16478-1-AP

antibody from Proteintech Group

Targeting: MVP LRP, VAULT1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

16478-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#16478-1-AP, RRID:AB_2147597

Product name

MVP/LRP antibody

Antibody type

Polyclonal

Description

KD/KO validated MVP/LRP antibody (Cat. #16478-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/Slug pathway.

Yu M, Zhang Q, Shang W, Wei S, Wen H, Huo S, Li X, Li X, Zhang H, Tian Y
Tissue & cell 2026 Feb;98:103145

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DUX4-induced HSATII RNA accumulation drives protein aggregation, impacting RNA processing pathways.

Arends T, Bennett SR, Tapscott SJ
The Journal of cell biology 2026 Feb 2;225(2)

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Major vault protein inhibits CSFV replication by promoting cell apoptosis.

Luo B, Su N, Quan Y, Li N, Chen C, Zhang L, Xu L, Guo K
Veterinary microbiology 2025 Nov;310:110745

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Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non-Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning.

Yuan Y, Jiang H, Xue R, Feng XJ, Liu BF, Li L, Peng B, Ren CS, Li SM, Li N, Li M, Wang DB, Zhang XE
Journal of extracellular vesicles 2025 May;14(5):e70078

---

ADAM9 mediates Cisplatin resistance in gastric cancer cells through DNA damage response pathway.

Zhang XY, Zhao CY, Dong JM, Du CP, Zhang CL, Yang AJ, Zhou Q, Liu W, Dang Y, Shang LN, Zhou YN, Wang YP, Wang CY, Wang M, Li M
Medical oncology (Northwood, London, England) 2025 Mar 20;42(4):122

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Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1.

Stok JE, van der Kooij SB, Gravekamp D, Ter Haar LR, de Wolf JW, Salgado-Benvindo C, Nelemans T, Grijmans BJM, Tjokrodirijo RTN, de Ru AH, van Veelen PA, van Hemert MJ, Kikkert M, van der Veen AG
Cell reports 2025 Jun 24;44(6):115823

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DUX4-induced HSATII RNA accumulation drives protein aggregation impacting RNA processing pathways.

Arends T, Bennett SR, Tapscott SJ
bioRxiv : the preprint server for biology 2025 Jan 22;

---

Unraveling the role of Major Vault Protein as a novel immune-related biomarker that promotes the proliferation and migration in pancreatic adenocarcinoma.

Wu X, Hao L, Lin J, Guo X, Luo Y, Li C
Frontiers in immunology 2024;15:1399222

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Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.

Li R, Xiong Z, Ma Y, Li Y, Yang Y, Ma S, Ha C
World journal of surgical oncology 2024 Mar 21;22(1):81

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Major vault protein is part of an extracellular cement material in the Atlantic salmon louse (Lepeophtheirus salmonis).

Slinning MS, Nthiga TM, Eichner C, Khadija S, Rome LH, Nilsen F, Dondrup M
Scientific reports 2024 Jul 2;14(1):15240

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LIPCAR levels in plasma-derived extracellular vesicles is associated with left ventricle remodeling post-myocardial infarction.

Turkieh A, Beseme O, Saura O, Charrier H, Michel JB, Amouyel P, Thum T, Bauters C, Pinet F
Journal of translational medicine 2024 Jan 6;22(1):31

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Tryptophan As a New Member of RNA-Induced Silencing Complexes Prevents Colon Cancer Liver Metastasis.

Xu F, Ren Y, Teng Y, Mu J, Tang J, Sundaram K, Zhang L, Park JW, Hwang JY, Yan J, Dryden G, Zhang HG
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(31):e2307937

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Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.

Yu C, Zhu Q, Ma C, Luo C, Nie L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Zhang C, Lu G, Lu Z, Zhu Y, Liu S
Frontiers in immunology 2023;14:1289795

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CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis.

Wu J, Zhou Z, Li J, Liu H, Zhang H, Zhang J, Huang W, He Y, Zhu S, Huo M, Liu M, Zhang C
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2023 Jan;66:100913

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Major Vault Protein (MVP) Associated With BRAF (V600E) Mutation Is an Immune Microenvironment-Related Biomarker Promoting the Progression of Papillary Thyroid Cancer via MAPK/ERK and PI3K/AKT Pathways.

Dong X, Akuetteh PDP, Song J, Ni C, Jin C, Li H, Jiang W, Si Y, Zhang X, Zhang Q, Huang G
Frontiers in cell and developmental biology 2021;9:688370

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Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes.

Li X, Chen R, Kemper S, Brigstock DR
Frontiers in cell and developmental biology 2021;9:640667

---

Differential RNA packaging into small extracellular vesicles by neurons and astrocytes.

Luo X, Jean-Toussaint R, Sacan A, Ajit SK
Cell communication and signaling : CCS 2021 Jul 10;19(1):75

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DEAD-box Helicase 27 Promotes Hepatocellular Carcinoma Progression Through ERK Signaling.

Xiaoqian W, Bing Z, Yangwei L, Yafei Z, Tingting Z, Yi W, Qingjun L, Suxia L, Ling Z, Bo W, Peng Z
Technology in cancer research & treatment 2021 Jan-Dec;20:15330338211055953

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The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.

Simsek D, Tiu GC, Flynn RA, Byeon GW, Leppek K, Xu AF, Chang HY, Barna M
Cell 2017 Jun 1;169(6):1051-1065.e18

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MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.

Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, Deng Z, Kumar A, Zhang L, Merchant ML, Yan J, Miller DM, Zhang HG
Nature communications 2017 Feb 17;8:14448

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Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.

Jiang YQ, Xu XP, Guo QM, Xu XC, Liu QY, An SH, Xu JL, Su F, Tai JB
Genetics and molecular research : GMR 2016 Sep 2;15(3)

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 16478-1-AP(MVP antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using MVP antibody 16478-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human lung using 16478-1-AP(MVP antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human lung using 16478-1-AP(MVP antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue