Antibody data

Product number
10-6002-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-TRF2 Antibody
Antibody type
Monoclonal
Description
TRF2 (Telomere Repeat Binding Factor 2), a subunit of the shelterin complex, binds to duplex telomeric DNA and plays a crucial role in telomere protection. TRF2 contains an N-terminal basic domain rich in glycines and arginines (the GAR domain), a central TRFH dimerization domain, a flexible linker region and a C-terminal Myb-like DNA binding domain. TRF2 undergoes extensive post-translational modification, which in turn regulates its stability, DNA binding and cellular localization. Ubiquitylation of TRF2 by Siah1, an E3 ligase, promotes TRF2 degradation and replicative senescence of human primary fibroblasts. TRF2 is phosphorylated in response to DNA damage and this phosphorylation has been implicated in DNA double strand break repair.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
Full length recombinant TRF2 protei
n was used as the immunogen for thi
s antibody.
Isotype
IgG
Antibody clone number
ABM10H3
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
TERF2 protein structure - 10-6002-25 shown in red.