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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Product number
- HPA042669 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA042669, RRID:AB_10794916
- Product name
- Anti-TMEM259
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human TMEM259, Gene description: transmembrane protein 259, Alternative Gene Names: ASBABP1, C19orf6, MBRL, MGC4022, Validated applications: IHC, WB, Uniprot ID: Q4ZIN3, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway.
Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.
Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment
ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
Veronese M, Kallabis S, Kaczmarek AT, Das A, Robers L, Schumacher S, Lofrano A, Brodesser S, Müller S, Hofmann K, Krüger M, Rugarli EI
Life science alliance 2024 Aug;7(8)
Life science alliance 2024 Aug;7(8)
Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.
van de Weijer ML, Krshnan L, Liberatori S, Guerrero EN, Robson-Tull J, Hahn L, Lebbink RJ, Wiertz EJHJ, Fischer R, Ebner D, Carvalho P
Molecular cell 2020 Sep 3;79(5):768-781.e7
Molecular cell 2020 Sep 3;79(5):768-781.e7
Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment
Jiang L, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez M, Yu H, Cleveland D, Ravits J, Da Cruz S, Long T, Zhang D, Huang T, Xu H
Journal of Clinical Investigation 2019;129(8):3103-3120
Journal of Clinical Investigation 2019;129(8):3103-3120
ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
Zhu B, Jiang L, Huang T, Zhao Y, Liu T, Zhong Y, Li X, Campos A, Pomeroy K, Masliah E, Zhang D, Xu H
Nature Communications 2017;8(1)
Nature Communications 2017;8(1)
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