611402

antibody from BioLegend
Targeting: APC DP2, DP2.5, DP3, PPP1R46
Provider product page for 611402
Western blot

Antibody data

Product number
611402 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#611402, RRID:AB_2075011
Product name
Purified anti-APC8
Antibody type
Polyclonal
Antigen
Recombinant (partial), N-terminal
Description
APC8 (anaphase-promoting complex subunit 8) is a member of the E3 enzyme family. This protein contains TPR repeats and has a molecular weight of approximately 68 kD. The APC8 protein is located in the nucleus during interphase and the centrosome during metaphase/anaphase. This protein is required for mitotic anaphase transition. The APC8 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC8 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. APC8 is phosphorylated by cdk1-cyclinB and PLK-1. The Poly6114 antibody has been shown to be useful for Western blotting of the human and mouse APC8 protein.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Vial size
200 µl
Storage
Upon receipt, store frozen at -20° C.
APC protein structure - 611402 shown in red.