11217-1-AP

antibody from Proteintech Group

Targeting: ALDOA

Provider product page for 11217-1-AP

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Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [92]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

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Product number: 11217-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11217-1-AP, RRID:AB_2224626
Product name: ALDOA antibody
Antibody type: Polyclonal
Description: KD/KO validated ALDOA antibody (Cat. #11217-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ALDOA protein structure - 11217-1-AP shown in red.

Submitted references ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression.

Yan K, Jiang Y, Yong Y, Zhang T, Zhang N, Zeng Q, Gong X, Meng L, Bi F, Liu Y
Annals of clinical and translational neurology 2026 Mar 24;

A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.

Thayer JA, Petersen JD, Huang X, Gruel Budet LM, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
The EMBO journal 2026 Jan;45(1):64-105

USP13 ameliorates myocardial infarction injury by inhibiting ferroptosis via stabilizing ALDOA.

Li P, Chen D, Zhang C, Gong Q, Yidilisi A, Fang J, Zhang Y, Jin J, Huang J, Jiang J
Redox biology 2026 Feb;89:103995

4632427E13Rik Facilitates Jaw Marrow-Derived Mesenchymal Stem Cells Osteogenesis and Angiogenesis Under Hypoxia Through miR-34a-5p/Aldoa/Hif-1α Pathway.

Wang Z, Zhang Y, Wang Y, Xue R, Qin Q, Zhang H, Xu Z, Liu S, Liu L, Jiang X, Xu L
International dental journal 2026 Apr;76(2):109364

Fructose-1,6-bisphosphate couples glycolytic activity to cell adhesion.

Hoffmann L, Duchmann M, Lazarow K, Huang YH, Lukas F, Lo WT, Feil R, Schmied C, Lehmann M, Lunn JE, Piazza I, von Kries JP, Haucke V, Maritzen T
Nature cell biology 2026 Apr;28(4):739-753

Proteomic Identification of ALDOA as a Pathogenic TDP-43 Interaction Partner in ALS.

Yan K, Deng J, Yong Y, Bi F
Degenerative neurological and neuromuscular disease 2025;15:123-132

Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis.

Chen J, Zhang J, Zhu Y, Zhu Y, Pang J, Wu Q, Wang Y, Zhan Q
Signal transduction and targeted therapy 2025 Sep 1;10(1):280

BCL-2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in AML.

Peng X, Li Y, Tang F, Ma Y, Bai J, Li L, Zhang L
Cancer science 2025 Oct;116(10):2657-2676

ATG16L1 controls mammalian vacuolar proton ATPase.

Duque TLA, Paddar M, Trosdal E, Javed R, Allers L, Mudd MH, Akepati P, Mishra SR, Salemi M, Phinney B, Bratton SB, Wileman T, Deretic V
The Journal of cell biology 2025 Oct 6;224(10)

Exosomal Proteome from Hepatocellular Carcinoma Patient-Derived Xenograft Mice Serves as Identity of Liver Cancer.

Zuo T, Chen P, Zhang Z, Mao M, Li Y, Li Z, Feng X, Wang Y, Sun Z, Jiao F, Gao F, Zhang T, Li Y, Zhang Y, Liu F, Zhang Y, Ruan Y, Chang L, Hu L, Zhang Y, Xu P
Journal of proteome research 2025 Oct 3;24(10):4977-4987

Prognostic evaluation of glycolysis markers in hepatocellular carcinoma: insights from meta-analysis and multi-omics approaches.

Li G, Li Y, Zhou J, Tang S, Guo H, Lin J
BMC medical genomics 2025 Nov 8;18(1):179

Patient-derived organotypic tissue cultures as a platform to evaluate metabolic reprogramming in breast cancer patients.

Fan TW, Yan J, Goncalves CFL, Islam JMM, Lin P, Kaddah MMY, Higashi RM, Lane AN, Wang X, Zhu C
The Journal of biological chemistry 2025 May;301(5):108495

Integrated multi-omic high-throughput strategies across-species identified potential key diagnostic, prognostic, and therapeutic targets for atherosclerosis under high glucose conditions.

Shen Z, Zhao M, Lu J, Chen H, Zhang Y, Chen S, Wang Z, Wang M, Liu X, Fu G, Huang H
Molecular and cellular biochemistry 2025 Mar;480(3):1785-1805

Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer.

