Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AFC-372CL - Provider product page
- Provider
- Creative Biolabs
- Product name
- Afuco? Anti-Human IGF2 ADCC Recombinant Antibody (DX-2647), ADCC Enhanced
- Antibody type
- Monoclonal
- Description
- Anti-IGF2 ADCC Enhanced Antibody (DX-2647) is an ADCC enhanced antibody produced by our Afuco? platform. This is a human monoclonal antibody against insulin-like growth factor-II that blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. DX-2647 inhibited IGF-II and, to a lesser extent, IGF-I-induced receptor tyrosine phosphorylation, cellular proliferation, and both anchorage-dependent and anchorage-independent colony formation in various cell lines. In addition, DX-2647 slowed tumor progression in the Hep3B xenograft model, causing decreased tumoral CD31 staining as well as reduced IGF-IIE and IGF-IR phosphorylation levels. Therefore, DX-2647 offers an alternative approach to targeting IGF-IR, blocking IGF-II signaling through both IGF-IR and IR-A.
- Reactivity
- Human
- Host
- Human
- Storage
- Store at 4¡ãC for up to 3 months. For longer term storage aliquot into small volumes and store at -20¡ãC.
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