ABIN968895

antibody from antibodies-online

Targeting: DNMT1 CXXC9, DNMT, MCMT

Western blot (Recommended by provider)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

ABIN968895

Provider

antibodies-online

Product name

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 476-670) antibody

Antibody type

Monoclonal

Antigen

Human DNMT1

Description

Purified from tissue culture supernatant or ascites by affinity chromatography.

Reactivity

Human

Host

Mouse

Epitope

AA 476-670

Isotype

IgG

Antibody clone number

18

Vial size

50 μg

Concentration

250 μg/ml

Storage

-20°C

References

Submitted references

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.

Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP
Nature genetics 2000 Jul;25(3):338-42

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The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.

Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA, Jones PA
Nucleic acids research 1999 Jun 1;27(11):2291-8

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New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.

Yoder JA, Yen RW, Vertino PM, Bestor TH, Baylin SB
The Journal of biological chemistry 1996 Dec 6;271(49):31092-7

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Isolation and characterization of the cDNA encoding human DNA methyltransferase.

Yen RW, Vertino PM, Nelkin BD, Yu JJ, el-Deiry W, Cumaraswamy A, Lennon GG, Trask BJ, Celano P, Baylin SB
Nucleic acids research 1992 May 11;20(9):2287-91