FNab07196

antibody from FineTest Biotech

Targeting: RBPJ CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

FNab07196

Provider

FineTest Biotech

Product name

RBPJ antibody

Antibody type

Monoclonal

Antigen

Recombinant protein fragment

Description

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins(Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions(4% oxygen)(PubMed:23303788).

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

recombination signal binding protei
n for immunoglobulin kappa J region


Epitope

IgG1

Isotype

IgG

Antibody clone number

2A10

Vial size

100¦Ìg

Concentration

Protein A+G purification

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

Handling

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)