FZD3

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

Description

Frizzled class receptor 3

Tissue specificity

Tissue enhanced (retina)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular, Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (28494205 - 28574267)

Ensembl ID

ENSG00000104290  (ver. 103.38)

Orthologs

Mouse Fzd3: ENSMUSG00000007989

UniProt

Q9NPG1

neXtProt

NX_Q9NPG1

Human splice variants
Mouse splice variants

Protein structure