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- References [24]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11315-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11315-1-AP, RRID:AB_2256373
- Product name
- TOLLIP antibody
- Antibody type
- Polyclonal
- Description
- TOLLIP antibody (Cat. #11315-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lactucopicrin promotes the autophagic degradation of MAP2K4/MKK4 by mediating CCDC50 palmitoylation to alleviate osteoarthritis progression.
Glaesserella parasuis serotype 5 disrupts the swine respiratory epithelial barrier via NBR1-mediated selective autophagic degradation of Claudin-1.
PRRSV-2 impedes lysosomes from eliminating secondary infected bacteria.
Activation of Sig-1R by afobazole attenuates Tollip/HMGB1-mediaded CCN2 autophagic degradation and NETs formation in sunitinib-induced cardiotoxicity in mice: Involvement of IRE 1α/ASK1/JNK/ AP-1 trajectory.
Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression.
Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice.
IDR-driven TOLLIP condensates antagonize the innate antiviral immunity by promoting the deSUMOylation of MAVS.
A bacterial RING ubiquitin ligase triggering stepwise degradation of BRISC via TOLLIP-mediated selective autophagy manipulates host inflammatory response.
Membralin Selects Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.
VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy.
Exploratory Analysis of Autophagy-Lysosomal Pathway Proteins in Dermal Fibroblasts as Potential Peripheral Biomarkers for Alzheimer's Disease: A Pilot Study.
µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.
RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation.
Zosuquidar Promotes Antitumor Immunity by Inducing Autophagic Degradation of PD-L1.
TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance.
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
TOLLIP-mediated autophagic degradation pathway links the VCP-TMEM63A-DERL1 signaling axis to triple-negative breast cancer progression.
VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.
African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation.
RNF167-mediated ubiquitination of Tollip inhibits TNF-α-triggered NF-κB and MAPK activation.
The MGF300-2R protein of African swine fever virus is associated with viral pathogenicity by promoting the autophagic degradation of IKKα and IKKβ through the recruitment of TOLLIP.
Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.
Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats.
The Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection.
Li W, Sun Q, Hu K, Tang D, Yang C, Xie Y, Peng X, Deng Y, Lu J, Qi Y, Lin Y, Sun H, Tian Q, Xu C, Tian X, Jiang H
Autophagy 2026 Mar;22(3):526-544
Autophagy 2026 Mar;22(3):526-544
Glaesserella parasuis serotype 5 disrupts the swine respiratory epithelial barrier via NBR1-mediated selective autophagic degradation of Claudin-1.
Wang Q, Song C, Song C, Fang K, Yuan Y, Wang J, Fan H
Veterinary microbiology 2026 Jun;317:111030
Veterinary microbiology 2026 Jun;317:111030
PRRSV-2 impedes lysosomes from eliminating secondary infected bacteria.
Zheng Z, Ling X, Qiao S, Wu J, Zhang S, Liu X, Li Y, Xie C, Ma Z, Guo X, Li Z, Feng Y, Xu L, Zhang J, Zheng H, Xiao S
PLoS pathogens 2026 Feb;22(2):e1014000
PLoS pathogens 2026 Feb;22(2):e1014000
Activation of Sig-1R by afobazole attenuates Tollip/HMGB1-mediaded CCN2 autophagic degradation and NETs formation in sunitinib-induced cardiotoxicity in mice: Involvement of IRE 1α/ASK1/JNK/ AP-1 trajectory.
Shafik MS, El-Tanbouly DM, Bishr A, Soubh AA, Attia AS, Muhammad RN
Toxicology and applied pharmacology 2025 Sep;502:117423
Toxicology and applied pharmacology 2025 Sep;502:117423
Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression.
Pan Y, Zhang N, Fu X, Wang X, Ma Y, Chen Q, Zhou Y, Liu H, Zhu Y, Xu L, Wang Q, Chen D, Wang Z, Wang L
Journal of experimental & clinical cancer research : CR 2025 Nov 25;44(1):310
Journal of experimental & clinical cancer research : CR 2025 Nov 25;44(1):310
Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice.
Han Z, Xiong S, Zeng K, Xiao Z, Zhang L, Zhang Y, Guo J, Peng W, Xie Y, Liu W, Yu X
Nature communications 2025 Nov 18;16(1):10109
Nature communications 2025 Nov 18;16(1):10109
IDR-driven TOLLIP condensates antagonize the innate antiviral immunity by promoting the deSUMOylation of MAVS.
Hou J, Zheng S, Zhang X, Zhuang M, Zhao X, Deng J, Yang H, Xia X, Gao C, Wang PH, Zheng Y
Cell reports 2025 Mar 25;44(3):115348
Cell reports 2025 Mar 25;44(3):115348
A bacterial RING ubiquitin ligase triggering stepwise degradation of BRISC via TOLLIP-mediated selective autophagy manipulates host inflammatory response.
Pan X, Sun Y, Liu J, Chen R, Zhang Z, Li C, Yao H, Ma J
Autophagy 2025 Jun;21(6):1353-1372
Autophagy 2025 Jun;21(6):1353-1372
Membralin Selects Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.
Zheng YH, Zhang J, Lu X, Li S, Wang T, Ahmad I
Research square 2025 Jun 23;
Research square 2025 Jun 23;
VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy.
