17023-1-AP

antibody from Proteintech Group

Targeting: COL6A1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

17023-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#17023-1-AP, RRID:AB_2229737

Product name

Collagen Type VI antibody

Antibody type

Polyclonal

Description

Collagen Type VI antibody (Cat. #17023-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Endothelial cells sense temozolomide resistance to facilitate monocyte-derived macrophage infiltration in glioblastoma.

Gao W, Huang J, Deng K, Lin X, Long X, Li X, Huang M, Wang X, She X, Liu Q, Wu M
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Jan;84:101329

---

Single-nuclei RNA-sequencing uncovers sexually divergent exercise signatures partially mimicked by TFEB overexpression in mouse skeletal muscle.

Granger K, Liu K, Joseph T, Adler A, Matthews I, Leon J, Baker C, Kim M, Wang H, Han X, Benayoun BA, Cortes CJ
bioRxiv : the preprint server for biology 2026 Jan 26;

---

Redefining the Collagen Composition of Human Fasciae: Emerging Collagen Types and Structural Heterogeneity.

Fede C, Clair C, Petrelli L, Sun Y, Biz C, Angelini A, Ruggieri P, Stecco C
International journal of molecular sciences 2026 Jan 20;27(2)

---

Deficiency of NF-Erythroid 2-Related Factor 2 Exacerbates the Scar Through ERK Signaling Pathway.

Hao X, Sun M, Wang R, Chen H, Huang J, Luo J, Yu H, Li Y, Xing W, Li X, Hu L
Immunity, inflammation and disease 2026 Feb;14(2):e70361

---

Immune microenvironment and fibroblast subpopulation in diabetic wound healing.

Gan J, Chen Y, Tang L, Dong H, Gao X, Huang Y, Pan Y, Hong J, Bai Z, Chen X, Lin Z, Zhu H
iScience 2025 Sep 19;28(9):113440

---

COL6A1, LAPTM5, and ZFAND2A as Crucial Biomolecules Driving Immunoregulation in Human Nucleus Pulposus Degeneration.

Lu ZY, Chen PB, Xu QY, Mardan M, You MJ, Li B, Jiang SD, Jiang LS, Zheng XF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71145

---

Vitamin A-Integrated Cinnamaldehyde Nanoemulsion: A Nanotherapeutic Approach To Counteract Liver Fibrosis via Gut-Liver Axis Modulation.

Niu X, Chang G, Xu N, Li R, Niu B, Mao R, Wang S, Li G, Jiang J, Wang L
ACS nano 2025 Mar 18;19(10):10433-10451

---

Insufficient expression of COL6A1 promotes the development of early-onset severe preeclampsia by inhibiting the APJ/AKT signaling pathway.

Qi G, Gong Y, Li Y, Jin Y, Chi S, Zhang W, Luo X
Cell death discovery 2025 Mar 1;11(1):81

---

Construction and validation of a prognostic nomogram model integrating machine learning-pathomics and clinical features in IDH-wildtype glioblastoma.

Li Y, Ouyang P, Zheng Z, Deng J, Guo A, Wang W, Liu Y, Peng Y, Liao Y, Wang X, Wang H, Wang Z, Mo Z, Weng J, Xv H, Zheng X, Liu J, Wang Y, Cao Y, Huang G, Zhang X, Qi S
Journal of translational medicine 2025 Jun 3;23(1):618

---

Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling.

Hu Y, Chen W, Lan S, Ming C, Xu D, Li H, Xu H, Shi D, Liu W, Dai Z, Wang J, He Z, Xu W, Shao Z, Liu Y, Tian H, Tong W
Nature communications 2025 Dec 17;16(1):11394

---

Mesenteric adipose-derived exosomal TINAGL1 enhances intestinal fibrosis in Crohn's Disease via SMAD4.

Chen Y, Li J, Zhang X, Li S, Cheng Y, Fu X, Li J, Zhu L
Journal of advanced research 2025 Apr;70:139-158

---

Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.

Xu X, Wang Y, Song Q, Zheng H, Lv J, Fu Z, Mao X, Li Y, Wu H, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632

---

Mitochondrial NADK2-dependent NADPH controls Tau oligomer uptake in human neurons.

Pardo E, Kim T, Wallrabe H, Zengeler KE, Sagar VK, Mingledorff G, Sun X, Periasamy A, Lukens JR, Bloom GS, Norambuena A
bioRxiv : the preprint server for biology 2024 Nov 1;

---

DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.

Zhang Z, Hu J
Journal of translational medicine 2024 Jul 3;22(1):617

---

Heterogeneous fibroblasts contribute to fibrotic scar formation after spinal cord injury in mice and monkeys.

