611101

antibody from BioLegend

Targeting: APC DP2, DP2.5, DP3, PPP1R46

Western blot (Data presented on provider website)

Antibody Data

Product number

611101

Provider

BioLegend

Proper citation

BioLegend Cat#611101, RRID:AB_2227120

Product name

Purified anti-APC5

Antibody type

Polyclonal

Antigen

Recombinant (partial), N-terminal

Description

APC5 (anaphase-promoting complex subunit 5) is a member of the E3 enzyme family. This protein has a molecular weight of approximately 79 kD. The APC5 protein is located in the nucleus during interphase and at the centrosome during metaphase/anaphase. This protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC5 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. The Poly6111 antibody has been shown to be useful for Western blotting of the human and mouse APC5 protein.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Vial size

50 µl

Storage

Upon receipt, store frozen at -20° C.