611501

antibody from BioLegend
Targeting: APC DP2, DP2.5, DP3, PPP1R46
Provider product page for 611501
Western blot

Antibody data

Product number
611501 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#611501, RRID:AB_2226987
Product name
Purified anti-APC10
Antibody type
Polyclonal
Antigen
Recombinant (partial), N-terminal
Description
APC10 (anaphase-promoting complex subunit 10) is a member of the E3 enzyme family. This protein contains a Doc domain and has a molecular weight of approximately 21 kD. The APC10 protein is located at the centrosomes and mitotic spindles throughout mitosis and the kinetochores from prophase to anaphase, and at the midbody during telophase and cytokinesis. The APC10 protein is involved in substrate recognition and acts as a processivity factor. The APC10 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC10 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. The Poly6115 antibody has been shown to be useful for Western blotting of the human and mouse APC10 protein.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Vial size
50 µl
Storage
Upon receipt, store frozen at -20° C.
APC protein structure - 611501 shown in red.