Huo R, Li W, Wu H, He K, Wang H, Zhang S, Jiang SH, Li R, Xue J
Cell death & disease 2025 Mar 3;16(1):149

Integration of metabolomics and transcriptomics reveals the mechanism of TMEM30A downregulation induced FSGS podocyte injury.

Hou Y, Chen S, Li Y, Huang L, Zhang H, Yu M, Xiong L, Zhong X, Wang L, Zhu X, Li G, Peng L
American journal of physiology. Renal physiology 2025 Mar 1;328(3):F389-F405

Jatrorrhizine Alleviates Calcific Aortic Valve Disease via Interfering With Glycolysis Targeting ALDOA K42 Lactylation.

Wu J, Wang S, Gao P, Wang S, Yu H, Du Q, Liu M, Hou S, Jiang S, Xu H, Ye S, Feng F, Wang C, Xu K
Phytotherapy research : PTR 2025 Jul;39(7):3212-3224

Aldolase A accelerates hepatocarcinogenesis by refactoring c-Jun transcription.

Yang X, Ma GY, Li XQ, Tang N, Sun Y, Hao XW, Wu KH, Wang YB, Tian W, Fan X, Li Z, Feng C, Chao X, Wang YF, Liu Y, Li D, Cao W
Journal of pharmaceutical analysis 2025 Jul;15(7):101169

Single-cell RNA sequencing in human atherosclerotic plaques reveals a novel smooth muscle cell subtype that possesses multi differentiation potential and shapes the microenvironment.

Ye W, Chen Z, Xia Z, Li D
Clinical and experimental medicine 2025 Jul 16;25(1):251

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.

Zhai X, Yang R, Chu Q, Guo Z, Hou P, Li X, Bai C, Lu Z, Qiao L, Fu Y, Niu J, Li B
Nature cell biology 2025 Jan;27(1):141-153

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions.

Shao C, Tang S, Yu S, Liu C, Zhang Y, Wan T, He Z, Yuan Q, Wu S, Zhang H, Wan N, Zhan M, Tan RX, Hao H, Ye H, Wang N
Nature communications 2025 Jan 8;16(1):227

ALDOA contributes to colorectal tumorigenesis and metastasis by targeting YAP.

Sun L, Lu T, Jiang L, Yao H, Xu Q, Sun J, Yang X, He S, Zhu X
Cell death discovery 2025 Jan 5;10(1):489

The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.

Lan T, Gao F, Cai Y, Lv Y, Zhu J, Liu H, Xie S, Wan H, He H, Xie K, Liu C, Wu H
Nature communications 2025 Jan 2;16(1):333

Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR.

Yu A, Wang Y, Duan C, Qin J, Liao M, Zhu H, Lei J, Liu J, Yang Z, Yu L, Gui H, Xin J, Tao W, Bao W, Dong Z
Communications biology 2025 Jan 17;8(1):71

Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.

Snaebjornsson MT, Poeller P, Komkova D, Röhrig F, Schlicker L, Winkelkotte AM, Chaves-Filho AB, Al-Shami KM, Caballero CD, Koltsaki I, Vogel FCE, Frias-Soler RC, Rudalska R, Schwarz JD, Wolf E, Dauch D, Steuer R, Schulze A
Nature metabolism 2025 Feb;7(2):348-366

ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.

Li R, Ji Q, Fu S, Gu J, Liu D, Wang L, Yuan X, Wen Y, Dai C, Li H
Cancer gene therapy 2025 Feb;32(2):240-253

Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.

Thayer JA, Petersen JD, Huang X, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
bioRxiv : the preprint server for biology 2025 Feb 20;

PFKFB3-Inhibitor 3PO-Mediated Glycolytic Reprogramming Promotes Inflammatory Dental Pulp Repair: An In Vitro and In Vivo Study.

Zhao Y, Peng Y, Wang D, Zhang L, Qiu Y, Cui J, Xie F, Zhu N, Qin M, Wang Y
International endodontic journal 2025 Dec;58(12):1872-1889

Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages.

Hu HH, Wang X, Lan B, Cheng H, Wen H, Chen F, Wu J, Li M, Chen J, Zhang J, Chen D, Lin S, Lin J, Yang M, Wu Z, Zheng ZZ, Chen F, Zhou J, Chen G, Chen Y, Deng X, Zhang CS, Liu J, Lin SC
Cell research 2025 Dec;35(12):934-953

Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling.

