ABIN189464

antibody from antibodies-online

Targeting: TERF2 TRBF2, TRF2

Provider product page for ABIN189464

Western blot

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Chromatin Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [47]
Comments [0]
Validations
Western blot [2]
Immunoprecipitation [1]
Immunohistochemistry [1]

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Product number: ABIN189464 - Provider product page
Provider: antibodies-online
Product name: anti-TBP-Like 1 (TBPL1) antibody
Antibody type: Polyclonal
Description: Immunogen affinity purified
Reactivity: Human, Mouse, Rat, Simian
Host: Rabbit
Vial size: 0.1 mL
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Handling: Avoid freeze-thaw cycles

TERF2 protein structure - ABIN189464 shown in red.

Submitted references The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma.

Knecht H, Mai S
Methods in molecular biology (Clifton, N.J.) 2017;1532:93-104

Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement.

Zhang J, Tu Z, Watanabe Y, Shibuya H
Cell reports 2017 Nov 14;21(7):1715-1726

Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation.

Tu Z, Bayazit MB, Liu H, Zhang J, Busayavalasa K, Risal S, Shao J, Satyanarayana A, Coppola V, Tessarollo L, Singh M, Zheng C, Han C, Chen Z, Kaldis P, Gustafsson JÅ, Liu K
Proceedings of the National Academy of Sciences of the United States of America 2017 Jan 17;114(3):592-597

E-type cyclins modulate telomere integrity in mammalian male meiosis.

Manterola M, Sicinski P, Wolgemuth DJ
Chromosoma 2016 Jun;125(2):253-64

Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma.

Benhamou Y, Picco V, Raybaud H, Sudaka A, Chamorey E, Brolih S, Monteverde M, Merlano M, Lo Nigro C, Ambrosetti D, Pagès G
Oncotarget 2016 Jul 12;7(28):44236-44251

A role for Separase in telomere protection.

Cipressa F, Morciano P, Bosso G, Mannini L, Galati A, Raffa GD, Cacchione S, Musio A, Cenci G
Nature communications 2016 Jan 18;7:10405

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.

Burla R, Carcuro M, Torre ML, Fratini F, Crescenzi M, D'Apice MR, Spitalieri P, Raffa GD, Astrologo L, Lattanzi G, Cundari E, Raimondo D, Biroccio A, Gatti M, Saggio I
Open biology 2016 Aug;6(8)

Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis.

Sishc BJ, Nelson CB, McKenna MJ, Battaglia CL, Herndon A, Idate R, Liber HL, Bailey SM
Frontiers in oncology 2015;5:257

MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.

Shibuya H, Hernández-Hernández A, Morimoto A, Negishi L, Höög C, Watanabe Y
Cell 2015 Nov 19;163(5):1252-1266

Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells.

Ci X, Li B, Ma X, Kong F, Zheng C, Björkholm M, Jia J, Xu D
Oncotarget 2015 Nov 10;6(35):38079-92

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

Badie S, Carlos AR, Folio C, Okamoto K, Bouwman P, Jonkers J, Tarsounas M
The EMBO journal 2015 Feb 3;34(3):410-24

Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.

Stimpson KM, Sullivan LL, Kuo ME, Sullivan BA
PloS one 2014;9(3):e92432

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells.

Arora R, Lee Y, Wischnewski H, Brun CM, Schwarz T, Azzalin CM
Nature communications 2014 Oct 21;5:5220

TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends.

Wood AM, Rendtlew Danielsen JM, Lucas CA, Rice EL, Scalzo D, Shimi T, Goldman RD, Smith ED, Le Beau MM, Kosak ST
Nature communications 2014 Nov 17;5:5467

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.

Robin JD, Ludlow AT, Batten K, Magdinier F, Stadler G, Wagner KR, Shay JW, Wright WE
Genes & development 2014 Nov 15;28(22):2464-76

c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA.

Islam MA, Thomas SD, Murty VV, Sedoris KJ, Miller DM
The Journal of biological chemistry 2014 Mar 21;289(12):8521-31

The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.

Shibuya H, Ishiguro K, Watanabe Y
Nature cell biology 2014 Feb;16(2):145-56

T-oligo as an anticancer agent in colorectal cancer.

