orb106907

antibody from Biorbyt

Targeting: KISS1R AXOR12, GPR54, HOT7T175

Western blot (Data presented on provider website)

Antibody Data

Product number

orb106907

Provider

Biorbyt

Product name

KISS1R antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide

Description

Rabbit polyclonal to KISS1R. Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antibody clone number

RB40407

Vial size

80 ul