Wu H, Guo Z, Hu P, Du J, Wang P, Ma J, Zhao B, Wei J, Li Z
Food & function 2025 Dec 8;16(24):9593-9608

Aldolase a coordinates macropinocytic nutrient scavenging and lysosomal degradation in lung cancer by interacting with V-ATPase.

Kim D, Jeong S, Lee S, Jin J, Yun JW, Lee J, Byun JK, Choi YK, Park KG
Cell communication and signaling : CCS 2025 Dec 20;24(1):43

Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.

Zhang X, Nie Z, Wang S, Ma Y, Han D, Hu T, Liu L, Men L, Zhang T, Wu X, Li X, Hu S, Yuan M, Liu L, Wang C, Xu P, Xiang L, Liu J, Zhang Y, Zhu D, Lei H, Zhang L, Li X, Zhao Y, Yan W
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12

Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.

Li WJ, Chen YC, Lin YA, Zou YQ, Hu GS, Yang JJ, Nie XY, Li MY, Wang YR, He YH, Zhao Y, Tan YH, Deng X, He WL, Cheng Y, Fu FM, Liu W
Cell reports 2025 Apr 22;44(4):115487

LINC00908 attenuates LUAD tumorigenesis through DEAD-box helicase 54.

Zhao J, Yang X, Gong W, Zhang L, Li C, Han X, Zhang Y, Chu X
American journal of cancer research 2024;14(5):2371-2389

Alternative splicing of ALDOA confers tamoxifen resistance in breast cancer.

Yu S, Wu R, Si Y, Fan Z, Wang Y, Yao C, Sun R, Xue Y, Chen Y, Wang Z, Dong S, Wang N, Ling X, Liang Z, Bi C, Yang Y, Dong W, Sun H
Oncogene 2024 Sep;43(39):2901-2913

Lactyllysine Esterification Enables Efficient Lactylprotein Expression via Genetic Code Expansion and Supports Functional Proteomics Studies.

Wang D, Liu C, Chen J, Zhang Y, Han R, Tang S, Wang N, Hao H, Shao C, Ye H
Journal of proteome research 2024 Oct 4;23(10):4614-4625

Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development.

Lagani GD, Sha M, Lin W, Natarajan S, Kankkunen M, Kistler SA, Lampl N, Waxman H, Harper ER, Emili A, Beffert U, Ho A
The Journal of neuroscience : the official journal of the Society for Neuroscience 2024 Oct 16;44(42)

Identification of TPI1 As a potential therapeutic target in pancreatic cancer with dependency of TP53 mutation using multi-omics analysis.

Toyoda T, Miura N, Kato S, Masuda T, Ohashi R, Matsushita A, Matsuda F, Ohtsuki S, Katakura A, Honda K
Cancer science 2024 Nov;115(11):3622-3635

BAP1 inactivation promotes lactate production by leveraging the subcellular localization of LDHA in melanoma.

Zheng G, Shi J, Li Q, Jin X, Fang Y, Zhang Z, Cao Q, Zhu L, Shen J
Cell death discovery 2024 Nov 26;10(1):483

The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis.

Zhao L, Yu N, Zhai Y, Yang Y, Wang Y, Yang Y, Gong Z, Zhang Y, Zhang X, Guo W
Cell death & disease 2024 Jul 13;15(7):502

Dopamine modification of glycolytic enzymes impairs glycolysis: possible implications for Parkinson's disease.

Chen B, Zhang Q, Zhong X, Zhang X, Liu X, Wang H, Yang F, Zhang J, Huang J, Wong YK, Luo P, Wang J, Sun J
Cell communication and signaling : CCS 2024 Jan 29;22(1):75

Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.

Cheng Z, Huang H, Li M, Chen Y
iScience 2024 Jan 19;27(1):108645

Acetyltransferase P300 Regulates Glucose Metabolic Reprogramming through Catalyzing Succinylation in Lung Cancer.

Ma Q, Zeng Q, Wang K, Qian M, Li J, Wang H, Zhang H, Jiang J, Chen Z, Huang W
International journal of molecular sciences 2024 Jan 15;25(2)

Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development.

