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- Product number
- 24206-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- DNMT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DNMT1 antibody (Cat. #24206-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting CPS1 attenuates lung cancer metastasis by regulating EMT through an epigenetic mechanism.
HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
Epigenetic reprogramming by organic arsenic CZ2 elicits potent antitumor responses in DLBCL through TMS1 restoration.
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Shexiang Tongxin dropping pills attenuate cardiac remodeling in myocardial infarction rats by inhibiting Glycolysis via ITGB2 methylation.
Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation.
Inhibition of KAT6A enhances immunotherapy efficacy in colorectal cancer by activating interferon response.
PARP1 promoter hypermethylation promotes arsenic-induced skin damage by driving telomere dysfunction-mediated keratinocyte senescence.
Maternal exposure to high level of ursodeoxycholic acid during pregnancy promotes hepatic lipid deposition in the offspring by reducing the methylation level of Fasn gene.
Arsenic promotes ROS-mediated malignant transformation of bronchial epithelial cells by specifically downregulating TXNL1 expression.
Genome-wide analysis reveals porcine LIFR regulated by DNA methylation promotes the implantation process via the STAT3 signaling.
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
C1q(+) Macrophage-Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma.
Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes.
Integrated Mendelian Randomization and Single-Cell Transcriptomics Analysis Identifies Critical Blood Biomarkers and Potential Mechanisms in Epilepsy.
IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A.
Inhibition of DNA Methyltransferase DNMT1 Reverses Th2 Response Polarisation and Alleviates Allergic Rhinitis.
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer.
Raddeanin A suppresses intracellular (5)Methylcytosine DNA modification engaged the metastasis of hepatocellular carcinoma.
The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress.
Neuronal hyperactivity becomes mTORC1 independent due to transcriptional changes in tuberous sclerosis complex disease models.
DNMT1 deficiency promotes pulmonary vascular remodeling in pulmonary hypertension through epigenetic upregulation of BMP7.
ZNF831-YTHDF1-DNMT1/3a feedback loop regulates lung carcinogenesis and progression through WNT7B-FZD5-β-catenin signalling axis.
Decitabine-Driven Foetal Haemoglobin Induction in Townes Mice and Human Erythroblasts.
Hypoxia Inhibitor Improves Iodine Uptake Disorder in Thyroid Cancer Through the hsa_circ_0023990/miR-448/DNMT1/NIS Axis.
NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming.
Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts.
Identification of DNA methylation-regulated WEE1 with potential implications in prognosis and immunotherapy for low-grade glioma.
Long non-coding RNA SIX1-1 promotes proliferation of cervical cancer cells via negative transcriptional regulation of RASD1.
KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer.
The role of DNA damage response in human embryonic stem cells exposed to atmospheric oxygen tension: Implications for embryo development and differentiation.
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis.
In ovo betaine injection improves breast muscle growth in newly hatched goslings through FXR/IGF-2 pathway.
Clitocine enhances the drug sensitivity of colon cancer cells by promoting FBXW7-mediated MCL-1 degradation via inhibiting the A2B/cAMP/ERK axis.
Milk derived extracellular vesicle uptake in human microglia regulates the DNA methylation machinery : Short title: milk-derived extracellular vesicles and the epigenetic machinery.
Histone MARylation regulates lipid metabolism in colorectal cancer by promoting IGFBP1 methylation.
Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.
5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells.
Parental betaine supplementation promotes gosling growth with epigenetic modulation of IGF gene family in the liver.
Efficacy of Yisui granule on myelodysplastic syndromes in SKM-1 mouse xenograft model through suppressing Wnt/β-catenin signaling pathway.
DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development.
The Immunohistochemical Profile of Mammary Tissue in Women With Macromastia and Its Potential Clinical Implications.
HOXD1 inhibits lung adenocarcinoma progression and is regulated by DNA methylation.
DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3.
Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5.
Vpr driving DNA methylation variation of CD4 + T cells in HIV-1 infection.
LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter.
Hypermethylation of microRNA-497-3p contributes to progression of thyroid cancer through activation of PAK1/β-catenin.
Cyhexatin causes developmental toxic effects by disrupting endocrine system and inducing behavioral inhibition, apoptosis and DNA hypomethylation in zebrafish (Danio rerio) larvae.
NARFL deficiency caused mitochondrial dysfunction in lung cancer cells by HIF-1α-DNMT1 axis.
DNA Methylation Dynamics During Esophageal Epithelial Regeneration Following Repair with Acellular Silk Fibroin Grafts in Rat.
Triptolide inhibits T-cell acute lymphoblastic leukaemia by affecting aberrant epigenetic events in the Wnt signalling pathway.
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis.
The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy.
Crosstalk between 5-methylcytosine and N(6)-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma.
Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion.
EBV infection of primary colonic epithelial cells causes inflammation, DDR and autophagy dysregulation, effects that may predispose to IBD and carcinogenesis.
High glucose environment induces NEDD4 deficiency that impairs angiogenesis and diabetic wound healing.
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease.
Lenvatinib inhibited HCC cell migration and invasion through regulating the transcription and ubiquitination of UHRF1 and DNMT1.
Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms.
Organic cation transporter 2 activation enhances sensitivity to oxaliplatin in human pancreatic ductal adenocarcinoma.
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis.
DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling.
Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma.
In ovo injection of betaine promotes adrenal steroidogenesis in pre-hatched chicken fetuses.
LPS-pretreatment adipose-derived mesenchymal stromal cells promote wound healing in diabetic rats by improving angiogenesis.
ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation.
Hypermethylation of PRKCZ Regulated by E6 Inhibits Invasion and EMT via Cdc42 in HPV-Related Head and Neck Squamous Cell Carcinoma.
FAM107A Inactivation Associated with Promoter Methylation Affects Prostate Cancer Progression through the FAK/PI3K/AKT Pathway.
Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.
Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury.
DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma.
Detection of the level of DNMT1 based on self-assembled probe signal amplification technique in plasma.
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Mechanical force inhibited hPDLSCs proliferation with the downregulation of MIR31HG via DNA methylation.
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis.
DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice.
NNK-mediated upregulation of DEPDC1 stimulates the progression of oral squamous cell carcinoma by inhibiting CYP27B1 expression.
SMYD2 suppresses APC2 expression to activate the Wnt/β-catenin pathway and promotes epithelial-mesenchymal transition in colorectal cancer.
Small Molecule Inhibitor C188-9 Synergistically Enhances the Demethylated Activity of Low-Dose 5-Aza-2'-Deoxycytidine Against Pancreatic Cancer.
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.
Long noncoding RNA PVT1 promoted gallbladder cancer proliferation by epigenetically suppressing miR-18b-5p via DNA methylation.
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p.
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Nanosecond pulsed electric fields enhance mesenchymal stem cells differentiation via DNMT1-regulated OCT4/NANOG gene expression.
Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas.
DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.
LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop.
Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA†.
Dietary betaine activates hepatic VTGII expression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression.
Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation.
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
Mechanism of prolactin inhibition of miR-135b via methylation in goat mammary epithelial cells.
Melatonin-induced increase of lipid droplets accumulation and in vitro maturation in porcine oocytes is mediated by mitochondrial quiescence.
The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.
In Vivo Ovarian Cancer Gene Therapy Using CRISPR-Cas9.
Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.
Regulatory Axis of miR-195/497 and HMGA1-Id3 Governs Muscle Cell Proliferation and Differentiation.
Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.
Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation.
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
HIC1 epigenetically represses CIITA transcription in B lymphocytes.
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.
In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.
Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.
Ding Y, Tian Y, Li M, Fu Y, Wang T, Du X, Wang M, Dong L, Gao F, Liu B, Lu Y, Zhang C, Mao L, Jiang J, Li L, Liao L, Li K
Theranostics 2026;16(4):1740-1761
Theranostics 2026;16(4):1740-1761
HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
Wang Y, Xiong Y, Liu S, Bao L, Qiu X, Korboukh I, Song X, Toffessi Tcheuyap V, Wu S, Chen M, Brugarolas J, Jin J, Wang Y, Luo W
Cell reports. Medicine 2026 Mar 17;7(3):102630
Cell reports. Medicine 2026 Mar 17;7(3):102630
Epigenetic reprogramming by organic arsenic CZ2 elicits potent antitumor responses in DLBCL through TMS1 restoration.
Mei W, Zhang M, Zhang D
Bioorganic chemistry 2026 Jun 15;174:109734
Bioorganic chemistry 2026 Jun 15;174:109734
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Xu G, Guo F, He C, Wang X, Xiang B, Fan L, Chen B, Peng J, Sun Y, Shi J, Xing X, Yao Y, Dai P, Li H, Xiong W, Liu H, Xiao R, Qing G, Jiang C, Jiang B, Lei X, Zhang J
Nature cancer 2026 Feb;7(2):283-303
Nature cancer 2026 Feb;7(2):283-303
Shexiang Tongxin dropping pills attenuate cardiac remodeling in myocardial infarction rats by inhibiting Glycolysis via ITGB2 methylation.
Xu X, Sun L, Zhang H, Pan H, Zhai C
Cytotechnology 2026 Apr;78(2):53
Cytotechnology 2026 Apr;78(2):53
Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation.
Gañez-Zapater A, Kourtis S, Elbæk CR, Espinar L, Toro-Márquez C, Coll-Manzano A, Smiriglia A, García-López L, Wiegand L, Guirola M, Fontaine F, Morandi A, Müller AC, Sdelci S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 21;:e01083
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 21;:e01083
Inhibition of KAT6A enhances immunotherapy efficacy in colorectal cancer by activating interferon response.
Han S, Chen Z, Hong C, Dang T, Bai F, Ruan Y, Yang R, Yu X, Li Y, Wang B, Ma Y, Chen F, Xiong R, Zhang Y, Liu C
Cancer letters 2025 Oct 28;631:217946
Cancer letters 2025 Oct 28;631:217946
PARP1 promoter hypermethylation promotes arsenic-induced skin damage by driving telomere dysfunction-mediated keratinocyte senescence.
Yang L, Wang W, Zhang A
Ecotoxicology and environmental safety 2025 Oct 1;304:119108
Ecotoxicology and environmental safety 2025 Oct 1;304:119108
Maternal exposure to high level of ursodeoxycholic acid during pregnancy promotes hepatic lipid deposition in the offspring by reducing the methylation level of Fasn gene.
