ABIN351193

antibody from antibodies-online

Targeting: TRPM2 EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, TRPC7

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN351193

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN351193, RRID:AB_10784991

Product name

anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) (4th Cytoplasmic Domain) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide from the 4th cytoplasmic domain of human TRPM2 (TRPC7, LTRPC2) conjugated to an immunogenic carrier protein was used as the immunogen.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

4th Cytoplasmic Domain

Vial size

100 μL

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.

Handling

Avoid freeze and thaw cycles.

References

Submitted references

A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death.

Zhang W, Chu X, Tong Q, Cheung JY, Conrad K, Masker K, Miller BA
The Journal of biological chemistry 2003 May 2;278(18):16222-9

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Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose.

Wehage E, Eisfeld J, Heiner I, Jüngling E, Zitt C, Lückhoff A
The Journal of biological chemistry 2002 Jun 28;277(26):23150-6

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LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.

Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y
Molecular cell 2002 Jan;9(1):163-73

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ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.

Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM
Nature 2001 May 31;411(6837):595-9

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Immunocyte Ca2+ influx system mediated by LTRPC2.

Sano Y, Inamura K, Miyake A, Mochizuki S, Yokoi H, Matsushime H, Furuichi K
Science (New York, N.Y.) 2001 Aug 17;293(5533):1327-30

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The DNA sequence of human chromosome 21.

Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML, Chromosome 21 mapping and sequencing consortium
Nature 2000 May 18;405(6784):311-9

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Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain.

Nagamine K, Kudoh J, Minoshima S, Kawasaki K, Asakawa S, Ito F, Shimizu N
Genomics 1998 Nov 15;54(1):124-31