CHRNA2

gene product
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
171 antibodies from 24 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Invitrogen Antibodies
6 antibodies
antibodies-online
61 antibodies
LifeSpan BioSciences, Inc.
30 antibodies
Novus Biologicals
3 antibodies
OriGene
3 antibodies
Biorbyt
18 antibodies
Aviva Systems Biology
2 antibodies
GeneTex
2 antibodies
Acris Antibodies GmbH
1 antibody
Abbexa
5 antibodies
ProSci
2 antibodies
Boster Biological Technology
1 antibody
Creative Biolabs
1 antibody
NovoPro Bioscience Inc.
1 antibody
St John's Laboratory
1 antibody
Creative Diagnostics
2 antibodies
MyBioSource
2 antibodies
United States Biological
13 antibodies
Abgent
1 antibody
GenWay
1 antibody
Leading Biology
1 antibody
Abnova Corporation
1 antibody
Sigma-Aldrich
1 antibody