Hu D, Wu X, Hou M, Song P, Chen Q, Ni Y
Biochemical pharmacology 2025 Nov;241:117156
Biochemical pharmacology 2025 Nov;241:117156
Arsenic promotes ROS-mediated malignant transformation of bronchial epithelial cells by specifically downregulating TXNL1 expression.
Zhao L, Jiao X, Li H, Chang Y, Li M, Liu Y, Xie Q, Huang C, Huang H
Communications biology 2025 Nov 22;8(1):1827
Communications biology 2025 Nov 22;8(1):1827
Genome-wide analysis reveals porcine LIFR regulated by DNA methylation promotes the implantation process via the STAT3 signaling.
Zhou C, Huang S, Zheng S, Pius L, Liu M, Xu D
International journal of biological macromolecules 2025 Mar;295:139450
International journal of biological macromolecules 2025 Mar;295:139450
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Xu Y, You J, Yao J, Hou B, Wang W, Hao Z
Urolithiasis 2025 Mar 29;53(1):61
Urolithiasis 2025 Mar 29;53(1):61
C1q(+) Macrophage-Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma.
Liu Y, Huang C, Luo M, Lu W, Zhang B, Bai L, Zheng S, Tan Y, Li S, Wang H, Gong L, Guan X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503434
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503434
Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes.
Patel D, Tiusanen V, Karttunen K, Pihlajamaa P, Sahu B
Communications biology 2025 Jul 3;8(1):992
Communications biology 2025 Jul 3;8(1):992
Integrated Mendelian Randomization and Single-Cell Transcriptomics Analysis Identifies Critical Blood Biomarkers and Potential Mechanisms in Epilepsy.
Shi J, Xie J, Yang Y, Fu B, Ye Z, Tang T, Liu Q, Xu J, Wei P, Shan Y, Zhao G
CNS neuroscience & therapeutics 2025 Jan;31(1):e70172
CNS neuroscience & therapeutics 2025 Jan;31(1):e70172
IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A.
Wang X, Yang Y, Zhou X, Yu S, Luo X, Lu L, Gao Z, Yang J
Cell death discovery 2025 Jan 16;11(1):9
Cell death discovery 2025 Jan 16;11(1):9
Inhibition of DNA Methyltransferase DNMT1 Reverses Th2 Response Polarisation and Alleviates Allergic Rhinitis.
Zou P, Li J, Li J, Wang J
Clinical and experimental pharmacology & physiology 2025 Feb;52(2):e70015
Clinical and experimental pharmacology & physiology 2025 Feb;52(2):e70015
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer.
Li L, Zhao L, Zhou D, Yu Y, Zhang P, Zheng J, Lin Z, Yu D, Ren J, Zhang J, Zhou P, Zhang D, Zhang T
Journal for immunotherapy of cancer 2025 Feb 25;13(2)
Journal for immunotherapy of cancer 2025 Feb 25;13(2)
Raddeanin A suppresses intracellular (5)Methylcytosine DNA modification engaged the metastasis of hepatocellular carcinoma.
Liu X, Xie X, Wang K, Liu X, Gong J, Yang Z, Li J
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119036
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119036
The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress.
Chen Y, Qiang G, Jin L, Sun Y, Zhang G, Hu F, Feng J, Wei F, Zeng S, Xue L, Zeng H, Ma S
Redox report : communications in free radical research 2025 Dec;30(1):2588086
Redox report : communications in free radical research 2025 Dec;30(1):2588086
Neuronal hyperactivity becomes mTORC1 independent due to transcriptional changes in tuberous sclerosis complex disease models.
Afshar-Saber W, Ruiz JF, Gisser I, Yang Z, Mehendale L, Teaney NA, Hobson R, Glass MR, Pham TT, Bainbridge E, Sahin M, Winden KD
Cell reports 2025 Dec 23;44(12):116664
Cell reports 2025 Dec 23;44(12):116664
DNMT1 deficiency promotes pulmonary vascular remodeling in pulmonary hypertension through epigenetic upregulation of BMP7.
Wang YB, Gao L, Wang JX, Mei Z, Fan YL, Gao X, Huang J, Sun BF, Gao YF, Sun N, Zheng XD, Wu BX
Respiratory research 2025 Dec 16;27(1):72
Respiratory research 2025 Dec 16;27(1):72
ZNF831-YTHDF1-DNMT1/3a feedback loop regulates lung carcinogenesis and progression through WNT7B-FZD5-β-catenin signalling axis.
Chen D, Chen H, Zeng Y, Shi Y, Guo F, Fan J, Zhang Z, Zhou S, Wang N, Deng S, Liu J, Cao J, Liu W
Free radical biology & medicine 2025 Dec 16;241:338-352
Free radical biology & medicine 2025 Dec 16;241:338-352
Decitabine-Driven Foetal Haemoglobin Induction in Townes Mice and Human Erythroblasts.
Carol Illa A, Chin DWL, Clark M, Petersen J, Skov S, Glenthøj A, Ley CD
EJHaem 2025 Aug;6(4):e70120
EJHaem 2025 Aug;6(4):e70120
Hypoxia Inhibitor Improves Iodine Uptake Disorder in Thyroid Cancer Through the hsa_circ_0023990/miR-448/DNMT1/NIS Axis.
