Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 611502 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#611502, RRID:AB_2226986
- Product name
- Purified anti-APC10
- Antibody type
- Polyclonal
- Antigen
- Recombinant (partial), N-terminal
- Description
- APC10 (anaphase-promoting complex subunit 10) is a member of the E3 enzyme family. This protein contains a Doc domain and has a molecular weight of approximately 21 kD. The APC10 protein is located at the centrosomes and mitotic spindles throughout mitosis and the kinetochores from prophase to anaphase, and at the midbody during telophase and cytokinesis. The APC10 protein is involved in substrate recognition and acts as a processivity factor. The APC10 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC10 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. The Poly6115 antibody has been shown to be useful for Western blotting of the human and mouse APC10 protein.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 200 µl
- Storage
- Upon receipt, store frozen at -20° C.
Submitted references Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits.
Tran K, Mahr JA, Choi J, Teodoro JG, Green MR, Spector DH
Journal of virology 2008 Jan;82(1):529-37
Journal of virology 2008 Jan;82(1):529-37
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