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LearnABIN252470
antibody from antibodies-online
Targeting: TERF2
TRBF2, TRF2
Western blot
ELISA
Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [89]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Flow cytometry [3]
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- Product number
- ABIN252470 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-TBP-Like 1 (TBPL1) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 4A794-15
- Vial size
- 0.1 mg
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.
Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends.
ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.
Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes.
G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells.
Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.
Oxidative guanine base damage regulates human telomerase activity.
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Identification of non-coding RNAs associated with telomeres using a combination of enChIP and RNA sequencing.
A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.
Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.
Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA.
A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.
Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells.
Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model.
Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.
Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells.
Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.
Human RECQL1 participates in telomere maintenance.
The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence.
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.
TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation.
Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.
DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.
Inhibition of telomerase induces alternative lengthening of telomeres during human esophageal carcinogenesis.
Inhibition of telomerase recruitment and cancer cell death.
Structural and functional association of androgen receptor with telomeres in prostate cancer cells.
Human sarcomas are mosaic for telomerase-dependent and telomerase-independent telomere maintenance mechanisms: implications for telomere-based therapies.
Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus.
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner.
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.
TIN2 stability is regulated by the E3 ligase Siah2.
RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage.
Visualization of human telomerase localization by fluorescence microscopy techniques.
The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress.
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion.
Regulation of Epstein-Barr virus OriP replication by poly(ADP-ribose) polymerase 1.
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Telomere dysfunction-induced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells.
Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes.
Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence.
Androgen receptor interacts with telomeric proteins in prostate cancer cells.
Creation of a novel telomere-cutting endonuclease based on the EN domain of telomere-specific non-long terminal repeat retrotransposon, TRAS1.
Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination.
Telomeric DNA mediates de novo PML body formation.
Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates.
DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair.
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.
MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.
Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres.
Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.
The telomeric protein TRF2 is critical for the protection of A549 cells from both telomere erosion and DNA double-strand breaks driven by salvicine.
Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation.
G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells.
Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation.
Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference.
FLASH is required for histone transcription and S-phase progression.
FLASH is an essential component of Cajal bodies.
Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells.
Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia.
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.
hSnm1B is a novel telomere-associated protein.
PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase.
TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells.
DNA damage-induced phosphorylation of the human telomere-associated protein TRF2.
Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells.
Characterization of the telomere complex, TERF1 and TERF2 genes in muntjac species with fusion karyotypes.
Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2.
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.
Multiple mechanisms of telomere maintenance exist in liposarcomas.
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.
TIN2 mediates functions of TRF2 at human telomeres.
Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation.
DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line.
Regulation of WRN helicase activity in human base excision repair.
Telomere repeat binding factors TRF1, TRF2, and hRAP1 modulate replication of Epstein-Barr virus OriP.
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
Telomeric proteins regulate episomal maintenance of Epstein-Barr virus origin of plasmid replication.
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.
The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis.
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.
TRF1 is a critical trans-acting factor required for de novo telomere formation in human cells.
Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores.
Jahn A, Rane G, Paszkowski-Rogacz M, Sayols S, Bluhm A, Han CT, Draškovič I, Londoño-Vallejo JA, Kumar AP, Buchholz F, Butter F, Kappei D
EMBO reports 2017 Jun;18(6):929-946
EMBO reports 2017 Jun;18(6):929-946
Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
Kim YH, Kim KT, Lee SJ, Hong SH, Moon JY, Yoon EK, Kim S, Kim EO, Kang SH, Kim SK, Choi SI, Goh SH, Kim D, Lee SW, Ju MH, Jeong JS, Kim IH
Theranostics 2016;6(3):357-68
Theranostics 2016;6(3):357-68
TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends.
Konishi A, Izumi T, Shimizu S
The Journal of biological chemistry 2016 Sep 23;291(39):20798-810
The Journal of biological chemistry 2016 Sep 23;291(39):20798-810
ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.
Picco V, Coste I, Giraud-Panis MJ, Renno T, Gilson E, Pagès G
Oncotarget 2016 Jul 19;7(29):46615-46627
Oncotarget 2016 Jul 19;7(29):46615-46627
Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes.