Gou R, Chen S, Lei Y, Wu P, Chen X, Zhang Q
Cancer science 2025 Aug;116(8):2113-2124
Cancer science 2025 Aug;116(8):2113-2124
NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming.
Li H, Gong T, Zhao Y, Luo Y, Tang S, Wang T, Lin H, Zhong M
Cancer & metabolism 2025 Aug 14;13(1):37
Cancer & metabolism 2025 Aug 14;13(1):37
Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts.
Peng G, Zhong L, Luo L, Ju Y, Lu Y, Ng L, Foo DC, Cheng F, Huang L, Ouyang M
Journal of translational medicine 2025 Aug 13;23(1):902
Journal of translational medicine 2025 Aug 13;23(1):902
Identification of DNA methylation-regulated WEE1 with potential implications in prognosis and immunotherapy for low-grade glioma.
Zhong WJ, Zhang LZ, Yue F, Yuan L, Zhang Q, Li X, Lin L
Cancer biomarkers : section A of Disease markers 2024;40(3-4):297-317
Cancer biomarkers : section A of Disease markers 2024;40(3-4):297-317
Long non-coding RNA SIX1-1 promotes proliferation of cervical cancer cells via negative transcriptional regulation of RASD1.
Hu X, Wang W, Ma T, Zhang W, Tang X, Zheng Y, Zheng X
Human cell 2024 Sep;37(5):1446-1461
Human cell 2024 Sep;37(5):1446-1461
KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer.
Zhao Y, Zheng Y, Fu J, Zhang J, Shao H, Liu S, Lai J, Zhou X, Liang R, Jia L, Cui W, Yang J, Wu C, Wang L
British journal of cancer 2024 Sep;131(4):655-667
British journal of cancer 2024 Sep;131(4):655-667
The role of DNA damage response in human embryonic stem cells exposed to atmospheric oxygen tension: Implications for embryo development and differentiation.
Zhou Y, Ye F, Zhang L, Kang Q, Luo Y, Jiang N, Lou L, Mao Y, Wang L, Jin F
Reproductive toxicology (Elmsford, N.Y.) 2024 Sep;128:108648
Reproductive toxicology (Elmsford, N.Y.) 2024 Sep;128:108648
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis.
Zhao S, Hao S, Zhou J, Chen X, Zhang T, Qi Z, Zhang T, Jalal S, Zhai C, Yin L, Bo Y, Teng H, Wang Y, Gao D, Zhang H, Huang L
Cellular & molecular biology letters 2024 Sep 27;29(1):125
Cellular & molecular biology letters 2024 Sep 27;29(1):125
In ovo betaine injection improves breast muscle growth in newly hatched goslings through FXR/IGF-2 pathway.
Ma S, Liu J, Zhao Y, Wang Y, Zhao R
Poultry science 2024 Oct;103(10):104075
Poultry science 2024 Oct;103(10):104075
Clitocine enhances the drug sensitivity of colon cancer cells by promoting FBXW7-mediated MCL-1 degradation via inhibiting the A2B/cAMP/ERK axis.
Ruan F, Ruan Y, Gu H, Sun J, Chen Q
American journal of physiology. Cell physiology 2024 Oct 1;327(4):C884-C900
American journal of physiology. Cell physiology 2024 Oct 1;327(4):C884-C900
Milk derived extracellular vesicle uptake in human microglia regulates the DNA methylation machinery : Short title: milk-derived extracellular vesicles and the epigenetic machinery.
Wijenayake S, Eisha S, Purohit MK, McGowan PO
Scientific reports 2024 Nov 19;14(1):28630
Scientific reports 2024 Nov 19;14(1):28630
Histone MARylation regulates lipid metabolism in colorectal cancer by promoting IGFBP1 methylation.
Wang C, Tang Y, Zhang S, Li M, Li Q, Xiao M, Yang L, Wang Y
Experimental cell research 2024 Nov 1;443(1):114308
Experimental cell research 2024 Nov 1;443(1):114308
Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.
Liang Q, Jing J, He H, Huang X, Liu J, Wang M, Qi Z, Zhang L, Huang Z, Yan Y, Liu S, Gao M, Zou Y
Environment international 2024 May;187:108672
Environment international 2024 May;187:108672
5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells.
Di Crosta M, Arena A, Benedetti R, Gilardini Montani MS, Cirone M
Current issues in molecular biology 2024 Mar 14;46(3):2468-2479
Current issues in molecular biology 2024 Mar 14;46(3):2468-2479
Parental betaine supplementation promotes gosling growth with epigenetic modulation of IGF gene family in the liver.
Ma S, Wang Y, Chen L, Wang W, Zhuang X, Liu Y, Zhao R
Journal of animal science 2024 Jan 3;102
Journal of animal science 2024 Jan 3;102
Efficacy of Yisui granule on myelodysplastic syndromes in SKM-1 mouse xenograft model through suppressing Wnt/β-catenin signaling pathway.
Jieya WU, Li H, Xiaoyuan Z, Gullen E, Chong G, Jing W
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Feb;44(1):78-87
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Feb;44(1):78-87
DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development.
Ghosh K, Zhou JJ, Shao JY, Chen SR, Pan HL
The Journal of biological chemistry 2024 Feb;300(2):105597
The Journal of biological chemistry 2024 Feb;300(2):105597
The Immunohistochemical Profile of Mammary Tissue in Women With Macromastia and Its Potential Clinical Implications.
