Antibody data
- Antibody Data
- Antigen structure
- References [48]
- Comments [0]
- Validations [0]
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Validation data
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- Product number
- 10934-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10934-1-AP, RRID:AB_2275319
- Product name
- Cyclin D2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Cyclin D2 antibody (Cat. #10934-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway.
IFRD2, a target of miR-2400, regulates myogenic differentiation of bovine skeletal muscle satellite cells via decreased phosphorylation of ERK1/2 proteins.
Downregulation of lncRNA NEAT1 interacts with miR-374b-5p/PGAP1 axis to aggravate the development of osteoarthritis.
Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.
Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice.
Effect of bovine myosin heavy chain 3 on proliferation and differentiation of myoblast.
Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia.
Progesterone Induces Apoptosis and Steroidogenesis in Porcine Placental Trophoblasts.
Bta-miR-493 Inhibits Bovine Preadipocytes Differentiation by Targeting BMPR1A via the TGFβ/BMP and p38MAPK Signaling Pathways.
Proliferation of bovine myoblast by LncPRRX1 via regulation of the miR-137/CDC42 axis.
NUP153 promotes HCC cells proliferation via c-Myc-mediated downregulation of P15(INK4b).
Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability.
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
Expression and Functional Analysis of lncRNAs Involved in Platelet-Derived Growth Factor-BB-Induced Proliferation of Human Aortic Smooth Muscle Cells.
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia.
Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells.
MiR-33a plays an crucial role in the proliferation of bovine preadipocytes.
Long non-coding RNA CRNDE exacerbates NPC advancement mediated by the miR-545-5p/CCND2 axis.
NEK7 promotes gastric cancer progression as a cell proliferation regulator.
MicroRNA miR-204 regulates proliferation and differentiation of oligodendroglia in culture.
Grape Extract Activates Brown Adipose Tissue Through Pathway Involving the Regulation of Gut Microbiota and Bile Acid.
LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer.
Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis.
ADAR1 may be involved in the proliferation of acute myeloid leukemia cells via regulation of the Wnt pathway.
MicroRNA-191 promotes hepatocellular carcinoma cell proliferation by has_circ_0000204/miR-191/KLF6 axis.
Cisplatin decreases cyclin D2 expression via upregulating miR‑93 to inhibit lung adenocarcinoma cell growth.
Chronic Dexamethasone exposure activates the TLR4-Mediated inflammation pathway and induces epithelial apoptosis in the goat colon.
Effects of chronic dexamethasone exposure on bile acid metabolism and cecal epithelia function in goats.
The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.
Transcription factor MafB may play an important role in secondary hyperparathyroidism.
Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma.
Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.
Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo.
Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.
Sj7170, a unique dual-function peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom.
De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression.
C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis.
Gene expression signatures differentiate uterine endometrial stromal sarcoma from leiomyosarcoma.
Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets.
Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma.
miR-29c induces cell cycle arrest in esophageal squamous cell carcinoma by modulating cyclin E expression.
Gene expression profile changes and possible molecular subtypes in differentiated-type nonkeratinizing nasopharyngeal carcinoma.
Xu J, Wu X, Zhu H, Zhu Y, Du K, Deng X, Wang C
Medical oncology (Northwood, London, England) 2024 Feb 12;41(3):72
Medical oncology (Northwood, London, England) 2024 Feb 12;41(3):72
IFRD2, a target of miR-2400, regulates myogenic differentiation of bovine skeletal muscle satellite cells via decreased phosphorylation of ERK1/2 proteins.
Gong Z, Zhang X, Cui J, Chen W, Huang X, Yang Q, Li T, Zhang W
Journal of muscle research and cell motility 2024 Dec;45(4):253-262
Journal of muscle research and cell motility 2024 Dec;45(4):253-262
Downregulation of lncRNA NEAT1 interacts with miR-374b-5p/PGAP1 axis to aggravate the development of osteoarthritis.
Huang F, Su Z, Yang J, Zhao X, Xu Y
Journal of orthopaedic surgery and research 2023 Sep 11;18(1):670
Journal of orthopaedic surgery and research 2023 Sep 11;18(1):670
Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation.
Qian X, Zhu L, Xu M, Liu H, Yu X, Shao Q, Qin J
Chemico-biological interactions 2023 Sep 1;382:110588
Chemico-biological interactions 2023 Sep 1;382:110588
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.