Jiang H, Xie Y, Hu Z, Lu J, Zhang J, Li H, Zeng K, Peng W, Yang C, Huang J, Han Z, Bai X, Yu X
PLoS biology 2025 Feb;23(2):e3002961
PLoS biology 2025 Feb;23(2):e3002961
Exploratory Analysis of Autophagy-Lysosomal Pathway Proteins in Dermal Fibroblasts as Potential Peripheral Biomarkers for Alzheimer's Disease: A Pilot Study.
Lee MS, Son SJ, Kim J, Go S, Hong CH, Roh HW, Chang J
Biomedicines 2025 Dec 23;14(1)
Biomedicines 2025 Dec 23;14(1)
µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.
Pan CR, Knutson SD, Huth SW, MacMillan DWC
Nature chemical biology 2025 Apr;21(4):490-500
Nature chemical biology 2025 Apr;21(4):490-500
RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation.
Li G, Zhang J, Zhao Z, Wang J, Li J, Xu W, Cui Z, Sun P, Yuan H, Wang T, Li K, Bai X, Ma X, Li P, Fu Y, Cao Y, Bao H, Li D, Liu Z, Zhu N, Tang L, Lu Z
EMBO reports 2024 Oct;25(10):4594-4624
EMBO reports 2024 Oct;25(10):4594-4624
Zosuquidar Promotes Antitumor Immunity by Inducing Autophagic Degradation of PD-L1.
Ding L, Guo H, Zhang J, Zheng M, Zhang W, Wang L, Du Q, Zhou C, Xu Y, Wu H, He Q, Yang B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2400340
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2400340
TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance.
Zhu YF, Yu RH, Zhou S, Tang PP, Zhang R, Wu YX, Xu R, Wei JM, Wang YY, Zhang JL, Li MK, Shi XJ, Zhang YW, Liu GZ, Thorne RF, Zhang XD, Wu M, Chen S
Zoological research 2024 Jul 18;45(4):937-950
Zoological research 2024 Jul 18;45(4):937-950
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
Ma Z, Bai J, Jiang C, Zhu H, Liu D, Pan M, Wang X, Pi J, Jiang P, Liu X
Autophagy 2023 May;19(5):1512-1532
Autophagy 2023 May;19(5):1512-1532
TOLLIP-mediated autophagic degradation pathway links the VCP-TMEM63A-DERL1 signaling axis to triple-negative breast cancer progression.
Zhang TM, Liao L, Yang SY, Huang MY, Zhang YL, Deng L, Hu SY, Yang F, Zhang FL, Shao ZM, Li DQ
Autophagy 2023 Mar;19(3):805-821
Autophagy 2023 Mar;19(3):805-821
VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.
Hu Z, Xie Y, Lu J, Yang J, Zhang J, Jiang H, Li H, Zhang Y, Wu D, Zeng K, Bai X, Yu X
Science advances 2023 Jun 23;9(25):eadg2339
Science advances 2023 Jun 23;9(25):eadg2339
African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation.
Cheng M, Kanyema MM, Sun Y, Zhao W, Lu Y, Wang J, Li X, Shi C, Wang J, Wang N, Yang W, Jiang Y, Huang H, Yang G, Zeng Y, Wang C, Cao X
Journal of virology 2023 Feb 28;97(2):e0192322
Journal of virology 2023 Feb 28;97(2):e0192322
RNF167-mediated ubiquitination of Tollip inhibits TNF-α-triggered NF-κB and MAPK activation.
Yan Z, Dai J, Wang J, Feng Q, Wang Y, Han T, Wu C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23089
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23089
The MGF300-2R protein of African swine fever virus is associated with viral pathogenicity by promoting the autophagic degradation of IKKα and IKKβ through the recruitment of TOLLIP.
Wang T, Luo R, Zhang J, Lu Z, Li LF, Zheng YH, Pan L, Lan J, Zhai H, Huang S, Sun Y, Qiu HJ
PLoS pathogens 2023 Aug;19(8):e1011580
PLoS pathogens 2023 Aug;19(8):e1011580
Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.
Jin S, He X, Ma L, Zhuang Z, Wang Y, Lin M, Cai S, Wei L, Wang Z, Zhao Z, Wu Y, Sun L, Li C, Xie W, Zhao Y, Songyang Z, Peng K, Zhao J, Cui J
Nature communications 2022 Sep 3;13(1):5204
Nature communications 2022 Sep 3;13(1):5204
Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats.
Sargin P, Roethle MF, Jia S, Pant T, Ciecko AE, Atkinson SN, Salzman NH, Teng RJ, Chen YG, Cabrera SM, Hessner MJ
Gut microbes 2022 Jan-Dec;14(1):2136467
Gut microbes 2022 Jan-Dec;14(1):2136467
The Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection.
Phan QT, Lin J, Solis NV, Eng M, Swidergall M, Wang F, Li S, Gaffen SL, Chou TF, Filler SG
mBio 2021 Dec 21;12(6):e0271621
mBio 2021 Dec 21;12(6):e0271621
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 11315-1-AP(TOLLIP antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TOLLIP antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TOLLIP. This antibody recognizes human,mouse,rat antigen. The TOLLIP antibody has been validated for the following applications: ELISA, WB, IHC analysis.
