wen K, Yan Y, Shi J, Hu L, Wang W, Liao H, Li H, Zhu Y, Mao K, Xiao Z
Frontiers in molecular biosciences 2021;8:809672
Frontiers in molecular biosciences 2021;8:809672
Vanadium Induces Oxidative Stress and Mitochondrial Quality Control Disorder in the Heart of Ducks.
Xiong Z, Xing C, Xu T, Yang Y, Liu G, Hu G, Cao H, Zhang C, Guo X, Yang F
Frontiers in veterinary science 2021;8:756534
Frontiers in veterinary science 2021;8:756534
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Wu X, Zhang T, Lyu P, Chen M, Ni G, Cheng H, Xu G, Li X, Wang L, Shang H
Frontiers in cardiovascular medicine 2021;8:698056
Frontiers in cardiovascular medicine 2021;8:698056
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Tai H, Jiang XL, Song N, Xiao HH, Li Y, Cheng MJ, Yin XM, Chen YR, Yang GL, Jiang XY, Kuang JS, Lan ZM, Jia LQ
Frontiers in medicine 2021;8:617393
Frontiers in medicine 2021;8:617393
Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1.
Hu X, Li M, Zhang C, Pang S
International journal of endocrinology 2021;2021:8867218
International journal of endocrinology 2021;2021:8867218
l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.
Zeng L, Lin L, Chen L, Xiao W, Gong Z
Oxidative medicine and cellular longevity 2021;2021:8850112
Oxidative medicine and cellular longevity 2021;2021:8850112
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
He H, Li C, Lu X, Li Y, Li X, Sun X, Tang B, Wu Y, Li C
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Protective Effects of Huangqi Shengmai Yin on Type 1 Diabetes-Induced Cardiomyopathy by Improving Myocardial Lipid Metabolism.
Cao Z, Pan J, Sui X, Fang C, Li N, Huang X, Qu X, Han D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5590623
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5590623
ZLN005 protects against ischemia-reperfusion-induced kidney injury by mitigating oxidative stress through the restoration of mitochondrial fatty acid oxidation.
Wang Z, Fu Z, Wang C, Xu J, Ma H, Jiang M, Xu T, Feng X, Zhang W
American journal of translational research 2021;13(9):10014-10037
American journal of translational research 2021;13(9):10014-10037
Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity.
Zhang Y, Fu Y, Jiang T, Liu B, Sun H, Zhang Y, Fan B, Li X, Qin X, Zheng Q
Frontiers in pharmacology 2021;12:771940
Frontiers in pharmacology 2021;12:771940
Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis.
Yin Z, Geng X, Zhang Z, Wang Y, Gao X
Frontiers in pharmacology 2021;12:746711
Frontiers in pharmacology 2021;12:746711
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
Yang Y, Wu Y, Zou J, Wang YH, Xu MX, Huang W, Yu DJ, Zhang L, Zhang YY, Sun XD
Frontiers in pharmacology 2021;12:687095
Frontiers in pharmacology 2021;12:687095
The Protective Effects of Sulforaphane on High-Fat Diet-Induced Obesity in Mice Through Browning of White Fat.
Liu Y, Fu X, Chen Z, Luo T, Zhu C, Ji Y, Bian Z
Frontiers in pharmacology 2021;12:665894
Frontiers in pharmacology 2021;12:665894
The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.
Zeng S, Zhao Z, Zheng S, Wu M, Song X, Li Y, Zheng Y, Liu B, Chen L, Gao C, Liu H
Redox biology 2021 Sep;45:102058
Redox biology 2021 Sep;45:102058
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
Fu F, Liu C, Shi R, Li M, Zhang M, Du Y, Wang Q, Li J, Wang G, Pei J, Ding M
Antioxidants & redox signaling 2021 Sep;35(8):618-641
Antioxidants & redox signaling 2021 Sep;35(8):618-641
A novel supplement with yeast β-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice.