Antoszewski B, Kasielska-Trojan A, Jones TE, Danilewicz M, Jones MW
Endocrinology 2024 Feb 20;165(4)
Endocrinology 2024 Feb 20;165(4)
HOXD1 inhibits lung adenocarcinoma progression and is regulated by DNA methylation.
Hu X, Zhang S, Zhang X, Liu H, Diao Y, Li L
Oncology reports 2024 Dec;52(6)
Oncology reports 2024 Dec;52(6)
DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3.
Yao W, Shang L, Wang Y, Xu L, Bai Y, Feng M, Jia X, Wu S
Journal of translational medicine 2024 Dec 31;22(1):1167
Journal of translational medicine 2024 Dec 31;22(1):1167
Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5.
Shi Z, Zhao T, Li D, Wang C, Luo Y, Zheng Y
Molecular immunology 2024 Apr;168:51-63
Molecular immunology 2024 Apr;168:51-63
Vpr driving DNA methylation variation of CD4 + T cells in HIV-1 infection.
Wang P, Meng Z, Deng K, Gao Z, Cai J
Virology journal 2024 Apr 26;21(1):97
Virology journal 2024 Apr 26;21(1):97
LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter.
Ren G, Li H, Hong D, Hu F, Jin R, Wu S, Sun W, Jin H, Zhao L, Zhang X, Liu D, Huang C, Huang H
BMC cancer 2023 Sep 23;23(1):898
BMC cancer 2023 Sep 23;23(1):898
Hypermethylation of microRNA-497-3p contributes to progression of thyroid cancer through activation of PAK1/β-catenin.
Fan Y, Fan X, Yan H, Liu Z, Wang X, Yuan Q, Xie J, Lu X, Yang Y
Cell biology and toxicology 2023 Oct;39(5):1979-1994
Cell biology and toxicology 2023 Oct;39(5):1979-1994
Cyhexatin causes developmental toxic effects by disrupting endocrine system and inducing behavioral inhibition, apoptosis and DNA hypomethylation in zebrafish (Danio rerio) larvae.
Jiao F, Zhao Y, Limbu SM, Kong L, Zhang D, Liu X, Yang S, Gui W, Rong H
Chemosphere 2023 Oct;339:139769
Chemosphere 2023 Oct;339:139769
NARFL deficiency caused mitochondrial dysfunction in lung cancer cells by HIF-1α-DNMT1 axis.
Liu H, Wu X, Yang T, Wang C, Huang F, Xu Y, Peng J
Scientific reports 2023 Oct 11;13(1):17176
Scientific reports 2023 Oct 11;13(1):17176
DNA Methylation Dynamics During Esophageal Epithelial Regeneration Following Repair with Acellular Silk Fibroin Grafts in Rat.
Urban LA, Li J, Gundogdu G, Trinh A, Shao H, Nguyen T, Mauney JR, Downing TL
Advanced biology 2023 May;7(5):e2200160
Advanced biology 2023 May;7(5):e2200160
Triptolide inhibits T-cell acute lymphoblastic leukaemia by affecting aberrant epigenetic events in the Wnt signalling pathway.
Ma Y, Li Y, Huang M, Meng Y
Journal of chemotherapy (Florence, Italy) 2023 May;35(3):240-249
Journal of chemotherapy (Florence, Italy) 2023 May;35(3):240-249
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis.
Liu B, Song A, Gui P, Wang J, Pan Y, Li C, Li S, Zhang Y, Jiang T, Xu Y, Pei D, Song J
Cell death & disease 2023 Jul 14;14(7):427
Cell death & disease 2023 Jul 14;14(7):427
The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy.
Zhao L, Xu H, Liu X, Cheng Y, Xie J
Journal of translational medicine 2023 Jul 10;21(1):455
Journal of translational medicine 2023 Jul 10;21(1):455
Crosstalk between 5-methylcytosine and N(6)-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma.
Tian Y, Xiao H, Yang Y, Zhang P, Yuan J, Zhang W, Chen L, Fan Y, Zhang J, Cheng H, Deng T, Yang L, Wang W, Chen G, Wang P, Gong P, Niu X, Zhang X
Molecular cancer 2023 Jan 10;22(1):5
Molecular cancer 2023 Jan 10;22(1):5
Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion.
Fu Y, Song Y, Zhang J, Wei LP, Sun XR
Journal of reproductive immunology 2023 Feb;155:103784
Journal of reproductive immunology 2023 Feb;155:103784
EBV infection of primary colonic epithelial cells causes inflammation, DDR and autophagy dysregulation, effects that may predispose to IBD and carcinogenesis.
Santarelli R, Evangelista L, Pompili C, Lo Presti S, Rossi A, Arena A, Gaeta A, Gonnella R, Gilardini Montani MS, Cirone M
Virus research 2023 Dec;338:199236
Virus research 2023 Dec;338:199236
High glucose environment induces NEDD4 deficiency that impairs angiogenesis and diabetic wound healing.
Guo Y, Wang Y, Liu H, Jiang X, Lei S
Journal of dermatological science 2023 Dec;112(3):148-157
Journal of dermatological science 2023 Dec;112(3):148-157
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease.