Xue X, Wu X, Fan Y, Han S, Zhang H, Sun Y, Yin Y, Yin M, Chen B, Sun Z, Zhao S, Zhang Q, Liu W, Zhang J, Li J, Shi Y, Xiao Z, Dai J, Zhao Y
Nature communications 2024 Jul 27;15(1):6321

---

The mechano-chemical circuit in fibroblasts and dendritic cells drives basal cell proliferation in psoriasis.

Jiang J, Shao X, Liu W, Wang M, Li Q, Wang M, Xiao Y, Li K, Liang H, Wang N, Xu X, Wu Y, Gao X, Xie Q, Xiang X, Liu W, Wu W, Yang L, Gu ZZ, Chen J, Lei M
Cell reports 2024 Jul 23;43(7):114513

---

Proteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection.

Jiang N, Chen Y, Li T, Sun Y, Su Y, Wang Y, Shen Y, Cao J
PLoS neglected tropical diseases 2024 Dec;18(12):e0012659

---

Schwann cell derived pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma.

Tian Z, Du Z, Bai G, Gong Q, You Y, Xu G, Liu J, Xiao M, Wang Y, He Y
Cancer gene therapy 2024 Apr;31(4):627-640

---

Sarcoma Cells Secrete Hypoxia-Modified Collagen VI to Weaken the Lung Endothelial Barrier and Promote Metastasis.

Liu Y, Murazzi I, Fuller AM, Pan H, Irizarry-Negron VM, Devine A, Katti R, Skuli N, Ciotti GE, Pak K, Pack MA, Simon MC, Weber K, Cooper K, Eisinger-Mathason TSK
Cancer research 2024 Apr 1;84(7):977-993

---

Exon-Skipping for a Pathogenic COL6A1 Variant in Ullrich Congenital Muscular Dystrophy.

Aguti S, Guirguis F, Bönnemann C, Muntoni F, Bolduc V, Zhou H
Methods in molecular biology (Clifton, N.J.) 2023;2587:387-407

---

High expression of COL6A1 predicts poor prognosis and response to immunotherapy in bladder cancer.

Zhang X, Liu J, Yang X, Jiao W, Shen C, Zhao X, Wang Y
Cell cycle (Georgetown, Tex.) 2023 Mar;22(5):610-618

---

Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation.

Chen G, Tang Q, Yu S, Shen Y, Sun J, Peng J, Yin Y, Feng G, Lu X, Mei G, Zhang Y, Wan Q, Zhang L, Chen L
Cell death and differentiation 2023 Jun;30(6):1503-1516

---

Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.

Chen WJ, Zhuang Y, Peng W, Cui W, Zhang SJ, Wang JW
Chinese medicine 2023 Jun 29;18(1):80

---

Chronic intermittent hypoxia impaired collagen synthesis in mouse genioglossus via ROS accumulation: A transcriptomic analysis.

Zhang MH, Han XX, Lu Y, Deng JJ, Zhang WH, Mao JQ, Mi J, Ding WH, Wu MJ, Yu LM, Liu YH
Respiratory physiology & neurobiology 2023 Feb;308:103980

---

In vivo rAAV-mediated human TGF-β overexpression reduces perifocal osteoarthritis and improves osteochondral repair in a large animal model at one year.

Schrenker S, Cucchiarini M, Goebel L, Oláh T, Venkatesan JK, Schmitt G, Speicher-Mentges S, Maihöfer J, Gao L, Zurakowski D, Menger MD, Laschke MW, Madry H
Osteoarthritis and cartilage 2023 Apr;31(4):467-481

---

Extracellular Matrix-Oriented Proteomic Analysis of Periodontal Ligament Under Mechanical Stress.

Thant L, Kaku M, Kakihara Y, Mizukoshi M, Kitami M, Arai M, Kitami K, Kobayashi D, Yoshida Y, Maeda T, Saito I, Uoshima K, Saeki M
Frontiers in physiology 2022;13:899699

---

Electroacupuncture remodels the extracellular matrix and promotes synaptic plasticity in a mouse model of depression.

Feng Y, Zhu G, Chen R, Shi G, Peng M, Zhou Y, Fu W, Zhou P
Biochemical and biophysical research communications 2022 Oct 20;626:44-50

---

Skeletal muscle proteome expression differentiates severity of cancer cachexia in mice and identifies loss of fragile X mental retardation syndrome-related protein 1.

Khamoui AV, Tokmina-Roszyk D, Feresin RG, Fields GB, Visavadiya NP
Proteomics 2022 May;22(10):e2100157

---

Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.

