Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS9228 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- Tollip (W151) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 120-168 of Human Tollip.
- Description
- Tollip (toll-interacting protein) serves as a suppressor of innate immunity signaling and links the serine/threonine kinase IRAK to the IL-1 receptor complex upon receptor activation. Overexpression of Tollip in HEK-293 cells inhibits NF°ÙB activation in response to TLR2 and TLR4 signaling. Negative regulation of TLR signaling by Tollip may limit the production of proinflammatory mediators during inflammation and infection. Tollip forms a complex with Tom1 to regulate endosomal trafficking of ubiquitinated proteins. The Tollip protein shows ubiquitous expression in mouse.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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