Liu Q, Zhu D, Li N, Chen S, Hu L, Yu J, Xiong Y
The EMBO journal 2023 Aug 1;42(15):e113410
The EMBO journal 2023 Aug 1;42(15):e113410
Lenvatinib inhibited HCC cell migration and invasion through regulating the transcription and ubiquitination of UHRF1 and DNMT1.
Fang T, Jiao Z, You Y, Cao J, Wang C, Liu J, Zhao W
Biochemical pharmacology 2023 Apr;210:115489
Biochemical pharmacology 2023 Apr;210:115489
Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms.
Cao YL, -Zhu L, Zhang H, Meng JH, Wu HJ, Wang X, Wu JH, Zou JL, Fang MS, An J, Chen YG
Frontiers in pharmacology 2022;13:888522
Frontiers in pharmacology 2022;13:888522
Organic cation transporter 2 activation enhances sensitivity to oxaliplatin in human pancreatic ductal adenocarcinoma.
Chiu CF, Park JM, Chen HH, Mau CZ, Chen PS, Su YH, Chen HA, Liu YR, Hsieh TH, Chiu CC, Hung SW, Kuo CY, Chen YM, Chang CF
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113520
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113520
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis.
Wang J, Xie SA, Li N, Zhang T, Yao W, Zhao H, Pang W, Han L, Liu J, Zhou J
Bioactive materials 2022 Nov;17:406-424
Bioactive materials 2022 Nov;17:406-424
DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling.
Li Y, Tang C, Liu F, Zhu C, Liu F, Zhu P, Wang L
Development (Cambridge, England) 2022 May 15;149(10)
Development (Cambridge, England) 2022 May 15;149(10)
Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma.
Feng X, Guo J, An G, Wu Y, Liu Z, Meng B, He N, Zhao X, Chen S, Zhu Y, Xia J, Li X, Yu Z, Li R, Ren G, Chen J, Wu M, He Y, Qiu L, Zhou J, Zhou W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(9):e2104491
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(9):e2104491
In ovo injection of betaine promotes adrenal steroidogenesis in pre-hatched chicken fetuses.
Abobaker H, Omer NA, Hu Y, Idriss AA, Zhao R
Poultry science 2022 Jun;101(6):101871
Poultry science 2022 Jun;101(6):101871
LPS-pretreatment adipose-derived mesenchymal stromal cells promote wound healing in diabetic rats by improving angiogenesis.
Wang K, Chen Z, Jin L, Zhao L, Meng L, Kong F, He C, Kong F, Zheng L, Liang F
Injury 2022 Dec;53(12):3920-3929
Injury 2022 Dec;53(12):3920-3929
ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation.
Meng J, Cai H, Sun Y, Wen S, Wu H, Ren D
Cellular oncology (Dordrecht, Netherlands) 2022 Dec;45(6):1421-1434
Cellular oncology (Dordrecht, Netherlands) 2022 Dec;45(6):1421-1434
Hypermethylation of PRKCZ Regulated by E6 Inhibits Invasion and EMT via Cdc42 in HPV-Related Head and Neck Squamous Cell Carcinoma.
Wang HF, Jiang J, Wu JS, Zhang M, Pang X, Dai L, Tang YL, Liang XH
Cancers 2022 Aug 27;14(17)
Cancers 2022 Aug 27;14(17)
FAM107A Inactivation Associated with Promoter Methylation Affects Prostate Cancer Progression through the FAK/PI3K/AKT Pathway.
Ke S, Liu Z, Wang Q, Zhai G, Shao H, Yu X, Guo J
Cancers 2022 Aug 13;14(16)
Cancers 2022 Aug 13;14(16)
Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.
Han J, Chen X, Xu J, Chu L, Li R, Sun N, Jiang Z, Liu H, Ge X, Zheng J, Yang J, Ikezoe T
International journal of medical sciences 2021;18(15):3437-3451
International journal of medical sciences 2021;18(15):3437-3451
Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury.
Li W, Li W, Wang Y, Leng Y, Xia Z
Cell death discovery 2021 Sep 29;7(1):267
Cell death discovery 2021 Sep 29;7(1):267
DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma.
Zhu B, Chen JJ, Feng Y, Yang JL, Huang H, Chung WY, Hu YL, Xue WJ
Journal of experimental & clinical cancer research : CR 2021 Nov 8;40(1):352
Journal of experimental & clinical cancer research : CR 2021 Nov 8;40(1):352
Detection of the level of DNMT1 based on self-assembled probe signal amplification technique in plasma.
Wan Z, Gong F, Zhang M, He L, Wang Y, Yu S, Liu J, Wu Y, Liu L, Wu Y, Qu L, Sun J, Yu F
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2021 Nov 15;261:120020
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2021 Nov 15;261:120020
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
Zhang Q, Wang Z, Chen X, Qiu H, Gu Y, Wang N, Wang T, Wang Z, Ma H, Zhao Y, Zhang B
International journal of molecular sciences 2021 May 24;22(11)
International journal of molecular sciences 2021 May 24;22(11)
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Zhou L, Zhang C, Yang X, Liu L, Hu J, Hou Y, Tao H, Sugimura H, Chen Z, Wang L, Chen K
Clinical and translational medicine 2021 Jun;11(6):e449
Clinical and translational medicine 2021 Jun;11(6):e449
Mechanical force inhibited hPDLSCs proliferation with the downregulation of MIR31HG via DNA methylation.
