10-3024-25

antibody from ABEOMICS Inc.
Targeting: TLR10 CD290
Provider product page for 10-3024-25

Antibody data

Product number
10-3024-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-TLR10 Antibody
Antibody type
Monoclonal
Description
TLR10 (Toll-Like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1Beta, specifically after exposure to TLR2 ligands. TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. Expression of TLR10 can be induced in B cells, dendritic cells, eosinophils, and neutrophils, as well as on nonimmune cells, such as trophoblasts.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant TLR10
protein (amino acids 100-369) was u
sed as the immunogen for this antib
ody.
Isotype
IgG
Antibody clone number
ABM3C85
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
TLR10 protein structure - 10-3024-25 shown in red.