Altieri P, Barisione C, Lazzarini E, Garuti A, Bezante GP, Canepa M, Spallarossa P, Tocchetti CG, Bollini S, Brunelli C, Ameri P
Journal of the American Heart Association 2016 Jan 8;5(1)
Journal of the American Heart Association 2016 Jan 8;5(1)
G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells.
Hasegawa D, Okabe S, Okamoto K, Nakano I, Shin-ya K, Seimiya H
Biochemical and biophysical research communications 2016 Feb 26;471(1):75-81
Biochemical and biophysical research communications 2016 Feb 26;471(1):75-81
Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.
Saquilabon Cruz GM, Kong X, Silva BA, Khatibzadeh N, Thai R, Berns MW, Yokomori K
Nucleic acids research 2016 Feb 18;44(3):e27
Nucleic acids research 2016 Feb 18;44(3):e27
Oxidative guanine base damage regulates human telomerase activity.
Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL
Nature structural & molecular biology 2016 Dec;23(12):1092-1100
Nature structural & molecular biology 2016 Dec;23(12):1092-1100
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R
Nature structural & molecular biology 2016 Apr;23(4):286-92
Nature structural & molecular biology 2016 Apr;23(4):286-92
Identification of non-coding RNAs associated with telomeres using a combination of enChIP and RNA sequencing.
Fujita T, Yuno M, Okuzaki D, Ohki R, Fujii H
PloS one 2015;10(4):e0123387
PloS one 2015;10(4):e0123387
A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.
Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR
Genome biology 2015 Nov 10;16:231
Genome biology 2015 Nov 10;16:231
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, La Torre M, Micheli E, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A, Cacchione S, Gatti M, Saggio I
PLoS genetics 2015 Jun;11(6):e1005167
PLoS genetics 2015 Jun;11(6):e1005167
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.
Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B
Science signaling 2015 Jun 16;8(381):ra58
Science signaling 2015 Jun 16;8(381):ra58
Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.
Clynes D, Jelinska C, Xella B, Ayyub H, Scott C, Mitson M, Taylor S, Higgs DR, Gibbons RJ
Nature communications 2015 Jul 6;6:7538
Nature communications 2015 Jul 6;6:7538
Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA.
Schertzer M, Jouravleva K, Perderiset M, Dingli F, Loew D, Le Guen T, Bardoni B, de Villartay JP, Revy P, Londoño-Vallejo A
Nucleic acids research 2015 Feb 18;43(3):1834-47
Nucleic acids research 2015 Feb 18;43(3):1834-47
A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.
Salvati E, Rizzo A, Iachettini S, Zizza P, Cingolani C, D'Angelo C, Porru M, Mondello C, Aiello A, Farsetti A, Gilson E, Leonetti C, Biroccio A
Nucleic acids research 2015 Feb 18;43(3):1759-69
Nucleic acids research 2015 Feb 18;43(3):1759-69
Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells.
Acharya S, Kaul Z, Gocha AS, Martinez AR, Harris J, Parvin JD, Groden J
PloS one 2014;9(8):e103819
PloS one 2014;9(8):e103819
Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model.
Das U, Manna K, Sinha M, Datta S, Das DK, Chakraborty A, Ghosh M, Saha KD, Dey S
PloS one 2014;9(5):e97599
PloS one 2014;9(5):e97599
Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.
Stimpson KM, Sullivan LL, Kuo ME, Sullivan BA
PloS one 2014;9(3):e92432
PloS one 2014;9(3):e92432
Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells.
Bai Y, Lathia JD, Zhang P, Flavahan W, Rich JN, Mattson MP
Glia 2014 Oct;62(10):1687-98
Glia 2014 Oct;62(10):1687-98
Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.
Kocak H, Ballew BJ, Bisht K, Eggebeen R, Hicks BD, Suman S, O'Neil A, Giri N, NCI DCEG Cancer Genomics Research Laboratory., NCI DCEG Cancer Sequencing Working Group., Maillard I, Alter BP, Keegan CE, Nandakumar J, Savage SA
Genes & development 2014 Oct 1;28(19):2090-102
Genes & development 2014 Oct 1;28(19):2090-102
Human RECQL1 participates in telomere maintenance.
Popuri V, Hsu J, Khadka P, Horvath K, Liu Y, Croteau DL, Bohr VA
Nucleic acids research 2014 May;42(9):5671-88
Nucleic acids research 2014 May;42(9):5671-88
The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence.