Lagani GD, Lin W, Natarajan S, Lampl N, Harper ER, Emili A, Beffert U, Ho A
bioRxiv : the preprint server for biology 2024 Jan 12;

Proteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection.

Jiang N, Chen Y, Li T, Sun Y, Su Y, Wang Y, Shen Y, Cao J
PLoS neglected tropical diseases 2024 Dec;18(12):e0012659

Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation.

Wen X, Zhang J, Xu Z, Li M, Dong X, Du Y, Xu Z, Yan L
Reproduction (Cambridge, England) 2024 Aug 1;168(2)

Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway.

Guan Y, Yao W, Yu H, Feng Y, Zhao Y, Zhan X, Wang Y
International journal of biological sciences 2023;19(7):2006-2019

Adipose-derived mesenchymal stem cell-loaded β-chitin nanofiber hydrogel activates the AldoA/HIF-1α pathway to promote diabetic wound healing.

Liu Y, Ma R, Juan D, Yuan Z, Sun J, Wang M, Li Y, Bao Y, Jin H
American journal of stem cells 2023;12(1):1-11

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.

Sun X, He L, Liu H, Thorne RF, Zeng T, Liu L, Zhang B, He M, Huang Y, Li M, Gao E, Ma M, Cheng C, Meng F, Lang C, Li H, Xiong W, Pan S, Ren D, Dang B, Yang Y, Wu M, Liu L
Cell metabolism 2023 Sep 5;35(9):1563-1579.e8

HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth.

Mao H, Wang R, Shao F, Zhao M, Tian D, Xia H, Zhao Y
Scientific reports 2023 Sep 5;13(1):14629

Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer.

Li Y, Tang S, Shi X, Lv J, Wu X, Zhang Y, Wang H, He J, Zhu Y, Ju Y, Zhang Y, Guo S, Yang W, Yin H, Chen L, Gao D, Jin G
Cell reports. Medicine 2023 Sep 19;4(9):101162

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability.

Han L, Jiang Y, Shi M, Gan L, Wu Z, Xue M, Zhu Y, Xiong C, Wang T, Lin X, Shen B, Jiang L, Chen H
Journal of translational medicine 2023 Nov 21;21(1):838

BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.

Gu R, Dai F, Xiang C, Chen J, Yang D, Tan W, Wang Z, Liu H, Cheng Y
The Journal of steroid biochemistry and molecular biology 2023 Dec;235:106410

Circ_0000235 targets MCT4 to promote glycolysis and progression of bladder cancer by sponging miR-330-5p.

Zhong J, Xu A, Xu P, Su M, Wang P, Liu Z, Li B, Liu C, Jiang N
Cell death discovery 2023 Aug 2;9(1):283

Associative analysis of multi-omics data indicates that acetylation modification is widely involved in cigarette smoke-induced chronic obstructive pulmonary disease.

Gao J, Liu H, Wang X, Wang L, Gu J, Wang Y, Yang Z, Liu Y, Yang J, Cai Z, Shu Y, Min L
Frontiers in medicine 2022;9:1030644

Application of adipose mesenchymal stem cell-derived exosomes-loaded β-chitin nanofiber hydrogel for wound healing.

Liu Y, Liu Y, Zhao Y, Wu M, Mao S, Cong P, Zou R, Hou M, Jin H, Bao Y
Folia histochemica et cytobiologica 2022;60(2):167-178

Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway.

Zou T, Gu L, Yang L, Wei J, Zhao Y, Shen J, Li M, Wu X, Du F, Chen Y, Ye Y, Xiao Z, Wu Z
Recent patents on anti-cancer drug discovery 2022;17(4):396-409

Aldolase A promotes cell proliferation and cisplatin resistance via the EGFR pathway in gastric cancer.

Gu M, Jiang B, Li H, Zhu D, Jiang Y, Xu W
American journal of translational research 2022;14(9):6586-6595

Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.

Zhang X, Luo F, Luo S, Li L, Ren X, Lin J, Liang Y, Ma C, Ding L, Zhang D, Ye T, Lin Y, Jin B, Gao S, Ye Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Sep;9(27):e2200705

TGF-β-Upregulated Lnc-Nr6a1 Acts as a Reservoir of miR-181 and Mediates Assembly of a Glycolytic Complex.

