610701

antibody from BioLegend

Targeting: APC DP2, DP2.5, DP3, PPP1R46

Western blot (Data presented on provider website)

Antibody Data

Product number

610701

Provider

BioLegend

Product name

Purified anti-APC1

Antibody type

Polyclonal

Antigen

Recombinant (partial), N-terminal

Description

APC1 (anaphase-promoting complex subunit 1) is a meiotic checkpoint regulator that is a member of the E3 enzyme family. This protein contains Rpn1/2 repeats and has a molecular weight of approximately 216 kD. The APC1 protein is located in the nucleus during interphase, and at the centrosome during metaphase/anaphase. This protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC1 protein functions as a probable scaffold for complex assembly, a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. The APC1 protein is phosphorylated by Cdk1-cyclin B and can also be ubiquitinated and targeted for degradation. The Poly6017 antibody has been shown to be useful for Western blotting of the human APC1 protein.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

50 µl

Storage

Upon receipt, store frozen at -20° C.