Nehmi VA, Murata GM, Moraes RCM, Lima GCA, De Miranda DA, Radloff K, Costa RGF, Jesus JCR, De Freitas JA, Viana NI, Pimenta R, Leite KRM, Otoch JP, Pessoa AFM
Journal of integrative medicine 2021 Sep;19(5):439-450
Journal of integrative medicine 2021 Sep;19(5):439-450
Effects of dietary ferulic acid supplementation on growth performance and skeletal muscle fiber type conversion in weaned piglets.
Wang Y, Chen X, Huang Z, Chen D, Yu B, Chen H, Yu J, Luo Y, Zheng P, He J
Journal of the science of food and agriculture 2021 Sep;101(12):5116-5123
Journal of the science of food and agriculture 2021 Sep;101(12):5116-5123
Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.
Zhang W, You B, Qi D, Qiu L, Ripley-Gonzalez JW, Zheng F, Fu S, Li C, Dun Y, Liu S
Scientific reports 2021 Sep 27;11(1):19116
Scientific reports 2021 Sep 27;11(1):19116
Multiplexed quantitative evaluation on mitochondrial toxicity of tris (2,3-dibromopropyl) phosphate in hepatocyte.
Ma X, Lu D, Liu Y, Le Y, Chen H, Li X, Wang C
Ecotoxicology and environmental safety 2021 Sep 15;221:112425
Ecotoxicology and environmental safety 2021 Sep 15;221:112425
DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model.
Cheng ZY, Hu YH, Xia QP, Wang C, He L
Brain research bulletin 2021 Oct;175:136-149
Brain research bulletin 2021 Oct;175:136-149
Vitellogenin 2 promotes muscle development and stimulates the browning of white fat.
Li Y, Sun X, Bai Y, Ji Y, Ren H, Yu X, Yan Y, He X, Dong Y, Zhang L, Luo X, Wang H
Aging 2021 Oct 5;13(19):22985-23003
Aging 2021 Oct 5;13(19):22985-23003
Differentiation of THP-1 monocytes to macrophages increased mitochondrial DNA copy number but did not increase expression of mitochondrial respiratory proteins or mitochondrial transcription factor A.
Okamoto M, Shimogishi M, Nakamura A, Suga Y, Sugawara K, Sato M, Nishi R, Fujisawa A, Yamamoto Y, Kashiba M
Archives of biochemistry and biophysics 2021 Oct 15;710:108988
Archives of biochemistry and biophysics 2021 Oct 15;710:108988
Naringin Promotes Skeletal Muscle Fiber Remodeling by the AdipoR1-APPL1-AMPK Signaling Pathway.
Li P, Zhang S, Song H, Traore SS, Li J, Raubenheimer D, Cui Z, Kou G
Journal of agricultural and food chemistry 2021 Oct 13;69(40):11890-11899
Journal of agricultural and food chemistry 2021 Oct 13;69(40):11890-11899
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
Li Z, Li Q, Wang L, Li C, Xu M, Duan Y, Ma L, Li T, Chen Q, Wang Y, Wang Y, Feng J, Yin X, Wang X, Han J, Lu C
Redox biology 2021 Nov;47:102156
Redox biology 2021 Nov;47:102156
Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.
Chen YT, Yang QY, Hu Y, Liu XD, de Avila JM, Zhu MJ, Nathanielsz PW, Du M
Nature communications 2021 Nov 25;12(1):6845
Nature communications 2021 Nov 25;12(1):6845
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
Zhang L, Wang YN, Ju JM, Shabanova A, Li Y, Fang RN, Sun JB, Guo YY, Jin TZ, Liu YY, Li TY, Shan HL, Liang HH, Yang BF
Acta pharmacologica Sinica 2021 May;42(5):691-700
Acta pharmacologica Sinica 2021 May;42(5):691-700
Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice via gut microbia-mediated regulation of FGF21 signaling pathway.
