Ab089133

antibody from Aladdin Scientific

Targeting: APC DP2, DP2.5, DP3, PPP1R46

Immunocytochemistry

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Validation data

Product number: Ab089133 - Provider product page
Provider: Aladdin Scientific
Product name: Recombinant APC Antibody
Antibody type: Recombinant
Description: Rabbit anti Human APC Antibody, Recombinant, could be used for WB, IF, ICC and so on.Application:WB: 1/500-1/1000IF: 1/50-1/200Protein functionTumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: AA 72-90
Vial size: 100_l,10_l,1ml,50_l
Concentration: 1,4 mg/ml
Storage: Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

APC protein structure - Ab089133 shown in red.