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Western blot
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [10]
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- Validations
- Western blot [2]
- Immunocytochemistry [2]
- Immunohistochemistry [1]
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- Product number
- GTX30142 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX30142, RRID:AB_370446
- Product name
- FANCD2 antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse, Canine, Simian
- Host
- Rabbit
Submitted references Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination.
Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication.
The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.
Diagnosis of Fanconi anemia in children with atypical clinical features: a primary study.
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.
Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival.
HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.
The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells.
Huehls AM, Huntoon CJ, Joshi PM, Baehr CA, Wagner JM, Wang X, Lee MY, Karnitz LM
Molecular pharmacology 2016 Jan;89(1):53-62
Molecular pharmacology 2016 Jan;89(1):53-62
Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication.
Truong LN, Li Y, Sun E, Ang K, Hwang PY, Wu X
The Journal of biological chemistry 2014 Oct 17;289(42):28910-23
The Journal of biological chemistry 2014 Oct 17;289(42):28910-23
The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.
Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B
Cell reports 2014 Aug 7;8(3):807-17
Cell reports 2014 Aug 7;8(3):807-17
Diagnosis of Fanconi anemia in children with atypical clinical features: a primary study.
Liu R, Hu T, Li JH, Liang C, Gu WY, Shi XD, Wang HX
Chinese medical journal 2013 Dec;126(23):4483-6
Chinese medical journal 2013 Dec;126(23):4483-6
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.
Geng L, Huntoon CJ, Karnitz LM
The Journal of cell biology 2010 Oct 18;191(2):249-57
The Journal of cell biology 2010 Oct 18;191(2):249-57
Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.
Hicks JK, Chute CL, Paulsen MT, Ragland RL, Howlett NG, Guéranger Q, Glover TW, Canman CE
Molecular and cellular biology 2010 Mar;30(5):1217-30
Molecular and cellular biology 2010 Mar;30(5):1217-30
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Boichuk S, Hu L, Hein J, Gjoerup OV
Journal of virology 2010 Aug;84(16):8007-20
Journal of virology 2010 Aug;84(16):8007-20
Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival.
Wagner JM, Karnitz LM
Molecular pharmacology 2009 Jul;76(1):208-14
Molecular pharmacology 2009 Jul;76(1):208-14
HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.
Spardy N, Duensing A, Hoskins EE, Wells SI, Duensing S
Cancer research 2008 Dec 1;68(23):9954-63
Cancer research 2008 Dec 1;68(23):9954-63
The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells.
Spardy N, Duensing A, Charles D, Haines N, Nakahara T, Lambert PF, Duensing S
Journal of virology 2007 Dec;81(23):13265-70
Journal of virology 2007 Dec;81(23):13265-70
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Detection of human FANCD2 in HeLa whole cell lysate (GTX80101) before and after exposure to gamma irradiation using the rabbit polyclonal antibody GTX30142
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Western Blot: FANCD2 Antibody GTX30142 - Analysis of FANCD2 in human PD20 cells.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to IR. Proliferating SiHa cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. Working dilution of FancD2 polyclonal antibody is 1:500
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to IR. Proliferating U2OS cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. Working dilution of FancD2 polyclonal antibody is 1:500
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Immunohistochemistry: FANCD2 Antibody (GTX30142) - Staining of human prostate, glandular epithelium
