51046-1-AP

antibody from Proteintech Group

Targeting: CD2AP CMS

Provider product page for 51046-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [14]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 51046-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#51046-1-AP, RRID:AB_670322
Product name: Cd2ap antibody
Antibody type: Polyclonal
Description: Cd2ap antibody (Cat. #51046-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CD2AP protein structure - 51046-1-AP shown in red.

Submitted references Antioxidative Japanese herbal medicine formula prevents diabetic renal complications.

Nakamoto H
Journal of natural medicines 2026 May;80(3):817-826

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer's disease.

Wei X, Munechika K, Sun Y, Wan Y, Xia T, Hou Y, Song W, Yugandhar K, Wang Y, Lee SI, Sha Z, Zhou Y, Feng W, Zhu J, Tang Y, Luo W, Cheng F, Gan L, Yu H
bioRxiv : the preprint server for biology 2026 Mar 16;

Identification of a ubiquitin-binding domain protein, CD2AP, in predicting the prognosis and treatment of lung adenocarcinoma.

Dai Q, Li L, He M, Huang J, Bo Z, Yin J, Ye Y
Frontiers in immunology 2025;16:1726531

Adult Neuronal Expression of the Alzheimer Risk Protein CD2AP is Enriched in NGF-Responsive Basal Forebrain Neurons, where it Collocates with Rab-5 Endosomes.

Fitzsimons LA, Atif-Sheikh M, Mueth M, Rice M, Howell G, Harrison BJ
bioRxiv : the preprint server for biology 2025 Sep 23;

Integrated Analysis of Disulfidptosis-Related Genes Identifies CD2AP as a Potential Therapeutic Target for Hepatocellular Carcinoma.

Shang N, Wang J, Liu Z, Wang Y, Zhang D, Liu H, Zhang Y, Dai G, Guan X
International journal of molecular sciences 2025 May 7;26(9)

CIN85 and CD2AP Are Novel Constituents of Dynamic Tubular Recycling Endosomes That Regulate Recycling Upon Recruitment by MICAL-L1.

Misri G, Murakonda AB, Naslavsky N, Caplan S
Traffic (Copenhagen, Denmark) 2025 Jul-Sep;26(7-9):e70015

Human cytomegalovirus pUL135 protein affects endothelial cell function via CD2AP in Kawasaki disease.

Yu L, Li Y, Zhang Y, Weng L, Shuai D, Zhu J, Niu C, Chu M, Jia C
International journal of cardiology 2024 Oct 15;413:132364

CD2AP promotes the progression of glioblastoma multiforme via TRIM5-mediated NF-kB signaling.

Zhang L, He J, Zhao W, Zhou Y, Li J, Li S, Zhao W, Zhang L, Tang Z, Tan G, Chen S, Zhang B, Zhang YW, Wang Z
Cell death & disease 2024 Oct 1;15(10):722

Microglial CD2AP deficiency exerts protection in an Alzheimer's disease model of amyloidosis.

Zhang L, Huang L, Zhou Y, Meng J, Zhang L, Zhou Y, Zheng N, Guo T, Zhao S, Wang Z, Huo Y, Zhao Y, Chen XF, Zheng H, Holtzman DM, Zhang YW
Molecular neurodegeneration 2024 Dec 18;19(1):95

The Rab GTPase-binding protein EHBP1L1 and its interactors CD2AP/CIN85 negatively regulate the length of primary cilia via actin remodeling.

Iwano T, Sobajima T, Takeda S, Harada A, Yoshimura SI
The Journal of biological chemistry 2023 Mar;299(3):102985

The Cleavage-Specific Tau 12A12mAb Exerts an Anti-Amyloidogenic Action by Modulating the Endocytic and Bioenergetic Pathways in Alzheimer's Disease Mouse Model.

Latina V, Atlante A, Malerba F, La Regina F, Balzamino BO, Micera A, Pignataro A, Stigliano E, Cavallaro S, Calissano P, Amadoro G
International journal of molecular sciences 2023 Jun 2;24(11)

Transforming growth factor-β1-induced podocyte injury is associated with increased microRNA-155 expression, enhanced inflammatory responses and MAPK pathway activation.

Zheng X, Zhong Q, Lin X, Gu X, Ling X, Liang Z, Qin Q, Du X
Experimental and therapeutic medicine 2021 Jun;21(6):620

Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.

Yoshida S, Wei X, Zhang G, O'Connor CL, Torres M, Zhou Z, Lin L, Menon R, Xu X, Zheng W, Xiong Y, Otto E, Tang CA, Hua R, Verma R, Mori H, Zhang Y, Hu CA, Liu M, Garg P, Hodgin JB, Sun S, Bitzer M, Qi L
The Journal of clinical investigation 2021 Apr 1;131(7)

Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes.

Shirata N, Ihara KI, Yamamoto-Nonaka K, Seki T, Makino SI, Oliva Trejo JA, Miyake T, Yamada H, Campbell KN, Nakagawa T, Mori K, Yanagita M, Mundel P, Nishimori K, Asanuma K
Journal of the American Society of Nephrology : JASN 2017 Sep;28(9):2654-2669

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse testis tissue were subjected to SDS PAGE followed by western blot with 51046-1-AP(Cd2ap antibody) at dilution of 1:200
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP result of anti-Cd2AP(51046-1-AP for IP and Detection).
Sample type: cell line