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- References [4]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 12557-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12557-1-AP, RRID:AB_2171964
- Product name
- PRMT8 antibody
- Antibody type
- Polyclonal
- Description
- PRMT8 antibody (Cat. #12557-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Discovery of the First-in-Class Protein Arginine Methyltransferase 1 PROTAC Degrader.
A novel 3-alkenylindol-2-one derivative selectively inhibits the growth of acute myeloid leukemia via modulation of the MYC-PRMT pathway.
Ribavirin inhibits cell proliferation and metastasis and prolongs survival in soft tissue sarcomas by downregulating both protein arginine methyltransferases 1 and 5.
Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5.
Guo S, Li J, Lin J, Chen Y, Liu C, Liu H, He Z, Zhu Y, Wang L, Yang F, Luo C, Li Z, Jin J, Ye F
Journal of medicinal chemistry 2026 Mar 26;69(6):6775-6789
Journal of medicinal chemistry 2026 Mar 26;69(6):6775-6789
A novel 3-alkenylindol-2-one derivative selectively inhibits the growth of acute myeloid leukemia via modulation of the MYC-PRMT pathway.
Dong S, Yang R, Wang Y, Fang X, Han X, Gu M, Chen S, Zhang B
Biochemical pharmacology 2025 Oct;240:117111
Biochemical pharmacology 2025 Oct;240:117111
Ribavirin inhibits cell proliferation and metastasis and prolongs survival in soft tissue sarcomas by downregulating both protein arginine methyltransferases 1 and 5.
Zhang Q, Yang R, Tian Y, Ge S, Nan X, Zhu S, Dong S, Zhang B
Basic & clinical pharmacology & toxicology 2022 Jul;131(1):18-33
Basic & clinical pharmacology & toxicology 2022 Jul;131(1):18-33
Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5.
Tian Y, Yang W, Yang R, Zhang Q, Hao L, Bian E, Yang Y, Huang X, Wu Y, Zhang B
Toxicology and applied pharmacology 2022 Jan 15;435:115829
Toxicology and applied pharmacology 2022 Jan 15;435:115829
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 12557-1-AP(PRMT8 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 12557-1-AP(PRMT8 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PRMT8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PRMT8. This antibody recognizes human, mouse, rat antigen. The PRMT8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