Polo-Generelo S, Torres B, Guerrero-Martínez JA, Camafeita E, Vázquez J, Reyes JC, Pintor-Toro JA
Non-coding RNA 2022 Sep 15;8(5)

Luo T, Peng J, Li Q, Zhang Y, Huang Y, Xu L, Yang G, Tan D, Zhang Q, Tan Y
International journal of molecular sciences 2022 Nov 8;23(22)

Generation and Utilization of a Monoclonal Antibody against Hepatitis B Virus Core Protein for a Comprehensive Interactome Analysis.

Nakai Y, Miyakawa K, Yamaoka Y, Hatayama Y, Nishi M, Suzuki H, Kimura H, Takahashi H, Kimura Y, Ryo A
Microorganisms 2022 Nov 30;10(12)

Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex.

Dong X, Zhang Q, Yu X, Wang D, Ma J, Ma J, Shi SH
Nature neuroscience 2022 Jul;25(7):865-875

Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis.

Sendi H, Yazdimamaghani M, Hu M, Sultanpuram N, Wang J, Moody AS, McCabe E, Zhang J, Graboski A, Li L, Rojas JD, Dayton PA, Huang L, Wang AZ
Cancer research 2022 Jan 1;82(1):105-113

PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis.

He Y, Wang X, Lu W, Zhang D, Huang L, Luo Y, Xiong L, Li H, Zhang P, Li Q, Liang S
Cell death & disease 2022 Feb 4;13(2):118

Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.

Li X, Zhang Y, Wang X, Lin F, Cheng X, Wang Z, Wang X
Cell biology and toxicology 2022 Dec;38(6):1027-1045

Glycolytic flux-signaling controls mouse embryo mesoderm development.

Miyazawa H, Snaebjornsson MT, Prior N, Kafkia E, Hammarén HM, Tsuchida-Straeten N, Patil KR, Beck M, Aulehla A
eLife 2022 Dec 5;11

Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis.

Li X, Yu C, Luo Y, Lin J, Wang F, Sun X, Gao Y, Tan W, Xia Q, Kong X
International journal of biological sciences 2021;17(7):1782-1794

Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.

Li R, Li H, Zhu L, Zhang X, Liu D, Li Q, Ni B, Hu L, Zhang Z, Zhang Y, Wang X, Jiang SH
Cell death & disease 2021 Nov 26;12(12):1106

The antitumor role of a newly discovered α-d-glucan from Holotrichia diomphalia Bates as a selective blocker of aldolase A.

Wang J, Li Z, Yang X, Qiao Y, Feng C, Yu S, Jing H, Liu W, Ren L, Duan Q, Li XQ, Cao W
Carbohydrate polymers 2021 Mar 1;255:117532

Trim21-mediated HIF-1α degradation attenuates aerobic glycolysis to inhibit renal cancer tumorigenesis and metastasis.

Chen X, Li Z, Yong H, Wang W, Wang D, Chu S, Li M, Hou P, Zheng J, Bai J
Cancer letters 2021 Jun 28;508:115-126

Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect.

Li Z, Yang L, Zhang S, Song J, Sun H, Shan C, Wang D, Liu S
Cell transplantation 2021 Jan-Dec;30:9636897211027524

Long non-coding RNA AC122108.1 promotes lung adenocarcinoma brain metastasis and progression through the Wnt/β-catenin pathway by directly binding to aldolase A.

Feng S, Liu H, Du P, Dong X, Pang Q, Guo H
Annals of translational medicine 2021 Dec;9(23):1729

Itaconate regulates the glycolysis/pentose phosphate pathway transition to maintain boar sperm linear motility by regulating redox homeostasis.

Zhu Z, Umehara T, Tsujita N, Kawai T, Goto M, Cheng B, Zeng W, Shimada M
Free radical biology & medicine 2020 Nov 1;159:44-53

Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis.

Wang C, Xu J, Yuan D, Bai Y, Pan Y, Zhang J, Shao C
Molecular and cellular biochemistry 2020 Jun;469(1-2):77-87

Activator of thyroid and retinoid receptor increases sorafenib resistance in hepatocellular carcinoma by facilitating the Warburg effect.

Ma L, Liu W, Xu A, Ji Q, Ma Y, Tai Y, Wang Y, Shen C, Liu Y, Wang T, Han J, Zhao C
Cancer science 2020 Jun;111(6):2028-2040

Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.