Ren Y, Zhu X, Fu K, Zhang H, Zhao W, Lin Y, Fang Q, Wang J, Chen Y, Guo D
Biochemical pharmacology 2023 Jan;207:115355
Biochemical pharmacology 2023 Jan;207:115355
Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice.
Zhang Y, Liu J, Li X, Zhou G, Sang Y, Zhang M, Gao L, Xue J, Zhao M, Yu H, Zhou X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113556
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113556
Effect of bovine myosin heavy chain 3 on proliferation and differentiation of myoblast.
Tang J, Yang B, Song G, Zhang X, Wang Z, Mo Z, Zan L, Wang H
Animal biotechnology 2023 Dec;34(9):4337-4346
Animal biotechnology 2023 Dec;34(9):4337-4346
Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia.
Issa H, Swart LE, Rasouli M, Ashtiani M, Nakjang S, Jyotsana N, Schuschel K, Heuser M, Blair H, Heidenreich O
Leukemia 2023 Apr;37(4):820-834
Leukemia 2023 Apr;37(4):820-834
Progesterone Induces Apoptosis and Steroidogenesis in Porcine Placental Trophoblasts.
Liu Y, Ding H, Yang Y, Liu Y, Cao X, Feng T
Animals : an open access journal from MDPI 2022 Oct 8;12(19)
Animals : an open access journal from MDPI 2022 Oct 8;12(19)
Bta-miR-493 Inhibits Bovine Preadipocytes Differentiation by Targeting BMPR1A via the TGFβ/BMP and p38MAPK Signaling Pathways.
Long F, Wang X, Wan Y, Zhang Z, Zhang W, Zan L, Cheng G
Journal of agricultural and food chemistry 2022 Nov 23;70(46):14641-14653
Journal of agricultural and food chemistry 2022 Nov 23;70(46):14641-14653
Proliferation of bovine myoblast by LncPRRX1 via regulation of the miR-137/CDC42 axis.
Zhang W, Sun B, Zhao Y, Raza SHA, Li Y, Wang J, Ma X, Almohaimeed HM, Shaheen S, Al-Sarraj F, Albiheyri R, Mei C, Zan L
International journal of biological macromolecules 2022 Nov 1;220:33-42
International journal of biological macromolecules 2022 Nov 1;220:33-42
NUP153 promotes HCC cells proliferation via c-Myc-mediated downregulation of P15(INK4b).
Gan C, Zhou K, Li M, Shang J, Liu L, Zhao Q
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2022 Dec;54(12):1706-1715
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2022 Dec;54(12):1706-1715
Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability.
Min Z, Xin H, Liu X, Wan J, Fan Z, Rao X, Fan J, Yang L, Li D
iScience 2022 Dec 22;25(12):105552
iScience 2022 Dec 22;25(12):105552
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
Song H, Zhuang L, Xu X, Shi J, Hu W, Liu Z, Shi S
Frontiers in medicine 2021;8:777563
Frontiers in medicine 2021;8:777563
Expression and Functional Analysis of lncRNAs Involved in Platelet-Derived Growth Factor-BB-Induced Proliferation of Human Aortic Smooth Muscle Cells.
Lin JJ, Chen W, Gong M, Xu X, Du MY, Wang SF, Yang LY, Wang Y, Liu KX, Kong P, Li B, Liu K, Li YM, Dong LH, Sun SG
Frontiers in cardiovascular medicine 2021;8:702718
Frontiers in cardiovascular medicine 2021;8:702718
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
Bai M, Cui M, Li M, Yao X, Wu Y, Zheng L, Sun L, Song Q, Wang S, Liu L, Yu C, Huang Y
International journal of biological sciences 2021;17(13):3493-3507
International journal of biological sciences 2021;17(13):3493-3507
GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia.
Zhou C, Du J, Zhao L, Liu W, Zhao T, Liang H, Fang P, Zhang K, Zeng H
Cell death & disease 2021 Mar 3;12(3):231
Cell death & disease 2021 Mar 3;12(3):231
Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.
Gong Y, Li Z, Zou S, Deng D, Lai P, Hu H, Yao Y, Hu L, Zhang S, Li K, Wei T, Zhao X, Xiao G, Chen Z, Jiang Y, Bai X, Zou Z
Developmental cell 2021 Jul 26;56(14):2103-2120.e9
Developmental cell 2021 Jul 26;56(14):2103-2120.e9
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
Ma L, Li C, Lian S, Xu B, Yuan J, Lu J, Yang H, Guo J, Ji H
Molecular and cellular endocrinology 2021 Jan 1;519:111055
Molecular and cellular endocrinology 2021 Jan 1;519:111055
Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells.
Nakatani K, Matsuo H, Harata Y, Higashitani M, Koyama A, Noura M, Nishinaka-Arai Y, Kamikubo Y, Adachi S
International journal of hematology 2021 Feb;113(2):243-253
International journal of hematology 2021 Feb;113(2):243-253
MiR-33a plays an crucial role in the proliferation of bovine preadipocytes.
Zhang W, Wang L, Raza SHA, Wang X, Wang G, Liang C, Cheng G, Li B, Zan L
Adipocyte 2021 Dec;10(1):189-200
Adipocyte 2021 Dec;10(1):189-200
Long non-coding RNA CRNDE exacerbates NPC advancement mediated by the miR-545-5p/CCND2 axis.
Ge S, Jiang C, Li M, Cheng Z, Feng X
Cancer cell international 2021 Dec 4;21(1):650
Cancer cell international 2021 Dec 4;21(1):650
NEK7 promotes gastric cancer progression as a cell proliferation regulator.
Li YK, Zhu XR, Zhan Y, Yuan WZ, Jin WL
Cancer cell international 2021 Aug 21;21(1):438
Cancer cell international 2021 Aug 21;21(1):438
MicroRNA miR-204 regulates proliferation and differentiation of oligodendroglia in culture.
Wittstatt J, Weider M, Wegner M, Reiprich S
Glia 2020 Oct;68(10):2015-2027
Glia 2020 Oct;68(10):2015-2027
Grape Extract Activates Brown Adipose Tissue Through Pathway Involving the Regulation of Gut Microbiota and Bile Acid.
Han X, Guo J, Yin M, Liu Y, You Y, Zhan J, Huang W
Molecular nutrition & food research 2020 May;64(10):e2000149
Molecular nutrition & food research 2020 May;64(10):e2000149
LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer.
Jin X, Ge LP, Li DQ, Shao ZM, Di GH, Xu XE, Jiang YZ
Molecular cancer 2020 May 11;19(1):87
Molecular cancer 2020 May 11;19(1):87
Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis.
Zha C, Meng X, Li L, Mi S, Qian D, Li Z, Wu P, Hu S, Zhao S, Cai J, Liu Y
Cancer biology & medicine 2020 Feb 15;17(1):154-168
Cancer biology & medicine 2020 Feb 15;17(1):154-168
ADAR1 may be involved in the proliferation of acute myeloid leukemia cells via regulation of the Wnt pathway.
Xiao H, Cheng Q, Wu X, Tang Y, Liu J, Li X
Cancer management and research 2019;11:8547-8555
Cancer management and research 2019;11:8547-8555
MicroRNA-191 promotes hepatocellular carcinoma cell proliferation by has_circ_0000204/miR-191/KLF6 axis.
Tian F, Yu C, Wu M, Wu X, Wan L, Zhu X
Cell proliferation 2019 Sep;52(5):e12635
Cell proliferation 2019 Sep;52(5):e12635
Cisplatin decreases cyclin D2 expression via upregulating miR‑93 to inhibit lung adenocarcinoma cell growth.
Xie N, Liu YR, Li YM, Yang YN, Pan L, Wei YB, Wang PY, Li YJ, Xie SY
Molecular medicine reports 2019 Oct;20(4):3355-3362
Molecular medicine reports 2019 Oct;20(4):3355-3362
Chronic Dexamethasone exposure activates the TLR4-Mediated inflammation pathway and induces epithelial apoptosis in the goat colon.
Cai L, Hua C, Geng Y, Chen Q, Niu L, Tao S, Ni Y, Zhao R
Biochemical and biophysical research communications 2019 Oct 8;518(1):7-13
Biochemical and biophysical research communications 2019 Oct 8;518(1):7-13
Effects of chronic dexamethasone exposure on bile acid metabolism and cecal epithelia function in goats.
Hua C, Geng Y, Chen Q, Niu L, Cai L, Tao S, Ni Y, Zhao R
Domestic animal endocrinology 2018 Oct;65:9-16
Domestic animal endocrinology 2018 Oct;65:9-16
The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.
Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Osborne C, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O
Cancer cell 2018 Oct 8;34(4):626-642.e8
Cancer cell 2018 Oct 8;34(4):626-642.e8
Transcription factor MafB may play an important role in secondary hyperparathyroidism.
Morito N, Yoh K, Usui T, Oishi H, Ojima M, Fujita A, Koshida R, Shawki HH, Hamada M, Muratani M, Yamagata K, Takahashi S
Kidney international 2018 Jan;93(1):54-68
Kidney international 2018 Jan;93(1):54-68
Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma.
Davidson B, Hellesylt E, Holth A, Danielsen HE, Skeie-Jensen T, Katz B
Virchows Archiv : an international journal of pathology 2017 Sep;471(3):355-362
Virchows Archiv : an international journal of pathology 2017 Sep;471(3):355-362
Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.
Yang Y, Li X, Sun Q, He B, Jia Y, Cai D, Zhao R
The international journal of biochemistry & cell biology 2016 Oct;79:222-230
The international journal of biochemistry & cell biology 2016 Oct;79:222-230
Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo.
Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, Liu X
International journal of oncology 2015 Jan;46(1):360-8
International journal of oncology 2015 Jan;46(1):360-8
Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.
Cai D, Yuan M, Jia Y, Liu H, Hu Y, Zhao R
The Journal of nutritional biochemistry 2015 Dec;26(12):1622-31
The Journal of nutritional biochemistry 2015 Dec;26(12):1622-31
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.
Boumahdi S, Driessens G, Lapouge G, Rorive S, Nassar D, Le Mercier M, Delatte B, Caauwe A, Lenglez S, Nkusi E, Brohée S, Salmon I, Dubois C, del Marmol V, Fuks F, Beck B, Blanpain C
Nature 2014 Jul 10;511(7508):246-50
Nature 2014 Jul 10;511(7508):246-50
Sj7170, a unique dual-function peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom.
Song Y, Gong K, Yan H, Hong W, Wang L, Wu Y, Li W, Li W, Cao Z
The Journal of biological chemistry 2014 Apr 25;289(17):11667-11680
The Journal of biological chemistry 2014 Apr 25;289(17):11667-11680
De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression.
Igawa T, Sato Y, Takata K, Iwaki N, Tanaka T, Asano N, Maeda Y, Orita Y, Nakamura N, Nakamura S, Yoshino T
Diagnostic pathology 2013 May 15;8:81
Diagnostic pathology 2013 May 15;8:81
C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis.
Hu HM, Chen Y, Liu L, Zhang CG, Wang W, Gong K, Huang Z, Guo MX, Li WX, Li W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Jan;27(1):163-73
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Jan;27(1):163-73
Gene expression signatures differentiate uterine endometrial stromal sarcoma from leiomyosarcoma.
Davidson B, Abeler VM, Hellesylt E, Holth A, Shih IeM, Skeie-Jensen T, Chen L, Yang Y, Wang TL
Gynecologic oncology 2013 Feb;128(2):349-55
Gynecologic oncology 2013 Feb;128(2):349-55
Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets.
Wang W, Peng B, Wang D, Ma X, Jiang D, Zhao J, Yu L
International journal of cancer 2011 Oct 1;129(7):1624-34
International journal of cancer 2011 Oct 1;129(7):1624-34
Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma.
Igawa T, Sato Y, Takata K, Fushimi S, Tamura M, Nakamura N, Maeda Y, Orita Y, Tanimoto M, Yoshino T
Cancer science 2011 Nov;102(11):2103-7
Cancer science 2011 Nov;102(11):2103-7
miR-29c induces cell cycle arrest in esophageal squamous cell carcinoma by modulating cyclin E expression.
Ding DP, Chen ZL, Zhao XH, Wang JW, Sun J, Wang Z, Tan FW, Tan XG, Li BZ, Zhou F, Shao K, Li N, Qiu B, He J
Carcinogenesis 2011 Jul;32(7):1025-32
Carcinogenesis 2011 Jul;32(7):1025-32
Gene expression profile changes and possible molecular subtypes in differentiated-type nonkeratinizing nasopharyngeal carcinoma.
Wang S, Li X, Li ZG, Lu J, Fang WY, Ding YQ, Yao KT
International journal of cancer 2011 Feb 15;128(4):753-62
International journal of cancer 2011 Feb 15;128(4):753-62
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No validations: Submit validation data