HPA022002

antibody from Atlas Antibodies

Targeting: SIRT5

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA022002

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA022002, RRID:AB_1856913

Product name

Anti-SIRT5

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human SIRT5, Gene description: sirtuin 5, Validated applications: WB, IHC, ICC, Uniprot ID: Q9NXA8, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.4 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice

Yuan T, Kumar S, Skinner M, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel T, Liu Y, Petrunak E, Saunders T, Lieberman A, Stuckey J, Neamati N, Al-Murshedi F, Alfadhel M, Spelbrink J, Rodenburg R, de Boer V, Lombard D
iScience 2024;27(6):109991

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Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice

Bhatt D, Mills C, Anderson K, Henriques B, Lucas T, Francisco S, Liu J, Ilkayeva O, Adams A, Kulkarni S, Backos D, Major M, Grimsrud P, Gomes C, Hirschey M
Journal of Biological Chemistry 2022;298(4):101723

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Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability

Wang H, Chen Y, Wang Y, Tao E, Tan J, Liu Q, Li C, Tong X, Gao Q, Hong J, Chen Y, Fang J
Nature Communications 2022;13(1)

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Succinylation Regulators Promote Clear Cell Renal Cell Carcinoma by Immune Regulation and RNA N6-Methyladenosine Methylation

Lu W, Che X, Qu X, Zheng C, Yang X, Bao B, Li Z, Wang D, Jin Y, Wang Y, Xiao J, Qi J, Liu Y
Frontiers in Cell and Developmental Biology 2021;9

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Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage

Liu X, Rong F, Tang J, Zhu C, Chen X, Jia S, Wang Z, Sun X, Deng H, Zha H, Ouyang G, Xiao W
Cell Death & Differentiation 2021;29(4):722-736

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Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells.

Haschler TN, Horsley H, Balys M, Anderson G, Taanman JW, Unwin RJ, Norman JT
Scientific reports 2021 Jul 30;11(1):15510

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Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

Wang Y, Wang H, Xu J, Tan J, Fu L, Wang J, Zou T, Sun D, Gao Q, Chen Y, Fang J
Nature Communications 2018;9(1)

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A Novel Role for SIRT3 in Regulating Mediators Involved in the Terminal Pathways of Human Labor and Delivery

Lim R, Barker G, Menon R, Lappas M
Biology of Reproduction 2016;95(5):95-95

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Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

Traba J, Kwarteng-Siaw M, Okoli T, Li J, Huffstutler R, Bray A, Waclawiw M, Han K, Pelletier M, Sauve A, Siegel R, Sack M
Journal of Clinical Investigation 2015;125(12):4592-4600