FNab04145

antibody from FineTest Biotech
Targeting: IFITM3 1-8U, DSPA2b
Provider product page for FNab04145
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
FNab04145 - Provider product page
Provider
FineTest Biotech
Product name
IFITM3 antibody
Antibody type
Monoclonal
Antigen
Recombinant protein fragment
Description
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus(SARS-CoV), Marburg virus(MARV) and Ebola virus(EBOV), Dengue virus(DNV), West Nile virus(WNV), human immunodeficiency virus type 1(HIV-1) and vesicular stomatitis virus(VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase(v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.This antibody recognizes both IFITM2 and IFITM3.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
IFITM2/3 fusion protein
Epitope
IgG1
Isotype
IgG
Antibody clone number
5H4
Vial size
100¦Ìg
Concentration
Protein A+G purification
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
IFITM3 protein structure - FNab04145 shown in red.