Münch S, Weidtkamp-Peters S, Klement K, Grigaravicius P, Monajembashi S, Salomoni P, Pandolfi PP, Weißhart K, Hemmerich P
Molecular and cellular biology 2014 May;34(10):1733-46
Molecular and cellular biology 2014 May;34(10):1733-46
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.
Edwards DN, Orren DK, Machwe A
Nucleic acids research 2014 Jul;42(12):7748-61
Nucleic acids research 2014 Jul;42(12):7748-61
TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation.
Ohishi T, Muramatsu Y, Yoshida H, Seimiya H
Molecular and cellular biology 2014 Jul;34(13):2464-78
Molecular and cellular biology 2014 Jul;34(13):2464-78
Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.
Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE
Cell 2014 Dec 4;159(6):1389-403
Cell 2014 Dec 4;159(6):1389-403
DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.
Saha B, Zitnik G, Johnson S, Nguyen Q, Risques RA, Martin GM, Oshima J
Frontiers in genetics 2013;4:129
Frontiers in genetics 2013;4:129
Inhibition of telomerase induces alternative lengthening of telomeres during human esophageal carcinogenesis.
Queisser A, Heeg S, Thaler M, von Werder A, Opitz OG
Cancer genetics 2013 Nov;206(11):374-86
Cancer genetics 2013 Nov;206(11):374-86
Inhibition of telomerase recruitment and cancer cell death.
Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR
The Journal of biological chemistry 2013 Nov 15;288(46):33171-80
The Journal of biological chemistry 2013 Nov 15;288(46):33171-80
Structural and functional association of androgen receptor with telomeres in prostate cancer cells.
Zhou J, Richardson M, Reddy V, Menon M, Barrack ER, Reddy GP, Kim SH
Aging 2013 Jan;5(1):3-17
Aging 2013 Jan;5(1):3-17
Human sarcomas are mosaic for telomerase-dependent and telomerase-independent telomere maintenance mechanisms: implications for telomere-based therapies.
Gocha AR, Nuovo G, Iwenofu OH, Groden J
The American journal of pathology 2013 Jan;182(1):41-8
The American journal of pathology 2013 Jan;182(1):41-8
Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus.
Kamranvar SA, Chen X, Masucci MG
Oncogene 2013 Dec 5;32(49):5522-30
Oncogene 2013 Dec 5;32(49):5522-30
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner.
Galati A, Magdinier F, Colasanti V, Bauwens S, Pinte S, Ricordy R, Giraud-Panis MJ, Pusch MC, Savino M, Cacchione S, Gilson E
PloS one 2012;7(4):e34386
PloS one 2012;7(4):e34386
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.
Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d'Adda di Fagagna F, Herbig U
The EMBO journal 2012 Jun 29;31(13):2839-51
The EMBO journal 2012 Jun 29;31(13):2839-51
TIN2 stability is regulated by the E3 ligase Siah2.
Bhanot M, Smith S
Molecular and cellular biology 2012 Jan;32(2):376-84
Molecular and cellular biology 2012 Jan;32(2):376-84
RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.
Ghosh AK, Rossi ML, Singh DK, Dunn C, Ramamoorthy M, Croteau DL, Liu Y, Bohr VA
The Journal of biological chemistry 2012 Jan 2;287(1):196-209
The Journal of biological chemistry 2012 Jan 2;287(1):196-209
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR
Nature 2012 Dec 13;492(7428):285-9
Nature 2012 Dec 13;492(7428):285-9
Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage.
Orlotti NI, Cimino-Reale G, Borghini E, Pennati M, Sissi C, Perrone F, Palumbo M, Daidone MG, Folini M, Zaffaroni N
Autophagy 2012 Aug;8(8):1185-96
Autophagy 2012 Aug;8(8):1185-96
Visualization of human telomerase localization by fluorescence microscopy techniques.
Abreu E, Terns RM, Terns MP
Methods in molecular biology (Clifton, N.J.) 2011;735:125-37
Methods in molecular biology (Clifton, N.J.) 2011;735:125-37
The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress.
Kamranvar SA, Masucci MG
Leukemia 2011 Jun;25(6):1017-25
Leukemia 2011 Jun;25(6):1017-25
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion.
Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J
Journal of cell science 2011 Jan 1;124(Pt 1):68-81
Journal of cell science 2011 Jan 1;124(Pt 1):68-81
Regulation of Epstein-Barr virus OriP replication by poly(ADP-ribose) polymerase 1.
Tempera I, Deng Z, Atanasiu C, Chen CJ, D'Erme M, Lieberman PM
Journal of virology 2010 May;84(10):4988-97
Journal of virology 2010 May;84(10):4988-97
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns RM, Lingner J, Terns MP
Molecular and cellular biology 2010 Jun;30(12):2971-82
Molecular and cellular biology 2010 Jun;30(12):2971-82
Telomere dysfunction-induced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells.
Brugat T, Nguyen-Khac F, Grelier A, Merle-Béral H, Delic J
Blood 2010 Jul 15;116(2):239-49
Blood 2010 Jul 15;116(2):239-49
Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes.
Stimpson KM, Song IY, Jauch A, Holtgreve-Grez H, Hayden KE, Bridger JM, Sullivan BA
PLoS genetics 2010 Aug 12;6(8)
PLoS genetics 2010 Aug 12;6(8)
Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence.
Benson EK, Lee SW, Aaronson SA
Journal of cell science 2010 Aug 1;123(Pt 15):2605-12
Journal of cell science 2010 Aug 1;123(Pt 15):2605-12
Androgen receptor interacts with telomeric proteins in prostate cancer cells.
Kim SH, Richardson M, Chinnakannu K, Bai VU, Menon M, Barrack ER, Reddy GP
The Journal of biological chemistry 2010 Apr 2;285(14):10472-6
The Journal of biological chemistry 2010 Apr 2;285(14):10472-6
Creation of a novel telomere-cutting endonuclease based on the EN domain of telomere-specific non-long terminal repeat retrotransposon, TRAS1.
Yoshitake K, Aoyagi H, Fujiwara H
Mobile DNA 2010 Apr 1;1(1):13
Mobile DNA 2010 Apr 1;1(1):13
Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination.
Draskovic I, Arnoult N, Steiner V, Bacchetti S, Lomonte P, Londoño-Vallejo A
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 15;106(37):15726-31
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 15;106(37):15726-31
Telomeric DNA mediates de novo PML body formation.
Brouwer AK, Schimmel J, Wiegant JC, Vertegaal AC, Tanke HJ, Dirks RW
Molecular biology of the cell 2009 Nov;20(22):4804-15
Molecular biology of the cell 2009 Nov;20(22):4804-15
Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates.
Bhattacharyya S, Keirsey J, Russell B, Kavecansky J, Lillard-Wetherell K, Tahmaseb K, Turchi JJ, Groden J
The Journal of biological chemistry 2009 May 29;284(22):14966-77
The Journal of biological chemistry 2009 May 29;284(22):14966-77
DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair.
Huda N, Tanaka H, Mendonca MS, Gilley D
Molecular and cellular biology 2009 Jul;29(13):3597-604
Molecular and cellular biology 2009 Jul;29(13):3597-604
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.
Cesare AJ, Kaul Z, Cohen SB, Napier CE, Pickett HA, Neumann AA, Reddel RR
Nature structural & molecular biology 2009 Dec;16(12):1244-51
Nature structural & molecular biology 2009 Dec;16(12):1244-51
MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.
Caslini C, Connelly JA, Serna A, Broccoli D, Hess JL
Molecular and cellular biology 2009 Aug;29(16):4519-26
Molecular and cellular biology 2009 Aug;29(16):4519-26
Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres.
Tatsumi Y, Ezura K, Yoshida K, Yugawa T, Narisawa-Saito M, Kiyono T, Ohta S, Obuse C, Fujita M
Genes to cells : devoted to molecular & cellular mechanisms 2008 Oct;13(10):1045-59
Genes to cells : devoted to molecular & cellular mechanisms 2008 Oct;13(10):1045-59
Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.
Kim SH, Davalos AR, Heo SJ, Rodier F, Zou Y, Beausejour C, Kaminker P, Yannone SM, Campisi J
The Journal of cell biology 2008 May 5;181(3):447-60
The Journal of cell biology 2008 May 5;181(3):447-60
The telomeric protein TRF2 is critical for the protection of A549 cells from both telomere erosion and DNA double-strand breaks driven by salvicine.