Wu L, Yan Q, Chen F, Cao C, Wang S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111187
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111187
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Li Y, Kang J, Fu J, Luo H, Liu Y, Li Y, Sun L
International journal of molecular sciences 2021 Mar 3;22(5)
International journal of molecular sciences 2021 Mar 3;22(5)
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1.
Chen YT, Hu Y, Yang QY, Liu XD, Son JS, de Avila JM, Zhu MJ, Du M
Science bulletin 2021 Mar 15;66(5):478-489
Science bulletin 2021 Mar 15;66(5):478-489
A New Perspective on Ameliorating Depression-Like Behaviors: Suppressing Neuroinflammation by Upregulating PGC-1α.
Fu X, Jiao J, Qin T, Yu J, Fu Q, Deng X, Ma S, Ma Z
Neurotoxicity research 2021 Jun;39(3):872-885
Neurotoxicity research 2021 Jun;39(3):872-885
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK.
Wu Y, Yang Y, Li F, Zou J, Wang YH, Xu MX, Wang YL, Li RX, Sun YT, Lu S, Zhang YY, Sun XD
Journal of clinical and translational hepatology 2021 Jun 28;9(3):373-383
Journal of clinical and translational hepatology 2021 Jun 28;9(3):373-383
Bezafibrate prevents aging in in vitro-matured porcine oocytes.
Kim JY, Zhou D, Cui XS
Journal of animal science and technology 2021 Jul;63(4):766-777
Journal of animal science and technology 2021 Jul;63(4):766-777
Theaflavin Promotes Mitochondrial Abundance and Glucose Absorption in Myotubes by Activating the CaMKK2-AMPK Signal Axis via Calcium-Ion Influx.
Qu Z, Liu A, Liu C, Tang Q, Zhan L, Xiao W, Huang J, Liu Z, Zhang S
Journal of agricultural and food chemistry 2021 Jul 28;69(29):8144-8159
Journal of agricultural and food chemistry 2021 Jul 28;69(29):8144-8159
TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS.
Huang C, Li J, Zhang G, Lin Y, Li C, Zheng X, Song X, Han B, Guo B, Tu Z, Zhang J, Sun Y, Wang Y, Zhang Z, Yan S
Human molecular genetics 2021 Jul 28;30(16):1484-1496
Human molecular genetics 2021 Jul 28;30(16):1484-1496
Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor-dependent manner.
Zheng J, Ding J, Liao M, Qiu Z, Yuan Q, Mai W, Dai Y, Zhang H, Wu H, Wang Y, Liao Y, Chen X, Cheng X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21157
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21157
Selenium Deficiency-Induced Damage and Altered Expression of Mitochondrial Biogenesis Markers in the Kidneys of Mice.
Lai H, Nie T, Zhang Y, Chen Y, Tao J, Lin T, Ge T, Li F, Li H
Biological trace element research 2021 Jan;199(1):185-196
Biological trace element research 2021 Jan;199(1):185-196
Zinc-α2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice.
Fan G, Li Y, Ma F, Zhao R, Yang X
Endocrine journal 2021 Jan 28;68(1):53-62
Endocrine journal 2021 Jan 28;68(1):53-62
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y
Life sciences 2021 Jan 15;265:118796
Life sciences 2021 Jan 15;265:118796
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
Liang J, Zhou X, Wang J, Fei ZY, Qin GC, Zhang DK, Zhou JY, Chen LX
Neuroreport 2021 Jan 13;32(2):144-156
Neuroreport 2021 Jan 13;32(2):144-156
PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cancer cells via nucleo-mitochondrial transcriptional feedback.
Shen L, Zhou L, Xia M, Lin N, Ma J, Dong D, Sun L
Experimental cell research 2021 Jan 1;398(1):112369
Experimental cell research 2021 Jan 1;398(1):112369
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y
Cell proliferation 2021 Feb;54(2):e12964
Cell proliferation 2021 Feb;54(2):e12964
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Kou G, Li P, Hu Y, Chen H, Nyantakyiwaa Amoah A, Seydou Traore S, Cui Z, Lyu Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway.