Liu X, Li N, Zhang C, Wu X, Zhang S, Dong G, Liu G
Translational oncology 2022 May;19:101389

---

Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility.

Ouni E, Nedbal V, Da Pian M, Cao H, Haas KT, Peaucelle A, Van Kerk O, Herinckx G, Marbaix E, Dolmans MM, Tuuri T, Otala M, Amorim CA, Vertommen D
Matrix biology : journal of the International Society for Matrix Biology 2022 May;109:91-120

---

Coaxial structured drug loaded dressing combined with induced stem cell differentiation for enhanced wound healing.

Gao C, Zhang L, Wang J, Cheng Y, Chen Z, Yang R, Zhao G
Biomaterials advances 2022 Mar;134:112542

---

The β8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development.

De A, Morales JE, Chen Z, Sebastian S, McCarty JH
Development (Cambridge, England) 2022 Mar 15;149(6)

---

Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts.

He ZQ, Yuan XW, Lu ZB, Li YH, Li YF, Liu X, Wang L, Zhang Y, Zhou Q, Li W
Fundamental research 2022 Jan;2(1):37-47

---

Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis.

Angelini A, Ortiz-Urbina J, Trial J, Reddy AK, Malovannaya A, Jain A, Entman ML, Taffet GE, Cieslik KA
American journal of physiology. Heart and circulatory physiology 2022 Aug 1;323(2):H285-H300

---

Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis.

Li M, Li X, Liu B, Lv L, Wang W, Gao D, Zhang Q, Jiang J, Chai M, Yun Z, Tan Y, Gong F, Wu Z, Zhu Y, Ma J, Leng L
Frontiers in cell and developmental biology 2021;9:783456

---

Gapmer Antisense Oligonucleotides to Selectively Suppress the Mutant Allele in COL6A Genes in Dominant Ullrich Congenital Muscular Dystrophy.

Aguti S, Marrosu E, Muntoni F, Zhou H
Methods in molecular biology (Clifton, N.J.) 2020;2176:221-230

---

MYCT1 Inhibits the Adhesion and Migration of Laryngeal Cancer Cells Potentially Through Repressing Collagen VI.

Wang PP, Ding SY, Sun YY, Li YH, Fu WN
Frontiers in oncology 2020;10:564733

---

Differentiation of diabetic foot ulcer-derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes.

Kashpur O, Smith A, Gerami-Naini B, Maione AG, Calabrese R, Tellechea A, Theocharidis G, Liang L, Pastar I, Tomic-Canic M, Mooney D, Veves A, Garlick JA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1262-1277

---

Priming integrin α5 promotes human dental pulp stem cells odontogenic differentiation due to extracellular matrix deposition and amplified extracellular matrix-receptor activity.

Wang H, Ning T, Song C, Luo X, Xu S, Zhang X, Deng Z, Ma D, Wu B
Journal of cellular physiology 2019 Aug;234(8):12897-12909

---

Proteomic analysis of mouse ovaries during the prepubertal stages.

Xiong J, Wu M, Zhang Q, Zhang C, Xiong G, Ma L, Lu Z, Wang S
Experimental cell research 2019 Apr 15;377(1-2):36-46

---

Differential effect of extracellular matrix derived from papillary and reticular fibroblasts on epidermal development in vitro.

Janson D, Rietveld M, Mahé C, Saintigny G, El Ghalbzouri A
European journal of dermatology : EJD 2017 Jun 1;27(3):237-246

---

Authentication of collagen VI antibodies.

Endicott J, Holden P, Fitzgerald J
BMC research notes 2017 Jul 29;10(1):358

---

Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI).

García-Palmero I, Torres S, Bartolomé RA, Peláez-García A, Larriba MJ, Lopez-Lucendo M, Peña C, Escudero-Paniagua B, Muñoz A, Casal JI
Oncogene 2016 Oct 6;35(40):5224-5236

---

Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients.

Wan F, Wang H, Shen Y, Zhang H, Shi G, Zhu Y, Dai B, Ye D
Oncotarget 2015 Sep 29;6(29):27378-87

---

Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth.

Zhu YP, Wan FN, Shen YJ, Wang HK, Zhang GM, Ye DW
Oncotarget 2015 Jun 10;6(16):14488-96

---

A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation.

Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A
PloS one 2013;8(9):e74469

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 17023-1-AP(COL6A1 antibody) at dilution of 1:500

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human kidney using 17023-1-AP(COL6A1 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human kidney using 17023-1-AP(COL6A1 antibody) at dilution of 1:100 (under 40x lens)

Sample type

tissue