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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Immunohistochemistry [2]
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- Product number
- NBP2-48430 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal MVP Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 7 ml
- Storage
- Store at 4C.
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: MVP Antibody (1032) - IHC-Prediluted [NBP2-48430] - Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MVP Monoclonal Antibody (1032).
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: MVP Antibody (1032) - IHC-Prediluted [NBP2-48430] - Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with MVP Monoclonal Antibody (1032).