Wang W, Xu RL, He P, Chen R
Journal of inflammation (London, England) 2021 Feb 8;18(1):8
Journal of inflammation (London, England) 2021 Feb 8;18(1):8
Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue.
Han X, Guo J, Gao Y, Zhan J, You Y, Huang W
Food & function 2021 Feb 15;12(3):1262-1270
Food & function 2021 Feb 15;12(3):1262-1270
Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease.
Zhang H, Lu J, Liu H, Guan L, Xu S, Wang Z, Qiu Y, Liu H, Peng L, Men X
Pharmacological research 2021 Dec;174:105964
Pharmacological research 2021 Dec;174:105964
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.
Chen N, Ge MM, Li DY, Wang XM, Liu DQ, Ye DW, Tian YK, Zhou YQ, Chen JP
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112331
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112331
Danqi Tablet () Regulates Energy Metabolism in Ischemic Heart Rat Model through AMPK/SIRT1-PGC-1α Pathway.
Meng H, Wang QY, Li N, He H, Lu WJ, Wang QX, Sun XQ, Jiao SH, Wang Y, Tu PF
Chinese journal of integrative medicine 2021 Aug;27(8):597-603
Chinese journal of integrative medicine 2021 Aug;27(8):597-603
A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer's Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3.
Li Y, Lu J, Cao X, Zhao H, Gao L, Xia P, Pei G
Oxidative medicine and cellular longevity 2020;2020:7698560
Oxidative medicine and cellular longevity 2020;2020:7698560
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089
Oxidative medicine and cellular longevity 2020;2020:3985089
Network Pharmacology Approach to Explore the Potential Mechanisms of Jieduan-Niwan Formula Treating Acute-on-Chronic Liver Failure.
Liang J, Wu M, Bai C, Ma C, Fang P, Hou W, Wei X, Zhang Q, Du Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:1041307
Evidence-based complementary and alternative medicine : eCAM 2020;2020:1041307
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
Zhu Z, Li H, Chen W, Cui Y, Huang A, Qi X
Frontiers in pharmacology 2020;11:94
Frontiers in pharmacology 2020;11:94
High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes.
Zheng L, Rao Z, Guo Y, Chen P, Xiao W
Frontiers in endocrinology 2020;11:561
Frontiers in endocrinology 2020;11:561
Postnatal growth retardation is associated with intestinal mucosa mitochondrial dysfunction and aberrant energy status in piglets.
Qi M, Wang J, Tan B, Liao S, Long C, Yin Y
Journal of cellular and molecular medicine 2020 Sep;24(17):10100-10111
Journal of cellular and molecular medicine 2020 Sep;24(17):10100-10111
SR18292 exerts potent antitumor effects in multiple myeloma via inhibition of oxidative phosphorylation.
Xiang Y, Fang B, Liu Y, Yan S, Cao D, Mei H, Wang Q, Hu Y, Guo T
Life sciences 2020 Sep 1;256:117971
Life sciences 2020 Sep 1;256:117971
MiR-23a-5p exacerbates intestinal ischemia-reperfusion injury by promoting oxidative stress via targeting PPAR alpha.
Li LX, Yin LH, Gao M, Xu LN, Qi Y, Peng JY
Biochemical pharmacology 2020 Oct;180:114194
Biochemical pharmacology 2020 Oct;180:114194
(-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels.
Li L, Chu X, Yao Y, Cao J, Li Q, Ma H
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11229-11241
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11229-11241
Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase.
Zhong X, Ma Z, Su Y, Li Z, Liao Y, Pan X, Zang L, Zhou S
Life sciences 2020 Oct 1;258:118156
Life sciences 2020 Oct 1;258:118156
OXPHOS-dependent metabolic reprogramming prompts metastatic potential of breast cancer cells under osteogenic differentiation.
Hu Y, Xu W, Zeng H, He Z, Lu X, Zuo D, Qin G, Chen W
British journal of cancer 2020 Nov;123(11):1644-1655
British journal of cancer 2020 Nov;123(11):1644-1655
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation.
Shen S, Faouzi S, Souquere S, Roy S, Routier E, Libenciuc C, André F, Pierron G, Scoazec JY, Robert C
Cell reports 2020 Nov 24;33(8):108421
Cell reports 2020 Nov 24;33(8):108421
A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility.
Wei M, Huang F, Zhao L, Zhang Y, Yang W, Wang S, Li M, Han X, Ge K, Qu C, Rajani C, Xie G, Zheng X, Zhao A, Bian Z, Jia W
EBioMedicine 2020 May;55:102766
EBioMedicine 2020 May;55:102766
Effect of sitagliptin on expression of skeletal muscle peroxisome proliferator-activated receptor γ coactivator-1α and irisin in a rat model of type 2 diabetes mellitus.
Liu Y, Xu F, Jiang P
The Journal of international medical research 2020 May;48(5):300060519885569
The Journal of international medical research 2020 May;48(5):300060519885569
Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway.
Luo J, Tang C, Chen X, Ren Z, Qu H, Chen R, Tong Z
International journal of environmental research and public health 2020 Mar 19;17(6)
International journal of environmental research and public health 2020 Mar 19;17(6)
Resveratrol prevents benzo(a)pyrene-induced disruption of mitochondrial homeostasis via the AMPK signaling pathway in primary cultured neurons.
Kang RR, Sun Q, Chen KG, Cao QT, Liu C, Liu K, Ma Z, Deng Y, Liu W, Xu B
Environmental pollution (Barking, Essex : 1987) 2020 Jun;261:114207
Environmental pollution (Barking, Essex : 1987) 2020 Jun;261:114207
p53/PGC‑1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis.
Li J, Li Y, Chen L, Yu B, Xue Y, Guo R, Su J, Liu Y, Sun L
Molecular medicine reports 2020 Jul;22(1):155-164
Molecular medicine reports 2020 Jul;22(1):155-164
Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.
Niu YJ, Zhou W, Nie ZW, Zhou D, Xu YN, Ock SA, Yan CG, Cui XS
Aging 2020 Jan 20;12(2):1256-1271
Aging 2020 Jan 20;12(2):1256-1271
Myopathy reversion in mice after restauration of mitochondrial complex I.
Pereira CV, Peralta S, Arguello T, Bacman SR, Diaz F, Moraes CT
EMBO molecular medicine 2020 Feb 7;12(2):e10674
EMBO molecular medicine 2020 Feb 7;12(2):e10674
Zinc-α2-glycoprotein promotes browning of white adipose tissue in cold-exposed male mice.
Fan G, Dang X, Li Y, Chen J, Zhao R, Yang X
Molecular and cellular endocrinology 2020 Feb 5;501:110669
Molecular and cellular endocrinology 2020 Feb 5;501:110669
Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice.
Li L, Chen X, Su C, Wang Q, Li R, Jiao W, Luo H, Tian Y, Tang J, Li X, Liu B, Wang W, Zhang D, Guo S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Dec;132:110817
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Dec;132:110817
Maternal Inactivity Programs Skeletal Muscle Dysfunction in Offspring Mice by Attenuating Apelin Signaling and Mitochondrial Biogenesis.
Son JS, Chae SA, Wang H, Chen Y, Bravo Iniguez A, de Avila JM, Jiang Z, Zhu MJ, Du M
Cell reports 2020 Dec 1;33(9):108461
Cell reports 2020 Dec 1;33(9):108461
Excessive Glucocorticoids During Pregnancy Impair Fetal Brown Fat Development and Predispose Offspring to Metabolic Dysfunctions.
Chen YT, Hu Y, Yang QY, Son JS, Liu XD, de Avila JM, Zhu MJ, Du M
Diabetes 2020 Aug;69(8):1662-1674
Diabetes 2020 Aug;69(8):1662-1674
(-)-Hydroxycitric acid regulates energy metabolism by activation of AMPK - PGC1α - NRF1 signal pathway in primary chicken hepatocytes.
Li L, Jiang Z, Yao Y, Yang Z, Ma H
Life sciences 2020 Aug 1;254:117785
Life sciences 2020 Aug 1;254:117785
TLR4 knockout upregulates the expression of Mfn2 and PGC-1α in a high-fat diet and ischemia-reperfusion mice model of liver injury.
Zhang C, Jia Y, Liu B, Wang G, Zhang Y
Life sciences 2020 Aug 1;254:117762
Life sciences 2020 Aug 1;254:117762
Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice.
Zhu R, Wei J, Liu H, Liu C, Wang L, Chen B, Li L, Jia Q, Tian Y, Li R, Zhao D, Mo F, Li Y, Gao S, Wang XD, Zhang D
The Journal of nutritional biochemistry 2020 Apr;78:108335
The Journal of nutritional biochemistry 2020 Apr;78:108335
Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice.
Son JS, Zhao L, Chen Y, Chen K, Chae SA, de Avila JM, Wang H, Zhu MJ, Jiang Z, Du M
Science advances 2020 Apr;6(16):eaaz0359
Science advances 2020 Apr;6(16):eaaz0359
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z
Nature communications 2020 Apr 3;11(1):1648
Nature communications 2020 Apr 3;11(1):1648
MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line.
Zhang Q, Ma XF, Dong MZ, Tan J, Zhang J, Zhuang LK, Liu SS, Xin YN
Lipids in health and disease 2020 Apr 16;19(1):76
Lipids in health and disease 2020 Apr 16;19(1):76
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
Tong Y, Dong Y, Feng Y, Li Z, Jia Y, Zhang X, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2019;2019:4929107
Oxidative medicine and cellular longevity 2019;2019:4929107
MOTS-c inhibits Osteolysis in the Mouse Calvaria by affecting osteocyte-osteoclast crosstalk and inhibiting inflammation.
Yan Z, Zhu S, Wang H, Wang L, Du T, Ye Z, Zhai D, Zhu Z, Tian X, Lu Z, Cao X
Pharmacological research 2019 Sep;147:104381
Pharmacological research 2019 Sep;147:104381
PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy.
Xu WN, Yang RZ, Zheng HL, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS
International journal of biological macromolecules 2019 Sep 1;136:1007-1017
International journal of biological macromolecules 2019 Sep 1;136:1007-1017
Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes.
Wang X, Li S, Liu L, Jian Z, Cui T, Yang Y, Guo S, Yi X, Wang G, Li C, Gao T, Li K
Journal of dermatological science 2019 Oct;96(1):33-41
Journal of dermatological science 2019 Oct;96(1):33-41
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Yang Q, Wang C, Jin Y, Ma X, Xie T, Wang J, Liu K, Sun H
Pharmacological research 2019 Oct;148:104414
Pharmacological research 2019 Oct;148:104414
High-intensity interval training changes the expression of muscle RING-finger protein-1 and muscle atrophy F-box proteins and proteins involved in the mechanistic target of rapamycin pathway and autophagy in rat skeletal muscle.
Cui X, Zhang Y, Wang Z, Yu J, Kong Z, Ružić L
Experimental physiology 2019 Oct;104(10):1505-1517
Experimental physiology 2019 Oct;104(10):1505-1517
Improvement of Mitochondrial Activity and Fibrosis by Resveratrol Treatment in Mice with Schistosoma japonicum Infection.
Chen TT, Peng S, Wang Y, Hu Y, Shen Y, Xu Y, Yin J, Liu C, Cao J
Biomolecules 2019 Oct 25;9(11)
Biomolecules 2019 Oct 25;9(11)
Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin-1 (SIRT1) Independent Manner.
Peng J, Xiong J, Cui C, Huang N, Zhang H, Wu X, Yang Y, Zhou Y, Wei H, Peng J
Molecular nutrition & food research 2019 Nov;63(21):e1900343
Molecular nutrition & food research 2019 Nov;63(21):e1900343
Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy.
Essandoh K, Wang X, Huang W, Deng S, Gardner G, Mu X, Li Y, Kranias EG, Wang Y, Fan GC
The Journal of biological chemistry 2019 Nov 29;294(48):18057-18068
The Journal of biological chemistry 2019 Nov 29;294(48):18057-18068
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
Lv X, Wang X, Wang Y, Zhou D, Li W, Wilson JX, Chang H, Huang G
Aging 2019 Nov 22;11(22):10356-10373
Aging 2019 Nov 22;11(22):10356-10373
(-)-Hydroxycitric Acid Suppresses Lipid Droplet Accumulation and Accelerates Energy Metabolism via Activation of the Adiponectin-AMPK Signaling Pathway in Broiler Chickens.
Li L, Zhang H, Yao Y, Yang Z, Ma H
Journal of agricultural and food chemistry 2019 Mar 20;67(11):3188-3197
Journal of agricultural and food chemistry 2019 Mar 20;67(11):3188-3197
Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice.
Shen X, Chen Y, Zhang J, Yan X, Liu W, Guo Y, Shan Q, Liu S
Environment international 2019 Jul;128:146-157
Environment international 2019 Jul;128:146-157
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Molecular nutrition & food research 2019 Feb;63(4):e1800795
FXR activation alleviates tacrolimus-induced post-transplant diabetes mellitus by regulating renal gluconeogenesis and glucose uptake.
Li L, Zhao H, Chen B, Fan Z, Li N, Yue J, Ye Q
Journal of translational medicine 2019 Dec 13;17(1):418
Journal of translational medicine 2019 Dec 13;17(1):418
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
Liu B, Jin J, Zhang Z, Zuo L, Jiang M, Xie C
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Aug;97(4):397-405
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Aug;97(4):397-405
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, Montagner A, Chretien D, Rugarli EI, Guillou H, Pende M, Panasyuk G
Nature communications 2019 Apr 5;10(1):1566
Nature communications 2019 Apr 5;10(1):1566
Zinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice.
Liu M, Zhu H, Dai Y, Pan H, Li N, Wang L, Yang H, Yan K, Gong F
Frontiers in physiology 2018;9:62
Frontiers in physiology 2018;9:62
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H, Wu YC
Frontiers in aging neuroscience 2018;10:121
Frontiers in aging neuroscience 2018;10:121
Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS.
Dervishi I, Gozutok O, Murnan K, Gautam M, Heller D, Bigio E, Ozdinler PH
Scientific reports 2018 Oct 3;8(1):14732
Scientific reports 2018 Oct 3;8(1):14732
Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression.
Wu G, Wen M, Sun L, Li H, Liu Y, Li R, Wu F, Yang R, Lin Y
RSC advances 2018 Nov 1;8(65):37117-37128
RSC advances 2018 Nov 1;8(65):37117-37128
The Role of Mitochondria in Methamphetamine-induced inhibitory effects on osteogenesis of Mesenchymal Stem Cells.
Shen Y, Wu L, Wang J, Wu X, Zhang X
European journal of pharmacology 2018 May 5;826:56-65
European journal of pharmacology 2018 May 5;826:56-65
AMPK/α-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.
He L, Huang N, Li H, Tian J, Zhou X, Li T, Yao K, Wu G, Yin Y
Journal of agricultural and food chemistry 2017 Mar 22;65(11):2287-2298
Journal of agricultural and food chemistry 2017 Mar 22;65(11):2287-2298
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, Sun B
Oncotarget 2016 Dec 6;7(49):81077-81089
Oncotarget 2016 Dec 6;7(49):81077-81089
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