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- Product number
- ABIN393917 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-X-Box Binding Protein 1 (XBP1) (AA 123-225) antibody
- Antibody type
- Monoclonal
- Description
- This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Mouse
- Epitope
- AA 123-225
- Isotype
- IgG
- Antibody clone number
- 4E4
- Vial size
- 100 μg
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Submitted references Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.
XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments.
Direct proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregation.
Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells.
From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis.
Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, Gwag BJ
Experimental & molecular medicine 2010 May 31;42(5):386-94
Experimental & molecular medicine 2010 May 31;42(5):386-94
XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments.
Bagratuni T, Wu P, Gonzalez de Castro D, Davenport EL, Dickens NJ, Walker BA, Boyd K, Johnson DC, Gregory W, Morgan GJ, Davies FE
Blood 2010 Jul 15;116(2):250-3
Blood 2010 Jul 15;116(2):250-3
Direct proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregation.
Navon A, Gatushkin A, Zelcbuch L, Shteingart S, Farago M, Hadar R, Tirosh B
FEBS letters 2010 Jan 4;584(1):67-73
FEBS letters 2010 Jan 4;584(1):67-73
Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells.
Becker E, Florin L, Pfizenmaier K, Kaufmann H
Journal of biotechnology 2010 Apr 15;146(4):198-206
Journal of biotechnology 2010 Apr 15;146(4):198-206
From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis.
Glimcher LH, Lee AH
Annals of the New York Academy of Sciences 2009 Sep;1173 Suppl 1:E2-9
Annals of the New York Academy of Sciences 2009 Sep;1173 Suppl 1:E2-9
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Supportive validation
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- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
