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- References [6]
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- Product number
- ABIN2845007 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Fragilis / IFITM3 (AA 1-30), (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 1-30, N-Term
- Antibody clone number
- RB13975
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots.
- Handling
- Avoid freeze-thaw cycles.
Submitted references RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression.
The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.
IFITM3 restricts the morbidity and mortality associated with influenza.
IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion.
Mäkelä SM, Österlund P, Westenius V, Latvala S, Diamond MS, Gale M Jr, Julkunen I
Journal of virology 2015 Dec;89(23):12014-25
Journal of virology 2015 Dec;89(23):12014-25
The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.
John SP, Chin CR, Perreira JM, Feeley EM, Aker AM, Savidis G, Smith SE, Elia AE, Everitt AR, Vora M, Pertel T, Elledge SJ, Kellam P, Brass AL
Journal of virology 2013 Jul;87(14):7837-52
Journal of virology 2013 Jul;87(14):7837-52
IFITM3 restricts the morbidity and mortality associated with influenza.
Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators., MOSAIC Investigators., Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P
Nature 2012 Mar 25;484(7395):519-23
Nature 2012 Mar 25;484(7395):519-23
IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.
Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL
PLoS pathogens 2011 Oct;7(10):e1002337
PLoS pathogens 2011 Oct;7(10):e1002337
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ
Cell 2009 Dec 24;139(7):1243-54
Cell 2009 Dec 24;139(7):1243-54
IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion.
Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP
Developmental cell 2005 Dec;9(6):745-56
Developmental cell 2005 Dec;9(6):745-56
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
