APC2

gene product
APCL
This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
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Novus Biologicals
3 antibodies
Invitrogen Antibodies
6 antibodies
antibodies-online
50 antibodies
OriGene
3 antibodies
LifeSpan BioSciences, Inc.
12 antibodies
Biorbyt
7 antibodies
Acris Antibodies GmbH
3 antibodies
GeneTex
1 antibody
Abnova Corporation
2 antibodies
Aviva Systems Biology
1 antibody
ProSci
2 antibodies
Abgent
3 antibodies
RayBiotech, Inc.
2 antibodies
Creative Diagnostics
2 antibodies
Atlas Antibodies
1 antibody
NSJ Bioreagents
1 antibody
Boster Biological Technology
1 antibody
GenWay
1 antibody
MyBioSource
1 antibody
Sigma-Aldrich
2 antibodies
United States Biological
1 antibody