Han Y, Yang Q, Huang Y, Li X, Zhu Y, Jia L, Zheng Y, Li W
Oral diseases 2021 Jul;27(5):1268-1282
Oral diseases 2021 Jul;27(5):1268-1282
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
Wang L, Xu L, Wang Y
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis.
Xu SS, Ding JF, Shi P, Shi KH, Tao H
Cardiovascular toxicology 2021 Dec;21(12):984-999
Cardiovascular toxicology 2021 Dec;21(12):984-999
DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice.
Zhu Y, Wang X, Zhou X, Ding L, Liu D, Xu H
Biological research 2021 Aug 6;54(1):25
Biological research 2021 Aug 6;54(1):25
NNK-mediated upregulation of DEPDC1 stimulates the progression of oral squamous cell carcinoma by inhibiting CYP27B1 expression.
Guo J, Zhou S, Huang P, Xu S, Zhang G, He H, Zeng Y, Xu CX, Kim H, Tan Y
American journal of cancer research 2020;10(6):1745-1760
American journal of cancer research 2020;10(6):1745-1760
SMYD2 suppresses APC2 expression to activate the Wnt/β-catenin pathway and promotes epithelial-mesenchymal transition in colorectal cancer.
Meng F, Liu X, Lin C, Xu L, Liu J, Zhang P, Zhang X, Song J, Yan Y, Ren Z, Zhang Y
American journal of cancer research 2020;10(3):997-1011
American journal of cancer research 2020;10(3):997-1011
Small Molecule Inhibitor C188-9 Synergistically Enhances the Demethylated Activity of Low-Dose 5-Aza-2'-Deoxycytidine Against Pancreatic Cancer.
Kong R, Sun G, Li X, Wu L, Li L, Li Y, Wang F, Xuan P, Yang S, Sun B, Hu J
Frontiers in oncology 2020;10:612
Frontiers in oncology 2020;10:612
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Sivalingam K, Samikkannu T
Brain sciences 2020 Sep 5;10(9)
Brain sciences 2020 Sep 5;10(9)
Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.
Zeng H, Li T, He X, Cai S, Luo H, Chen P, Chen Y
Respiratory research 2020 Sep 3;21(1):229
Respiratory research 2020 Sep 3;21(1):229
Long noncoding RNA PVT1 promoted gallbladder cancer proliferation by epigenetically suppressing miR-18b-5p via DNA methylation.
Jin L, Cai Q, Wang S, Wang S, Wang J, Quan Z
Cell death & disease 2020 Oct 16;11(10):871
Cell death & disease 2020 Oct 16;11(10):871
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p.
Xue WL, Chen RQ, Zhang QQ, Li XH, Cao L, Li MY, Li Y, Lin G, Chen Y, Wang MJ, Zhu YC
American journal of physiology. Cell physiology 2020 May 1;318(5):C857-C869
American journal of physiology. Cell physiology 2020 May 1;318(5):C857-C869
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Yang S, Zhao N, Sun B, Yang Y, Hu Y, Zhao R
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Omer NA, Hu Y, Idriss AA, Abobaker H, Hou Z, Yang S, Ma W, Zhao R
Poultry science 2020 Jun;99(6):3121-3132
Poultry science 2020 Jun;99(6):3121-3132
Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Hu Y, Feng Y, Ding Z, Lv L, Sui Y, Sun Q, Abobaker H, Cai D, Zhao R
Poultry science 2020 Jun;99(6):3111-3120
Poultry science 2020 Jun;99(6):3111-3120
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Wu C, Guo E, Ming J, Sun W, Nie X, Sun L, Peng S, Luo M, Liu D, Zhang L, Mei Q, Long G, Hu G, Hu G
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Nanosecond pulsed electric fields enhance mesenchymal stem cells differentiation via DNMT1-regulated OCT4/NANOG gene expression.
Li K, Ning T, Wang H, Jiang Y, Zhang J, Ge Z
Stem cell research & therapy 2020 Jul 22;11(1):308
Stem cell research & therapy 2020 Jul 22;11(1):308
Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
Yang Y, Jiang W, Yang S, Qi F, Zhao R
Molecular nutrition & food research 2020 Apr;64(8):e1900823
Molecular nutrition & food research 2020 Apr;64(8):e1900823
ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas.
Chen D, Feng X, Lv Z, Xu X, Lu Y, Wu W, Wu H, Liu H, Cao L, Ye S, Chen J, Wu J
Aging 2019 Oct 25;11(20):8825-8844
Aging 2019 Oct 25;11(20):8825-8844
DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.
Yang Y, Yang S, Liu J, Feng Y, Qi F, Zhao R
Molecular nutrition & food research 2019 Jun;63(12):e1801334
Molecular nutrition & food research 2019 Jun;63(12):e1801334
LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop.
Zhu X, Du J, Yu J, Guo R, Feng Y, Qiao L, Xu Z, Yang F, Zhong G, Liu F, Cheng F, Chu M, Lin J
Journal of molecular and cellular cardiology 2019 Jan;126:60-69
Journal of molecular and cellular cardiology 2019 Jan;126:60-69
Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA†.
