BS1120

antibody from Bioworld Technology, Inc
Targeting: FANCD2 FA-D2, FACD, FAD, FANCD
Provider product page for BS1120
Western blot
Immunohistochemistry

Antibody data

Product number
BS1120 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1120, RRID:AB_1663304
Product name
FANCD2 (P216) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 182-234 of Human FANCD2.
Description
The FA proteins lack sequence homologies or motifs that could point to a molecular function. Phosphorylation of FANC(Fanconi anemia complementation group) proteins are thought to be important for the function of the FA pathway. Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451 amino acid nuclear protein that exists as two protein isoforms.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
FANCD2 protein structure - BS1120 shown in red.