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Western blot
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Other assayAntibody data
- Antibody Data
- Antigen structure
- References [17]
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- Other assay [1]
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- Product number
- MA5-12712 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Cyclin D2 Monoclonal Antibody (DCS-3.1)
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MA5-12712 targets Cyclin D2 in FACS, IF, IP, and WB applications and shows reactivity with Human, mouse, and Rat samples. The MA5-12712 immunogen is purified human recombinant full length cyclin D2 protein.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- DCS-3.1
- Vial size
- 500 µL
- Concentration
- 0.2 mg/mL
- Storage
- 4° C
Submitted references Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults.
GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1).
Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.
β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis.
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.
Adaptive beta-cell proliferation is severely restricted with advanced age.
Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine.
Molecular characterization of spontaneous mesenchymal stem cell transformation.
Selective cortical interneuron and GABA deficits in cyclin D2-null mice.
Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice.
Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation.
Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.
Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation.
Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells.
v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity.
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity.
Regulation of exit from quiescence by p27 and cyclin D1-CDK4.
Yang Y, Chang BH, Chan L
EMBO molecular medicine 2013 Jan;5(1):92-104
EMBO molecular medicine 2013 Jan;5(1):92-104
GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1).
Stein J, Milewski WM, Hara M, Steiner DF, Dey A
Islets 2011 Jan-Feb;3(1):21-34
Islets 2011 Jan-Feb;3(1):21-34
Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.
Zhang Q, Sakamoto K, Liu C, Triplett AA, Lin WC, Rui H, Wagner KU
Cancer research 2011 Dec 15;71(24):7513-24
Cancer research 2011 Dec 15;71(24):7513-24
β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis.
Mirando AJ, Maruyama T, Fu J, Yu HM, Hsu W
BMC developmental biology 2010 Nov 26;10:116
BMC developmental biology 2010 Nov 26;10:116
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.
Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG Jr, Bommi-Reddy A
Cancer cell 2009 Nov 6;16(5):413-24
Cancer cell 2009 Nov 6;16(5):413-24
Adaptive beta-cell proliferation is severely restricted with advanced age.
Rankin MM, Kushner JA
Diabetes 2009 Jun;58(6):1365-72
Diabetes 2009 Jun;58(6):1365-72
Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine.
Zheng Y, Bie W, Yang R, Perekatt AO, Poole AJ, Tyner AL
Cancer biology & therapy 2008 Jun;7(6):873-9
Cancer biology & therapy 2008 Jun;7(6):873-9
Molecular characterization of spontaneous mesenchymal stem cell transformation.
Rubio D, Garcia S, Paz MF, De la Cueva T, Lopez-Fernandez LA, Lloyd AC, Garcia-Castro J, Bernad A
PloS one 2008 Jan 2;3(1):e1398
PloS one 2008 Jan 2;3(1):e1398
Selective cortical interneuron and GABA deficits in cyclin D2-null mice.
Glickstein SB, Moore H, Slowinska B, Racchumi J, Suh M, Chuhma N, Ross ME
Development (Cambridge, England) 2007 Nov;134(22):4083-93
Development (Cambridge, England) 2007 Nov;134(22):4083-93
Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice.
Andreu-Vieyra C, Chen R, Matzuk MM
Endocrinology 2007 Aug;148(8):3837-49
Endocrinology 2007 Aug;148(8):3837-49
Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation.
Pogoriler J, Millen K, Utset M, Du W
Development (Cambridge, England) 2006 Oct;133(19):3929-37
Development (Cambridge, England) 2006 Oct;133(19):3929-37
Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.
Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H
Proceedings of the National Academy of Sciences of the United States of America 2005 Oct 11;102(41):14813-8
Proceedings of the National Academy of Sciences of the United States of America 2005 Oct 11;102(41):14813-8
Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation.
Chen B, Pollard JW
Molecular endocrinology (Baltimore, Md.) 2003 Jul;17(7):1368-81
Molecular endocrinology (Baltimore, Md.) 2003 Jul;17(7):1368-81
Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells.
Gupta S, Afaq F, Mukhtar H
Oncogene 2002 May 23;21(23):3727-38
Oncogene 2002 May 23;21(23):3727-38
v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity.
Clark W, Black EJ, MacLaren A, Kruse U, LaThangue N, Vogt PK, Gillespie DA
Molecular and cellular biology 2000 Apr;20(7):2529-42
Molecular and cellular biology 2000 Apr;20(7):2529-42
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity.
Tsutsui T, Hesabi B, Moons DS, Pandolfi PP, Hansel KS, Koff A, Kiyokawa H
Molecular and cellular biology 1999 Oct;19(10):7011-9
Molecular and cellular biology 1999 Oct;19(10):7011-9
Regulation of exit from quiescence by p27 and cyclin D1-CDK4.
Ladha MH, Lee KY, Upton TM, Reed MF, Ewen ME
Molecular and cellular biology 1998 Nov;18(11):6605-15
Molecular and cellular biology 1998 Nov;18(11):6605-15
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoprecipitation of Cyclin D2 using Cyclin D2 Monoclonal Antibody (MA5-12712) on Native Mouse MAD109 Cells.
