Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 22124-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- TBC1D1 antibody
- Antibody type
- Polyclonal
- Description
- TBC1D1 antibody (Cat. #22124-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Secreted EMC10 inhibits muscle GLUT4 activity and glucose uptake in mice.
Novel prognostic biomarker TBC1D1 is associated with immunotherapy resistance in gliomas.
Stevioside Ameliorates Palmitic Acid-Induced Abnormal Glucose Uptake via the PDK4/AMPK/TBC1D1 Pathway in C2C12 Myotubes.
GPR30 selective agonist G-1 induced insulin resistance in ovariectomized mice on high fat diet and its mechanism.
TBC1D1 represses glioma progression by altering the integrity of the cytoskeleton.
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise.
AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores.
Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle.
The insulin-sensitizing effect of a single exercise bout is similar in type I and type II human muscle fibres.
Coumarins ameliorate diabetogenic action of dexamethasone via Akt activation and AMPK signaling in skeletal muscle.
Cooperative actions of Tbc1d1 and AS160/Tbc1d4 in GLUT4-trafficking activities.
Quercetin oppositely regulates insulin-mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation.
Jin S, Wu W, Liu S, Wang Y, Huang Q, He K, Ni Y, Chen K, Huang J, Liu L, Dai J, Zhan C, Wang X, Guan Y, Blüher M, Wang X
The Journal of biological chemistry 2025 Jul;301(7):110296
The Journal of biological chemistry 2025 Jul;301(7):110296
Novel prognostic biomarker TBC1D1 is associated with immunotherapy resistance in gliomas.
Song D, Yang Q, Li L, Wei Y, Zhang C, Du H, Ren G, Li H
Frontiers in immunology 2024;15:1372113
Frontiers in immunology 2024;15:1372113
Stevioside Ameliorates Palmitic Acid-Induced Abnormal Glucose Uptake via the PDK4/AMPK/TBC1D1 Pathway in C2C12 Myotubes.
Zhang C, Li S, Li L, Wang R, Luo S, Li G
Endocrinology, diabetes & metabolism 2024 May;7(3):e00482
Endocrinology, diabetes & metabolism 2024 May;7(3):e00482
GPR30 selective agonist G-1 induced insulin resistance in ovariectomized mice on high fat diet and its mechanism.
Lu C, Liu D, Li M, Shi X, Guan J, Song G, Yin Y, Zheng M, Ma F, Liu G
Biochemical and biophysical research communications 2024 Jul 5;716:150026
Biochemical and biophysical research communications 2024 Jul 5;716:150026
TBC1D1 represses glioma progression by altering the integrity of the cytoskeleton.
Cai J, Jiang Y, Chen P, Liang J, Zhang Y, Yuan R, Fan H, Zhong Y, Cai J, Cheng S, Zhang Y
Aging 2024 Jan 5;16(1):431-444
Aging 2024 Jan 5;16(1):431-444
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise.
Kristensen JM, Kjøbsted R, Larsen TJ, Carl CS, Hingst JR, Onslev J, Birk JB, Thorup A, Steenberg DE, Knudsen JR, Henriksen NS, Needham EJ, Halling JF, Gudiksen A, Rundsten CF, Hanghøj KE, Stinson SE, Hoier B, Hansen CC, Jensen TE, Hellsten Y, Pilegaard H, Grarup N, Olesen J, Humphrey SJ, James DE, Pedersen ML, Richter EA, Hansen T, Jørgensen ME, Wojtaszewski JFP
Nature metabolism 2024 Dec;6(12):2254-2266
Nature metabolism 2024 Dec;6(12):2254-2266
AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores.
Kido K, Eskesen NO, Henriksen NS, Onslev J, Kristensen JM, Larsen MR, Hingst JR, Knudsen JR, Birk JB, Andersen NR, Jensen TE, Pehmøller C, Wojtaszewski JFP, Kjøbsted R
Diabetes 2023 Oct 1;72(10):1397-1408
Diabetes 2023 Oct 1;72(10):1397-1408
Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle.
Larsen JK, Larsen MR, Birk JB, Steenberg DE, Hingst JR, Højlund K, Chadt A, Al-Hasani H, Deshmukh AS, Wojtaszewski JFP, Kjøbsted R
Diabetes 2022 May 1;71(5):906-920
Diabetes 2022 May 1;71(5):906-920
The insulin-sensitizing effect of a single exercise bout is similar in type I and type II human muscle fibres.
Larsen MR, Steenberg DE, Birk JB, Sjøberg KA, Kiens B, Richter EA, Wojtaszewski JFP
The Journal of physiology 2020 Dec;598(24):5687-5699
The Journal of physiology 2020 Dec;598(24):5687-5699
Coumarins ameliorate diabetogenic action of dexamethasone via Akt activation and AMPK signaling in skeletal muscle.
Mo Z, Li L, Yu H, Wu Y, Li H
Journal of pharmacological sciences 2019 Mar;139(3):151-157
Journal of pharmacological sciences 2019 Mar;139(3):151-157
Cooperative actions of Tbc1d1 and AS160/Tbc1d4 in GLUT4-trafficking activities.
Hatakeyama H, Morino T, Ishii T, Kanzaki M
The Journal of biological chemistry 2019 Jan 25;294(4):1161-1172
The Journal of biological chemistry 2019 Jan 25;294(4):1161-1172
Quercetin oppositely regulates insulin-mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation.
Liu K, Mei F, Wang Y, Xiao N, Yang L, Wang Y, Li J, Huang F, Kou J, Liu B, Qi LW
Molecular nutrition & food research 2016 Mar;60(3):551-65
Molecular nutrition & food research 2016 Mar;60(3):551-65
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 22124-1-AP(TBC1D1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The TBC1D1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TBC1D1. This antibody recognizes human, mouse antigen. The TBC1D1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.