Jia L, Zeng Y, Hu Y, Liu J, Yin C, Niu Y, Wang C, Li J, Jia Y, Hong J, Zhao R
Biology of reproduction 2019 Apr 1;100(4):907-916
Biology of reproduction 2019 Apr 1;100(4):907-916
Dietary betaine activates hepatic VTGII expression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression.
Omer NA, Hu Y, Hu Y, Idriss AA, Abobaker H, Hou Z, Dong H, Zhao R
Journal of animal science and biotechnology 2018;9:2
Journal of animal science and biotechnology 2018;9:2
Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation.
Idriss AA, Hu Y, Hou Z, Hu Y, Sun Q, Omer NA, Abobaker H, Ni Y, Zhao R
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Mar;217:14-20
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Mar;217:14-20
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Li Y, Li L, Qian Z, Lin B, Chen J, Luo Y, Qu J, Raj JU, Gou D
Journal of the American Heart Association 2018 Mar 7;7(6)
Journal of the American Heart Association 2018 Mar 7;7(6)
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Yang S, Zhao N, Yang Y, Hu Y, Dong H, Zhao R
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
Hu Y, Sun Q, Hu Y, Hou Z, Zong Y, Omer NA, Abobaker H, Zhao R
The Journal of nutrition 2018 Mar 1;148(3):316-325
The Journal of nutrition 2018 Mar 1;148(3):316-325
Mechanism of prolactin inhibition of miR-135b via methylation in goat mammary epithelial cells.
Chen Z, Luo J, Zhang C, Ma Y, Sun S, Zhang T, Loor JJ
Journal of cellular physiology 2018 Jan;233(1):651-662
Journal of cellular physiology 2018 Jan;233(1):651-662
Melatonin-induced increase of lipid droplets accumulation and in vitro maturation in porcine oocytes is mediated by mitochondrial quiescence.
He B, Yin C, Gong Y, Liu J, Guo H, Zhao R
Journal of cellular physiology 2018 Jan;233(1):302-312
Journal of cellular physiology 2018 Jan;233(1):302-312
The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.
Zhang X, Feng Y, Wang XY, Zhang YN, Yuan CN, Zhang SF, Shen YM, Fu YF, Zhou CY, Li X, Cheng XD, Lu WG, Xie X
Cell death & disease 2018 Jan 24;9(2):93
Cell death & disease 2018 Jan 24;9(2):93
In Vivo Ovarian Cancer Gene Therapy Using CRISPR-Cas9.
He ZY, Zhang YG, Yang YH, Ma CC, Wang P, Du W, Li L, Xiang R, Song XR, Zhao X, Yao SH, Wei YQ
Human gene therapy 2018 Feb;29(2):223-233
Human gene therapy 2018 Feb;29(2):223-233
Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.
Hou Z, Sun Q, Hu Y, Yang S, Zong Y, Zhao R
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Apr;218:30-36
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Apr;218:30-36
Regulatory Axis of miR-195/497 and HMGA1-Id3 Governs Muscle Cell Proliferation and Differentiation.
Qiu H, Zhong J, Luo L, Tang Z, Liu N, Kang K, Li L, Gou D
International journal of biological sciences 2017;13(2):157-166
International journal of biological sciences 2017;13(2):157-166
Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.
Wang X, Wang Z, Wang Q, Wang H, Liang H, Liu D
Research in veterinary science 2017 Oct;114:363-369
Research in veterinary science 2017 Oct;114:363-369
Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation.
Idriss AA, Hu Y, Sun Q, Jia L, Jia Y, Omer NA, Abobaker H, Zhao R
Poultry science 2017 Jun 1;96(6):1715-1724
Poultry science 2017 Jun 1;96(6):1715-1724
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268
Oncotarget 2017 Jul 18;8(29):47250-47268
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
Jia L, Li J, He B, Jia Y, Niu Y, Wang C, Zhao R
Scientific reports 2016 Jan 13;6:19436
Scientific reports 2016 Jan 13;6:19436
HIC1 epigenetically represses CIITA transcription in B lymphocytes.
Zeng S, Yang Y, Cheng X, Zhou B, Li P, Zhao Y, Kong X, Xu Y
Biochimica et biophysica acta 2016 Dec;1859(12):1481-1489
Biochimica et biophysica acta 2016 Dec;1859(12):1481-1489
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.
Wang X, Liang Z, Xu X, Li J, Zhu Y, Meng S, Li S, Wang S, Xie B, Ji A, Liu B, Zheng X, Xie L
Cell death & disease 2016 Dec 1;7(12):e2503
Cell death & disease 2016 Dec 1;7(12):e2503
In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.
Hu Y, Sun Q, Li X, Wang M, Cai D, Li X, Zhao R
PloS one 2015;10(4):e0122643
PloS one 2015;10(4):e0122643
Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.
Li X, Sun Q, Li X, Cai D, Sui S, Jia Y, Song H, Zhao R
European journal of nutrition 2015 Oct;54(7):1201-10
European journal of nutrition 2015 Oct;54(7):1201-10
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 24206-1-AP( DNMT1 Antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DNMT1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human DNMT1. This antibody recognizes human antigen. The DNMT1 antibody has been validated for the following applications: ELISA, IP, WB, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-DNMT1 (IP:24206-1-AP, 5ug; Detection:24206-1-AP 1:500) with HEK-293 cells lysate 2500ug.
- Sample type
- cell line
