23045-1-AP

antibody from Proteintech Group

Targeting: OXTR

Provider product page for 23045-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [34]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 23045-1-AP - Provider product page
Provider: Proteintech Group
Product name: OXTR antibody
Antibody type: Polyclonal
Description: OXTR antibody (Cat. #23045-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

OXTR protein structure - 23045-1-AP shown in red.

Submitted references Arachidonic Acid-Induced Contraction of Smooth Muscle Is Mediated by MLC Phosphorylation in Preterm Birth.

Chen X, Chen J, Qiu J, Yan Y, Zhang R
Journal of pregnancy 2026;2026(1):e8266780

The Oxytocin Receptor in Spermatozoa May Originate From Both Spermatogenesis and Epididymal Maturation, and Regulates Capacitation.

Martínez-Hernández J, Garriga F, Ahmad A, Padilla L, Maside C, Bonet S, Barranco I, Roca J, Pastor LM, Yeste M
Andrology 2026 Mar;14(3):747-765

Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits.

Li S, Yang J, Cai M, Zhao Z, Zhao X, Li H, Ning S, Yang G, Shen W, Wang H, Wu H
Neuron 2026 Mar 26;

Early life adversity impairs visually evoked innate defensive behaviors via oxytocin signaling.

Tan H, Su J, Ma S, Chen S, Liu Q, Yang X, Wang L
Communications biology 2026 Feb 21;9(1)

In the gravid human uterus, oxytocin induces smooth muscle cell contraction via transient receptor potential vanilloid 4 channel activation.

Fornes D, Ansari JR, Michel G, Alvira CM, Cornfield DN
The Journal of physiology 2026 Apr;604(7):3135-3158

Oxytocin Regulated Neuroinflammation through OTR/Mitochondria Mediated Pathway to Improve Hypoxia-Induced Brain Injury.

Yang X, Li K, Chen L, Wang L, Wang X, Lu K, Bai Y, Hou Y, Hou J, Wang C, Cheng X, Oldam J, Yu J, Wu J, Sun B
Molecular neurobiology 2025 Oct;62(10):12907-12923

Reduced oxytocin signaling in the dBNST drives the transition from acute pain to persistent anxiety.

Fang S, Qin Y, Lian H, Zhong Y, Yang Y, Yu XD, Yang S, Liang J, Xiao W, Wen S, Zhang XM, Li B, Huang L
Current biology : CB 2025 Nov 3;35(21):5150-5166.e8

Intranasal oxytocin alleviates postsurgical pain and comorbid anxiety in mice: Participation of BK(Ca) channels in the hippocampus.

Tang YB, Tang L, Chen B, Fan MJ, Chen GJ, Ou YN, Yang F, Wu XZ
Neuropharmacology 2025 Mar 1;265:110243

Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling.

Mia S, Siokatas G, Sidiropoulou R, Hoffman M, Fragkiadakis K, Markopoulou E, Elesawy MI, Roy R, Blair S, Kuwabara Y, Rapushi E, Chaudhuri D, Makarewich CA, Gao E, Koch WJ, Schilling JD, Molkentin JD, Marketou M, Drosatos K
Cell reports. Medicine 2025 Jun 17;6(6):102125

Sex Differences in Pain Contagion Determined by the Balance of Oxytocin and Corticosterone in the Anterior Cingulate Cortex in Rodents.

Xie Z, Yuan W, Zhou L, Xiao J, Liao H, Hu JJ, Song XJ
Neuroscience bulletin 2025 Dec;41(12):2167-2183

Atosiban-conjugated 3WJ-pRNA nanoparticles delivering GAS1-enhanced extracellular vesicles: targeting the decidua to combat recurrent miscarriage.

Li YX, Wei SQ, Zheng PS
Journal of nanobiotechnology 2025 Dec 20;23(1):780

OXTR overexpression induces polycystic ovary syndrome-like phenotype via prolactin/p-STAT3 signaling in mice.

Wang S, Bao X, Liu Z, San M, Zhang L, Liu Y, Yang M, Zheng Y, Li D
Molecular and cellular endocrinology 2025 Dec 1;610:112668

Role of Sex and Early Life Stress Experience on Porcine Cardiac and Brain Tissue Expression of the Oxytocin and H(2)S Systems.

Münz F, Abele N, Zink F, Wolfschmitt EM, Hogg M, Barck C, Anetzberger J, Hoffmann A, Gröger M, Calzia E, Waller C, Radermacher P, Merz T
Biomolecules 2024 Oct 30;14(11)

Effects of oxytocin receptor agonists on hair growth promotion.

Kageyama T, Seo J, Yan L, Fukuda J
Scientific reports 2024 Oct 13;14(1):23935

In need of a specific antibody against the oxytocin receptor for neuropsychiatric research: A KO validation study.

DelaCuesta-Barrutia J, Hidema S, Caldwell HK, Nishimori K, Erdozain AM, Peñagarikano O
Journal of psychiatric research 2024 May;173:260-270

Oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal ERK signaling and Aβ deposition.

Wu G, Ou Y, Feng Z, Xiong Z, Li K, Che M, Qi S, Zhou M
Translational psychiatry 2024 May 25;14(1):208

The Effect of Targeted Hyperoxemia on Brain Immunohistochemistry after Long-Term, Resuscitated Porcine Acute Subdural Hematoma and Hemorrhagic Shock.

Münz F, Datzmann T, Hoffmann A, Gröger M, Mathieu R, Mayer S, Zink F, Gässler H, Wolfschmitt EM, Hogg M, Calzia E, Asfar P, Radermacher P, Kapapa T, Merz T
International journal of molecular sciences 2024 Jun 14;25(12)

Effects of oxytocin on the hair growth ability of dermal papilla cells.

Kageyama T, Seo J, Yan L, Fukuda J
Scientific reports 2023 Oct 20;13(1):15587

Co-culture of iNeurons with primary human skin cells provides a reliable model to examine intercellular communication.

Labarrade F, Botto JM, Imbert I
Journal of cosmetic dermatology 2023 Jul;22(7):2090-2098

Phloroglucinol inhibits oxytocin-induced contraction in rat gastric circular muscle and uterine smooth muscle.

Yang W, Guo H, Niu J, Liu J, Su R, Bai Y, Zhang S, Liu Q, Sun N
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2023 Dec;43(1):2130208

Brain Histology and Immunohistochemistry After Resuscitation From Hemorrhagic Shock in Swine With Pre-Existing Atherosclerosis and Sodium Thiosulfate (Na(2)S(2)O(3)) Treatment.

Denoix N, McCook O, Scheuerle A, Kapapa T, Hoffmann A, Gündel H, Waller C, Szabo C, Radermacher P, Merz T
Frontiers in medicine 2022;9:925433

Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening.

Yan Y, Gu Z, Li B, Guo X, Zhang Z, Zhang R, Bian Z, Qiu J
Reproductive biology and endocrinology : RB&E 2022 Sep 6;20(1):135

Synergistic antitumor activity of 5-fluorouracil and atosiban against microsatellite stable colorectal cancer through restoring GATA3.

Wang M, Guo X, Yang M, Zhang Y, Meng F, Chen Y, Chen M, Qiu T, Li J, Li Z, Zhang Q, Xu F, Zhang H, Wang W
Biochemical pharmacology 2022 May;199:115025

Prognostic role of oxytocin receptor in colon adenocarcinoma.

Sun J, Xu Z, Mao Y, Zhang T, Qin Y, Hua D
Open medicine (Warsaw, Poland) 2021;16(1):1762-1776

The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition.

Chen C, Zhu S, Bai L, Sui M, Chen D
Frontiers in pharmacology 2021;12:696697

ΔMST and the Regulation of Cardiac CSE and OTR Expression in Trauma and Hemorrhage.

Trautwein B, Merz T, Denoix N, Szabo C, Calzia E, Radermacher P, McCook O
Antioxidants (Basel, Switzerland) 2021 Feb 3;10(2)

Oxytocin Facilitates Dentinogenesis of Rat Dental Pulp Cells.

Kato Y, Yokose S
Journal of endodontics 2021 Apr;47(4):592-599

Oxytocin modulates neural processing of mitral/tufted cells in the olfactory bulb.

Sun C, Yin Z, Li BZ, Du H, Tang K, Liu P, Hang Pun S, Lei TC, Li A
Acta physiologica (Oxford, England) 2021 Apr;231(4):e13626

Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine γ-Lyase Expression in Mice.

Wigger DC, Gröger N, Lesse A, Krause S, Merz T, Gündel H, Braun K, McCook O, Radermacher P, Bock J, Waller C
Oxidative medicine and cellular longevity 2020;2020:4309605

Cerebral Immunohistochemical Characterization of the H(2)S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma.

Denoix N, Merz T, Unmuth S, Hoffmann A, Nespoli E, Scheuerle A, Huber-Lang M, Gündel H, Waller C, Radermacher P, McCook O
Frontiers in neurology 2020;11:649

Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia.

McKay EC, Beck JS, Khoo SK, Dykema KJ, Cottingham SL, Winn ME, Paulson HL, Lieberman AP, Counts SE
Journal of neuropathology and experimental neurology 2019 May 1;78(5):436-452

Interaction of the hydrogen sulfide system with the oxytocin system in the injured mouse heart.

Merz T, Lukaschewski B, Wigger D, Rupprecht A, Wepler M, Gröger M, Hartmann C, Whiteman M, Szabo C, Wang R, Waller C, Radermacher P, McCook O
Intensive care medicine experimental 2018 Oct 19;6(1):41

Unexpected evolutionarily conserved rapid effects of viral infection on oxytocin receptor and TGF-β/pSmad3.

Liu Y, Conboy I
Skeletal muscle 2017 May 15;7(1):7

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.

Elabd C, Cousin W, Upadhyayula P, Chen RY, Chooljian MS, Li J, Kung S, Jiang KP, Conboy IM
Nature communications 2014 Jun 10;5:4082

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 23045-1-AP(OXTR antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Oxytocin Receptor antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Oxytocin Receptor. This antibody recognizes human antigen. The Oxytocin Receptor antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 23045-1-AP.pdf

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