Hu J, Chen Z, Bao L, Zhou L, Hou Y, Liu L, Xiong M, Zhang Y, Wang B, Tao Z, Chen K
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jul 8;28(7):1658-1672

Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.

Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092

Recombinant Viral Capsid Protein L2 (rVL2) of HPV 16 Suppresses Cell Proliferation and Glucose Metabolism via ITGB7/C/EBPβ Signaling Pathway in Cervical Cancer Cell Lines.

Chai Z, Yang Y, Gu Z, Cai X, Ye W, Kong L, Qiu X, Ying L, Wang Z, Wang L
OncoTargets and therapy 2019;12:10415-10425

Accumulation of fructose 1,6-bisphosphate protects clear cell renal cell carcinoma from oxidative stress.

Wang J, Wu Q, Qiu J
Laboratory investigation; a journal of technical methods and pathology 2019 Jun;99(6):898-908

C/D-Box Snord105b Promotes Tumorigenesis in Gastric Cancer via ALDOA/C-Myc Pathway.

Zhang C, Zhao LM, Wu H, Tian G, Dai SL, Zhao RY, Shan BE
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(6):2471-2482

Aldolase A as a prognostic factor and mediator of progression via inducing epithelial-mesenchymal transition in gastric cancer.

Jiang Z, Wang X, Li J, Yang H, Lin X
Journal of cellular and molecular medicine 2018 Sep;22(9):4377-4386

Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.

Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q
Cancer cell 2018 Mar 12;33(3):368-385.e7

Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth.

Ma D, Chen X, Zhang PY, Zhang H, Wei LJ, Hu S, Tang JZ, Zhou MT, Xie C, Ou R, Xu Y, Tang KF
Oncogene 2018 Feb 22;37(8):1041-1048

Hepatic, Metabolic, and Toxicity Evaluation of Repeated Oral Administration of SnS2 Nanoflowers in Mice.

Bai D, Li Q, Xiong Y, Wang C, Shen P, Bai L, Yuan L, Wu P
Toxicological sciences : an official journal of the Society of Toxicology 2018 Aug 1;164(2):501-511

Characterization of GALNTL5 gene sequence and expression in ovine testes and sperm.

Yao X, Yang H, Zhang Y, Ren C, Nie H, Fan Y, Zhou W, Wang S, Feng X, Wang F
Theriogenology 2017 Jun;95:54-61

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.

Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A
Developmental cell 2017 Feb 27;40(4):331-341.e4

Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.

Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S
PloS one 2016;11(9):e0163622

Alteration of sperm protein profile induced by cigarette smoking.

Chen X, Xu W, Miao M, Zhu Z, Dai J, Chen Z, Fang P, Wu J, Nie D, Wang L, Wang Z, Qiao Z, Shi H
Acta biochimica et biophysica Sinica 2015 Jul;47(7):504-15

Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.

Liu C, Lin JJ, Yang ZY, Tsai CC, Hsu JL, Wu YJ
Journal of agricultural and food chemistry 2014 Dec 3;62(48):11672-80

Identification and validation of mouse sperm proteins correlated with epididymal maturation.

Ijiri TW, Merdiushev T, Cao W, Gerton GL
Proteomics 2011 Oct;11(20):4047-62

Malignant pleural effusion cells show aberrant glucose metabolism gene expression.

Lin CC, Chen LC, Tseng VS, Yan JJ, Lai WW, Su WP, Lin CH, Huang CY, Su WC
The European respiratory journal 2011 Jun;37(6):1453-65

Antipsychotic treatment alters protein expression associated with presynaptic function and nervous system development in rat frontal cortex.

Ma D, Chan MK, Lockstone HE, Pietsch SR, Jones DN, Cilia J, Hill MD, Robbins MJ, Benzel IM, Umrania Y, Guest PC, Levin Y, Maycox PR, Bahn S
Journal of proteome research 2009 Jul;8(7):3284-97

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11217-1-AP(ALDOA antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using ALDOA antibody 11217-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-ALDOA (IP:11217-1-AP, 3ug; Detection:11217-1-AP 1:1000) with HepG2 cells lysate 6000ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skeletal muscle using 11217-1-AP(ALDOA antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skeletal muscle using 11217-1-AP(ALDOA antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue