Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [4]
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Validation data
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- Product number
- 10-6002-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-TRF2 Antibody
- Antibody type
- Monoclonal
- Description
- TRF2 (Telomere Repeat Binding Factor 2), a subunit of the shelterin complex, binds to duplex telomeric DNA and plays a crucial role in telomere protection. TRF2 contains an N-terminal basic domain rich in glycines and arginines (the GAR domain), a central TRFH dimerization domain, a flexible linker region and a C-terminal Myb-like DNA binding domain. TRF2 undergoes extensive post-translational modification, which in turn regulates its stability, DNA binding and cellular localization. Ubiquitylation of TRF2 by Siah1, an E3 ligase, promotes TRF2 degradation and replicative senescence of human primary fibroblasts. TRF2 is phosphorylated in response to DNA damage and this phosphorylation has been implicated in DNA double strand break repair.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
Full length recombinant TRF2 protei
n was used as the immunogen for thi
s antibody.- Isotype
- IgG
- Antibody clone number
- ABM10H3
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of TRF2. Anti- TRF2 antibody (Clone: ABM10H3) was used at 2 µg/ml on Ramos and Raji lysates.
- Protocol
- Protocol
Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of TRF2 in human Breast tissue using TRF2 antibody (Clone: ABM10H3) at 5 µg/ml.
- Protocol
- Protocol
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of TRF2 in human Colon tissue using TRF2 antibody (Clone: ABM10H3) at 5 µg/ml.
- Protocol
- Protocol
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of TRF2 in human Skin tissue using TRF2 antibody (Clone: ABM10H3) at 5 µg/ml.
- Protocol
- Protocol
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of TRF2 in Squamous cell carcinoma of Lungs using TRF2 antibody (Clone: ABM10H3) at 5 µg/ml.
- Protocol
- Protocol