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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [15]
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- Validations
- Western blot [1]
- Immunocytochemistry [2]
- Immunohistochemistry [1]
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- Product number
- ABIN250520 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Fanconi Anemia, Complementation Group D2 (FANCD2) (N-Term) antibody (Biotin)
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Canine, Simian
- Host
- Rabbit
- Conjugate
- Biotin
- Epitope
- N-Term
- Vial size
- 0.05 mL
- Storage
- Store at 4°C in the dark.
Submitted references Hsp90 regulates the Fanconi anemia DNA damage response pathway.
Proteasome function is required for DNA damage response and fanconi anemia pathway activation.
Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.
Activation of the Fanconi anemia/BRCA pathway and recombination repair in the cellular response to solar ultraviolet light.
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway.
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors.
FANCF methylation contributes to chemoselectivity in ovarian cancer.
Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links.
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia.
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia.
Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links.
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
Oda T, Hayano T, Miyaso H, Takahashi N, Yamashita T
Blood 2007 Jun 1;109(11):5016-26
Blood 2007 Jun 1;109(11):5016-26
Proteasome function is required for DNA damage response and fanconi anemia pathway activation.
Jacquemont C, Taniguchi T
Cancer research 2007 Aug 1;67(15):7395-405
Cancer research 2007 Aug 1;67(15):7395-405
Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.
Mukhopadhyay SS, Leung KS, Hicks MJ, Hastings PJ, Youssoufian H, Plon SE
The Journal of cell biology 2006 Oct 23;175(2):225-35
The Journal of cell biology 2006 Oct 23;175(2):225-35
Activation of the Fanconi anemia/BRCA pathway and recombination repair in the cellular response to solar ultraviolet light.
Dunn J, Potter M, Rees A, Rünger TM
Cancer research 2006 Dec 1;66(23):11140-7
Cancer research 2006 Dec 1;66(23):11140-7
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J
The Journal of cell biology 2006 Apr 24;173(2):195-206
The Journal of cell biology 2006 Apr 24;173(2):195-206
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.
Donahue SL, Campbell C
Nucleic acids research 2004;32(10):3248-57
Nucleic acids research 2004;32(10):3248-57
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway.
Rothfuss A, Grompe M
Molecular and cellular biology 2004 Jan;24(1):123-34
Molecular and cellular biology 2004 Jan;24(1):123-34
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors.
Taniguchi T, Tischkowitz M, Ameziane N, Hodgson SV, Mathew CG, Joenje H, Mok SC, D'Andrea AD
Nature medicine 2003 May;9(5):568-74
Nature medicine 2003 May;9(5):568-74
FANCF methylation contributes to chemoselectivity in ovarian cancer.
Olopade OI, Wei M
Cancer cell 2003 May;3(5):417-20
Cancer cell 2003 May;3(5):417-20
Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links.
Sridharan D, Brown M, Lambert WC, McMahon LW, Lambert MW
Journal of cell science 2003 Mar 1;116(Pt 5):823-35
Journal of cell science 2003 Mar 1;116(Pt 5):823-35
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia.
Lensch MW, Tischkowitz M, Christianson TA, Reifsteck CA, Speckhart SA, Jakobs PM, O'Dwyer ME, Olson SB, Le Beau MM, Hodgson SV, Mathew CG, Larson RA, Bagby GC Jr
Blood 2003 Jul 1;102(1):7-16
Blood 2003 Jul 1;102(1):7-16
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD
Blood 2002 Oct 1;100(7):2414-20
Blood 2002 Oct 1;100(7):2414-20
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia.
Digweed M, Rothe S, Demuth I, Scholz R, Schindler D, Stumm M, Grompe M, Jordan A, Sperling K
Carcinogenesis 2002 Jul;23(7):1121-6
Carcinogenesis 2002 Jul;23(7):1121-6
Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links.
McMahon LW, Sangerman J, Goodman SR, Kumaresan K, Lambert MW
Biochemistry 2001 Jun 19;40(24):7025-34
Biochemistry 2001 Jun 19;40(24):7025-34
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD
Molecular cell 2001 Feb;7(2):249-62
Molecular cell 2001 Feb;7(2):249-62
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to IR. Proliferating U2OS cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope.
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to IR. Proliferating SiHa cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