Wojdyla L, Stone AL, Sethakorn N, Uppada SB, Devito JT, Bissonnette M, Puri N
Biochemical and biophysical research communications 2014 Apr 4;446(2):596-601

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma.

Pitman RT, Wojdyla L, Puri N
Oncotarget 2013 May;4(5):761-71

Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas.

Castro-Vega LJ, Jouravleva K, Liu WY, Martinez C, Gestraud P, Hupé P, Servant N, Albaud B, Gentien D, Gad S, Richard S, Bacchetti S, Londoño-Vallejo A
Carcinogenesis 2013 May;34(5):1173-80

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.

Kappei D, Butter F, Benda C, Scheibe M, Draškovič I, Stevense M, Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R, Jessberger R, Londoño-Vallejo JA, Mann M, Buchholz F
The EMBO journal 2013 Jun 12;32(12):1681-701

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.

Chang FT, McGhie JD, Chan FL, Tang MC, Anderson MA, Mann JR, Andy Choo KH, Wong LH
Nucleic acids research 2013 Apr;41(8):4447-58

Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells.

Kar A, Saha D, Purohit G, Singh A, Kumar P, Yadav VK, Kumar P, Thakur RK, Chowdhury S
Nucleic acids research 2012 Mar;40(6):2554-65

A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.

Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y
The Journal of cell biology 2012 Jul 23;198(2):165-72

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.

Conomos D, Stutz MD, Hills M, Neumann AA, Bryan TM, Reddel RR, Pickett HA
The Journal of cell biology 2012 Dec 10;199(6):893-906

Five dysfunctional telomeres predict onset of senescence in human cells.

Kaul Z, Cesare AJ, Huschtscha LI, Neumann AA, Reddel RR
EMBO reports 2011 Dec 23;13(1):52-9

Cohesin SMC1beta protects telomeres in meiocytes.

Adelfalk C, Janschek J, Revenkova E, Blei C, Liebe B, Göb E, Alsheimer M, Benavente R, de Boer E, Novak I, Höög C, Scherthan H, Jessberger R
The Journal of cell biology 2009 Oct 19;187(2):185-99

Telomere protection by mammalian Pot1 requires interaction with Tpp1.

Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD
Nature structural & molecular biology 2007 Aug;14(8):754-61

Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.

Hockemeyer D, Daniels JP, Takai H, de Lange T
Cell 2006 Jul 14;126(1):63-77

Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase.

van Overbeek M, de Lange T
Current biology : CB 2006 Jul 11;16(13):1295-302

MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres.

Dimitrova N, de Lange T
Genes & development 2006 Dec 1;20(23):3238-43

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.

Celli GB, de Lange T
Nature cell biology 2005 Jul;7(7):712-8

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end.

Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T
The EMBO journal 2005 Jul 20;24(14):2667-78

Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.

Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T
Genes & development 2004 Sep 1;18(17):2108-19

Homologous recombination generates T-loop-sized deletions at human telomeres.

Wang RC, Smogorzewska A, de Lange T
Cell 2004 Oct 29;119(3):355-68

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.

Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T
The Journal of biological chemistry 2004 Nov 5;279(45):47264-71

TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.

Ye JZ, de Lange T
Nature genetics 2004 Jun;36(6):618-23

Significant role for p16INK4a in p53-independent telomere-directed senescence.

Jacobs JJ, de Lange T
Current biology : CB 2004 Dec 29;14(24):2302-8

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.

Karlseder J, Hoke K, Mirzoeva OK, Bakkenist C, Kastan MB, Petrini JH, de Lange T
PLoS biology 2004 Aug;2(8):E240

DNA damage foci at dysfunctional telomeres.

Takai H, Smogorzewska A, de Lange T
Current biology : CB 2003 Sep 2;13(17):1549-56

POT1 as a terminal transducer of TRF1 telomere length control.

Loayza D, De Lange T
Nature 2003 Jun 26;423(6943):1013-8

Rap1 affects the length and heterogeneity of human telomeres.

Li B, de Lange T
Molecular biology of the cell 2003 Dec;14(12):5060-8