Zhang YW, Zhang ZX, Miao ZH, Ding J
Molecular pharmacology 2008 Mar;73(3):824-32
Molecular pharmacology 2008 Mar;73(3):824-32
Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation.
Muramatsu Y, Tahara H, Ono T, Tsuruo T, Seimiya H
Experimental cell research 2008 Mar 10;314(5):1115-24
Experimental cell research 2008 Mar 10;314(5):1115-24
G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells.
Huang FC, Chang CC, Lou PJ, Kuo IC, Chien CW, Chen CT, Shieh FY, Chang TC, Lin JJ
Molecular cancer research : MCR 2008 Jun;6(6):955-64
Molecular cancer research : MCR 2008 Jun;6(6):955-64
Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation.
Cristofari G, Adolf E, Reichenbach P, Sikora K, Terns RM, Terns MP, Lingner J
Molecular cell 2007 Sep 21;27(6):882-9
Molecular cell 2007 Sep 21;27(6):882-9
Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference.
Jiang WQ, Zhong ZH, Henson JD, Reddel RR
Oncogene 2007 Jul 12;26(32):4635-47
Oncogene 2007 Jul 12;26(32):4635-47
FLASH is required for histone transcription and S-phase progression.
Barcaroli D, Bongiorno-Borbone L, Terrinoni A, Hofmann TG, Rossi M, Knight RA, Matera AG, Melino G, De Laurenzi V
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 3;103(40):14808-12
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 3;103(40):14808-12
FLASH is an essential component of Cajal bodies.
Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 3;103(40):14802-7
Proceedings of the National Academy of Sciences of the United States of America 2006 Oct 3;103(40):14802-7
Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells.
Raz V, Carlotti F, Vermolen BJ, van der Poel E, Sloos WC, Knaän-Shanzer S, de Vries AA, Hoeben RC, Young IT, Tanke HJ, Garini Y, Dirks RW
Journal of cell science 2006 Oct 15;119(Pt 20):4247-56
Journal of cell science 2006 Oct 15;119(Pt 20):4247-56
Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia.
Bellon M, Datta A, Brown M, Pouliquen JF, Couppie P, Kazanji M, Nicot C
International journal of cancer 2006 Nov 1;119(9):2090-7
International journal of cancer 2006 Nov 1;119(9):2090-7
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.
Tahara H, Shin-Ya K, Seimiya H, Yamada H, Tsuruo T, Ide T
Oncogene 2006 Mar 23;25(13):1955-66
Oncogene 2006 Mar 23;25(13):1955-66
hSnm1B is a novel telomere-associated protein.
Freibaum BD, Counter CM
The Journal of biological chemistry 2006 Jun 2;281(22):15033-6
The Journal of biological chemistry 2006 Jun 2;281(22):15033-6
PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase.
Luciani JJ, Depetris D, Usson Y, Metzler-Guillemain C, Mignon-Ravix C, Mitchell MJ, Megarbane A, Sarda P, Sirma H, Moncla A, Feunteun J, Mattei MG
Journal of cell science 2006 Jun 15;119(Pt 12):2518-31
Journal of cell science 2006 Jun 15;119(Pt 12):2518-31
TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells.
Biroccio A, Rizzo A, Elli R, Koering CE, Belleville A, Benassi B, Leonetti C, Stevens MF, D'Incalci M, Zupi G, Gilson E
European journal of cancer (Oxford, England : 1990) 2006 Aug;42(12):1881-8
European journal of cancer (Oxford, England : 1990) 2006 Aug;42(12):1881-8
DNA damage-induced phosphorylation of the human telomere-associated protein TRF2.
Tanaka H, Mendonca MS, Bradshaw PS, Hoelz DJ, Malkas LH, Meyn MS, Gilley D
Proceedings of the National Academy of Sciences of the United States of America 2005 Oct 25;102(43):15539-44
Proceedings of the National Academy of Sciences of the United States of America 2005 Oct 25;102(43):15539-44
Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells.
