Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 334504 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#334504, RRID:AB_2204272
- Product name
- Biotin anti-human CD281 (TLR1)
- Antibody type
- Monoclonal
- Antigen
- Human TLR1 transfected Ba/F3
- Description
- Toll-like receptors (TLRs) are type I transmembrane signaling receptors characterized by containing leucine-rich repeats (LRR) extracellular domain and IL-1 receptor like intracellular domain. TLRs are responsible for recognizing pathogen-associated molecule patterns (PAMPs). They are primary sensors of both innate and adaptive immune systems. To date a total of 12 TLRs have been indentified. Toll-like receptor 1 (TLR1), known as CD281, is expressed on monocytes/macrophages, dendritic cells, and granulocytes and some lymphocytes at low levels. By association with TLR2, TLR1 is a coreceptor involved in the response to diverse set of pathogens, such as triacylated lipopeptidess (but not diacylated lipopeptides), peptidoglycans, lipoteichoic acid.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Biotin
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C. Do not freeze.
Submitted references Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells.
Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 2005 Feb 1;174(3):1566-73
Journal of immunology (Baltimore, Md. : 1950) 2005 Feb 1;174(3):1566-73
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood monocytes stained with biotinylated TLR1.136, followed Sav-PE
- Conjugate
- Biotin