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- References [19]
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- Product number
- 12059-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12059-1-AP, RRID:AB_2170454
- Product name
- PSMD14/POH1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PSMD14/POH1 antibody (Cat. #12059-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PSMD14-mediated PFKFB2 deubiquitination activates H3K27 lactylation to drive cancer stemness in gastric adenocarcinoma.
PSMD14 drives lung adenocarcinoma progression through HMMR stabilization and dual activation of TGF-β/Smad and PI3K/AKT/mTOR signaling.
PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region.
IL27RA promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating TGFβR1.
PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.
Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m(6)A modification in triple-negative breast cancer.
Blocking PSMD14-mediated E2F1/ERK/AKT signaling pathways suppresses the progression of anaplastic thyroid cancer.
Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11.
POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis.
Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4.
Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.
The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation.
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa.
Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells.
RPN11 deubiquitinase promotes proliferation and migration of breast cancer cells.
POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.
Zhao X, Li M, Fu Y, Chen C, Chen Y, Xu L, Bao L, Ma Z, Xu J, Zhou S, Qian Y, Wang B, Wang Q, He J, Ding Q, Wang M, Wang Q, Wang Z, Wang S
Cell death and differentiation 2026 Apr;33(4):813-830
Cell death and differentiation 2026 Apr;33(4):813-830
PSMD14 drives lung adenocarcinoma progression through HMMR stabilization and dual activation of TGF-β/Smad and PI3K/AKT/mTOR signaling.
Chen R, Wang S, Xie J
Frontiers in immunology 2025;16:1720799
Frontiers in immunology 2025;16:1720799
PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region.
Takahashi M, Kondo T, Kimura S, Nakazono A, Yoshida S, Wada T, Watanabe M, Hatakeyama S
Journal of biomedical science 2025 Sep 11;32(1):88
Journal of biomedical science 2025 Sep 11;32(1):88
IL27RA promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating TGFβR1.
Zhang Y, Wu Y, Zhang Q, Xiong J, Xiao B, Zuo S
Scientific reports 2025 Oct 30;15(1):37959
Scientific reports 2025 Oct 30;15(1):37959
PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.
Lu RS, Ren LK, Fei XB, Liu SB, Gao YJ, Hou JY, Wang C, Liu P, Zhu CH, Wang X, Pan YZ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e05762
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e05762
Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m(6)A modification in triple-negative breast cancer.
Yu Y, Hu J, Wang W, Lei H, Xi Z, Zhang P, Zhao E, Lu C, Chen H, Liu C, Li L
Science advances 2025 May 9;11(19):eadr3173
Science advances 2025 May 9;11(19):eadr3173
Blocking PSMD14-mediated E2F1/ERK/AKT signaling pathways suppresses the progression of anaplastic thyroid cancer.
Wang Y, Duan Y, Yue K, Li L, Cao J, Shi W, Liu J, Wu Y, Wang X, Jing C
Cellular signalling 2025 Aug;132:111826
Cellular signalling 2025 Aug;132:111826
Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11.
Zhou B, Luo Y, Bi H, Zhang N, Ma M, Dong Z, Ji N, Zhang S, Wang X, Liu Y, Guo X, Wei W, Xie C, Wu L, Wan X, Zheng MH, Zhao B, Li Y, Hu C, Lu Y
Cell metabolism 2024 Oct 1;36(10):2228-2244.e7
Cell metabolism 2024 Oct 1;36(10):2228-2244.e7
POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis.
Yuan Y, Li Y, Wu X, Bo J, Zhang L, Zhang J, Hu Y, Chen Y, Zeng Y, Wei X, Zhang H
Cancer letters 2024 Feb 1;582:216526
Cancer letters 2024 Feb 1;582:216526
Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4.
Jia C, Zhang X, Qu T, Wu X, Li Y, Zhao Y, Sun L, Wang Q
PeerJ 2023;11:e14654
PeerJ 2023;11:e14654
Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.
Zhao Z, Xu H, Wei Y, Sun L, Song Y
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166594
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166594
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.
Jing C, Duan Y, Zhou M, Yue K, Zhuo S, Li X, Liu D, Ye B, Lai Q, Li L, Yao X, Wei H, Zhang W, Wu Y, Wang X
Theranostics 2021;11(6):2655-2669
Theranostics 2021;11(6):2655-2669
The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation.
Jing C, Li X, Zhou M, Zhang S, Lai Q, Liu D, Ye B, Li L, Wu Y, Li H, Yue K, Chen P, Yao X, Wu Y, Duan Y, Wang X
Theranostics 2021;11(12):5847-5862
Theranostics 2021;11(12):5847-5862
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
Xiao M, Liu J, Xiang L, Zhao K, He D, Zeng Q, Zhang Q, Xie D, Deng M, Zhu Y, Zhang Y, Liu Y, Bo H, Liu X, Chen X, Gong L, Bao Y, Hu Y, Cheng Y, Deng L, Zhu R, Xing X, Zhou M, Xiong W, Zhou Y, Zhou J, Li X, Cao K
Clinical and translational medicine 2020 Dec;10(8):e241
Clinical and translational medicine 2020 Dec;10(8):e241
Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa.
Byrd AS, Carmona-Rivera C, O'Neil LJ, Carlucci PM, Cisar C, Rosenberg AZ, Kerns ML, Caffrey JA, Milner SM, Sacks JM, Aliu O, Broderick KP, Reichner JS, Miller LS, Kang S, Robinson WH, Okoye GA, Kaplan MJ
Science translational medicine 2019 Sep 4;11(508)
Science translational medicine 2019 Sep 4;11(508)
Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells.
Ahmed ZSO, Li X, Li F, Cheaito HA, Patel K, Mosallam EM, Elbargeesy GAEH, Dou QP
Journal of cellular biochemistry 2018 Nov;119(11):9006-9016
Journal of cellular biochemistry 2018 Nov;119(11):9006-9016
RPN11 deubiquitinase promotes proliferation and migration of breast cancer cells.
Luo G, Hu N, Xia X, Zhou J, Ye C
Molecular medicine reports 2017 Jul;16(1):331-338
Molecular medicine reports 2017 Jul;16(1):331-338
POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.
Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y
Nature communications 2015 Oct 29;6:8704
Nature communications 2015 Oct 29;6:8704
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.
Sparks A, Dayal S, Das J, Robertson P, Menendez S, Saville MK
Oncogene 2014 Sep 18;33(38):4685-96
Oncogene 2014 Sep 18;33(38):4685-96
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 12059-1-AP(PSMD14 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PSMD14 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PSMD14. This antibody recognizes human, mouse, rat antigen. The PSMD14 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