Nijjar T, Bassett E, Garbe J, Takenaka Y, Stampfer MR, Gilley D, Yaswen P
Oncogene 2005 May 5;24(20):3369-76
Oncogene 2005 May 5;24(20):3369-76
Characterization of the telomere complex, TERF1 and TERF2 genes in muntjac species with fusion karyotypes.
Hartmann N, Scherthan H
Experimental cell research 2005 May 15;306(1):64-74
Experimental cell research 2005 May 15;306(1):64-74
Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2.
Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell MJ, Campisi J, Lelièvre SA
Journal of cell science 2005 Mar 15;118(Pt 6):1321-30
Journal of cell science 2005 Mar 15;118(Pt 6):1321-30
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T
Cancer cell 2005 Jan;7(1):25-37
Cancer cell 2005 Jan;7(1):25-37
Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.
Bradshaw PS, Stavropoulos DJ, Meyn MS
Nature genetics 2005 Feb;37(2):193-7
Nature genetics 2005 Feb;37(2):193-7
Multiple mechanisms of telomere maintenance exist in liposarcomas.
Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Aug 1;11(15):5347-55
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Aug 1;11(15):5347-55
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.
Houghtaling BR, Cuttonaro L, Chang W, Smith S
Current biology : CB 2004 Sep 21;14(18):1621-31
Current biology : CB 2004 Sep 21;14(18):1621-31
TIN2 mediates functions of TRF2 at human telomeres.
Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J
The Journal of biological chemistry 2004 Oct 15;279(42):43799-804
The Journal of biological chemistry 2004 Oct 15;279(42):43799-804
Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation.
Seimiya H, Muramatsu Y, Smith S, Tsuruo T
Molecular and cellular biology 2004 Mar;24(5):1944-55
Molecular and cellular biology 2004 Mar;24(5):1944-55
DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line.
Fotiadou P, Henegariu O, Sweasy JB
Cancer research 2004 Jun 1;64(11):3830-7
Cancer research 2004 Jun 1;64(11):3830-7
Regulation of WRN helicase activity in human base excision repair.
Ahn B, Harrigan JA, Indig FE, Wilson DM 3rd, Bohr VA
The Journal of biological chemistry 2004 Dec 17;279(51):53465-74
The Journal of biological chemistry 2004 Dec 17;279(51):53465-74
Telomere repeat binding factors TRF1, TRF2, and hRAP1 modulate replication of Epstein-Barr virus OriP.
Deng Z, Atanasiu C, Burg JS, Broccoli D, Lieberman PM
Journal of virology 2003 Nov;77(22):11992-2001
Journal of virology 2003 Nov;77(22):11992-2001
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA
The Journal of biological chemistry 2002 Oct 25;277(43):41110-9
The Journal of biological chemistry 2002 Oct 25;277(43):41110-9
Telomeric proteins regulate episomal maintenance of Epstein-Barr virus origin of plasmid replication.
Deng Z, Lezina L, Chen CJ, Shtivelband S, So W, Lieberman PM
Molecular cell 2002 Mar;9(3):493-503
Molecular cell 2002 Mar;9(3):493-503
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.
Cook BD, Dynek JN, Chang W, Shostak G, Smith S
Molecular and cellular biology 2002 Jan;22(1):332-42
Molecular and cellular biology 2002 Jan;22(1):332-42
The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis.
Stavropoulos DJ, Bradshaw PS, Li X, Pasic I, Truong K, Ikura M, Ungrin M, Meyn MS
Human molecular genetics 2002 Dec 1;11(25):3135-44
Human molecular genetics 2002 Dec 1;11(25):3135-44
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.
Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L
The EMBO journal 2001 Feb 15;20(4):905-13
The EMBO journal 2001 Feb 15;20(4):905-13
TRF1 is a critical trans-acting factor required for de novo telomere formation in human cells.
Okabe J, Eguchi A, Masago A, Hayakawa T, Nakanishi M
Human molecular genetics 2000 Nov 1;9(18):2639-50
Human molecular genetics 2000 Nov 1;9(18):2639-50
Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores.
Scherthan H, Jerratsch M, Li B, Smith S, Hultén M, Lock T, de Lange T
Molecular biology of the cell 2000 Dec;11(12):4189-203
Molecular biology of the cell 2000 Dec;11(12):4189-203
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